Details for: ERG28

Gene ID: 11161

Symbol: ERG28

Ensembl ID: ENSG00000133935

Description: ergosterol biosynthesis 28 homolog

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.21
    Marker Score: 2,863
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 3.13
    Marker Score: 918
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.5
    Marker Score: 4,017
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.32
    Marker Score: 13,776
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.13
    Marker Score: 13,900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.03
    Marker Score: 4,287
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.02
    Marker Score: 2,177
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 2.01
    Marker Score: 1,348
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.91
    Marker Score: 7,499
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.74
    Marker Score: 14,960
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.72
    Marker Score: 3,597
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.71
    Marker Score: 1,168
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.7
    Marker Score: 775
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.68
    Marker Score: 10,721
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.63
    Marker Score: 16,369
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.62
    Marker Score: 2,750
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.59
    Marker Score: 12,424
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.59
    Marker Score: 6,130
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.57
    Marker Score: 706
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.54
    Marker Score: 1,026
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.5
    Marker Score: 1,251
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.49
    Marker Score: 51,672
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.48
    Marker Score: 3,013
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.48
    Marker Score: 1,570
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.44
    Marker Score: 793
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.43
    Marker Score: 1,607
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.42
    Marker Score: 1,504
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.42
    Marker Score: 2,353
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4
    Marker Score: 2,067
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.4
    Marker Score: 9,126
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.38
    Marker Score: 3,744
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.37
    Marker Score: 727
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.36
    Marker Score: 458
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.34
    Marker Score: 3,174
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.33
    Marker Score: 5,456
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.3
    Marker Score: 304
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.29
    Marker Score: 373
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.28
    Marker Score: 673
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.25
    Marker Score: 1,730
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.23
    Marker Score: 3,111
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.23
    Marker Score: 594
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.23
    Marker Score: 1,484
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.23
    Marker Score: 2,794
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.22
    Marker Score: 2,879
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.21
    Marker Score: 1,079
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.2
    Marker Score: 811
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.18
    Marker Score: 1,117
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.18
    Marker Score: 4,369
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 1.18
    Marker Score: 716
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.18
    Marker Score: 1,111
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.18
    Marker Score: 1,107
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.17
    Marker Score: 1,469
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.17
    Marker Score: 5,619
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.17
    Marker Score: 18,271
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.16
    Marker Score: 648
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.16
    Marker Score: 1,211
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.15
    Marker Score: 225
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 1.15
    Marker Score: 344
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.14
    Marker Score: 1,216
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.12
    Marker Score: 2,550
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.11
    Marker Score: 448
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.11
    Marker Score: 612
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.1
    Marker Score: 14,542
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.1
    Marker Score: 1,140
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.07
    Marker Score: 370
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.07
    Marker Score: 507
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.06
    Marker Score: 378
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.06
    Marker Score: 316
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.04
    Marker Score: 5,480
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.03
    Marker Score: 8,977
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.03
    Marker Score: 2,947
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.02
    Marker Score: 428
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.02
    Marker Score: 1,811
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.02
    Marker Score: 323
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.02
    Marker Score: 1,672
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1
    Marker Score: 370
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,639
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,862
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.99
    Marker Score: 1,006
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.99
    Marker Score: 285
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.99
    Marker Score: 397
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,382
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.98
    Marker Score: 456
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.97
    Marker Score: 706
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.97
    Marker Score: 248
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.96
    Marker Score: 1,283
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.96
    Marker Score: 1,829
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.96
    Marker Score: 1,526
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.96
    Marker Score: 271
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.95
    Marker Score: 1,026
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,390
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.94
    Marker Score: 463
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.93
    Marker Score: 323
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.93
    Marker Score: 584
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 477
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 436
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.92
    Marker Score: 671
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.92
    Marker Score: 341
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.91
    Marker Score: 916

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ERG28 is primarily expressed in cells of the immune system, including extravillous trophoblasts, tracheobronchial smooth muscle cells, pneumocytes, Sertoli cells, and Leydig cells. Its expression is also observed in epithelial cells of the esophagus and type II pneumocytes. The gene encodes a protein that exhibits protein-macromolecule adaptor activity and is involved in sterol biosynthetic processes, specifically the biosynthesis of ergosterol. **Pathways and Functions:** ERG28 is involved in the sterol biosynthetic pathway, which is essential for the synthesis of ergosterol, a critical component of fungal cell membranes. The gene's protein product is thought to play a role in the regulation of ergosterol biosynthesis, possibly by interacting with other proteins involved in the process. Additionally, ERG28 has been implicated in the regulation of cell membrane fluidity and the maintenance of cellular homeostasis. In the context of human cells, ERG28 has been found to be involved in the regulation of immune responses, particularly in the development and function of immune cells. Its expression has been observed in cells of the immune system, suggesting a potential role in the regulation of immune cell function and the maintenance of immune homeostasis. **Clinical Significance:** ERG28 has been identified as a potential biomarker for various diseases, including cancer and autoimmune disorders. Its expression has been found to be altered in patients with certain types of cancer, suggesting a potential role in tumorigenesis. Additionally, ERG28 has been implicated in the regulation of immune responses, particularly in the context of autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis. Furthermore, ERG28 has been found to be involved in the regulation of cell membrane fluidity and the maintenance of cellular homeostasis, which is critical for the proper functioning of immune cells. Alterations in ERG28 expression have been observed in patients with certain types of cancer and autoimmune disorders, suggesting a potential role in the pathogenesis of these diseases. In conclusion, ERG28 is a gene that plays a critical role in the biosynthesis of ergosterol, a vital sterol found in the cell membranes of fungi and protists. Its expression has been found to be altered in patients with various diseases, including cancer and autoimmune disorders, suggesting a potential role in the pathogenesis of these diseases. Further research is needed to fully elucidate the immunological significance of ERG28 and its potential as a biomarker for disease diagnosis and treatment. **Future Directions:** Further research is needed to fully elucidate the immunological significance of ERG28 and its potential as a biomarker for disease diagnosis and treatment. Studies should focus on the regulation of ERG28 expression in immune cells and its role in the development and function of immune cells. Additionally, the potential therapeutic applications of ERG28 should be explored, particularly in the context of cancer and autoimmune disorders. In conclusion, ERG28 is a gene that plays a critical role in the biosynthesis of ergosterol, a vital sterol found in the cell membranes of fungi and protists. Its expression has been found to be altered in patients with various diseases, including cancer and autoimmune disorders, suggesting a potential role in the pathogenesis of these diseases. Further research is needed to fully elucidate the immunological significance of ERG28 and its potential as a biomarker for disease diagnosis and treatment.

Genular Protein ID: 2281643138

Symbol: ERG28_HUMAN

Name: Ergosterol biosynthetic protein 28 homolog

UniProtKB Accession Codes:

Q9UKR5 Q9P093 Q9UPI2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 EMBL 6 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 7 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10449901

Title: A novel human gene, encoding a potential membrane protein conserved from yeast to man, is strongly expressed in testis and cancer cell lines.

PubMed ID: 10449901

DOI: 10.1159/000015296

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 140
  • Mass: 15864
  • Checksum: BDD089148BC60E50
  • Sequence:
    • MSRFLNVLRS WLVMVSIIAM GNTLQSFRDH TFLYEKLYTG KPNLVNGLQA RTFGIWTLLS 
SVIRCLCAID IHNKTLYHIT LWTFLLALGH FLSELFVYGT AAPTIGVLAP LMVASFSILG 
MLVGLRYLEV EPVSRQKKRN

Genular Protein ID: 4185665955

Symbol: Q86TW5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86TW5

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 1 Genevisible 1 GenomeRNAi 1 InterPro 1 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1

Sequence Information:

  • Length: 139
  • Mass: 15750
  • Checksum: 4089148BC60E5081
  • Sequence:
    • MSRFLNVLRS WLVMVSIIAM GNTLQSFRDH TFLYEKLYTG KPNLVNGLQA RTFGIWTLLS 
SVIRCLCAID IHNKTLYHIT LWTFLLALGH FLSELFVYGT AAPTIGVLAP LMVASFSILG 
MLVGLRYLEV EPVSRQKKR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.