Details for: RABL2B

Gene ID: 11158

Symbol: RABL2B

Ensembl ID: ENSG00000079974

Description: RAB, member of RAS oncogene family like 2B

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.54
    Marker Score: 22,053
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.94
    Marker Score: 920
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.79
    Marker Score: 3,410
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.49
    Marker Score: 1,455
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.32
    Marker Score: 2,035
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.28
    Marker Score: 12,205
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.22
    Marker Score: 74,726
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.21
    Marker Score: 11,428
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.16
    Marker Score: 9,960
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.04
    Marker Score: 38,332
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,740
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,965
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.99
    Marker Score: 34,357
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 481
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 436
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,715
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4,961
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,259
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.86
    Marker Score: 394
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.85
    Marker Score: 756
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.84
    Marker Score: 366
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.84
    Marker Score: 31,951
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.84
    Marker Score: 1,360
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.78
    Marker Score: 15,463
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.75
    Marker Score: 3,112
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.73
    Marker Score: 1,534
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.73
    Marker Score: 5,618
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 557
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.73
    Marker Score: 2,814
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.73
    Marker Score: 15,531
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 291
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.71
    Marker Score: 734
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.7
    Marker Score: 9,368
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.7
    Marker Score: 465
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 635
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2,873
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.68
    Marker Score: 202
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.66
    Marker Score: 362
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.65
    Marker Score: 360
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.63
    Marker Score: 347
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.62
    Marker Score: 9,294
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.61
    Marker Score: 144
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.61
    Marker Score: 297
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.61
    Marker Score: 1,037
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.59
    Marker Score: 641
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.56
    Marker Score: 1,936
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.53
    Marker Score: 425
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.53
    Marker Score: 104
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.53
    Marker Score: 319
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.52
    Marker Score: 343
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.51
    Marker Score: 577
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.51
    Marker Score: 1,037
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.51
    Marker Score: 177
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.5
    Marker Score: 148
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.5
    Marker Score: 293
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.5
    Marker Score: 524
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.5
    Marker Score: 265
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.5
    Marker Score: 835
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.49
    Marker Score: 2,055
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.49
    Marker Score: 346
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.49
    Marker Score: 1,391
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.48
    Marker Score: 2,234
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.48
    Marker Score: 1,133
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.48
    Marker Score: 2,055
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.48
    Marker Score: 104
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.47
    Marker Score: 681
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.47
    Marker Score: 342
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.47
    Marker Score: 136
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.47
    Marker Score: 315
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.47
    Marker Score: 343
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.47
    Marker Score: 197
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.47
    Marker Score: 429
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.46
    Marker Score: 1,321
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.46
    Marker Score: 296
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.46
    Marker Score: 488
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.46
    Marker Score: 391
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.46
    Marker Score: 137
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.45
    Marker Score: 480
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.45
    Marker Score: 185
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.44
    Marker Score: 417
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.44
    Marker Score: 109
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.44
    Marker Score: 202
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.44
    Marker Score: 476
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.44
    Marker Score: 5,876
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.43
    Marker Score: 175
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.43
    Marker Score: 434
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.43
    Marker Score: 1,042
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.43
    Marker Score: 491
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.42
    Marker Score: 90
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.42
    Marker Score: 265
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.42
    Marker Score: 168
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.42
    Marker Score: 22,049
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.42
    Marker Score: 106
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.41
    Marker Score: 1,110
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.41
    Marker Score: 610

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **GTPase activity**: RABL2B is a GTPase, which means it can bind and hydrolyze GTP, regulating its activity and influencing various cellular processes. 2. **Intracellular protein transport**: RABL2B is involved in the transport of proteins within the cell, which is crucial for maintaining cellular homeostasis and regulating cellular functions. 3. **Cilium assembly**: RABL2B plays a key role in the assembly and maintenance of cilia, which are essential for respiratory and neural function. 4. **Cell-specific expression**: RABL2B is significantly expressed in ciliated cells of the tracheobronchial tree, lung ciliated cells, and other neuronal populations, highlighting its specific role in these cell types. **Pathways and Functions** 1. **Centriole and ciliary basal body formation**: RABL2B is involved in the formation and maintenance of centrioles and ciliary basal bodies, which are essential for cilium assembly and function. 2. **Intraciliary transport**: RABL2B regulates the transport of proteins within the cilium, which is crucial for maintaining cilium function and overall cellular homeostasis. 3. **Endomembrane system regulation**: RABL2B is involved in the regulation of the endomembrane system, which is essential for maintaining cellular homeostasis and regulating cellular functions. 4. **GTP binding and hydrolysis**: RABL2B's GTPase activity regulates its binding and hydrolysis, influencing various cellular processes, including protein transport and cilium assembly. **Clinical Significance** 1. **Respiratory diseases**: Abnormalities in RABL2B expression or function may contribute to respiratory diseases, such as primary ciliary dyskinesia (PCD), which is characterized by chronic respiratory infections and infertility. 2. **Neurological disorders**: RABL2B's role in neuronal function and cilia assembly highlights its potential involvement in neurological disorders, such as autism spectrum disorder and Parkinson's disease. 3. **Cancer**: RABL2B's involvement in cellular homeostasis and protein transport suggests its potential role in cancer development and progression. 4. **Gene therapy**: Understanding RABL2B's functions and regulation may provide insights into developing gene therapies for diseases associated with RABL2B dysfunction. In conclusion, RABL2B is a critical gene involved in various cellular processes, including intracellular protein transport, cilium assembly, and endomembrane system regulation. Its specific expression in ciliated cells and neuronal populations highlights its unique role in maintaining cellular homeostasis and overall health. Further research is necessary to fully understand RABL2B's functions and clinical significance, which may lead to the development of novel therapeutic strategies for diseases associated with RABL2B dysfunction.

Genular Protein ID: 1157427879

Symbol: RBL2B_HUMAN

Name: Rab-like protein 2B

UniProtKB Accession Codes:

Q9UNT1 Q5TZT8 Q96C33

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 6 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 19 SAM 1 SMART 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10444334

Title: Two novel human RAB genes with near identical sequence each map to a telomere-associated region: the subtelomeric region of 22q13.3 and the ancestral telomere band 2q13.

PubMed ID: 10444334

DOI: 10.1006/geno.1999.5889

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23055941

Title: RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly.

PubMed ID: 23055941

DOI: 10.1371/journal.pgen.1002969

PubMed ID: 28625565

Title: The CEP19-RABL2 GTPase complex binds IFT-B to initiate intraflagellar transport at the ciliary base.

PubMed ID: 28625565

DOI: 10.1016/j.devcel.2017.05.016

PubMed ID: 28428259

Title: RABL2 interacts with the intraflagellar transport-B complex and CEP19 and participates in ciliary assembly.

PubMed ID: 28428259

DOI: 10.1091/mbc.e17-01-0017

Sequence Information:

  • Length: 228
  • Mass: 26101
  • Checksum: C2F4335FA0AAFD61
  • Sequence:
    • MAEDKTKPSE LDQGKYDADD NVKIICLGDS AVGKSKLMER FLMDGFQPQQ LSTYALTLYK 
HTATVDGRTI LVDFWDTAGQ ERFQSMHASY YHKAHACIMV FDVQRKVTYR NLSTWYTELR 
EFRPEIPCIV VANKIDDINV TQKSFNFAKK FSLPLYFVSA ADGTNVVKLF NDAIRLAVSY 
KQNSQDFMDE IFQELENFSL EQEEEDVPDQ EQSSSIETPS EEAASPHS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.