Details for: SOX21

Gene ID: 11166

Symbol: SOX21

Ensembl ID: ENSG00000125285

Description: SRY-box transcription factor 21

Associated with

  • Brain development
    (GO:0007420)
  • Cellular_component
    (GO:0005575)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Hair follicle development
    (GO:0001942)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuron differentiation
    (GO:0030182)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Stem cell differentiation
    (GO:0048863)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 5.58
    Marker Score: 8,007
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.15
    Marker Score: 3,166
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.19
    Marker Score: 1,508
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.38
    Marker Score: 8,824
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 868
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,817
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,042
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,354
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.93
    Marker Score: 545
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,742
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.9
    Marker Score: 688
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,283
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.77
    Marker Score: 1,466
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.67
    Marker Score: 1,528
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.67
    Marker Score: 440
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.63
    Marker Score: 312
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.62
    Marker Score: 1,262
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.61
    Marker Score: 484
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.56
    Marker Score: 262
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.56
    Marker Score: 1,016
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.55
    Marker Score: 231
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.55
    Marker Score: 159
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.5
    Marker Score: 336
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.49
    Marker Score: 635
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 474
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.48
    Marker Score: 4,123
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.47
    Marker Score: 583
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.46
    Marker Score: 241
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.45
    Marker Score: 254
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.44
    Marker Score: 1,236
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.43
    Marker Score: 3,217
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.43
    Marker Score: 6,737
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.4
    Marker Score: 239
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.39
    Marker Score: 1,337
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.37
    Marker Score: 2,248
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.37
    Marker Score: 396
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.37
    Marker Score: 1,152
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 372
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.37
    Marker Score: 3,185
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.36
    Marker Score: 737
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.34
    Marker Score: 298
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.29
    Marker Score: 400
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.29
    Marker Score: 1,898
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.27
    Marker Score: 127
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.26
    Marker Score: 174
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.24
    Marker Score: 5,219
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.24
    Marker Score: 946
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.24
    Marker Score: 132
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.23
    Marker Score: 156
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.22
    Marker Score: 1,718
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.22
    Marker Score: 155
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.21
    Marker Score: 174
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.2
    Marker Score: 134
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.2
    Marker Score: 108
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.19
    Marker Score: 84
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.19
    Marker Score: 59
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.18
    Marker Score: 50
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.18
    Marker Score: 183
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.17
    Marker Score: 92
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.17
    Marker Score: 70
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.16
    Marker Score: 433
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.16
    Marker Score: 2,167
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.16
    Marker Score: 184
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.15
    Marker Score: 172
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.14
    Marker Score: 152
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.14
    Marker Score: 93
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.14
    Marker Score: 39
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.13
    Marker Score: 64
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.13
    Marker Score: 78
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.13
    Marker Score: 186
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.13
    Marker Score: 119
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.13
    Marker Score: 133
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.13
    Marker Score: 45
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.12
    Marker Score: 60
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.12
    Marker Score: 31
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.12
    Marker Score: 33
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.11
    Marker Score: 33
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.11
    Marker Score: 88
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.11
    Marker Score: 60
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.11
    Marker Score: 42
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.11
    Marker Score: 27
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.11
    Marker Score: 201
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.1
    Marker Score: 28
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.1
    Marker Score: 35
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.1
    Marker Score: 32
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1
    Marker Score: 105
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.1
    Marker Score: 32
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.1
    Marker Score: 406
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.09
    Marker Score: 53
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.09
    Marker Score: 33
  • Cell Name: serous cell of epithelium of trachea (CL1000330)
    Fold Change: 0.09
    Marker Score: 33
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.09
    Marker Score: 32

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Transcriptional Regulator**: SOX21 is a transcription factor, meaning it regulates gene expression by binding to specific DNA sequences and modulating the activity of RNA polymerase II. 2. **Developmental Role**: SOX21 is involved in the development of various tissues and organs, including the brain, hair follicles, and stem cells. 3. **Cellular Specificity**: SOX21 is expressed in multiple cell types, including neurons, stem cells, and immune cells, underscoring its role in regulating cellular homeostasis and differentiation. 4. **Regulatory Mechanisms**: SOX21 can act as a transcriptional activator or repressor, depending on the context and target genes. **Pathways and Functions** 1. **Neural Development**: SOX21 plays a crucial role in the development of the central nervous system, particularly in the specification of GABAergic interneurons and the regulation of neural differentiation. 2. **Stem Cell Differentiation**: SOX21 is involved in the differentiation of stem cells into specific cell types, including neurons and immune cells. 3. **Gene Regulation**: SOX21 regulates the expression of target genes involved in cellular homeostasis, including those involved in DNA repair, cell cycle regulation, and apoptosis. 4. **Immunological Functions**: SOX21 is expressed in immune cells, including conventional dendritic cells and granulocyte-monocyte progenitor cells, highlighting its role in immune regulation and response. **Clinical Significance** 1. **Neurological Disorders**: Alterations in SOX21 expression have been implicated in various neurological disorders, including autism spectrum disorder, schizophrenia, and Alzheimer's disease. 2. **Cancer**: SOX21 has been identified as a tumor suppressor gene in several types of cancer, including leukemia and lymphoma. 3. **Immunological Disorders**: SOX21 dysregulation has been linked to immune-related disorders, including autoimmune diseases and immunodeficiency disorders. 4. **Stem Cell Therapies**: Understanding the role of SOX21 in stem cell differentiation and regulation may provide insights into the development of novel stem cell therapies for various diseases. In conclusion, SOX21 is a multifunctional transcription factor that plays a critical role in regulating cellular development, differentiation, and homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of SOX21 function and its clinical applications.

Genular Protein ID: 16554896

Symbol: SOX21_HUMAN

Name: Transcription factor SOX-21

UniProtKB Accession Codes:

Q9Y651 P35715 Q15504 Q5TBS1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10441749

Title: The isolation and high-resolution chromosomal mapping of human SOX14 and SOX21; two members of the SOX gene family related to SOX1, SOX2, and SOX3.

PubMed ID: 10441749

DOI: 10.1007/s003359901118

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 1614875

Title: A conserved family of genes related to the testis determining gene, SRY.

PubMed ID: 1614875

DOI: 10.1093/nar/20.11.2887

Sequence Information:

  • Length: 276
  • Mass: 28580
  • Checksum: 99DC899B7EC9A96B
  • Sequence:
    • MSKPVDHVKR PMNAFMVWSR AQRRKMAQEN PKMHNSEISK RLGAEWKLLT ESEKRPFIDE 
AKRLRAMHMK EHPDYKYRPR RKPKTLLKKD KFAFPVPYGL GGVADAEHPA LKAGAGLHAG 
AGGGLVPESL LANPEKAAAA AAAAAARVFF PQSAAAAAAA AAAAAAGSPY SLLDLGSKMA 
EISSSSSGLP YASSLGYPTA GAGAFHGAAA AAAAAAAAAG GHTHSHPSPG NPGYMIPCNC 
SAWPSPGLQP PLAYILLPGM GKPQLDPYPA AYAAAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.