Details for: FSTL1

Gene ID: 11167

Symbol: FSTL1

Ensembl ID: ENSG00000163430

Description: follistatin like 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 3.75
    Marker Score: 2,118
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.63
    Marker Score: 5,591
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 3.32
    Marker Score: 2,185
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.26
    Marker Score: 43,014
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.14
    Marker Score: 106,815
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.9
    Marker Score: 3,984
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.81
    Marker Score: 7,347
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.35
    Marker Score: 10,135
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.34
    Marker Score: 976
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.32
    Marker Score: 26,112
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.3
    Marker Score: 51,366
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.28
    Marker Score: 525
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.23
    Marker Score: 716
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.21
    Marker Score: 5,199
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.19
    Marker Score: 829
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.16
    Marker Score: 613
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.14
    Marker Score: 556
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.11
    Marker Score: 13,744
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 2.1
    Marker Score: 473
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.07
    Marker Score: 515
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.05
    Marker Score: 2,362
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.05
    Marker Score: 515
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.99
    Marker Score: 1,428
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.99
    Marker Score: 1,160
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.99
    Marker Score: 17,472
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.95
    Marker Score: 2,424
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.94
    Marker Score: 1,131
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.92
    Marker Score: 3,687
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.82
    Marker Score: 1,554
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.8
    Marker Score: 1,713
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.78
    Marker Score: 1,720
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.78
    Marker Score: 37,942
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.77
    Marker Score: 2,180
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.77
    Marker Score: 1,114
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.75
    Marker Score: 866
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.74
    Marker Score: 992
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.73
    Marker Score: 744
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.72
    Marker Score: 3,591
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.72
    Marker Score: 6,744
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.7
    Marker Score: 420
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.69
    Marker Score: 1,593
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.61
    Marker Score: 1,733
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.56
    Marker Score: 1,106
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.53
    Marker Score: 530
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.52
    Marker Score: 3,045
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.52
    Marker Score: 847
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.51
    Marker Score: 2,568
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.51
    Marker Score: 831
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.51
    Marker Score: 6,311
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.5
    Marker Score: 836
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.47
    Marker Score: 964
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.36
    Marker Score: 5,671
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.36
    Marker Score: 1,768
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.35
    Marker Score: 395
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.35
    Marker Score: 4,805
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.35
    Marker Score: 899
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.34
    Marker Score: 1,853
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.32
    Marker Score: 20,682
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.31
    Marker Score: 1,396
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.28
    Marker Score: 6,268
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.27
    Marker Score: 465
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.27
    Marker Score: 1,345
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.26
    Marker Score: 2,373
  • Cell Name: adipose microvascular endothelial cell (CL2000072)
    Fold Change: 1.26
    Marker Score: 374
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.26
    Marker Score: 1,181
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.25
    Marker Score: 1,339
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.24
    Marker Score: 316
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.23
    Marker Score: 1,660
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.23
    Marker Score: 348
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.22
    Marker Score: 295
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.17
    Marker Score: 682
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.16
    Marker Score: 449
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.15
    Marker Score: 556
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.13
    Marker Score: 4,755
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.13
    Marker Score: 39,007
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.1
    Marker Score: 734
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.1
    Marker Score: 280
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.07
    Marker Score: 951
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.06
    Marker Score: 4,110
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.06
    Marker Score: 247
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.06
    Marker Score: 425
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.06
    Marker Score: 2,153
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.04
    Marker Score: 244
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.04
    Marker Score: 2,445
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.04
    Marker Score: 2,535
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 1.03
    Marker Score: 463
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.02
    Marker Score: 3,490
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.01
    Marker Score: 605
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.01
    Marker Score: 913
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.01
    Marker Score: 479
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1
    Marker Score: 241
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,732
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,956
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.99
    Marker Score: 883
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,404
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.98
    Marker Score: 5,892
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.98
    Marker Score: 219
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.98
    Marker Score: 1,227
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.97
    Marker Score: 2,636

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FSTL1 is a member of the follistatin family, characterized by its ability to bind to and neutralize activins, a class of growth factors involved in various physiological processes. The gene is primarily expressed in cells of mesodermal origin, including endocardial cells, mesenchymal stem cells, and fibroblasts. FSTL1's expression is also found in cells of connective tissue, such as fibroblasts in the mammary gland and prostate, as well as in decidual cells. **Pathways and Functions:** FSTL1's functions are intricately linked to various signaling pathways, including: 1. **Calcium ion binding:** FSTL1's interaction with calcium ions modulates its activity and regulates the binding of activins to their receptors. 2. **Cell differentiation:** FSTL1's expression is crucial for the differentiation of endothelial cells, which is essential for vascular development and maintenance. 3. **Endothelial cell migration:** FSTL1's involvement in endothelial cell migration is critical for angiogenesis and wound healing. 4. **Regulation of BMP signaling pathway:** FSTL1's interaction with BMPs (Bone Morphogenetic Proteins) modulates their activity and regulates their signaling pathways. 5. **Regulation of insulin-like growth factor (IGF) transport and uptake:** FSTL1's expression is involved in the regulation of IGF transport and uptake by IGF-binding proteins (IGFBPs), which is essential for growth and development. **Clinical Significance:** FSTL1's functions have significant implications for various diseases and disorders, including: 1. **Hematopoietic disorders:** FSTL1's involvement in hematopoietic stem cell homeostasis makes it a potential target for the treatment of hematological malignancies, such as leukemia and lymphoma. 2. **Vascular diseases:** FSTL1's role in endothelial cell differentiation and migration makes it a potential therapeutic target for the treatment of vascular diseases, such as atherosclerosis and restenosis. 3. **Cancer:** FSTL1's expression in cancer cells and its involvement in angiogenesis and metastasis make it a potential target for cancer therapy. 4. **Reproductive disorders:** FSTL1's expression in decidual cells and its involvement in implantation and pregnancy make it a potential target for the treatment of reproductive disorders, such as infertility and miscarriage. In conclusion, FSTL1 is a multifaceted gene that plays a critical role in various biological processes, including cell differentiation, migration, and homeostasis. Its functions have significant implications for various diseases and disorders, making it a potential target for the development of novel therapeutic strategies. Further research is necessary to fully elucidate the functions of FSTL1 and its potential applications in medicine.

Genular Protein ID: 480515202

Symbol: FSTL1_HUMAN

Name: Follistatin-related protein 1

UniProtKB Accession Codes:

Q12841 A8K523 B4DTT5 D3DN90 Q549Z0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7957230

Title: Characterization of a rat C6 glioma-secreted follistatin-related protein (FRP). Cloning and sequence of the human homologue.

PubMed ID: 7957230

DOI: 10.1111/j.1432-1033.1994.0937b.x

PubMed ID: 9786430

Title: Cloning of follistatin-related protein as a novel autoantigen in systemic rheumatic diseases.

PubMed ID: 9786430

DOI: 10.1093/intimm/10.9.1305

PubMed ID: 15638044

Title: Follistatin-related protein gene (FRP) is expressed in the synovial tissues of rheumatoid arthritis, but its polymorphisms are not associated with genetic susceptibility.

PubMed ID: 15638044

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 20860622

Title: DIP2 disco-interacting protein 2 homolog A (Drosophila) is a candidate receptor for follistatin-related protein/follistatin-like 1--analysis of their binding with TGF-beta superfamily proteins.

PubMed ID: 20860622

DOI: 10.1111/j.1742-4658.2010.07816.x

PubMed ID: 20054002

Title: DIP2A functions as a FSTL1 receptor.

PubMed ID: 20054002

DOI: 10.1074/jbc.m109.069468

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22265692

Title: Follistatin-related protein/follistatin-like 1 evokes an innate immune response via CD14 and toll-like receptor 4.

PubMed ID: 22265692

DOI: 10.1016/j.febslet.2012.01.010

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 29212066

Title: Fstl1 Promotes Glioma Growth Through the BMP4/Smad1/5/8 Signaling Pathway.

PubMed ID: 29212066

DOI: 10.1159/000485759

Sequence Information:

  • Length: 308
  • Mass: 34986
  • Checksum: BD4C651FAFF24800
  • Sequence:
    • MWKRWLALAL ALVAVAWVRA EEELRSKSKI CANVFCGAGR ECAVTEKGEP TCLCIEQCKP 
HKRPVCGSNG KTYLNHCELH RDACLTGSKI QVDYDGHCKE KKSVSPSASP VVCYQSNRDE 
LRRRIIQWLE AEIIPDGWFS KGSNYSEILD KYFKNFDNGD SRLDSSEFLK FVEQNETAIN 
ITTYPDQENN KLLRGLCVDA LIELSDENAD WKLSFQEFLK CLNPSFNPPE KKCALEDETY 
ADGAETEVDC NRCVCACGNW VCTAMTCDGK NQKGAQTQTE EEMTRYVQEL QKHQETAEKT 
KRVSTKEI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.