Details for: NUDT5

Gene ID: 11164

Symbol: NUDT5

Ensembl ID: ENSG00000165609

Description: nudix hydrolase 5

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.48
    Marker Score: 2,587
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.83
    Marker Score: 7,495
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.74
    Marker Score: 17,677
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.72
    Marker Score: 949
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.69
    Marker Score: 1,701
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.65
    Marker Score: 10,569
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.62
    Marker Score: 2,606
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.61
    Marker Score: 4,386
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.55
    Marker Score: 13,341
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.54
    Marker Score: 3,206
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.51
    Marker Score: 2,013
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.51
    Marker Score: 13,091
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.49
    Marker Score: 5,871
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.48
    Marker Score: 739
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.46
    Marker Score: 973
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.45
    Marker Score: 1,532
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.45
    Marker Score: 1,545
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.44
    Marker Score: 414
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.43
    Marker Score: 1,791
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.42
    Marker Score: 3,007
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.42
    Marker Score: 1,334
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.36
    Marker Score: 2,975
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.34
    Marker Score: 495
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.34
    Marker Score: 10,433
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.33
    Marker Score: 46,140
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.33
    Marker Score: 776
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.33
    Marker Score: 8,641
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.32
    Marker Score: 627
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.32
    Marker Score: 4,889
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.32
    Marker Score: 2,244
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.31
    Marker Score: 1,852
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.3
    Marker Score: 5,614
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.28
    Marker Score: 14,933
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.28
    Marker Score: 932
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.28
    Marker Score: 441
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.27
    Marker Score: 78,290
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.27
    Marker Score: 1,534
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.27
    Marker Score: 621
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.27
    Marker Score: 46,694
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.26
    Marker Score: 1,863
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.26
    Marker Score: 3,470
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.25
    Marker Score: 12,389
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.24
    Marker Score: 2,036
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 1.23
    Marker Score: 395
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.22
    Marker Score: 2,905
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.22
    Marker Score: 3,328
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.21
    Marker Score: 344
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.21
    Marker Score: 2,304
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.21
    Marker Score: 493
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.21
    Marker Score: 766
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.21
    Marker Score: 1,008
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.2
    Marker Score: 1,297
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.2
    Marker Score: 583
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.19
    Marker Score: 4,840
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.18
    Marker Score: 7,018
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.17
    Marker Score: 1,686
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.17
    Marker Score: 2,040
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.17
    Marker Score: 792
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.16
    Marker Score: 793
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.16
    Marker Score: 1,065
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.16
    Marker Score: 11,955
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.16
    Marker Score: 789
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.15
    Marker Score: 1,832
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.15
    Marker Score: 1,082
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.14
    Marker Score: 10,845
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.14
    Marker Score: 4,410
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.14
    Marker Score: 563
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.14
    Marker Score: 714
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.13
    Marker Score: 12,727
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.13
    Marker Score: 270
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 1.13
    Marker Score: 605
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.13
    Marker Score: 264
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.13
    Marker Score: 1,004
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.12
    Marker Score: 2,562
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.12
    Marker Score: 1,735
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.12
    Marker Score: 3,852
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.12
    Marker Score: 3,321
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.12
    Marker Score: 42,436
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.11
    Marker Score: 464
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.1
    Marker Score: 319
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.09
    Marker Score: 1,163
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.09
    Marker Score: 14,399
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.08
    Marker Score: 1,301
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.07
    Marker Score: 1,254
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.07
    Marker Score: 21,354
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.07
    Marker Score: 265
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.07
    Marker Score: 490
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.07
    Marker Score: 564
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.07
    Marker Score: 1,121
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.07
    Marker Score: 522
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.07
    Marker Score: 2,512
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.07
    Marker Score: 614
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.07
    Marker Score: 10,035
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.07
    Marker Score: 1,375
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.06
    Marker Score: 15,915
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.06
    Marker Score: 341
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.06
    Marker Score: 6,829
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.06
    Marker Score: 3,770
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.05
    Marker Score: 269
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.05
    Marker Score: 1,621

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** NUDT5 possesses a wide range of enzymatic activities, including 5'-(n(7)-methylguanosine 5'-triphospho)-[mrna] hydrolase activity, adp-ribose diphosphatase activity, and 8-oxo-dgdp phosphatase activity, which are involved in nucleotide metabolism and DNA repair. 2. **Cellular Localization:** NUDT5 is primarily localized in the cytosol and nucleus, where it interacts with various proteins and regulates cellular processes. 3. **Regulation of Metabolic Pathways:** NUDT5 modulates various metabolic pathways, including nucleotide metabolism, adp-ribose diphosphatase activity, and chromatin remodeling. 4. **Immune Function:** NUDT5 has been implicated in immune function, particularly in T cell and B cell development, where it regulates the expression of surface molecules and the activation of immune responses. **Pathways and Functions:** 1. **Nucleotide Metabolism:** NUDT5 regulates nucleotide metabolism by dephosphorylating nucleoside phosphates and nucleotides, which is essential for maintaining nucleotide homeostasis. 2. **DNA Repair:** NUDT5 participates in DNA repair processes, including the removal of 8-oxo-dgdp and 8-oxo-gdp, which are DNA lesions caused by oxidative stress. 3. **Chromatin Remodeling:** NUDT5 modulates chromatin remodeling by interacting with chromatin-associated proteins and regulating the expression of genes involved in immune responses. 4. **Adp-ribose Diphosphatase Activity:** NUDT5 possesses adp-ribose diphosphatase activity, which is involved in the regulation of protein function and signaling pathways. 5. **Immune Cell Development:** NUDT5 regulates the development and maturation of immune cells, including T cells and B cells, where it modulates the expression of surface molecules and the activation of immune responses. **Clinical Significance:** 1. **Cancer:** NUDT5 has been implicated in cancer development and progression, particularly in hematological malignancies, such as leukemia and lymphoma. 2. **Neurodegenerative Diseases:** NUDT5 has been linked to neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, where it regulates nucleotide metabolism and DNA repair. 3. **Immune-Mediated Diseases:** NUDT5 has been implicated in immune-mediated diseases, including autoimmune disorders, such as rheumatoid arthritis and lupus, where it regulates immune cell development and function. 4. **Pharmacological Applications:** NUDT5 has been targeted by small molecule inhibitors, which have been shown to modulate its enzymatic activity and regulate its role in various cellular processes. In conclusion, NUDT5 is a multifunctional enzyme that plays a crucial role in various cellular processes, including nucleotide metabolism, DNA repair, and immune function. Its dysregulation has been implicated in various diseases, including cancer, neurodegenerative diseases, and immune-mediated disorders. Further research is needed to elucidate the mechanisms by which NUDT5 regulates cellular processes and to explore its therapeutic potential.

Genular Protein ID: 4037350995

Symbol: NUDT5_HUMAN

Name: ADP-sugar pyrophosphatase

UniProtKB Accession Codes:

Q9UKK9 A8K516 Q6IAG0 Q9UH49

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 3 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 22 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 3 EMBL 7 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 65 PDBsum 62 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 3 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10567213

Title: Cloning, expression and characterization of YSA1H, a human adenosine 5'-diphosphosugar pyrophosphatase possessing a MutT motif.

PubMed ID: 10567213

DOI: 10.1042/bj3440331

PubMed ID: 10722730

Title: Cloning and characterization of a new member of the Nudix hydrolases from human and mouse.

PubMed ID: 10722730

DOI: 10.1074/jbc.275.12.8844

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19699693

Title: NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with broad substrate specificity.

PubMed ID: 19699693

DOI: 10.1016/j.dnarep.2009.07.011

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21389046

Title: Cleavage of oxidized guanine nucleotide and ADP sugar by human NUDT5 protein.

PubMed ID: 21389046

DOI: 10.1093/jb/mvr028

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 27257257

Title: ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling.

PubMed ID: 27257257

DOI: 10.1126/science.aad9335

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 17052728

Title: Crystal structures of human NUDT5 reveal insights into the structural basis of the substrate specificity.

PubMed ID: 17052728

DOI: 10.1016/j.jmb.2006.09.078

PubMed ID: 18462755

Title: Molecular mechanism of ADP-ribose hydrolysis by human NUDT5 from structural and kinetic studies.

PubMed ID: 18462755

DOI: 10.1016/j.jmb.2008.04.006

PubMed ID: 21768126

Title: Diverse substrate recognition and hydrolysis mechanisms of human NUDT5.

PubMed ID: 21768126

DOI: 10.1093/nar/gkr575

Sequence Information:

  • Length: 219
  • Mass: 24328
  • Checksum: 6574E0BF1EA2BB26
  • Sequence:
    • MESQEPTESS QNGKQYIISE ELISEGKWVK LEKTTYMDPT GKTRTWESVK RTTRKEQTAD 
GVAVIPVLQR TLHYECIVLV KQFRPPMGGY CIEFPAGLID DGETPEAAAL RELEEETGYK 
GDIAECSPAV CMDPGLSNCT IHIVTVTING DDAENARPKP KPGDGEFVEV ISLPKNDLLQ 
RLDALVAEEH LTVDARVYSY ALALKHANAK PFEVPFLKF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.