CHI3L1 | ENSG00000133048 | NCBI 1116

Details for: CHI3L1

Gene ID: 1116

Symbol: CHI3L1

Ensembl ID: ENSG00000133048

Description: chitinase 3 like 1

Associated with

Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Neutrophil degranulation
(R-HSA-6798695)
Activation of nf-kappab-inducing kinase activity
(GO:0007250)
Apoptotic process
(GO:0006915)
Carbohydrate binding
(GO:0030246)
Carbohydrate metabolic process
(GO:0005975)
Cartilage development
(GO:0051216)
Cellular response to tumor necrosis factor
(GO:0071356)
Chitinase activity
(GO:0004568)
Chitin binding
(GO:0008061)
Chitin catabolic process
(GO:0006032)
Cytoplasm
(GO:0005737)
Endoplasmic reticulum
(GO:0005783)
Extracellular exosome
(GO:0070062)
Extracellular matrix
(GO:0031012)
Extracellular matrix structural constituent
(GO:0005201)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Inflammatory response
(GO:0006954)
Lung development
(GO:0030324)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of interleukin-8 production
(GO:0032757)
Positive regulation of peptidyl-threonine phosphorylation
(GO:0010800)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Protein binding
(GO:0005515)
Response to interleukin-1
(GO:0070555)
Response to interleukin-6
(GO:0070741)
Response to mechanical stimulus
(GO:0009612)
Response to tumor necrosis factor
(GO:0034612)
Specific granule lumen
(GO:0035580)

Other Information

Proteins

Chitinase-3-like protein 1

Genular Protein ID: 518039285

Symbol: CH3L1_HUMAN

Name: Chitinase-3-like protein 1

UniProtKB Accession Codes:

P36222 B2R7B0 P30923 Q8IVA4 Q96HI7

Database IDs:

Citations:

PubMed ID: 8245017

Title: Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family.

PubMed ID: 8245017

DOI: 10.1016/s0021-9258(19)74461-5

PubMed ID: 9244440

Title: Molecular characterization of the gene for human cartilage gp-39 (CHI3L1), a member of the chitinase protein family and marker for late stages of macrophage differentiation.

PubMed ID: 9244440

DOI: 10.1006/geno.1997.4778

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2375755

Title: Human synovial cells secrete a 39 kDa protein similar to a bovine mammary protein expressed during the non-lactating period.

PubMed ID: 2375755

DOI: 10.1042/bj2690265

PubMed ID: 9492324

Title: Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages.

PubMed ID: 9492324

DOI: 10.1046/j.1432-1327.1998.2510504.x

PubMed ID: 16472595

Title: Chitinase 3-like-1 exacerbates intestinal inflammation by enhancing bacterial adhesion and invasion in colonic epithelial cells.

PubMed ID: 16472595

DOI: 10.1053/j.gastro.2005.12.007

PubMed ID: 17160890

Title: Functional variants in the promoter region of Chitinase 3-like 1 (CHI3L1) and susceptibility to schizophrenia.

PubMed ID: 17160890

DOI: 10.1086/510438

PubMed ID: 19414556

Title: Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis.

PubMed ID: 19414556

DOI: 10.1084/jem.20081271

PubMed ID: 20558631

Title: The chitinase-like proteins breast regression protein-39 and YKL-40 regulate hyperoxia-induced acute lung injury.

PubMed ID: 20558631

DOI: 10.1164/rccm.200912-1793oc

PubMed ID: 20051317

Title: The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis.

PubMed ID: 20051317

DOI: 10.1016/j.schres.2009.12.002

PubMed ID: 12775711

Title: Structure and ligand-induced conformational change of the 39-kDa glycoprotein from human articular chondrocytes.

PubMed ID: 12775711

DOI: 10.1074/jbc.m303371200

PubMed ID: 12851408

Title: Crystal structure and carbohydrate-binding properties of the human cartilage glycoprotein-39.

PubMed ID: 12851408

DOI: 10.1074/jbc.m303137200

PubMed ID: 18403759

Title: Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function.

PubMed ID: 18403759

DOI: 10.1056/nejmoa0708801

Sequence Information:

Length: 383
Mass: 42625
Checksum: 6C9EF133BDC7C2D1
Sequence:

MGVKASQTGF VVLVLLQCCS AYKLVCYYTS WSQYREGDGS CFPDALDRFL CTHIIYSFAN 
ISNDHIDTWE WNDVTLYGML NTLKNRNPNL KTLLSVGGWN FGSQRFSKIA SNTQSRRTFI 
KSVPPFLRTH GFDGLDLAWL YPGRRDKQHF TTLIKEMKAE FIKEAQPGKK QLLLSAALSA 
GKVTIDSSYD IAKISQHLDF ISIMTYDFHG AWRGTTGHHS PLFRGQEDAS PDRFSNTDYA 
VGYMLRLGAP ASKLVMGIPT FGRSFTLASS ETGVGAPISG PGIPGRFTKE AGTLAYYEIC 
DFLRGATVHR ILGQQVPYAT KGNQWVGYDD QESVKSKVQY LKDRQLAGAM VWALDLDDFQ 
GSFCGQDLRF PLTNAIKDAL AAT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CHI3L1

Associated with

Other Information

Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family. PubMed ID: 8245017

Molecular characterization of the gene for human cartilage gp-39 (CHI3L1), a member of the chitinase protein family and marker for late stages of macrophage differentiation. PubMed ID: 9244440

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human synovial cells secrete a 39 kDa protein similar to a bovine mammary protein expressed during the non-lactating period. PubMed ID: 2375755

Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages. PubMed ID: 9492324

Chitinase 3-like-1 exacerbates intestinal inflammation by enhancing bacterial adhesion and invasion in colonic epithelial cells. PubMed ID: 16472595

Functional variants in the promoter region of Chitinase 3-like 1 (CHI3L1) and susceptibility to schizophrenia. PubMed ID: 17160890

Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis. PubMed ID: 19414556

The chitinase-like proteins breast regression protein-39 and YKL-40 regulate hyperoxia-induced acute lung injury. PubMed ID: 20558631

The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis. PubMed ID: 20051317

Structure and ligand-induced conformational change of the 39-kDa glycoprotein from human articular chondrocytes. PubMed ID: 12775711

Crystal structure and carbohydrate-binding properties of the human cartilage glycoprotein-39. PubMed ID: 12851408

Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function. PubMed ID: 18403759