Details for: NUDT4

Gene ID: 11163

Symbol: NUDT4

Ensembl ID: ENSG00000173598

Description: nudix hydrolase 4

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.94
    Marker Score: 65,718
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.84
    Marker Score: 7,620
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.79
    Marker Score: 3,756
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.79
    Marker Score: 2,958
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.56
    Marker Score: 5,615
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.29
    Marker Score: 2,188
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.28
    Marker Score: 5,188
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.25
    Marker Score: 9,433
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.23
    Marker Score: 653
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.15
    Marker Score: 2,604
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.03
    Marker Score: 2,818
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.01
    Marker Score: 1,428
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2
    Marker Score: 7,863
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.9
    Marker Score: 2,795
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.87
    Marker Score: 16,252
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.87
    Marker Score: 1,994
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.86
    Marker Score: 3,501
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.85
    Marker Score: 1,579
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.83
    Marker Score: 4,619
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.78
    Marker Score: 5,599
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.75
    Marker Score: 863
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.7
    Marker Score: 993
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.66
    Marker Score: 1,720
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.66
    Marker Score: 101,819
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.65
    Marker Score: 959
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.63
    Marker Score: 2,306
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.59
    Marker Score: 1,704
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.54
    Marker Score: 13,229
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.51
    Marker Score: 3,193
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.49
    Marker Score: 867
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.48
    Marker Score: 689
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.45
    Marker Score: 49,504
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166,446
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.44
    Marker Score: 1,031
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.43
    Marker Score: 13,568
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.43
    Marker Score: 1,448
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.42
    Marker Score: 483
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.41
    Marker Score: 330
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.39
    Marker Score: 2,648
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 1.34
    Marker Score: 366
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.34
    Marker Score: 725
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 1.33
    Marker Score: 609
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.32
    Marker Score: 1,037
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.32
    Marker Score: 1,241
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.31
    Marker Score: 1,639
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.3
    Marker Score: 1,027
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.29
    Marker Score: 426
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.29
    Marker Score: 12,170
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.28
    Marker Score: 1,232
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.27
    Marker Score: 4,514
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.27
    Marker Score: 879
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.26
    Marker Score: 19,704
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.24
    Marker Score: 1,340
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.24
    Marker Score: 534
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.23
    Marker Score: 4,234
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.23
    Marker Score: 276
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.22
    Marker Score: 12,387
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.22
    Marker Score: 7,931
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.22
    Marker Score: 310
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.22
    Marker Score: 9,057
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.21
    Marker Score: 1,142
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.21
    Marker Score: 2,965
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.19
    Marker Score: 285
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.19
    Marker Score: 377
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.19
    Marker Score: 434
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.18
    Marker Score: 490
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.17
    Marker Score: 728
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.16
    Marker Score: 234
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.16
    Marker Score: 878
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.15
    Marker Score: 494
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.14
    Marker Score: 243
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.14
    Marker Score: 749
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.13
    Marker Score: 551
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.13
    Marker Score: 321
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.13
    Marker Score: 702
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.12
    Marker Score: 758
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.11
    Marker Score: 1,166
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.11
    Marker Score: 375
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.1
    Marker Score: 695
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.09
    Marker Score: 412
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.09
    Marker Score: 1,091
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.09
    Marker Score: 380
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.09
    Marker Score: 560
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.08
    Marker Score: 454
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.08
    Marker Score: 1,138
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.08
    Marker Score: 2,554
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.08
    Marker Score: 1,011
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.08
    Marker Score: 244
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.07
    Marker Score: 508
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.07
    Marker Score: 1,251
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.06
    Marker Score: 262
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.06
    Marker Score: 367
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.06
    Marker Score: 282
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 1.06
    Marker Score: 321
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.05
    Marker Score: 675
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.05
    Marker Score: 616
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.05
    Marker Score: 1,784
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.05
    Marker Score: 2,561
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.05
    Marker Score: 240
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.05
    Marker Score: 455

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NUDT4 is a cytosolic enzyme that exhibits a high degree of structural similarity to other nudix hydrolases. Its enzymatic activities are characterized by the hydrolysis of high-energy phosphate compounds, such as diadenosine hexaphosphate and bis(5'-adenosyl)-hexaphosphates. These activities are crucial for regulating cellular metabolism, signal transduction, and metal ion homeostasis. NUDT4 also interacts with various proteins, including snRNP components and metal ions, further highlighting its multifunctional nature. **Pathways and Functions:** The enzymatic activities of NUDT4 are intricately linked to various cellular processes, including: 1. **RNA metabolism:** NUDT4 participates in the hydrolysis of 5'-(n(7)-methylguanosine 5'-triphospho)-[mrna], a process essential for regulating RNA stability and translation. 2. **Signal transduction:** NUDT4 interacts with various signaling molecules, including cyclic nucleotides and metal ions, to modulate cellular responses to external stimuli. 3. **Metabolism:** NUDT4 regulates the catabolism of high-energy phosphate compounds, such as diadenosine hexaphosphate and bis(5'-adenosyl)-hexaphosphates, to maintain cellular energy homeostasis. 4. **Metal ion regulation:** NUDT4 binds to metal ions, such as zinc and magnesium, to regulate their availability and activity within the cell. **Clinical Significance:** The dysregulation of NUDT4 activity has been implicated in various diseases, including: 1. **Cardiovascular disease:** Altered NUDT4 expression and activity have been linked to cardiac arrhythmias and heart failure. 2. **Neurodegenerative disorders:** NUDT4 dysfunction has been associated with neurodegenerative diseases, such as Alzheimer's and Parkinson's. 3. **Cancer:** Aberrant NUDT4 expression has been observed in various types of cancer, including breast, lung, and colon cancer. In conclusion, NUDT4 is a multifunctional enzyme that plays a critical role in regulating cellular metabolism, signal transduction, and metal ion homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of NUDT4 in maintaining cellular homeostasis and overall health. Further research is needed to fully elucidate the mechanisms by which NUDT4 regulates cellular processes and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 4250671164

Symbol: NUDT4_HUMAN

Name: Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2

UniProtKB Accession Codes:

Q9NZJ9 B7Z916 Q4AEJ6 Q53EZ2 Q68DD7 Q9NPC5 Q9NS30 Q9NZK0 Q9NZK1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 16 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 EC 3 EMBL 14 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 8 Rhea 2 SABIO-RK 1 SMR 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10777568

Title: Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. The expanding NUDT family.

PubMed ID: 10777568

DOI: 10.1074/jbc.275.17.12730

PubMed ID: 9455484

Title: Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.

PubMed ID: 9455484

DOI: 10.1093/dnares/4.5.345

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12121577

Title: Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases.

PubMed ID: 12121577

DOI: 10.1186/1471-2091-3-20

PubMed ID: 12370170

Title: Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate.

PubMed ID: 12370170

DOI: 10.1074/jbc.m209795200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 180
  • Mass: 20306
  • Checksum: 86D766F8F5B22D13
  • Sequence:
    • MMKFKPNQTR TYDREGFKKR AACLCFRSEQ EDEVLLVSSS RYPDQWIVPG GGMEPEEEPG 
GAAVREVYEE AGVKGKLGRL LGIFENQDRK HRTYVYVLTV TEILEDWEDS VNIGRKREWF 
KVEDAIKVLQ CHKPVHAEYL EKLKLGCSPA NGNSTVPSLP DNNALFVTAA QTSGLPSSVR

Genular Protein ID: 180511946

Symbol: NUD4B_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A024RBG1

Database IDs:

AGR 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChEBI 6 ChiTaRS 1 DNASU 1 EC 1 EMBL 3 EPD 1 Ensembl 1 GO 13 Gene3D 1 GeneCards 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 Pumba 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UniProtKB 3 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 181
  • Mass: 20434
  • Checksum: CB3C131FAD21A4AA
  • Sequence:
    • MMKFKPNQTR TYDREGFKKR AACLCFRSEQ EDEVLLVSSS RYPDQWIVPG GGMEPEEEPG 
GAAVREVYEE AGVKGKLGRL LGIFEQNQDR KHRTYVYVLT VTEILEDWED SVNIGRKREW 
FKVEDAIKVL QCHKPVHAEY LEKLKLGCSP ANGNSTVPSL PDNNALFVTA AQTSGLPSSV 
R

Genular Protein ID: 4098081843

Symbol: A0A0C4DGJ4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0C4DGJ4

Database IDs:

ARBA 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 EPD 1 Ensembl 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 2 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 Pfam 1 Proteomes 2 RefSeq 4 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 128
  • Mass: 14267
  • Checksum: 668C49D066C254B8
  • Sequence:
    • MEPEEEPGGA AVREVYEEAG VKGKLGRLLG IFENQDRKHR TYVYVLTVTE ILEDWEDSVN 
IGRKREWFKV EDAIKVLQCH KPVHAEYLEK LKLGCSPANG NSTVPSLPDN NALFVTAAQT 
SGLPSSVR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.