Details for: FICD

Gene ID: 11153

Symbol: FICD

Ensembl ID: ENSG00000198855

Description: FIC domain protein adenylyltransferase

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 1.17
    Marker Score: 1,681
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.07
    Marker Score: 2,265
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,796
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,021
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 489
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,410
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 443
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,730
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5,156
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,273
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.84
    Marker Score: 566
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1,241
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 379
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 652
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.71
    Marker Score: 545
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.71
    Marker Score: 11,088
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.71
    Marker Score: 1,342
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2,901
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.67
    Marker Score: 1,649
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.66
    Marker Score: 265
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.6
    Marker Score: 1,223
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.57
    Marker Score: 1,331
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.55
    Marker Score: 172
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 429
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5
    Marker Score: 322
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.5
    Marker Score: 423
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.48
    Marker Score: 156
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.47
    Marker Score: 826
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.47
    Marker Score: 328
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.47
    Marker Score: 106
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.46
    Marker Score: 1,050
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.43
    Marker Score: 430
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.42
    Marker Score: 252
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.37
    Marker Score: 181
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.36
    Marker Score: 208
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.36
    Marker Score: 114
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.35
    Marker Score: 169
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.35
    Marker Score: 465
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.34
    Marker Score: 215
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.33
    Marker Score: 227
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.33
    Marker Score: 1,270
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.33
    Marker Score: 82
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.33
    Marker Score: 82
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.32
    Marker Score: 140
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.32
    Marker Score: 282
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.32
    Marker Score: 508
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.31
    Marker Score: 125
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.31
    Marker Score: 128
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3
    Marker Score: 10,354
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.29
    Marker Score: 3,027
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.29
    Marker Score: 1,261
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.29
    Marker Score: 121
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.29
    Marker Score: 190
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.29
    Marker Score: 76
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.29
    Marker Score: 1,863
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.28
    Marker Score: 102
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.28
    Marker Score: 200
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.28
    Marker Score: 73
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.27
    Marker Score: 282
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.26
    Marker Score: 65
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.26
    Marker Score: 109
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.26
    Marker Score: 89
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.26
    Marker Score: 74
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.26
    Marker Score: 132
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.25
    Marker Score: 105
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.25
    Marker Score: 49
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.25
    Marker Score: 357
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.25
    Marker Score: 54
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.25
    Marker Score: 165
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.25
    Marker Score: 448
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.25
    Marker Score: 435
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.25
    Marker Score: 100
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.24
    Marker Score: 49
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.24
    Marker Score: 51
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.24
    Marker Score: 96
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.24
    Marker Score: 135
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.24
    Marker Score: 103
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.24
    Marker Score: 82
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.23
    Marker Score: 261
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.23
    Marker Score: 109
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.23
    Marker Score: 103
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.23
    Marker Score: 53
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.23
    Marker Score: 53
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.22
    Marker Score: 51
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.22
    Marker Score: 410
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.22
    Marker Score: 223
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.22
    Marker Score: 54
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.22
    Marker Score: 1,904
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.22
    Marker Score: 52
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.22
    Marker Score: 81
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.22
    Marker Score: 54
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.22
    Marker Score: 412
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.22
    Marker Score: 743
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.22
    Marker Score: 346
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.21
    Marker Score: 48

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FICD is a member of the FIC domain protein family, characterized by the presence of a conserved FIC domain. This domain is responsible for the protein's ability to interact with other proteins and regulate various cellular processes. FICD is a transmembrane protein with adenylyltransferase activity, allowing it to modify and regulate the activity of other proteins. The protein's ability to bind to heat shock proteins (Hsp70) and other proteins, such as Huntingtin, highlights its role in protein-protein interactions and cellular stress response. **Pathways and Functions:** FICD's involvement in multiple signaling pathways underscores its importance in maintaining cellular homeostasis. The protein's adenylyltransferase activity allows it to modify and regulate the activity of other proteins, including those involved in the unfolded protein response (UPR). FICD's interaction with Hsp70 and other chaperones suggests its role in protein folding and degradation. The protein's regulation of GTPase activity and its involvement in the UPR response to endoplasmic reticulum stress highlight its importance in maintaining cellular homeostasis. FICD's functions can be broadly categorized into the following: 1. **Regulation of protein-protein interactions:** FICD's ability to bind to other proteins, such as Huntingtin and Hsp70, highlights its role in regulating protein-protein interactions and maintaining cellular homeostasis. 2. **Modification of protein activity:** FICD's adenylyltransferase activity allows it to modify and regulate the activity of other proteins, including those involved in the UPR response. 3. **Regulation of protein folding and degradation:** FICD's interaction with Hsp70 and other chaperones suggests its role in protein folding and degradation. 4. **Response to endoplasmic reticulum stress:** FICD's involvement in the UPR response to endoplasmic reticulum stress highlights its importance in maintaining cellular homeostasis. **Clinical Significance:** FICD's involvement in multiple signaling pathways and its ability to regulate protein-protein interactions make it an attractive candidate for further investigation. Dysregulation of FICD has been implicated in various diseases, including neurodegenerative disorders and cancer. For example, alterations in FICD expression have been observed in Huntington's disease, a neurodegenerative disorder characterized by protein misfolding and aggregation. Additionally, FICD's role in regulating protein-protein interactions and its involvement in the UPR response suggest its potential as a therapeutic target for diseases characterized by cellular stress and protein misfolding. In conclusion, FICD is a multifunctional protein that plays a crucial role in maintaining cellular homeostasis. Its involvement in multiple signaling pathways and its ability to regulate protein-protein interactions make it an attractive candidate for further investigation. Further studies are needed to elucidate the role of FICD in disease and to explore its potential as a therapeutic target.

Genular Protein ID: 445786104

Symbol: FICD_HUMAN

Name: Huntingtin-interacting protein 13

UniProtKB Accession Codes:

Q9BVA6 O75406

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 20 DIP 1 DMDM 1 DNASU 1 EC 2 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 22 PDBsum 14 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 Rhea 9 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9700202

Title: Huntingtin interacts with a family of WW domain proteins.

PubMed ID: 9700202

DOI: 10.1093/hmg/7.9.1463

PubMed ID: 19362538

Title: The fic domain: regulation of cell signaling by adenylylation.

PubMed ID: 19362538

DOI: 10.1016/j.molcel.2009.03.008

PubMed ID: 22266942

Title: Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins.

PubMed ID: 22266942

DOI: 10.1038/nature10729

PubMed ID: 25601083

Title: A novel link between Fic (filamentation induced by cAMP)-mediated adenylylation/AMPylation and the unfolded protein response.

PubMed ID: 25601083

DOI: 10.1074/jbc.m114.618348

PubMed ID: 25435325

Title: Crystal structure of the human, FIC-domain containing protein HYPE and implications for its functions.

PubMed ID: 25435325

DOI: 10.1016/j.str.2014.10.007

Sequence Information:

  • Length: 458
  • Mass: 51778
  • Checksum: 8393EAA46D61C48E
  • Sequence:
    • MMLIPMASVM AVTEPKWVSV WSRFLWVTLL SMVLGSLLAL LLPLGAVEEQ CLAVLKGLYL 
LRSKPDRAQH AATKCTSPST ELSITSRGAT LLVAKTKASP AGKLEARAAL NQALEMKRQG 
KREKAQKLFM HALKMDPDFV DALTEFGIFS EEDKDIIQAD YLYTRALTIS PYHEKALVNR 
DRTLPLVEEI DQRYFSIIDS KVKKVMSIPK GNSALRRVME ETYYHHIYHT VAIEGNTLTL 
SEIRHILETR YAVPGKSLEE QNEVIGMHAA MKYINTTLVS RIGSVTISDV LEIHRRVLGY 
VDPVEAGRFR TTQVLVGHHI PPHPQDVEKQ MQEFVQWLNS EEAMNLHPVE FAALAHYKLV 
YIHPFIDGNG RTSRLLMNLI LMQAGYPPIT IRKEQRSDYY HVLEAANEGD VRPFIRFIAK 
CTETTLDTLL FATTEYSVAL PEAQPNHSGF KETLPVKP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.