Details for: PTP4A3

Gene ID: 11156

Symbol: PTP4A3

Ensembl ID: ENSG00000184489

Description: protein tyrosine phosphatase 4A3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.24
    Marker Score: 6,381
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.14
    Marker Score: 638
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.12
    Marker Score: 670
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.1
    Marker Score: 2,003
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.05
    Marker Score: 17,973
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.94
    Marker Score: 43,395
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.82
    Marker Score: 3,985
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.71
    Marker Score: 1,217
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.68
    Marker Score: 3,154
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.59
    Marker Score: 603
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,827
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.4
    Marker Score: 1,321
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.23
    Marker Score: 406
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.2
    Marker Score: 4,257
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.16
    Marker Score: 606
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.16
    Marker Score: 626
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.14
    Marker Score: 478
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.06
    Marker Score: 1,710
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.05
    Marker Score: 267
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,744
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1
    Marker Score: 1,453
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,764
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,988
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.98
    Marker Score: 288
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,402
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.96
    Marker Score: 2,262
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 486
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 441
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.93
    Marker Score: 3,883
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.93
    Marker Score: 1,003
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.92
    Marker Score: 1,607
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,718
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,173
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.9
    Marker Score: 256
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.9
    Marker Score: 377
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.89
    Marker Score: 356
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.88
    Marker Score: 249
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.87
    Marker Score: 222
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.87
    Marker Score: 508
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,258
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.85
    Marker Score: 232
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.84
    Marker Score: 1,390
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.82
    Marker Score: 2,096
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,262
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.77
    Marker Score: 5,038
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 0.76
    Marker Score: 426
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.74
    Marker Score: 410
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.74
    Marker Score: 829
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 377
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 552
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3,016
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.71
    Marker Score: 3,707
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.7
    Marker Score: 220
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.7
    Marker Score: 1,479
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.69
    Marker Score: 240
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.69
    Marker Score: 913
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.68
    Marker Score: 2,531
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 623
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.67
    Marker Score: 1,837
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.67
    Marker Score: 444
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.67
    Marker Score: 151
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.65
    Marker Score: 1,098
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.64
    Marker Score: 206
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.64
    Marker Score: 485
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.63
    Marker Score: 1,040
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.63
    Marker Score: 580
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.63
    Marker Score: 677
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.63
    Marker Score: 631
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.62
    Marker Score: 251
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.62
    Marker Score: 1,242
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.61
    Marker Score: 2,559
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.61
    Marker Score: 426
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.59
    Marker Score: 271
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.58
    Marker Score: 1,374
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.58
    Marker Score: 7,628
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.57
    Marker Score: 348
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.57
    Marker Score: 211
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.56
    Marker Score: 354
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.56
    Marker Score: 145
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.56
    Marker Score: 499
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.56
    Marker Score: 5,599
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.55
    Marker Score: 501
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 437
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.54
    Marker Score: 1,090
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.54
    Marker Score: 141
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.52
    Marker Score: 6,955
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.52
    Marker Score: 1,261
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.52
    Marker Score: 144
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.51
    Marker Score: 1,071
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.51
    Marker Score: 305
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.5
    Marker Score: 162
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.5
    Marker Score: 208
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.5
    Marker Score: 720
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.5
    Marker Score: 353
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.49
    Marker Score: 335
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.49
    Marker Score: 165

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PTP4A3 is a type IVA protein tyrosine phosphatase, characterized by its ability to dephosphorylate tyrosine residues on proteins. The gene is highly conserved across species, suggesting its importance in fundamental cellular processes. PTP4A3 is also known to be prenylated, a post-translational modification that anchors proteins to the plasma membrane, where it can interact with other signaling molecules. **Pathways and Functions:** PTP4A3 is involved in multiple signaling pathways, including: 1. **Notch signaling pathway**: PTP4A3 regulates the activity of Notch receptors, which are critical for cell fate decisions, cell migration, and differentiation. 2. **Vascular endothelial growth factor (VEGF) signaling pathway**: PTP4A3 modulates the activity of VEGF receptors, influencing angiogenesis, vascular permeability, and endothelial cell migration. 3. **Cytoplasmic signaling**: PTP4A3 regulates the activity of cytoplasmic kinases, such as Src and FAK, which are involved in cell migration, adhesion, and survival. 4. **DNA-templated transcription**: PTP4A3 regulates the activity of transcription factors, influencing gene expression and cellular differentiation. **Clinical Significance:** The dysregulation of PTP4A3 has been implicated in various diseases, including: 1. **Cancer**: PTP4A3 is overexpressed in several types of cancer, including breast, lung, and colon cancer, where it promotes tumor growth, invasion, and metastasis. 2. **Cardiovascular disease**: PTP4A3 is involved in the regulation of vascular permeability and endothelial cell migration, which are critical in the development of cardiovascular diseases, such as atherosclerosis and hypertension. 3. **Neurological disorders**: PTP4A3 has been implicated in the regulation of neuronal signaling pathways, which are disrupted in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. In conclusion, PTP4A3 is a multifunctional protein tyrosine phosphatase that plays a critical role in regulating various cellular processes, including signal transduction, cell migration, and gene expression. Its dysregulation has been implicated in several diseases, highlighting the importance of further research into the mechanisms of PTP4A3 and its potential therapeutic applications.

Genular Protein ID: 3348333201

Symbol: TP4A3_HUMAN

Name: Protein tyrosine phosphatase type IVA 3

UniProtKB Accession Codes:

O75365 Q8IVN5 Q99849 Q9BTW5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DEPOD 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 2 EMBL 5 EPD 1 Ensembl 16 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 4 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 6 Rhea 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9633825

Title: Multiple phosphotyrosine phosphatase mRNAs are expressed in the human lung fibroblast cell line WI-38.

PubMed ID: 9633825

PubMed ID: 11355880

Title: Role of PRL-3, a human muscle-specific tyrosine phosphatase, in angiotensin-II signaling.

PubMed ID: 11355880

DOI: 10.1006/bbrc.2001.4881

PubMed ID: 11598267

Title: A phosphatase associated with metastasis of colorectal cancer.

PubMed ID: 11598267

DOI: 10.1126/science.1065817

PubMed ID: 12235145

Title: The tyrosine phosphatase PRL-1 localizes to the endoplasmic reticulum and the mitotic spindle and is required for normal mitosis.

PubMed ID: 12235145

DOI: 10.1074/jbc.m206407200

PubMed ID: 12516958

Title: Pentamidine is an inhibitor of PRL phosphatases with anticancer activity.

PubMed ID: 12516958

PubMed ID: 12782572

Title: PRL-3 and PRL-1 promote cell migration, invasion, and metastasis.

PubMed ID: 12782572

PubMed ID: 15135076

Title: Structure of human PRL-3, the phosphatase associated with cancer metastasis.

PubMed ID: 15135076

DOI: 10.1016/j.febslet.2004.03.062

PubMed ID: 14704153

Title: Structural insights into molecular function of the metastasis-associated phosphatase PRL-3.

PubMed ID: 14704153

DOI: 10.1074/jbc.m312905200

Sequence Information:

  • Length: 173
  • Mass: 19535
  • Checksum: 15DF01999A9A3573
  • Sequence:
    • MARMNRPAPV EVSYKHMRFL ITHNPTNATL STFIEDLKKY GATTVVRVCE VTYDKTPLEK 
DGITVVDWPF DDGAPPPGKV VEDWLSLVKA KFCEAPGSCV AVHCVAGLGR APVLVALALI 
ESGMKYEDAI QFIRQKRRGA INSKQLTYLE KYRPKQRLRF KDPHTHKTRC CVM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.