Details for: NUDT3

Gene ID: 11165

Symbol: NUDT3

Ensembl ID: ENSG00000272325

Description: nudix hydrolase 3

Associated with

  • Inositol phosphate metabolism
    (R-HSA-1483249)
  • Metabolism
    (R-HSA-1430728)
  • Synthesis of pyrophosphates in the cytosol
    (R-HSA-1855167)
  • 5'-(n(7)-methyl 5'-triphosphoguanosine)-[mrna] diphosphatase activity
    (GO:0140932)
  • 5'-(n(7)-methylguanosine 5'-triphospho)-[mrna] hydrolase activity
    (GO:0140933)
  • Adenosine 5'-(hexahydrogen pentaphosphate) catabolic process
    (GO:1901911)
  • Bis(5'-adenosyl)-hexaphosphatase activity
    (GO:0034431)
  • Bis(5'-adenosyl)-pentaphosphatase activity
    (GO:0034432)
  • Cell-cell signaling
    (GO:0007267)
  • Cytoplasm
    (GO:0005737)
  • Cytosol
    (GO:0005829)
  • Diadenosine hexaphosphate catabolic process
    (GO:1901909)
  • Diadenosine pentaphosphate catabolic process
    (GO:1901907)
  • Diadenosine polyphosphate catabolic process
    (GO:0015961)
  • Diphosphoinositol-polyphosphate diphosphatase activity
    (GO:0008486)
  • Diphosphoinositol polyphosphate catabolic process
    (GO:0071544)
  • Diphosphoinositol polyphosphate metabolic process
    (GO:0071543)
  • Endopolyphosphatase activity
    (GO:0000298)
  • Inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
    (GO:0052848)
  • Inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity
    (GO:0052845)
  • Inositol diphosphate pentakisphosphate diphosphatase activity
    (GO:0052842)
  • Inositol diphosphate tetrakisphosphate diphosphatase activity
    (GO:0052840)
  • Magnesium ion binding
    (GO:0000287)
  • Manganese ion binding
    (GO:0030145)
  • Nucleus
    (GO:0005634)
  • Protein binding
    (GO:0005515)
  • Rna decapping
    (GO:0110154)
  • Zinc ion binding
    (GO:0008270)

Other Information

Genular Protein ID: 3711814404

Symbol: NUDT3_HUMAN

Name: Diadenosine hexaphosphate hydrolase

UniProtKB Accession Codes:

O95989 B2R8N4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 4 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 45 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 9 EMBL 9 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 20 PDBsum 17 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 13 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9822604

Title: A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase.

PubMed ID: 9822604

DOI: 10.1093/emboj/17.22.6599

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10419486

Title: The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein.

PubMed ID: 10419486

DOI: 10.1074/jbc.274.31.21735

PubMed ID: 10585413

Title: Site-directed mutagenesis of diphosphoinositol polyphosphate phosphohydrolase, a dual specificity NUDT enzyme that attacks diadenosine polyphosphates and diphosphoinositol polyphosphates.

PubMed ID: 10585413

DOI: 10.1074/jbc.274.50.35434

PubMed ID: 12370170

Title: Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate.

PubMed ID: 12370170

DOI: 10.1074/jbc.m209795200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 26932476

Title: Nudt3 is an mRNA decapping enzyme that modulates cell migration.

PubMed ID: 26932476

DOI: 10.1261/rna.055699.115

PubMed ID: 32727897

Title: InsP7 is a small-molecule regulator of NUDT3-mediated mRNA decapping and processing-body dynamics.

PubMed ID: 32727897

DOI: 10.1073/pnas.1922284117

PubMed ID: 34788624

Title: Polyphosphate degradation by Nudt3-Zn2+ mediates oxidative stress response.

PubMed ID: 34788624

DOI: 10.1016/j.celrep.2021.110004

PubMed ID: 19585659

Title: Crystal structure of human diphosphoinositol phosphatase 1.

PubMed ID: 19585659

DOI: 10.1002/prot.22489

Sequence Information:

  • Length: 172
  • Mass: 19471
  • Checksum: DE823FECF5C6438A
  • Sequence:
    • MMKLKSNQTR TYDGDGYKKR AACLCFRSES EEEVLLVSSS RHPDRWIVPG GGMEPEEEPS 
VAAVREVCEE AGVKGTLGRL VGIFENQERK HRTYVYVLIV TEVLEDWEDS VNIGRKREWF 
KIEDAIKVLQ YHKPVQASYF ETLRQGYSAN NGTPVVATTY SVSAQSSMSG IR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.