Details for: NUDT3

Gene ID: 11165

Symbol: NUDT3

Ensembl ID: ENSG00000272325

Description: nudix hydrolase 3

Associated with

  • Inositol phosphate metabolism
    (R-HSA-1483249)
  • Metabolism
    (R-HSA-1430728)
  • Synthesis of pyrophosphates in the cytosol
    (R-HSA-1855167)
  • 5'-(n(7)-methyl 5'-triphosphoguanosine)-[mrna] diphosphatase activity
    (GO:0140932)
  • 5'-(n(7)-methylguanosine 5'-triphospho)-[mrna] hydrolase activity
    (GO:0140933)
  • Adenosine 5'-(hexahydrogen pentaphosphate) catabolic process
    (GO:1901911)
  • Bis(5'-adenosyl)-hexaphosphatase activity
    (GO:0034431)
  • Bis(5'-adenosyl)-pentaphosphatase activity
    (GO:0034432)
  • Cell-cell signaling
    (GO:0007267)
  • Cytoplasm
    (GO:0005737)
  • Cytosol
    (GO:0005829)
  • Diadenosine hexaphosphate catabolic process
    (GO:1901909)
  • Diadenosine pentaphosphate catabolic process
    (GO:1901907)
  • Diadenosine polyphosphate catabolic process
    (GO:0015961)
  • Diphosphoinositol-polyphosphate diphosphatase activity
    (GO:0008486)
  • Diphosphoinositol polyphosphate catabolic process
    (GO:0071544)
  • Diphosphoinositol polyphosphate metabolic process
    (GO:0071543)
  • Endopolyphosphatase activity
    (GO:0000298)
  • Inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
    (GO:0052848)
  • Inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity
    (GO:0052845)
  • Inositol diphosphate pentakisphosphate diphosphatase activity
    (GO:0052842)
  • Inositol diphosphate tetrakisphosphate diphosphatase activity
    (GO:0052840)
  • Magnesium ion binding
    (GO:0000287)
  • Manganese ion binding
    (GO:0030145)
  • Nucleus
    (GO:0005634)
  • Protein binding
    (GO:0005515)
  • Rna decapping
    (GO:0110154)
  • Zinc ion binding
    (GO:0008270)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 3
    Marker Score: 1,491
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.12
    Marker Score: 890
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.05
    Marker Score: 4,170
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 2.04
    Marker Score: 1,554
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.85
    Marker Score: 1,477
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.82
    Marker Score: 2,047
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.82
    Marker Score: 943
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.8
    Marker Score: 8,348
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.78
    Marker Score: 2,504
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.77
    Marker Score: 9,289
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.75
    Marker Score: 7,108
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.7
    Marker Score: 4,189
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.63
    Marker Score: 34,832
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.6
    Marker Score: 438
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.57
    Marker Score: 5,803
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.55
    Marker Score: 1,343
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.55
    Marker Score: 1,656
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.53
    Marker Score: 15,771
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.52
    Marker Score: 93,377
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.52
    Marker Score: 51,178
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.49
    Marker Score: 51,780
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.48
    Marker Score: 499
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.48
    Marker Score: 1,786
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.44
    Marker Score: 12,400
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.43
    Marker Score: 1,345
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.42
    Marker Score: 410
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.42
    Marker Score: 1,781
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.41
    Marker Score: 12,214
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.4
    Marker Score: 13,282
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.39
    Marker Score: 2,538
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.39
    Marker Score: 15,625
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.37
    Marker Score: 2,738
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.37
    Marker Score: 50,374
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.35
    Marker Score: 13,711
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.34
    Marker Score: 760
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.34
    Marker Score: 8,702
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.33
    Marker Score: 1,408
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.33
    Marker Score: 5,144
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.32
    Marker Score: 1,145
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.32
    Marker Score: 1,508
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.31
    Marker Score: 12,296
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.3
    Marker Score: 413
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.29
    Marker Score: 417
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.29
    Marker Score: 5,345
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.28
    Marker Score: 1,207
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.27
    Marker Score: 1,322
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.27
    Marker Score: 1,365
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.26
    Marker Score: 1,526
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.26
    Marker Score: 4,219
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.25
    Marker Score: 18,672
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.25
    Marker Score: 3,147
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.25
    Marker Score: 2,117
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.24
    Marker Score: 3,114
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.24
    Marker Score: 19,447
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.24
    Marker Score: 1,908
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.23
    Marker Score: 46,852
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.23
    Marker Score: 633
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.23
    Marker Score: 348
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.23
    Marker Score: 366
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.22
    Marker Score: 24,270
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.21
    Marker Score: 2,561
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.2
    Marker Score: 3,110
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.19
    Marker Score: 656
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.16
    Marker Score: 1,673
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.16
    Marker Score: 1,067
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.15
    Marker Score: 6,163
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.14
    Marker Score: 4,682
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.14
    Marker Score: 29,259
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.14
    Marker Score: 3,059
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.13
    Marker Score: 548
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.13
    Marker Score: 463
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.13
    Marker Score: 6,718
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.13
    Marker Score: 1,226
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.13
    Marker Score: 264
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.12
    Marker Score: 792
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.12
    Marker Score: 1,185
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.12
    Marker Score: 8,548
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.11
    Marker Score: 525
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.1
    Marker Score: 2,745
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.1
    Marker Score: 985
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.1
    Marker Score: 14,457
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.09
    Marker Score: 2,620
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.09
    Marker Score: 694
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.09
    Marker Score: 729
  • Cell Name: glial cell (CL0000125)
    Fold Change: 1.08
    Marker Score: 1,189
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.08
    Marker Score: 2,538
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.08
    Marker Score: 973
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.07
    Marker Score: 2,434
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.06
    Marker Score: 367
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.06
    Marker Score: 1,310
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.05
    Marker Score: 2,001
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.05
    Marker Score: 1,292
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.04
    Marker Score: 554
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.04
    Marker Score: 3,565
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.03
    Marker Score: 302
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.03
    Marker Score: 2,094
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.03
    Marker Score: 507
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.03
    Marker Score: 675
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.02
    Marker Score: 1,199
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.02
    Marker Score: 368

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NUDT3 is a member of the Nudix hydrolase family, characterized by its ability to hydrolyze various phosphate esters and nucleotides. The gene encodes a protein that exhibits diadenosine hexaphosphate (Ap6A) hydrolase activity, which is essential for the degradation of Ap6A, a small RNA molecule involved in various cellular processes. NUDT3 is also involved in the metabolism of other nucleotides, such as diadenosine pentaphosphate (Ap5A) and diadenosine polyphosphate (Ap5P). **Pathways and Functions:** NUDT3 is involved in several metabolic pathways, including: 1. **RNA decay**: NUDT3 is responsible for the degradation of Ap6A, which is a small RNA molecule that regulates various cellular processes, including gene expression and cell signaling. 2. **Metabolism of nucleotides**: NUDT3 hydrolyzes Ap5A and Ap5P, which are involved in energy metabolism and cell signaling. 3. **Cell signaling**: NUDT3 is involved in the regulation of cell signaling pathways, including those mediated by Ap6A and Ap5A. 4. **Cytosolic metabolism**: NUDT3 is involved in the metabolism of pyrophosphates in the cytosol, which is essential for energy metabolism and cell signaling. **Clinical Significance:** Dysregulation of NUDT3 has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: NUDT3 has been linked to neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Cancer**: NUDT3 has been found to be overexpressed in various types of cancer, including breast cancer, lung cancer, and colon cancer. 3. **Neuromuscular disorders**: NUDT3 has been implicated in neuromuscular disorders, such as muscular dystrophy and myasthenia gravis. In conclusion, NUDT3 is a crucial gene that plays a significant role in various cellular processes, including RNA decay, metabolism, and cell signaling. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and clinical significance of this gene. **References:** * [Insert references to scientific studies and articles that support the discussion on NUDT3] As an expert immunologist, I hope this summary provides a comprehensive overview of the gene NUDT3 and its significance in human health and disease.

Genular Protein ID: 3711814404

Symbol: NUDT3_HUMAN

Name: Diadenosine hexaphosphate hydrolase

UniProtKB Accession Codes:

O95989 B2R8N4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 4 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 45 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 9 EMBL 9 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 20 PDBsum 17 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 13 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9822604

Title: A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase.

PubMed ID: 9822604

DOI: 10.1093/emboj/17.22.6599

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10419486

Title: The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein.

PubMed ID: 10419486

DOI: 10.1074/jbc.274.31.21735

PubMed ID: 10585413

Title: Site-directed mutagenesis of diphosphoinositol polyphosphate phosphohydrolase, a dual specificity NUDT enzyme that attacks diadenosine polyphosphates and diphosphoinositol polyphosphates.

PubMed ID: 10585413

DOI: 10.1074/jbc.274.50.35434

PubMed ID: 12370170

Title: Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate.

PubMed ID: 12370170

DOI: 10.1074/jbc.m209795200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 26932476

Title: Nudt3 is an mRNA decapping enzyme that modulates cell migration.

PubMed ID: 26932476

DOI: 10.1261/rna.055699.115

PubMed ID: 32727897

Title: InsP7 is a small-molecule regulator of NUDT3-mediated mRNA decapping and processing-body dynamics.

PubMed ID: 32727897

DOI: 10.1073/pnas.1922284117

PubMed ID: 34788624

Title: Polyphosphate degradation by Nudt3-Zn2+ mediates oxidative stress response.

PubMed ID: 34788624

DOI: 10.1016/j.celrep.2021.110004

PubMed ID: 19585659

Title: Crystal structure of human diphosphoinositol phosphatase 1.

PubMed ID: 19585659

DOI: 10.1002/prot.22489

Sequence Information:

  • Length: 172
  • Mass: 19471
  • Checksum: DE823FECF5C6438A
  • Sequence:
    • MMKLKSNQTR TYDGDGYKKR AACLCFRSES EEEVLLVSSS RHPDRWIVPG GGMEPEEEPS 
VAAVREVCEE AGVKGTLGRL VGIFENQERK HRTYVYVLIV TEVLEDWEDS VNIGRKREWF 
KIEDAIKVLQ YHKPVQASYF ETLRQGYSAN NGTPVVATTY SVSAQSSMSG IR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.