Details for: NUDT6

Gene ID: 11162

Symbol: NUDT6

Ensembl ID: ENSG00000170917

Description: nudix hydrolase 6

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169,272
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.15
    Marker Score: 4,450
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,798
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,023
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 496
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 450
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,409
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.93
    Marker Score: 859
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,730
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5,124
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,276
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,268
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 386
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 568
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.73
    Marker Score: 1,124
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 663
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.71
    Marker Score: 286
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2,814
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.65
    Marker Score: 6,192
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.64
    Marker Score: 1,126
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.6
    Marker Score: 2,497
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.6
    Marker Score: 801
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.59
    Marker Score: 36,088
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.57
    Marker Score: 5,365
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.55
    Marker Score: 670
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.55
    Marker Score: 20,385
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.55
    Marker Score: 4,744
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.53
    Marker Score: 1,244
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.51
    Marker Score: 349
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.51
    Marker Score: 8,004
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.49
    Marker Score: 155
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.49
    Marker Score: 1,919
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.48
    Marker Score: 601
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.48
    Marker Score: 279
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.47
    Marker Score: 1,264
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.46
    Marker Score: 294
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.45
    Marker Score: 163
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.45
    Marker Score: 1,870
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.44
    Marker Score: 9,496
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.44
    Marker Score: 4,577
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.43
    Marker Score: 1,544
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.43
    Marker Score: 461
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.41
    Marker Score: 984
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.41
    Marker Score: 274
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.41
    Marker Score: 828
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.41
    Marker Score: 430
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.41
    Marker Score: 15,394
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.4
    Marker Score: 94
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.4
    Marker Score: 1,000
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.4
    Marker Score: 124
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.39
    Marker Score: 1,512
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.39
    Marker Score: 407
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.39
    Marker Score: 7,738
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.39
    Marker Score: 387
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.38
    Marker Score: 1,595
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.38
    Marker Score: 119
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.37
    Marker Score: 392
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.37
    Marker Score: 809
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.37
    Marker Score: 97
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.37
    Marker Score: 213
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.36
    Marker Score: 2,177
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.36
    Marker Score: 753
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.36
    Marker Score: 267
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.35
    Marker Score: 283
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.35
    Marker Score: 5,227
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.33
    Marker Score: 201
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.33
    Marker Score: 331
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.33
    Marker Score: 355
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.33
    Marker Score: 105
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.32
    Marker Score: 1,323
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.32
    Marker Score: 136
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.32
    Marker Score: 281
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.32
    Marker Score: 134
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.32
    Marker Score: 878
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.32
    Marker Score: 463
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.32
    Marker Score: 168
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.31
    Marker Score: 151
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.31
    Marker Score: 174
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.31
    Marker Score: 1,148
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.31
    Marker Score: 589
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.3
    Marker Score: 127
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.3
    Marker Score: 200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.3
    Marker Score: 474
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.29
    Marker Score: 143
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.29
    Marker Score: 598
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.29
    Marker Score: 297
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.29
    Marker Score: 184
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.29
    Marker Score: 492
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.29
    Marker Score: 290
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.29
    Marker Score: 84
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.29
    Marker Score: 2,202
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.29
    Marker Score: 297
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.28
    Marker Score: 1,829
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.28
    Marker Score: 99
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.28
    Marker Score: 188
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.28
    Marker Score: 127

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Catalytic Domain:** NUDT6 contains a catalytic domain that enables the hydrolysis of NDPs, which are crucial for various cellular processes, including energy metabolism, DNA repair, and cell cycle regulation. 2. **NDP Hydrolysis:** NUDT6 specifically hydrolyzes NDPs, leading to the release of free nucleosides, which can then participate in various cellular reactions, including energy production, DNA synthesis, and cell signaling. 3. **Regulation of Cell Cycle:** NUDT6 has been implicated in the regulation of the cell cycle, particularly in the negative control of cell population proliferation. By modulating NDP hydrolysis, NUDT6 can influence the activity of key cell cycle regulators, such as cyclin-dependent kinases (CDKs). 4. **Interactions with Other Proteins:** NUDT6 interacts with various proteins, including nucleoside diphosphate kinases (NDKs), which are involved in energy metabolism and DNA repair. **Pathways and Functions:** 1. **Adp-ribose diphosphatase activity:** NUDT6 hydrolyzes NDPs, which are generated during the adp-ribose diphosphatase activity of NDKs. This reaction is essential for maintaining the balance of NDPs and modulating cellular metabolism. 2. **NAD+ metabolism:** NUDT6 regulates NAD+ metabolism by hydrolyzing NDPs, which are involved in NAD+ synthesis and degradation. This has significant implications for energy metabolism, as NAD+ is a critical cofactor for various cellular processes. 3. **Cytoplasmic and mitochondrial localization:** NUDT6 is localized to both the cytoplasm and mitochondria, highlighting its involvement in both energy metabolism and cell signaling pathways. 4. **Negative regulation of cell cycle:** NUDT6 modulates the activity of CDKs, which are essential for cell cycle progression. By inhibiting CDK activity, NUDT6 can regulate cell population proliferation and prevent uncontrolled cell growth. **Clinical Significance:** 1. **Cancer:** NUDT6 has been implicated in various cancers, including colorectal cancer, where it is often overexpressed. This overexpression can contribute to enhanced cell proliferation and tumorigenesis. 2. **Neurological disorders:** NUDT6 has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, where its dysregulation can contribute to neuronal dysfunction and degeneration. 3. **Metabolic disorders:** NUDT6 plays a crucial role in energy metabolism, and its dysregulation can contribute to metabolic disorders, such as diabetes and metabolic syndrome. 4. **Infectious diseases:** NUDT6 has been implicated in the regulation of immune responses, and its dysregulation can contribute to the development of infectious diseases. In conclusion, NUDT6 is a multifunctional enzyme that plays a critical role in regulating various cellular processes, including energy metabolism, cell cycle progression, and immune responses. Its dysregulation has been implicated in various diseases, highlighting the importance of NUDT6 in maintaining cellular homeostasis. Further research is necessary to fully elucidate the functions of NUDT6 and its role in human disease.

Genular Protein ID: 3340524829

Symbol: NUDT6_HUMAN

Name: Nucleoside diphosphate-linked moiety X motif 6

UniProtKB Accession Codes:

P53370 A8K756 O95097 Q9UQD9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 5 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10022609

Title: Characterization of the promoter for the human antisense fibroblast growth factor-2 gene; regulation by Ets in Jurkat T cells.

PubMed ID: 10022609

DOI: 10.1002/(sici)1097-4644(19990315)72:4<492::aid-jcb5>3.3.co;2-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7984147

Title: Identification and characterization of an antisense RNA transcript (gfg) from the human basic fibroblast growth factor gene.

PubMed ID: 7984147

DOI: 10.1210/mend.8.7.7984147

PubMed ID: 11266510

Title: The endogenous fibroblast growth factor-2 antisense gene product regulates pituitary cell growth and hormone production.

PubMed ID: 11266510

DOI: 10.1210/mend.15.4.0626

PubMed ID: 17569023

Title: Alternative splicing of the FGF antisense gene: differential subcellular localization in human tissues and esophageal adenocarcinoma.

PubMed ID: 17569023

DOI: 10.1007/s00109-007-0219-9

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 316
  • Mass: 35679
  • Checksum: 41EC95893B52180A
  • Sequence:
    • MRQPLSWGRW RAMLARTYGP GPSAGYRWAS GAQGYVRNPP VGACDLQGEL DRFGGISVRL 
ARLDALDRLD AAAFQKGLQA AVQQWRSEGR TAVWLHIPIL QSRFIAPAAS LGFCFHHAES 
DSSTLTLWLR EGPSRLPGYA SHQVGVAGAV FDESTRKILV VQDRNKLKNM WKFPGGLSEP 
EEDIGDTAVR EVFEETGIKS EFRSVLSIRQ QHTNPGAFGK SDMYIICRLK PYSFTINFCQ 
EECLRCEWMD LNDLAKTENT TPITSRVARL LLYGYREGFD KIDLTVEELP AVYTGLFYKL 
YHKELPENYK TMKGID

Genular Protein ID: 1904965512

Symbol: B4DG76_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DG76

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SUPFAM 1

Sequence Information:

  • Length: 147
  • Mass: 17054
  • Checksum: 81925AE61AAB6882
  • Sequence:
    • MWKFPGGLSE PEEDIGDTAV REVFEETGIK SEFRSVLSIQ QQHTNPGAFG KSDMYIICRL 
KPYSFTINFC QEECLRCEWM DLNDLAKTEN TTPITSRVAR LLLYGYREGF DKIDLTVEEL 
PAVYTGLFYK LYHKELPENY KTMKGID

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.