NUDT5 | ENSG00000165609 | NCBI 11164

Details for: NUDT5

Gene ID: 11164

Symbol: NUDT5

Ensembl ID: ENSG00000165609

Description: nudix hydrolase 5

Associated with

Metabolism
(R-HSA-1430728)
Metabolism of nucleotides
(R-HSA-15869)
Nucleotide catabolism
(R-HSA-8956319)
Phosphate bond hydrolysis by nudt proteins
(R-HSA-2393930)
Purine catabolism
(R-HSA-74259)
5'-(n(7)-methylguanosine 5'-triphospho)-[mrna] hydrolase activity
(GO:0140933)
8-oxo-dgdp phosphatase activity
(GO:0044715)
8-oxo-gdp phosphatase activity
(GO:0044716)
Adp-ribose diphosphatase activity
(GO:0047631)
Adp-sugar diphosphatase activity
(GO:0019144)
Atp generation from poly-adp-d-ribose
(GO:1990966)
Chromatin remodeling
(GO:0006338)
Cytosol
(GO:0005829)
D-ribose catabolic process
(GO:0019303)
Extracellular exosome
(GO:0070062)
Identical protein binding
(GO:0042802)
Magnesium ion binding
(GO:0000287)
Nucleobase-containing small molecule metabolic process
(GO:0055086)
Nucleoside phosphate metabolic process
(GO:0006753)
Nucleotide metabolic process
(GO:0009117)
Nucleotidyltransferase activity
(GO:0016779)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Ribonucleoside diphosphate catabolic process
(GO:0009191)
Ribose phosphate metabolic process
(GO:0019693)
Snorna binding
(GO:0030515)

Other Information

Proteins

ADP-sugar pyrophosphatase

Genular Protein ID: 4037350995

Symbol: NUDT5_HUMAN

Name: ADP-sugar pyrophosphatase

UniProtKB Accession Codes:

Q9UKK9 A8K516 Q6IAG0 Q9UH49

Database IDs:

Citations:

PubMed ID: 10567213

Title: Cloning, expression and characterization of YSA1H, a human adenosine 5'-diphosphosugar pyrophosphatase possessing a MutT motif.

PubMed ID: 10567213

DOI: 10.1042/bj3440331

PubMed ID: 10722730

Title: Cloning and characterization of a new member of the Nudix hydrolases from human and mouse.

PubMed ID: 10722730

DOI: 10.1074/jbc.275.12.8844

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19699693

Title: NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with broad substrate specificity.

PubMed ID: 19699693

DOI: 10.1016/j.dnarep.2009.07.011

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21389046

Title: Cleavage of oxidized guanine nucleotide and ADP sugar by human NUDT5 protein.

PubMed ID: 21389046

DOI: 10.1093/jb/mvr028

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 27257257

Title: ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling.

PubMed ID: 27257257

DOI: 10.1126/science.aad9335

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 17052728

Title: Crystal structures of human NUDT5 reveal insights into the structural basis of the substrate specificity.

PubMed ID: 17052728

DOI: 10.1016/j.jmb.2006.09.078

PubMed ID: 18462755

Title: Molecular mechanism of ADP-ribose hydrolysis by human NUDT5 from structural and kinetic studies.

PubMed ID: 18462755

DOI: 10.1016/j.jmb.2008.04.006

PubMed ID: 21768126

Title: Diverse substrate recognition and hydrolysis mechanisms of human NUDT5.

PubMed ID: 21768126

DOI: 10.1093/nar/gkr575

Sequence Information:

Length: 219
Mass: 24328
Checksum: 6574E0BF1EA2BB26
Sequence:

MESQEPTESS QNGKQYIISE ELISEGKWVK LEKTTYMDPT GKTRTWESVK RTTRKEQTAD 
GVAVIPVLQR TLHYECIVLV KQFRPPMGGY CIEFPAGLID DGETPEAAAL RELEEETGYK 
GDIAECSPAV CMDPGLSNCT IHIVTVTING DDAENARPKP KPGDGEFVEV ISLPKNDLLQ 
RLDALVAEEH LTVDARVYSY ALALKHANAK PFEVPFLKF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: NUDT5

Associated with

Other Information

Cloning, expression and characterization of YSA1H, a human adenosine 5'-diphosphosugar pyrophosphatase possessing a MutT motif. PubMed ID: 10567213

Cloning and characterization of a new member of the Nudix hydrolases from human and mouse. PubMed ID: 10722730

Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. PubMed ID: 11042152

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with broad substrate specificity. PubMed ID: 19699693

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Cleavage of oxidized guanine nucleotide and ADP sugar by human NUDT5 protein. PubMed ID: 21389046

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Resveratrol-induced changes of the human adipocyte secretion profile. PubMed ID: 22905912

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling. PubMed ID: 27257257

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Crystal structures of human NUDT5 reveal insights into the structural basis of the substrate specificity. PubMed ID: 17052728

Molecular mechanism of ADP-ribose hydrolysis by human NUDT5 from structural and kinetic studies. PubMed ID: 18462755

Diverse substrate recognition and hydrolysis mechanisms of human NUDT5. PubMed ID: 21768126