Details for: LDB3

Gene ID: 11155

Symbol: LDB3

Ensembl ID: ENSG00000122367

Description: LIM domain binding 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 7.79
    Marker Score: 5,924
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 5.41
    Marker Score: 120,992
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 3.99
    Marker Score: 14,173
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 3.31
    Marker Score: 44,018
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.1
    Marker Score: 6,801
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.53
    Marker Score: 1,370
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.39
    Marker Score: 5,991
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.24
    Marker Score: 706
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.91
    Marker Score: 11,486
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.82
    Marker Score: 1,731
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.78
    Marker Score: 4,273
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.71
    Marker Score: 564
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1,167
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169,092
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.4
    Marker Score: 709
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 868
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.36
    Marker Score: 21,224
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 853
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 486
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.17
    Marker Score: 533
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,810
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 502
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.05
    Marker Score: 435
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,818
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,043
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.99
    Marker Score: 314
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.97
    Marker Score: 1,976
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,313
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.93
    Marker Score: 442
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,287
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.85
    Marker Score: 608
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.84
    Marker Score: 1,988
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.81
    Marker Score: 237
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.8
    Marker Score: 999
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.8
    Marker Score: 207
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 609
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,260
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.74
    Marker Score: 222
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 461
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.72
    Marker Score: 203
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.7
    Marker Score: 225
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.7
    Marker Score: 226
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.66
    Marker Score: 167
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.65
    Marker Score: 184
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.65
    Marker Score: 391
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.63
    Marker Score: 966
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.59
    Marker Score: 1,398
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.56
    Marker Score: 368
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.54
    Marker Score: 3,607
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.54
    Marker Score: 1,010
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.52
    Marker Score: 196
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.51
    Marker Score: 271
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.51
    Marker Score: 227
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.5
    Marker Score: 278
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.49
    Marker Score: 817
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.45
    Marker Score: 119
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.43
    Marker Score: 249
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.39
    Marker Score: 123
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.37
    Marker Score: 165
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.37
    Marker Score: 112
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.36
    Marker Score: 177
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.35
    Marker Score: 1,374
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.35
    Marker Score: 148
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.35
    Marker Score: 985
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.34
    Marker Score: 112
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.33
    Marker Score: 137
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.32
    Marker Score: 104
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.32
    Marker Score: 88
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.32
    Marker Score: 147
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.31
    Marker Score: 127
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.3
    Marker Score: 306
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.29
    Marker Score: 167
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.28
    Marker Score: 240
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.27
    Marker Score: 510
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.27
    Marker Score: 195
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.27
    Marker Score: 484
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.26
    Marker Score: 321
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.26
    Marker Score: 169
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.26
    Marker Score: 107
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.25
    Marker Score: 15,339
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.24
    Marker Score: 241
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.24
    Marker Score: 386
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.23
    Marker Score: 69
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.23
    Marker Score: 655
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.23
    Marker Score: 131
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.23
    Marker Score: 137

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LDB3 is a protein with a LIM domain, which is a functional domain involved in protein-protein interactions. The LDB3 protein is characterized by its ability to bind to various partners, including actin, muscle alpha-actinin, and protein kinase C. This binding capacity is crucial for its role in regulating the actin cytoskeleton, adherens junctions, and sarcomere structure. LDB3 is also known to interact with other proteins, such as muscle-specific kinase (MSK) and protein phosphatase 2A (PP2A), which further underscores its involvement in signaling pathways. **Pathways and Functions:** LDB3 is involved in several signaling pathways that regulate muscle development, contraction, and cellular processes. These pathways include: 1. **Actin cytoskeleton organization**: LDB3 interacts with actin and muscle alpha-actinin to regulate the organization of the actin cytoskeleton, which is essential for muscle contraction and cell motility. 2. **Adherens junction**: LDB3 binds to adherens junction proteins, such as cadherins, to regulate cell-cell adhesion and maintain tissue integrity. 3. **Sarcomere organization**: LDB3 interacts with proteins involved in sarcomere structure, such as troponin and tropomyosin, to regulate muscle contraction and relaxation. 4. **Muscle development**: LDB3 is involved in the regulation of muscle development, including the formation of sarcomeres and the organization of the actin cytoskeleton. 5. **Cytoskeletal protein binding**: LDB3 binds to various cytoskeletal proteins, including actin, muscle alpha-actinin, and protein kinase C, to regulate their activity and localization. **Clinical Significance:** Dysregulation of LDB3 has been implicated in various diseases, including: 1. **Muscular dystrophy**: Mutations in the LDB3 gene have been associated with muscular dystrophy, a group of genetic disorders characterized by progressive muscle weakness and degeneration. 2. **Cardiac arrhythmias**: Abnormalities in LDB3 expression and function have been linked to cardiac arrhythmias, including atrial fibrillation and ventricular tachycardia. 3. **Cancer**: LDB3 has been implicated in cancer progression, including the regulation of cell migration, invasion, and metastasis. In conclusion, LDB3 is a protein that plays a crucial role in regulating the actin cytoskeleton, adherens junctions, and sarcomere structure. Its dysregulation has been implicated in various diseases, including muscular dystrophy, cardiac arrhythmias, and cancer. Further research is needed to fully understand the mechanisms underlying LDB3 function and its role in disease pathogenesis.

Genular Protein ID: 4016980932

Symbol: LDB3_HUMAN

Name: LIM domain-binding protein 3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10427098

Title: ZASP: a new Z-band alternatively spliced PDZ-motif protein.

PubMed ID: 10427098

DOI: 10.1083/jcb.146.2.465

PubMed ID: 9734811

Title: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9734811

DOI: 10.1093/dnares/5.3.169

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11842093

Title: Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins.

PubMed ID: 11842093

DOI: 10.1074/jbc.m200712200

PubMed ID: 15062084

Title: Solution structure of ZASP PDZ domain; implications for sarcomere ultrastructure and enigma family redundancy.

PubMed ID: 15062084

DOI: 10.1016/j.str.2004.02.019

PubMed ID: 14662268

Title: Mutations in Cypher/ZASP in patients with dilated cardiomyopathy and left ventricular non-compaction.

PubMed ID: 14662268

DOI: 10.1016/j.jacc.2003.10.021

PubMed ID: 14660611

Title: A Cypher/ZASP mutation associated with dilated cardiomyopathy alters the binding affinity to protein kinase C.

PubMed ID: 14660611

DOI: 10.1074/jbc.m311849200

PubMed ID: 15668942

Title: Mutations in ZASP define a novel form of muscular dystrophy in humans.

PubMed ID: 15668942

DOI: 10.1002/ana.20376

Sequence Information:

  • Length: 727
  • Mass: 77135
  • Checksum: 67B5B699D2B2AB68
  • Sequence:
  • MSYSVTLTGP GPWGFRLQGG KDFNMPLTIS RITPGSKAAQ SQLSQGDLVV AIDGVNTDTM 
    THLEAQNKIK SASYNLSLTL QKSKRPIPIS TTAPPVQTPL PVIPHQKDPA LDTNGSLVAP 
    SPSPEARASP GTPGTPELRP TFSPAFSRPS AFSSLAEASD PGPPRASLRA KTSPEGARDL 
    LGPKALPGSS QPRQYNNPIG LYSAETLREM AQMYQMSLRG KASGVGLPGG SLPIKDLAVD 
    SASPVYQAVI KSQNKPEDEA DEWARRSSNL QSRSFRILAQ MTGTEFMQDP DEEALRRSST 
    PIEHAPVCTS QATTPLLPAS AQPPAAASPS AASPPLATAA AHTAIASAST TAPASSPADS 
    PRPQASSYSP AVAASSAPAT HTSYSEGPAA PAPKPRVVTT ASIRPSVYQP VPASTYSPSP 
    GANYSPTPYT PSPAPAYTPS PAPAYTPSPV PTYTPSPAPA YTPSPAPNYN PAPSVAYSGG 
    PAEPASRPPW VTDDSFSQKF APGKSTTSIS KQTLPRGGPA YTPAGPQVPP LARGTVQRAE 
    RFPASSRTPL CGHCNNVIRG PFLVAMGRSW HPEEFTCAYC KTSLADVCFV EEQNNVYCER 
    CYEQFFAPLC AKCNTKIMGE VMHALRQTWH TTCFVCAACK KPFGNSLFHM EDGEPYCEKD 
    YINLFSTKCH GCDFPVEAGD KFIEALGHTW HDTCFICAVC HVNLEGQPFY SKKDRPLCKK 
    HAHTINL

Genular Protein ID: 2647594253

Symbol: A0A0S2Z530_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 283
  • Mass: 30999
  • Checksum: 099A4472DB4D9258
  • Sequence:
  • MSYSVTLTGP GPWGFRLQGG KDFNMPLTIS RITPGSKAAQ SQLSQGDLVV AIDGVNTDTM 
    THLEAQNKIK SASYNLSLTL QKSKRPIPIS TTAPPVQTPL PVIPHQKVVV NSPANADYQE 
    RFNPSALKDS ALSTHKPIEV KGLGGKATII HAQYNTPISM YSQDAIMDAI AGQAQAQGSD 
    FSGSLPIKDL AVDSASPVYQ AVIKSQNKPE DEADEWARRS SNLQSRSFRI LAQMTGTEFM 
    QDPDEEALRR SRERFETERN SPRFAKLRNW HHGLSAQILN VKS

Genular Protein ID: 2773813693

Symbol: A0A0S2Z501_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 330
  • Mass: 35637
  • Checksum: F6B8A00A6EF9B7E0
  • Sequence:
  • MSYSVTLTGP GPWGFRLQGG KDFNMPLTIS RITPGSKAAQ SQLSQGDLVV AIDGVNTDTM 
    THLEAQNKIK SASYNLSLTL QKSKRPIPIS TTAPPVQTPL PVIPHQKDPA LDTNGSLVAP 
    SPSPEARASP GTPGTPELRP TFSPAFSRPS AFSSLAEASD PGPPRASLRA KTSPEGARDL 
    LGPKALPGSS QPRQYNNPIG LYSAETLREM AQMYQMSLRG KASGVGLPGG SLPIKDLAVD 
    SASPVYQAVI KSQNKPEDEA DEWARRSSNL QSRSFRILAQ MTGTEFMQDP DEEALRRSRE 
    RFETERNSPR FAKLRNWHHG LSAQILNVKS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.