Details for: LSM6
Gene ID: 11157
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: LSM6
Ensembl ID: ENSG00000164167
Description: LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 37.2rCSI 38.88%PRS 33.02
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CSI 32.21rCSI 27.89%PRS 36.01
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CSI 25.9rCSI 44.37%PRS 41.64
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CSI 24.04rCSI 21.71%PRS 30
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CSI 22.95rCSI 52.07%PRS 39.33
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CSI 20.24rCSI 16.36%PRS 32.88
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CSI 17.54rCSI 25.3%PRS 42.34
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CSI 15.78rCSI 19.81%PRS 41.12
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CSI 15.57rCSI 10.82%PRS 39.29
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CSI 14.19rCSI 18.59%PRS 44.52
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CSI 14.04rCSI 16.07%PRS 56.04
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CSI 13.94rCSI 39.78%PRS 48.23
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CSI 13.43rCSI 10.41%PRS 32.25
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CSI 11.77rCSI 9.07%PRS 31.13
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CSI 11.35rCSI 9.47%PRS 59.28
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CSI 11.15rCSI 36.16%PRS 36.79
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CSI 10.36rCSI 7.7%PRS 44.87
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CSI 10.26rCSI 11.85%PRS 28.58
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CSI 10.07rCSI 15.99%PRS 41.46
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CSI 9.88rCSI 18.69%PRS 57.45
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CSI 8.93rCSI 14.47%PRS 32.01
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CSI 7.97rCSI 10.66%PRS 54.76
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CSI 7.75rCSI 7.47%PRS 25.07
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CSI 7.6rCSI 5.05%PRS 36.96
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CSI 7.56rCSI 19.96%PRS 38.51
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CSI 6.97rCSI 9.68%PRS 32.82
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CSI 6.95rCSI 15.59%PRS 21.19
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CSI 6.79rCSI 4.01%PRS 45.04
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CSI 6.68rCSI 36.04%PRS 48.07
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CSI 6.54rCSI 18.76%PRS 47.7
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CSI 6.12rCSI 10.82%PRS 19.97
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CSI 5.82rCSI 5.38%PRS 52.61
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CSI 5.77rCSI 11.22%PRS 33.89
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CSI 5.6rCSI 6.97%PRS 34.94
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CSI 5.44rCSI 6.63%PRS 39.43
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CSI 5.42rCSI 4.12%PRS 42.24
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CSI 5.24rCSI 3.97%PRS 43.52
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CSI 5.2rCSI 22.85%PRS 52.76
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CSI 4.98rCSI 5.85%PRS 36.24
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CSI 4.92rCSI 4.32%PRS 37.1
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CSI 4.82rCSI 3.79%PRS 38.36
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CSI 4.8rCSI 6.54%PRS 61.48
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CSI 4.68rCSI 3.7%PRS 23
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CSI 4.68rCSI 9.01%PRS 62.76
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CSI 4.52rCSI 23.32%PRS 56
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CSI 4.45rCSI 19.31%PRS 49.28
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CSI 4.32rCSI 8.1%PRS 53.78
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CSI 4.19rCSI 24.01%PRS 43.91
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CSI 4.15rCSI 4.1%PRS 72.79
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CSI 4.13rCSI 6.62%PRS 64.01
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CSI 4.1rCSI 12.22%PRS 58.02
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CSI 4.02rCSI 3.71%PRS 33.75
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CSI 4rCSI 7.63%PRS 48.49
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CSI 3.99rCSI 8.79%PRS 36.34
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CSI 3.93rCSI 3.12%PRS 53.26
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CSI 3.91rCSI 4.97%PRS 37.3
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CSI 3.77rCSI 5.15%PRS 36.49
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CSI 3.73rCSI 6.01%PRS 43.5
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CSI 3.63rCSI 3.62%PRS 28.03
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CSI 3.55rCSI 5.48%PRS 30.95
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CSI 3.52rCSI 5.05%PRS 40.57
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CSI 3.51rCSI 3.61%PRS 48.89
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CSI 3.45rCSI 18.55%PRS 49.27
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CSI 3.38rCSI 5.16%PRS 50.46
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CSI 3.27rCSI 4.52%PRS 39.67
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CSI 3.26rCSI 3.2%PRS 46.9
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CSI 3.25rCSI 7.4%PRS 32.29
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CSI 3.18rCSI 2.55%PRS 53
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CSI 3.13rCSI 2.59%PRS 31.11
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CSI 3.09rCSI 4.2%PRS 45.14
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CSI 3.07rCSI 2.13%PRS 44.06
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CSI 3.07rCSI 2.54%PRS 33.23
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CSI 3.07rCSI 3.21%PRS 30.49
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CSI 3.03rCSI 2.78%PRS 38.62
-
CSI 3.02rCSI 3.87%PRS 31.19
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CSI 3rCSI 3.19%PRS 48.59
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CSI 2.97rCSI 3.03%PRS 44.52
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CSI 2.96rCSI 6.61%PRS 37.97
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CSI 2.86rCSI 4.71%PRS 37.54
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CSI 2.85rCSI 3.82%PRS 34.55
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CSI 2.85rCSI 4.5%PRS 33.22
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CSI 2.84rCSI 2.52%PRS 32.3
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CSI 2.84rCSI 2.98%PRS 34.59
-
CSI 2.8rCSI 8.27%PRS 37.25
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CSI 2.77rCSI 16.1%PRS 44.27
-
CSI 2.71rCSI 2.38%PRS 24.2
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CSI 2.7rCSI 3.25%PRS 31.47
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CSI 2.69rCSI 3.25%PRS 38.97
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CSI 2.68rCSI 1.92%PRS 43.57
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CSI 2.65rCSI 5.51%PRS 31.82
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CSI 2.62rCSI 3.8%PRS 47.3
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CSI 2.6rCSI 3.23%PRS 43.32
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CSI 2.58rCSI 2.44%PRS 33.82
-
CSI 2.52rCSI 58.79%PRS 90.48
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CSI 2.49rCSI 5.7%PRS 32.15
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CSI 2.46rCSI 3.27%PRS 36.12
-
CSI 2.46rCSI 2.06%PRS 37.52
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CSI 2.46rCSI 3.59%PRS 34.79
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CSI 2.45rCSI 6.2%PRS 39.66
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CSI 2.43rCSI 2.53%PRS 33.25
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CSI 0.1rCSI 3.6%PRS 64.0%
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CSI 0.2rCSI 0.9%PRS 44.8%
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CSI 0.2rCSI 3.1%PRS 73.4%
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CSI 0.2rCSI 3.8%PRS 80.5%
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CSI 0.3rCSI 0.8%PRS 26.2%
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CSI 0.3rCSI 2.3%PRS 52.2%
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CSI 0.3rCSI 3.0%PRS 61.6%
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CSI 0.4rCSI 0.6%PRS 48.2%
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CSI 0.4rCSI 0.9%PRS 30.3%
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CSI 0.4rCSI 2.9%PRS 65.4%
-
CSI 0.5rCSI 2.2%PRS 42.7%
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CSI 0.5rCSI 1.5%PRS 21.6%
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CSI 0.5rCSI 1.7%PRS 47.0%
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CSI 0.5rCSI 0.8%PRS 27.6%
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CSI 0.6rCSI 1.4%PRS 20.0%
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CSI 0.6rCSI 2.8%PRS 57.8%
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CSI 0.6rCSI 2.8%PRS 31.5%
-
CSI 0.6rCSI 2.8%PRS 72.2%
-
CSI 0.7rCSI 2.0%PRS 35.5%
-
CSI 0.8rCSI 2.8%PRS 49.3%
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CSI 0.8rCSI 2.7%PRS 44.2%
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CSI 0.8rCSI 1.3%PRS 25.5%
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CSI 0.8rCSI 3.7%PRS 56.2%
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CSI 0.8rCSI 3.2%PRS 51.3%
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CSI 0.8rCSI 1.7%PRS 50.2%
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CSI 0.9rCSI 2.7%PRS 41.4%
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CSI 0.9rCSI 4.3%PRS 79.6%
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CSI 0.9rCSI 2.1%PRS 48.5%
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CSI 0.9rCSI 23.2%PRS 79.8%
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CSI 0.9rCSI 1.1%PRS 51.7%
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CSI 1.0rCSI 2.8%PRS 54.5%
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CSI 1.0rCSI 3.5%PRS 71.9%
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CSI 1.0rCSI 7.1%PRS 63.1%
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CSI 1.0rCSI 1.8%PRS 30.9%
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CSI 1.0rCSI 1.5%PRS 33.8%
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CSI 1.0rCSI 6.7%PRS 69.5%
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CSI 1.0rCSI 19.6%PRS 86.6%
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CSI 1.0rCSI 1.7%PRS 20.6%
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CSI 1.1rCSI 1.7%PRS 36.8%
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CSI 1.2rCSI 2.8%PRS 44.8%
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CSI 1.2rCSI 4.8%PRS 31.4%
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CSI 1.2rCSI 2.1%PRS 25.4%
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CSI 1.2rCSI 3.1%PRS 25.5%
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CSI 1.2rCSI 2.2%PRS 31.8%
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CSI 1.3rCSI 2.7%PRS 47.4%
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CSI 1.3rCSI 1.8%PRS 34.4%
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CSI 1.3rCSI 7.6%PRS 59.4%
-
CSI 1.3rCSI 1.6%PRS 45.7%
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CSI 1.3rCSI 16.8%PRS 68.7%
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CSI 1.3rCSI 1.9%PRS 46.4%
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CSI 1.3rCSI 2.0%PRS 40.9%
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CSI 1.3rCSI 4.6%PRS 68.4%
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CSI 1.4rCSI 2.0%PRS 42.0%
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CSI 1.4rCSI 1.8%PRS 37.1%
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CSI 1.4rCSI 2.0%PRS 35.4%
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CSI 1.4rCSI 2.5%PRS 48.4%
-
CSI 1.4rCSI 1.8%PRS 29.1%
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CSI 1.5rCSI 1.1%PRS 50.3%
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CSI 1.5rCSI 1.6%PRS 30.5%
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CSI 1.5rCSI 2.3%PRS 30.3%
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CSI 1.5rCSI 3.7%PRS 43.9%
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CSI 1.5rCSI 2.1%PRS 53.6%
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CSI 1.6rCSI 4.1%PRS 55.6%
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CSI 1.6rCSI 1.4%PRS 40.4%
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CSI 1.6rCSI 1.9%PRS 24.8%
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CSI 1.6rCSI 2.9%PRS 27.5%
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CSI 1.6rCSI 7.2%PRS 28.4%
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CSI 1.6rCSI 3.1%PRS 41.2%
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CSI 1.7rCSI 2.5%PRS 33.0%
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CSI 1.7rCSI 3.1%PRS 68.8%
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CSI 1.7rCSI 4.1%PRS 44.4%
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CSI 1.7rCSI 1.1%PRS 40.7%
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CSI 1.7rCSI 3.2%PRS 24.7%
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CSI 1.8rCSI 1.3%PRS 46.7%
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CSI 1.8rCSI 1.4%PRS 33.6%
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CSI 1.8rCSI 2.7%PRS 48.8%
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CSI 1.8rCSI 2.4%PRS 28.2%
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CSI 1.8rCSI 7.1%PRS 48.9%
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CSI 1.8rCSI 3.8%PRS 40.7%
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CSI 1.8rCSI 4.6%PRS 30.8%
-
CSI 1.9rCSI 3.6%PRS 56.9%
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CSI 1.9rCSI 1.7%PRS 46.9%
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CSI 1.9rCSI 3.0%PRS 60.2%
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CSI 2.0rCSI 3.1%PRS 27.9%
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CSI 2.0rCSI 1.7%PRS 43.0%
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CSI 2.0rCSI 2.4%PRS 63.3%
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CSI 2.0rCSI 2.0%PRS 64.5%
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CSI 2.1rCSI 2.8%PRS 31.2%
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CSI 2.1rCSI 1.6%PRS 47.1%
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CSI 2.1rCSI 62.4%PRS 58.1%
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CSI 2.1rCSI 2.0%PRS 57.0%
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CSI 2.1rCSI 2.4%PRS 48.0%
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CSI 2.1rCSI 1.6%PRS 35.1%
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CSI 2.1rCSI 3.3%PRS 38.4%
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CSI 2.2rCSI 36.5%PRS 70.6%
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CSI 2.2rCSI 2.4%PRS 36.2%
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CSI 2.2rCSI 1.9%PRS 48.5%
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CSI 2.3rCSI 3.1%PRS 35.3%
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CSI 2.3rCSI 2.2%PRS 34.8%
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CSI 2.3rCSI 4.6%PRS 24.7%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2381384963
Symbol: LSM6_HUMAN
Name: U6 snRNA-associated Sm-like protein LSm6
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10369684
Title: Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin.
PubMed ID: 10369684
PubMed ID: 10523320
Title: A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro.
PubMed ID: 10523320
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12515382
Title: The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci.
PubMed ID: 12515382
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 26912367
Title: Molecular architecture of the human U4/U6.U5 tri-snRNP.
PubMed ID: 26912367
PubMed ID: 28781166
Title: Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.
PubMed ID: 28781166
Sequence Information:
- Length: 80
- Mass: 9128
- Checksum: 21167891FDE804F1
- Sequence:
MSLRKQTPSD FLKQIIGRPV VVKLNSGVDY RGVLACLDGY MNIALEQTEE YVNGQLKNKY GDAFIRGNNV LYISTQKRRM