Details for: PSIP1
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: glycinergic neuron (CL1001509)
Fold Change: 2.89
Marker Score: 3,487 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: 2.85
Marker Score: 11,879 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 2.74
Marker Score: 7,825 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 2.73
Marker Score: 5,542 - Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 2.59
Marker Score: 2,445 - Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 2.52
Marker Score: 2,371 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.44
Marker Score: 15,849 - Cell Name: neural crest cell (CL0011012)
Fold Change: 2.43
Marker Score: 2,594 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 2.41
Marker Score: 717 - Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 2.4
Marker Score: 2,689 - Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 2.37
Marker Score: 8,773 - Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 2.34
Marker Score: 6,366 - Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 2.26
Marker Score: 119,575 - Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 2.25
Marker Score: 1,415 - Cell Name: rod bipolar cell (CL0000751)
Fold Change: 2.23
Marker Score: 1,167 - Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 2.18
Marker Score: 761 - Cell Name: neural progenitor cell (CL0011020)
Fold Change: 2.14
Marker Score: 8,296 - Cell Name: granulosa cell (CL0000501)
Fold Change: 2.11
Marker Score: 21,186 - Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 2.11
Marker Score: 1,052 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 2.08
Marker Score: 79,027 - Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 2.07
Marker Score: 8,877 - Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 2.06
Marker Score: 1,494 - Cell Name: oogonial cell (CL0000024)
Fold Change: 2.06
Marker Score: 2,955 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.05
Marker Score: 40,778 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.04
Marker Score: 6,058 - Cell Name: pro-T cell (CL0000827)
Fold Change: 2.01
Marker Score: 8,235 - Cell Name: mesodermal cell (CL0000222)
Fold Change: 2.01
Marker Score: 26,470 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.99
Marker Score: 29,732 - Cell Name: motor neuron (CL0000100)
Fold Change: 1.98
Marker Score: 1,176 - Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 1.98
Marker Score: 1,850 - Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 1.97
Marker Score: 2,782 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.92
Marker Score: 70,996 - Cell Name: Unknown (CL0000548)
Fold Change: 1.92
Marker Score: 1,399 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.91
Marker Score: 14,671 - Cell Name: male germ cell (CL0000015)
Fold Change: 1.91
Marker Score: 550 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.91
Marker Score: 16,731 - Cell Name: Unknown (CL0002371)
Fold Change: 1.88
Marker Score: 2,001 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.88
Marker Score: 7,258 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.85
Marker Score: 7,677 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 1.84
Marker Score: 8,532 - Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.84
Marker Score: 5,014 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.83
Marker Score: 112,749 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.83
Marker Score: 1,839 - Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 1.81
Marker Score: 853 - Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 1.8
Marker Score: 4,392 - Cell Name: neuron (CL0000540)
Fold Change: 1.8
Marker Score: 7,317 - Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 1.8
Marker Score: 629 - Cell Name: class switched memory B cell (CL0000972)
Fold Change: 1.79
Marker Score: 1,685 - Cell Name: centroblast (CL0009112)
Fold Change: 1.79
Marker Score: 883 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.79
Marker Score: 16,849 - Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 1.78
Marker Score: 597 - Cell Name: mature T cell (CL0002419)
Fold Change: 1.77
Marker Score: 17,493 - Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.75
Marker Score: 2,198 - Cell Name: supporting cell (CL0000630)
Fold Change: 1.75
Marker Score: 3,293 - Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 1.74
Marker Score: 558 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.73
Marker Score: 16,413 - Cell Name: germinal center B cell (CL0000844)
Fold Change: 1.71
Marker Score: 1,039 - Cell Name: IgG memory B cell (CL0000979)
Fold Change: 1.7
Marker Score: 1,025 - Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 1.69
Marker Score: 3,014 - Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 1.68
Marker Score: 520 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.68
Marker Score: 7,017 - Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 1.67
Marker Score: 4,691 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.67
Marker Score: 6,572 - Cell Name: memory B cell (CL0000787)
Fold Change: 1.67
Marker Score: 1,263 - Cell Name: Leydig cell (CL0000178)
Fold Change: 1.66
Marker Score: 1,793 - Cell Name: type I NK T cell (CL0000921)
Fold Change: 1.66
Marker Score: 1,304 - Cell Name: Sertoli cell (CL0000216)
Fold Change: 1.65
Marker Score: 9,815 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.65
Marker Score: 483 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.65
Marker Score: 14,140 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.63
Marker Score: 1,972 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.63
Marker Score: 16,794 - Cell Name: enteric neuron (CL0007011)
Fold Change: 1.62
Marker Score: 863 - Cell Name: oocyte (CL0000023)
Fold Change: 1.62
Marker Score: 400 - Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 1.61
Marker Score: 1,178 - Cell Name: lymphocyte (CL0000542)
Fold Change: 1.6
Marker Score: 809 - Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 1.59
Marker Score: 685 - Cell Name: pro-B cell (CL0000826)
Fold Change: 1.58
Marker Score: 1,525 - Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.57
Marker Score: 2,582 - Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 1.57
Marker Score: 1,378 - Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 1.57
Marker Score: 1,692 - Cell Name: naive T cell (CL0000898)
Fold Change: 1.56
Marker Score: 1,007 - Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.56
Marker Score: 3,123 - Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 1.56
Marker Score: 1,535 - Cell Name: erythroblast (CL0000765)
Fold Change: 1.55
Marker Score: 966 - Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 1.54
Marker Score: 469 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.54
Marker Score: 368 - Cell Name: keratocyte (CL0002363)
Fold Change: 1.53
Marker Score: 353 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.53
Marker Score: 757 - Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 1.53
Marker Score: 1,043 - Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 1.53
Marker Score: 579 - Cell Name: cell in vitro (CL0001034)
Fold Change: 1.53
Marker Score: 52,976 - Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 1.53
Marker Score: 1,439 - Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 1.52
Marker Score: 489 - Cell Name: glial cell (CL0000125)
Fold Change: 1.52
Marker Score: 1,671 - Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 1.52
Marker Score: 1,304 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.51
Marker Score: 2,036 - Cell Name: papillary tips cell (CL1000597)
Fold Change: 1.51
Marker Score: 305 - Cell Name: Mueller cell (CL0000636)
Fold Change: 1.51
Marker Score: 2,094 - Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 1.51
Marker Score: 1,143 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.51
Marker Score: 878
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1420022053
Symbol: PSIP1_HUMAN
Name: PC4 and SFRS1-interacting protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9822615
Title: Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation.
PubMed ID: 9822615
PubMed ID: 10623627
Title: Lens epithelium-derived growth factor: effects on growth and survival of lens epithelial cells, keratinocytes, and fibroblasts.
PubMed ID: 10623627
PubMed ID: 10721720
Title: Lens epithelium-derived growth factor (LEDGF/p75) and p52 are derived from a single gene by alternative splicing.
PubMed ID: 10721720
PubMed ID: 12200376
Title: Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX.
PubMed ID: 12200376
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10856157
Title: Autoantibodies to DFS 70 kd/transcription coactivator p75 in atopic dermatitis and other conditions.
PubMed ID: 10856157
PubMed ID: 15642333
Title: Lens epithelium-derived growth factor (LEDGF/p75) expression in fetal and adult human brain.
PubMed ID: 15642333
PubMed ID: 15475359
Title: Lens epithelium-derived growth factor/p75 prevents proteasomal degradation of HIV-1 integrase.
PubMed ID: 15475359
PubMed ID: 15749713
Title: The interaction of LEDGF/p75 with integrase is lentiviral-specific and promotes DNA binding.
PubMed ID: 15749713
PubMed ID: 15797927
Title: Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering.
PubMed ID: 15797927
DOI: 10.1242/jcs.02299
PubMed ID: 9885563
Title: A novel transcriptional coactivator, p52, functionally interacts with the essential splicing factor ASF/SF2.
PubMed ID: 9885563
PubMed ID: 15725483
Title: t(9;11)(p22;p15) with NUP98-LEDGF fusion gene in pediatric acute myeloid leukemia.
PubMed ID: 15725483
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 17525332
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
PubMed ID: 17525332
PubMed ID: 19367720
Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.
PubMed ID: 19367720
DOI: 10.1021/pr800500r
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 18318008
Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.
PubMed ID: 18318008
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19244240
Title: Lens epithelium-derived growth factor/p75 interacts with the transposase-derived DDE domain of PogZ.
PubMed ID: 19244240
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 15895093
Title: Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75.
PubMed ID: 15895093
DOI: 10.1038/nsmb937
PubMed ID: 16260736
Title: Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.
PubMed ID: 16260736
PubMed ID: 22327296
Title: The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.
PubMed ID: 22327296
DOI: 10.1038/nature10806
PubMed ID: 25305204
Title: The same site on the integrase-binding domain of lens epithelium-derived growth factor is a therapeutic target for MLL leukemia and HIV.
PubMed ID: 25305204
PubMed ID: 25082813
Title: Validation and structural characterization of the LEDGF/p75-MLL interface as a new target for the treatment of MLL-dependent leukemia.
PubMed ID: 25082813
PubMed ID: 29997176
Title: Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation.
PubMed ID: 29997176
Sequence Information:
- Length: 530
- Mass: 60103
- Checksum: 4B653D02B1D0E174
- Sequence:
MTRDFKPGDL IFAKMKGYPH WPARVDEVPD GAVKPPTNKL PIFFFGTHET AFLGPKDIFP YSENKEKYGK PNKRKGFNEG LWEIDNNPKV KFSSQQAATK QSNASSDVEV EEKETSVSKE DTDHEEKASN EDVTKAVDIT TPKAARRGRK RKAEKQVETE EAGVVTTATA SVNLKVSPKR GRPAATEVKI PKPRGRPKMV KQPCPSESDI ITEEDKSKKK GQEEKQPKKQ PKKDEEGQKE EDKPRKEPDK KEGKKEVESK RKNLAKTGVT STSDSEEEGD DQEGEKKRKG GRNFQTAHRR NMLKGQHEKE AADRKRKQEE QMETEQQNKD EGKKPEVKKV EKKRETSMDS RLQRIHAEIK NSLKIDNLDV NRCIEALDEL ASLQVTMQQA QKHTEMITTL KKIRRFKVSQ VIMEKSTMLY NKFKNMFLVG EGDSVITQVL NKSLAEQRQH EEANKTKDQG KKGPNKKLEK EQTGSKTLNG GSDAQDGNQP QHNGESNEDS KDNHEASTKK KPSSEERETE ISLKDSTLDN
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.