Details for: PSIP1

Gene ID: 11168

Symbol: PSIP1

Ensembl ID: ENSG00000164985

Description: PC4 and SRSF1 interacting protein 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.89
    Marker Score: 3,487
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.85
    Marker Score: 11,879
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.74
    Marker Score: 7,825
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.73
    Marker Score: 5,542
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.59
    Marker Score: 2,445
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.52
    Marker Score: 2,371
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.44
    Marker Score: 15,849
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.43
    Marker Score: 2,594
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.41
    Marker Score: 717
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.4
    Marker Score: 2,689
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.37
    Marker Score: 8,773
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.34
    Marker Score: 6,366
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.26
    Marker Score: 119,575
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.25
    Marker Score: 1,415
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2.23
    Marker Score: 1,167
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 2.18
    Marker Score: 761
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.14
    Marker Score: 8,296
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.11
    Marker Score: 21,186
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.11
    Marker Score: 1,052
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.08
    Marker Score: 79,027
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.07
    Marker Score: 8,877
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.06
    Marker Score: 1,494
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.06
    Marker Score: 2,955
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.05
    Marker Score: 40,778
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.04
    Marker Score: 6,058
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.01
    Marker Score: 8,235
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.01
    Marker Score: 26,470
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.99
    Marker Score: 29,732
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.98
    Marker Score: 1,176
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.98
    Marker Score: 1,850
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.97
    Marker Score: 2,782
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.92
    Marker Score: 70,996
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.92
    Marker Score: 1,399
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.91
    Marker Score: 14,671
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.91
    Marker Score: 550
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.91
    Marker Score: 16,731
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.88
    Marker Score: 2,001
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.88
    Marker Score: 7,258
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.85
    Marker Score: 7,677
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.84
    Marker Score: 8,532
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.84
    Marker Score: 5,014
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.83
    Marker Score: 112,749
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.83
    Marker Score: 1,839
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.81
    Marker Score: 853
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.8
    Marker Score: 4,392
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.8
    Marker Score: 7,317
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.8
    Marker Score: 629
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.79
    Marker Score: 1,685
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.79
    Marker Score: 883
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.79
    Marker Score: 16,849
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.78
    Marker Score: 597
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.77
    Marker Score: 17,493
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.75
    Marker Score: 2,198
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.75
    Marker Score: 3,293
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.74
    Marker Score: 558
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.73
    Marker Score: 16,413
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.71
    Marker Score: 1,039
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.7
    Marker Score: 1,025
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.69
    Marker Score: 3,014
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.68
    Marker Score: 520
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.68
    Marker Score: 7,017
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.67
    Marker Score: 4,691
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.67
    Marker Score: 6,572
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.67
    Marker Score: 1,263
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.66
    Marker Score: 1,793
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.66
    Marker Score: 1,304
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.65
    Marker Score: 9,815
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.65
    Marker Score: 483
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.65
    Marker Score: 14,140
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.63
    Marker Score: 1,972
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.63
    Marker Score: 16,794
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.62
    Marker Score: 863
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.62
    Marker Score: 400
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.61
    Marker Score: 1,178
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.6
    Marker Score: 809
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.59
    Marker Score: 685
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.58
    Marker Score: 1,525
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.57
    Marker Score: 2,582
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.57
    Marker Score: 1,378
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.57
    Marker Score: 1,692
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 1.56
    Marker Score: 1,007
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.56
    Marker Score: 3,123
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.56
    Marker Score: 1,535
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.55
    Marker Score: 966
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.54
    Marker Score: 469
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.54
    Marker Score: 368
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.53
    Marker Score: 353
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.53
    Marker Score: 757
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.53
    Marker Score: 1,043
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.53
    Marker Score: 579
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.53
    Marker Score: 52,976
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.53
    Marker Score: 1,439
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.52
    Marker Score: 489
  • Cell Name: glial cell (CL0000125)
    Fold Change: 1.52
    Marker Score: 1,671
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.52
    Marker Score: 1,304
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.51
    Marker Score: 2,036
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.51
    Marker Score: 305
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.51
    Marker Score: 2,094
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.51
    Marker Score: 1,143
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.51
    Marker Score: 878

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PSIP1 is a protein-coding gene that interacts with various RNA-binding proteins, including PC4 and SRSF1. Its expression is widespread, with significant levels detected in glycinergic neurons, GABAergic neurons, retinal rod cells, and other cell types. The gene's involvement in chromatin remodeling and epigenetic regulation of gene expression has been established, suggesting its potential role in modulating cellular responses to environmental cues. Notably, PSIP1 has been linked to the regulation of HIV-1 life cycles, with its products interacting with viral proteins and influencing viral integration and nuclear import. **Pathways and Functions:** PSIP1's involvement in various cellular processes can be attributed to its interactions with multiple RNA-binding proteins and its role in chromatin remodeling. Its functions can be broadly categorized into the following: 1. **Gene Expression and Regulation:** PSIP1 modulates gene expression by interacting with RNA-binding proteins, influencing the splicing and processing of RNA molecules. 2. **Chromatin Remodeling:** PSIP1 participates in chromatin remodeling complexes, facilitating the regulation of gene expression and transcription. 3. **Viral Life Cycles:** PSIP1 interacts with viral proteins, influencing the integration and nuclear import of HIV-1. 4. **Immune Regulation:** PSIP1's role in modulating the immune response, particularly in the context of HIV-1 infection, remains poorly understood and warrants further investigation. **Clinical Significance:** The clinical significance of PSIP1 lies in its potential role in modulating the immune response to HIV-1 infection. As a multifunctional gene, PSIP1 may contribute to the development of novel therapeutic strategies for managing HIV-1-related diseases. Additionally, its involvement in chromatin remodeling and epigenetic regulation suggests its potential as a biomarker for various diseases, including those affecting the nervous system and gonads. In conclusion, PSIP1's enigmatic nature and multifaceted functions highlight the need for further research into its role in immune regulation, particularly in the context of HIV-1 infection. As our understanding of this gene deepens, it is likely to reveal new avenues for therapeutic intervention and biomarker development, ultimately improving our ability to manage and treat diseases associated with PSIP1 dysfunction.

Genular Protein ID: 1420022053

Symbol: PSIP1_HUMAN

Name: PC4 and SFRS1-interacting protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9822615

Title: Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation.

PubMed ID: 9822615

DOI: 10.1093/emboj/17.22.6723

PubMed ID: 10623627

Title: Lens epithelium-derived growth factor: effects on growth and survival of lens epithelial cells, keratinocytes, and fibroblasts.

PubMed ID: 10623627

DOI: 10.1006/bbrc.1999.1979

PubMed ID: 10721720

Title: Lens epithelium-derived growth factor (LEDGF/p75) and p52 are derived from a single gene by alternative splicing.

PubMed ID: 10721720

DOI: 10.1016/s0378-1119(99)00506-5

PubMed ID: 12200376

Title: Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX.

PubMed ID: 12200376

DOI: 10.1182/blood-2002-02-0513

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10856157

Title: Autoantibodies to DFS 70 kd/transcription coactivator p75 in atopic dermatitis and other conditions.

PubMed ID: 10856157

DOI: 10.1067/mai.2000.107039

PubMed ID: 15642333

Title: Lens epithelium-derived growth factor (LEDGF/p75) expression in fetal and adult human brain.

PubMed ID: 15642333

DOI: 10.1016/j.exer.2004.08.022

PubMed ID: 15475359

Title: Lens epithelium-derived growth factor/p75 prevents proteasomal degradation of HIV-1 integrase.

PubMed ID: 15475359

DOI: 10.1074/jbc.m408508200

PubMed ID: 15749713

Title: The interaction of LEDGF/p75 with integrase is lentiviral-specific and promotes DNA binding.

PubMed ID: 15749713

DOI: 10.1074/jbc.m411681200

PubMed ID: 15797927

Title: Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering.

PubMed ID: 15797927

DOI: 10.1242/jcs.02299

PubMed ID: 9885563

Title: A novel transcriptional coactivator, p52, functionally interacts with the essential splicing factor ASF/SF2.

PubMed ID: 9885563

DOI: 10.1016/s1097-2765(00)80290-7

PubMed ID: 15725483

Title: t(9;11)(p22;p15) with NUP98-LEDGF fusion gene in pediatric acute myeloid leukemia.

PubMed ID: 15725483

DOI: 10.1016/j.leukres.2004.09.002

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19244240

Title: Lens epithelium-derived growth factor/p75 interacts with the transposase-derived DDE domain of PogZ.

PubMed ID: 19244240

DOI: 10.1074/jbc.m807781200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 15895093

Title: Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75.

PubMed ID: 15895093

DOI: 10.1038/nsmb937

PubMed ID: 16260736

Title: Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.

PubMed ID: 16260736

DOI: 10.1073/pnas.0506924102

PubMed ID: 22327296

Title: The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.

PubMed ID: 22327296

DOI: 10.1038/nature10806

PubMed ID: 25305204

Title: The same site on the integrase-binding domain of lens epithelium-derived growth factor is a therapeutic target for MLL leukemia and HIV.

PubMed ID: 25305204

DOI: 10.1182/blood-2014-01-550079

PubMed ID: 25082813

Title: Validation and structural characterization of the LEDGF/p75-MLL interface as a new target for the treatment of MLL-dependent leukemia.

PubMed ID: 25082813

DOI: 10.1158/0008-5472.can-13-3602

PubMed ID: 29997176

Title: Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation.

PubMed ID: 29997176

DOI: 10.1073/pnas.1803909115

Sequence Information:

  • Length: 530
  • Mass: 60103
  • Checksum: 4B653D02B1D0E174
  • Sequence:
  • MTRDFKPGDL IFAKMKGYPH WPARVDEVPD GAVKPPTNKL PIFFFGTHET AFLGPKDIFP 
    YSENKEKYGK PNKRKGFNEG LWEIDNNPKV KFSSQQAATK QSNASSDVEV EEKETSVSKE 
    DTDHEEKASN EDVTKAVDIT TPKAARRGRK RKAEKQVETE EAGVVTTATA SVNLKVSPKR 
    GRPAATEVKI PKPRGRPKMV KQPCPSESDI ITEEDKSKKK GQEEKQPKKQ PKKDEEGQKE 
    EDKPRKEPDK KEGKKEVESK RKNLAKTGVT STSDSEEEGD DQEGEKKRKG GRNFQTAHRR 
    NMLKGQHEKE AADRKRKQEE QMETEQQNKD EGKKPEVKKV EKKRETSMDS RLQRIHAEIK 
    NSLKIDNLDV NRCIEALDEL ASLQVTMQQA QKHTEMITTL KKIRRFKVSQ VIMEKSTMLY 
    NKFKNMFLVG EGDSVITQVL NKSLAEQRQH EEANKTKDQG KKGPNKKLEK EQTGSKTLNG 
    GSDAQDGNQP QHNGESNEDS KDNHEASTKK KPSSEERETE ISLKDSTLDN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.