Details for: ERLIN2

Gene ID: 11160

Symbol: ERLIN2

Ensembl ID: ENSG00000147475

Description: ER lipid raft associated 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.55
    Marker Score: 1,238
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.26
    Marker Score: 2,195
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.21
    Marker Score: 4,149
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.16
    Marker Score: 2,635
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1
    Marker Score: 1,624
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.05
    Marker Score: 2,643
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.04
    Marker Score: 2,787
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.03
    Marker Score: 8,980
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,736
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,960
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.98
    Marker Score: 1,019
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,398
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.95
    Marker Score: 554
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.95
    Marker Score: 632
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,401
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 483
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 440
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.92
    Marker Score: 1,868
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,710
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,292
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.87
    Marker Score: 30,223
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.87
    Marker Score: 2,127
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.86
    Marker Score: 1,425
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4,880
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.85
    Marker Score: 13,327
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.85
    Marker Score: 1,796
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.82
    Marker Score: 385
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.82
    Marker Score: 236
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.81
    Marker Score: 2,989
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.81
    Marker Score: 1,140
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.8
    Marker Score: 851
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,265
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.77
    Marker Score: 1,455
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 584
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 305
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.76
    Marker Score: 244
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.73
    Marker Score: 15,625
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 377
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.71
    Marker Score: 5,301
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2,860
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.67
    Marker Score: 282
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 614
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.67
    Marker Score: 427
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.66
    Marker Score: 365
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.65
    Marker Score: 1,481
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.65
    Marker Score: 657
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.64
    Marker Score: 504
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.64
    Marker Score: 305
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.64
    Marker Score: 640
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.64
    Marker Score: 1,523
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.63
    Marker Score: 201
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.63
    Marker Score: 148
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.62
    Marker Score: 143
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.62
    Marker Score: 422
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.62
    Marker Score: 1,458
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.62
    Marker Score: 2,194
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.61
    Marker Score: 412
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.6
    Marker Score: 2,331
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.6
    Marker Score: 296
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6
    Marker Score: 630
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.6
    Marker Score: 272
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.6
    Marker Score: 2,857
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.59
    Marker Score: 641
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.59
    Marker Score: 207
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.59
    Marker Score: 396
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.59
    Marker Score: 741
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.59
    Marker Score: 649
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.58
    Marker Score: 614
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.58
    Marker Score: 3,683
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.57
    Marker Score: 1,006
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.57
    Marker Score: 1,778
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.56
    Marker Score: 353
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.56
    Marker Score: 368
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.55
    Marker Score: 30,961
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.55
    Marker Score: 208
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.54
    Marker Score: 317
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.54
    Marker Score: 702
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.54
    Marker Score: 380
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 429
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.54
    Marker Score: 464
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.53
    Marker Score: 372
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.53
    Marker Score: 461
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.53
    Marker Score: 818
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.53
    Marker Score: 2,086
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.53
    Marker Score: 166
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.53
    Marker Score: 758
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.52
    Marker Score: 392
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.52
    Marker Score: 5,389
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.52
    Marker Score: 320
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.52
    Marker Score: 855
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.52
    Marker Score: 475
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.51
    Marker Score: 256
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.51
    Marker Score: 274
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.51
    Marker Score: 499
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.51
    Marker Score: 3,060
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.51
    Marker Score: 1,382
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.51
    Marker Score: 594
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.51
    Marker Score: 125

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Lipid raft-associated protein**: ERLIN2 resides in lipid rafts, which are dynamic microdomains of the plasma membrane involved in signaling and membrane trafficking. 2. **Cholesterol and fatty acid biosynthesis regulator**: ERLIN2 negatively regulates the cholesterol and fatty acid biosynthetic processes, ensuring proper lipid homeostasis in cells. 3. **Protein-protein interactions**: ERLIN2 interacts with various proteins, including ABC transporters, to modulate membrane dynamics and facilitate the transport of small molecules. 4. **Signaling pathway modulator**: ERLIN2 influences signaling pathways mediated by growth factor receptors and second messengers, including the SREBP signaling pathway. **Pathways and Functions:** 1. **Abc-family proteins mediated transport**: ERLIN2 interacts with ABC transporters to regulate the transport of small molecules across the plasma membrane. 2. **Cholesterol metabolic process**: ERLIN2 negatively regulates the cholesterol biosynthetic process, ensuring proper lipid homeostasis in cells. 3. **Fatty acid biosynthetic process**: ERLIN2 also regulates the fatty acid biosynthetic process, maintaining proper lipid homeostasis in cells. 4. **Signaling by growth factor receptors and second messengers**: ERLIN2 influences signaling pathways mediated by growth factor receptors and second messengers, including the SREBP signaling pathway. 5. **Regulation of transmembrane transporters**: ERLIN2 regulates the activity of transmembrane transporters, including the defective CFTR protein associated with cystic fibrosis. **Clinical Significance:** 1. **Cystic fibrosis**: Aberrant ERLIN2 expression has been linked to cystic fibrosis, a genetic disorder characterized by defective CFTR protein function. 2. **Disorders of transmembrane transporters**: ERLIN2 regulates the activity of transmembrane transporters, including those involved in cystic fibrosis. 3. **Diseases of signal transduction by growth factor receptors and second messengers**: ERLIN2 influences signaling pathways mediated by growth factor receptors and second messengers, including those involved in cancer and neurodegenerative diseases. 4. **Endoplasmic reticulum disorders**: ERLIN2 is involved in the regulation of cholesterol and fatty acid biosynthesis, which is crucial for proper endoplasmic reticulum function. In conclusion, ERLIN2 plays a critical role in regulating lipid raft-associated signaling and disease pathogenesis. Its dysregulation has been linked to various diseases, including cystic fibrosis, disorders of transmembrane transporters, and diseases of signal transduction by growth factor receptors and second messengers. Further research is needed to elucidate the mechanisms by which ERLIN2 regulates lipid homeostasis and signaling pathways, and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 2509955860

Symbol: ERLN2_HUMAN

Name: Erlin-2

UniProtKB Accession Codes:

O94905 A0JLQ1 A8K5S9 B4DM38 D3DSW0 Q6NW21 Q86VS6 Q86W49

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTAC 2 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 12 EPD 1 Ensembl 6 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PRIDE 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 4 RefSeq 5 SMART 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 2 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10449903

Title: Cloning and characterization of a novel gene (C8orf2), a human representative of a novel gene family with homology to C. elegans C42.C1.9.

PubMed ID: 10449903

DOI: 10.1159/000015298

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19240031

Title: An endoplasmic reticulum (ER) membrane complex composed of SPFH1 and SPFH2 mediates the ER-associated degradation of inositol 1,4,5-trisphosphate receptors.

PubMed ID: 19240031

DOI: 10.1074/jbc.m809801200

PubMed ID: 16835267

Title: Erlin-1 and erlin-2 are novel members of the prohibitin family of proteins that define lipid-raft-like domains of the ER.

PubMed ID: 16835267

DOI: 10.1242/jcs.03060

PubMed ID: 17502376

Title: SPFH2 mediates the endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors and other substrates in mammalian cells.

PubMed ID: 17502376

DOI: 10.1074/jbc.m701862200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21330303

Title: A frameshift mutation of ERLIN2 in recessive intellectual disability, motor dysfunction and multiple joint contractures.

PubMed ID: 21330303

DOI: 10.1093/hmg/ddr070

PubMed ID: 21343306

Title: Membrane-associated ubiquitin ligase complex containing gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

PubMed ID: 21343306

DOI: 10.1074/jbc.m110.211326

PubMed ID: 21610068

Title: RNF170 protein, an endoplasmic reticulum membrane ubiquitin ligase, mediates inositol 1,4,5-trisphosphate receptor ubiquitination and degradation.

PubMed ID: 21610068

DOI: 10.1074/jbc.m111.251983

PubMed ID: 24217618

Title: Erlins restrict SREBP activation in the ER and regulate cellular cholesterol homeostasis.

PubMed ID: 24217618

DOI: 10.1083/jcb.201305076

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30352685

Title: Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development.

PubMed ID: 30352685

DOI: 10.1016/j.bbrc.2018.10.073

Sequence Information:

  • Length: 339
  • Mass: 37840
  • Checksum: 3CF322548FD58DB0
  • Sequence:
    • MAQLGAVVAV ASSFFCASLF SAVHKIEEGH IGVYYRGGAL LTSTSGPGFH LMLPFITSYK 
SVQTTLQTDE VKNVPCGTSG GVMIYFDRIE VVNFLVPNAV YDIVKNYTAD YDKALIFNKI 
HHELNQFCSV HTLQEVYIEL FDQIDENLKL ALQQDLTSMA PGLVIQAVRV TKPNIPEAIR 
RNYELMESEK TKLLIAAQKQ KVVEKEAETE RKKALIEAEK VAQVAEITYG QKVMEKETEK 
KISEIEDAAF LAREKAKADA ECYTAMKIAE ANKLKLTPEY LQLMKYKAIA SNSKIYFGKD 
IPNMFMDSAG SVSKQFEGLA DKLSFGLEDE PLETATKEN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.