Details for: CHI3L1

Gene ID: 1116

Symbol: CHI3L1

Ensembl ID: ENSG00000133048

Description: chitinase 3 like 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myelocyte (CL0002193)
    Fold Change: 2.77
    Marker Score: 1199
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.3
    Marker Score: 817
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.05
    Marker Score: 600
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 2.02
    Marker Score: 455
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.84
    Marker Score: 2953
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.58
    Marker Score: 899
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.53
    Marker Score: 9965
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.26
    Marker Score: 2237
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.21
    Marker Score: 495
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.05
    Marker Score: 688
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.01
    Marker Score: 900
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71807
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48032
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.96
    Marker Score: 20408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5317
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.91
    Marker Score: 382
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2735
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.89
    Marker Score: 4384
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5281
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 702
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 585
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.75
    Marker Score: 1706
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.73
    Marker Score: 6156
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.69
    Marker Score: 421
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.66
    Marker Score: 1086
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.62
    Marker Score: 393
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.62
    Marker Score: 411
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.55
    Marker Score: 205
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.54
    Marker Score: 866
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.53
    Marker Score: 136
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5
    Marker Score: 8016
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.49
    Marker Score: 2561
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 469
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.48
    Marker Score: 319
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.48
    Marker Score: 969
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.45
    Marker Score: 5998
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.44
    Marker Score: 136
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.44
    Marker Score: 106987
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.44
    Marker Score: 1893
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.44
    Marker Score: 133
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.43
    Marker Score: 790
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.43
    Marker Score: 6737
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.43
    Marker Score: 394
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.41
    Marker Score: 292
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.41
    Marker Score: 132
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.41
    Marker Score: 153
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.41
    Marker Score: 138
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.4
    Marker Score: 552
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.39
    Marker Score: 193
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.38
    Marker Score: 244
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.38
    Marker Score: 171
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.37
    Marker Score: 161
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.37
    Marker Score: 418
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.36
    Marker Score: 143
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.35
    Marker Score: 667
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.34
    Marker Score: 119
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.34
    Marker Score: 525
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.34
    Marker Score: 123
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.33
    Marker Score: 88.5
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.32
    Marker Score: 287
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.32
    Marker Score: 3229
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.32
    Marker Score: 181
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.32
    Marker Score: 330
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.32
    Marker Score: 391
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.32
    Marker Score: 305
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.31
    Marker Score: 258
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.31
    Marker Score: 307.5
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.31
    Marker Score: 423
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.29
    Marker Score: 18042
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.29
    Marker Score: 142
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.28
    Marker Score: 127
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.28
    Marker Score: 136
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.27
    Marker Score: 159
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.27
    Marker Score: 234
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.27
    Marker Score: 142
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.27
    Marker Score: 1442
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 89
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.25
    Marker Score: 172
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.25
    Marker Score: 114
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.24
    Marker Score: 146
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.24
    Marker Score: 113
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.24
    Marker Score: 434
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.24
    Marker Score: 305
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.23
    Marker Score: 2021
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.23
    Marker Score: 226
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.23
    Marker Score: 84
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.22
    Marker Score: 549.5
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.22
    Marker Score: 44
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.22
    Marker Score: 107
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.21
    Marker Score: 307
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.21
    Marker Score: 260
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.21
    Marker Score: 229
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.2
    Marker Score: 214
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.2
    Marker Score: 524

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Other Information

**Key characteristics:** * The CHI3L1 gene is located on chromosome 17q21.1. * It is a highly expressed gene in many tissues, including the lung, mammary gland, and small intestine. * The protein encoded by CHI3L1 is a transmembrane protein that is expressed on the surface of cells. * It is a key regulator of inflammation and cell death. **Pathways and functions:** * CHI3L1 is involved in a variety of cellular processes, including activation of the nf-kappab-inducing kinase (NF-kappaB) pathway, apoptosis, and regulation of the immune response. * It is a key regulator of inflammation and cell death in response to injury or infection. * It is also involved in the development and maintenance of the lung. **Clinical significance:** * Mutations in the CHI3L1 gene have been linked to several human diseases, including cancer, fibrosis, and inflammatory diseases. * Targeting CHI3L1 has been investigated as a potential therapy for these diseases. * Chi3l1 inhibitors are currently being evaluated in clinical trials for the treatment of cancer, fibrosis, and inflammatory diseases. **Additional information:** * The CHI3L1 gene is also known as ITGA4, CD11a, and MARCO. * It is a highly conserved gene, with a similar gene found in mice and rats. * The protein encoded by CHI3L1 is a large protein that is composed of multiple domains. * The N-terminal domain of CHI3L1 is responsible for binding to chitin, while the C-terminal domain is involved in protein-protein interactions.

Genular Protein ID: 518039285

Symbol: CH3L1_HUMAN

Name: Chitinase-3-like protein 1

UniProtKB Accession Codes:

P36222 B2R7B0 P30923 Q8IVA4 Q96HI7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CDD 1 CTD 1 ChEBI 6 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 28 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 9 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8245017

Title: Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family.

PubMed ID: 8245017

DOI: 10.1016/s0021-9258(19)74461-5

PubMed ID: 9244440

Title: Molecular characterization of the gene for human cartilage gp-39 (CHI3L1), a member of the chitinase protein family and marker for late stages of macrophage differentiation.

PubMed ID: 9244440

DOI: 10.1006/geno.1997.4778

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2375755

Title: Human synovial cells secrete a 39 kDa protein similar to a bovine mammary protein expressed during the non-lactating period.

PubMed ID: 2375755

DOI: 10.1042/bj2690265

PubMed ID: 9492324

Title: Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages.

PubMed ID: 9492324

DOI: 10.1046/j.1432-1327.1998.2510504.x

PubMed ID: 16472595

Title: Chitinase 3-like-1 exacerbates intestinal inflammation by enhancing bacterial adhesion and invasion in colonic epithelial cells.

PubMed ID: 16472595

DOI: 10.1053/j.gastro.2005.12.007

PubMed ID: 17160890

Title: Functional variants in the promoter region of Chitinase 3-like 1 (CHI3L1) and susceptibility to schizophrenia.

PubMed ID: 17160890

DOI: 10.1086/510438

PubMed ID: 19414556

Title: Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis.

PubMed ID: 19414556

DOI: 10.1084/jem.20081271

PubMed ID: 20558631

Title: The chitinase-like proteins breast regression protein-39 and YKL-40 regulate hyperoxia-induced acute lung injury.

PubMed ID: 20558631

DOI: 10.1164/rccm.200912-1793oc

PubMed ID: 20051317

Title: The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis.

PubMed ID: 20051317

DOI: 10.1016/j.schres.2009.12.002

PubMed ID: 12775711

Title: Structure and ligand-induced conformational change of the 39-kDa glycoprotein from human articular chondrocytes.

PubMed ID: 12775711

DOI: 10.1074/jbc.m303371200

PubMed ID: 12851408

Title: Crystal structure and carbohydrate-binding properties of the human cartilage glycoprotein-39.

PubMed ID: 12851408

DOI: 10.1074/jbc.m303137200

PubMed ID: 18403759

Title: Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function.

PubMed ID: 18403759

DOI: 10.1056/nejmoa0708801

Sequence Information:

  • Length: 383
  • Mass: 42625
  • Checksum: 6C9EF133BDC7C2D1
  • Sequence:
    • MGVKASQTGF VVLVLLQCCS AYKLVCYYTS WSQYREGDGS CFPDALDRFL CTHIIYSFAN 
ISNDHIDTWE WNDVTLYGML NTLKNRNPNL KTLLSVGGWN FGSQRFSKIA SNTQSRRTFI 
KSVPPFLRTH GFDGLDLAWL YPGRRDKQHF TTLIKEMKAE FIKEAQPGKK QLLLSAALSA 
GKVTIDSSYD IAKISQHLDF ISIMTYDFHG AWRGTTGHHS PLFRGQEDAS PDRFSNTDYA 
VGYMLRLGAP ASKLVMGIPT FGRSFTLASS ETGVGAPISG PGIPGRFTKE AGTLAYYEIC 
DFLRGATVHR ILGQQVPYAT KGNQWVGYDD QESVKSKVQY LKDRQLAGAM VWALDLDDFQ 
GSFCGQDLRF PLTNAIKDAL AAT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.