Details for: RABL2A

Gene ID: 11159

Symbol: RABL2A

Ensembl ID: ENSG00000144134

Description: RAB, member of RAS oncogene family like 2A

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.86
    Marker Score: 881
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.83
    Marker Score: 15,920
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.34
    Marker Score: 2,074
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.33
    Marker Score: 12,599
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.27
    Marker Score: 10,948
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.27
    Marker Score: 11,937
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.25
    Marker Score: 77,038
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.24
    Marker Score: 2,363
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.1
    Marker Score: 882
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.02
    Marker Score: 4,150
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,784
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,009
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.99
    Marker Score: 36,598
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 489
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 443
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,728
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5,113
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.89
    Marker Score: 3,075
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,294
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 312
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.85
    Marker Score: 32,276
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.82
    Marker Score: 3,187
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.82
    Marker Score: 16,266
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.8
    Marker Score: 6,157
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.8
    Marker Score: 17,001
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,268
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.78
    Marker Score: 3,217
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.76
    Marker Score: 3,203
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.76
    Marker Score: 3,180
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.75
    Marker Score: 7,730
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 562
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 380
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.72
    Marker Score: 10,781
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 288
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.72
    Marker Score: 328
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 654
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.7
    Marker Score: 1,985
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.68
    Marker Score: 1,139
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.67
    Marker Score: 23,053
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.66
    Marker Score: 649
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.62
    Marker Score: 9,753
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.58
    Marker Score: 713
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.55
    Marker Score: 740
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.55
    Marker Score: 1,144
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.55
    Marker Score: 128
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 435
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.54
    Marker Score: 159
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.54
    Marker Score: 471
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.54
    Marker Score: 580
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.53
    Marker Score: 356
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.53
    Marker Score: 292
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.5
    Marker Score: 328
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.49
    Marker Score: 177
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.48
    Marker Score: 308
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.47
    Marker Score: 804
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.47
    Marker Score: 543
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.46
    Marker Score: 458
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.46
    Marker Score: 267
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.46
    Marker Score: 552
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.45
    Marker Score: 262
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.44
    Marker Score: 236
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.44
    Marker Score: 191
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.42
    Marker Score: 152
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.42
    Marker Score: 1,924
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.41
    Marker Score: 188
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.4
    Marker Score: 966
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.4
    Marker Score: 78
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.39
    Marker Score: 399
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.39
    Marker Score: 420
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.39
    Marker Score: 489
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.38
    Marker Score: 157
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.37
    Marker Score: 719
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.37
    Marker Score: 812
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.36
    Marker Score: 738
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.36
    Marker Score: 152
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.36
    Marker Score: 133
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.36
    Marker Score: 106
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.36
    Marker Score: 234
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.35
    Marker Score: 273
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.35
    Marker Score: 111
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.35
    Marker Score: 111
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.35
    Marker Score: 338
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.35
    Marker Score: 322
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.34
    Marker Score: 11,583
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.34
    Marker Score: 108
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.34
    Marker Score: 482
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.34
    Marker Score: 590
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.34
    Marker Score: 790
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.33
    Marker Score: 85
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.33
    Marker Score: 160
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.33
    Marker Score: 166
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.32
    Marker Score: 132
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.32
    Marker Score: 88
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.32
    Marker Score: 178
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.32
    Marker Score: 81
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.32
    Marker Score: 95
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.31
    Marker Score: 278

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene Family:** RABL2A belongs to the RAB oncogene family, which consists of a group of small GTPases that regulate various cellular processes, including cell growth, differentiation, and survival. 2. **GTPase Activity:** RABL2A exhibits GTPase activity, which is essential for regulating its interaction with downstream effectors and modulating its signaling pathways. 3. **Intracellular Trafficking:** RABL2A is involved in regulating protein transport and vesicle formation, which is critical for maintaining cellular homeostasis and function. 4. **Cellular Expression:** The gene is significantly expressed in lung ciliated cells, ciliated columnar cells of the tracheobronchial tree, and certain types of neurons, suggesting its involvement in maintaining cellular homeostasis and function in these tissues. **Pathways and Functions:** 1. **Endomembrane System:** RABL2A regulates protein transport and vesicle formation in the endomembrane system, which is essential for maintaining cellular homeostasis and function. 2. **GTP Binding:** RABL2A binds to GTP, which activates its GTPase activity and allows it to interact with downstream effectors. 3. **Intracellular Protein Transport:** RABL2A regulates the transport of proteins and vesicles within the cell, which is critical for maintaining cellular homeostasis and function. 4. **Cellular Signaling:** RABL2A is involved in regulating cellular signaling pathways, including those involved in cell growth, differentiation, and survival. **Clinical Significance:** 1. **Respiratory Diseases:** RABL2A dysregulation has been implicated in various respiratory diseases, including chronic obstructive pulmonary disease (COPD) and asthma. 2. **Neurological Disorders:** RABL2A dysregulation has also been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Cancer:** RABL2A is involved in regulating cellular signaling pathways that are critical for cancer cell growth and survival. 4. **Therapeutic Targeting:** RABL2A is a potential therapeutic target for diseases characterized by impaired cellular trafficking and signaling, including respiratory and neurological disorders. In conclusion, RABL2A is a novel gene that plays a crucial role in regulating intracellular trafficking and signaling pathways in various cell types. Its dysregulation has been implicated in various diseases, including respiratory and neurological disorders, making it a potential therapeutic target for the development of novel treatments. Further studies are needed to fully understand the mechanisms of RABL2A and its role in disease pathogenesis.

Genular Protein ID: 1826128659

Symbol: RBL2A_HUMAN

Name: Rab-like protein 2A

UniProtKB Accession Codes:

Q9UBK7 B7ZBD6 Q9NU37

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 3 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 EPD 1 Ensembl 5 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 8 SAM 1 SMART 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10444334

Title: Two novel human RAB genes with near identical sequence each map to a telomere-associated region: the subtelomeric region of 22q13.3 and the ancestral telomere band 2q13.

PubMed ID: 10444334

DOI: 10.1006/geno.1999.5889

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 23055941

Title: RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly.

PubMed ID: 23055941

DOI: 10.1371/journal.pgen.1002969

Sequence Information:

  • Length: 228
  • Mass: 26115
  • Checksum: 96947DD254886B3C
  • Sequence:
    • MAEDKTKPSE LDQGKYDADD NVKIICLGDS AVGKSKLMER FLMDGFQPQQ LSTYALTLYK 
HTATVDGKTI LVDFWDTAGQ ERFQSMHASY YHKAHACIMV FDIQRKVTYR NLSTWYTELR 
EFRPEIPCIV VANKIDDINV TQKSFNFAKK FSLPLYFVSA ADGTNVVKLF NDAIRLAVSY 
KQNSQDFMDE IFQELENFSL EQEEEDVPDQ EQSSSIETPS EEVASPHS

Genular Protein ID: 2609053156

Symbol: Q6IC14_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6IC14

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 6 ExpressionAtlas 1 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 Pfam 1 RefSeq 11 SAM 1 SMART 4 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 229
  • Mass: 26186
  • Checksum: 20148DE39EC474A5
  • Sequence:
    • MAEDKTKPSE LDQGKYDADD NVKIICLGDS AVGKSKLMER FLMDGFQPQQ LSTYALTLYK 
HTATVDGKTI LVDFWDTAGQ ERFQSMHASY YHKAHACIMV FDIQRKVTYR NLSTWYTELR 
EFRPEIPCIV VANKIDADIN VTQKSFNFAK KFSLPLYFVS AADGTNVVKL FNDAIRLAVS 
YKQNSQDFMD EIFQELENFS LEQEEEDVPD QEQSSSIETP SEEVASPHS

Genular Protein ID: 1831027867

Symbol: Q2TAB6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q2TAB6

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Gene3D 1 GenomeRNAi 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 165
  • Mass: 18433
  • Checksum: 5C026A0219517BC8
  • Sequence:
    • MAEDKTKPSE LDQGKYDADD NVKIICPGDS AVGKSKLMER FLMDGFQPQQ LSTYALTLYK 
HTATVDGKTI LVADINVTQK SFNFAKKFSL PLYFVSAADG TSVVKLFNDA IRLAVSYKQN 
SQDFMDEIFQ ELENFSLEQE EEDVPDQEQS SSIETPSEEV ASPHS

Genular Protein ID: 3912444460

Symbol: B7ZBD5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7ZBD5

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 Ensembl 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 4 SAM 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 165
  • Mass: 18477
  • Checksum: 59F3348EB23D7BD5
  • Sequence:
    • MAEDKTKPSE LDQGKYDADD NVKIICLGDS AVGKSKLMER FLMDGFQPQQ LSTYALTLYK 
HTATVDGKTI LVADINVTQK SFNFAKKFSL PLYFVSAADG TNVVKLFNDA IRLAVSYKQN 
SQDFMDEIFQ ELENFSLEQE EEDVPDQEQS SSIETPSEEV ASPHS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.