Details for: WDHD1

Gene ID: 11169

Symbol: WDHD1

Ensembl ID: ENSG00000198554

Description: WD repeat and HMG-box DNA binding protein 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169,266
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.21
    Marker Score: 2,293
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.02
    Marker Score: 689
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,799
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,023
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 496
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 449
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,410
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.93
    Marker Score: 14,575
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.91
    Marker Score: 1,311
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,731
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 363
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5,143
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.9
    Marker Score: 673
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.88
    Marker Score: 2,077
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.84
    Marker Score: 505
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.79
    Marker Score: 2,153
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.78
    Marker Score: 1,591
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,256
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.76
    Marker Score: 919
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 386
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 566
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.74
    Marker Score: 6,995
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.72
    Marker Score: 1,109
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.71
    Marker Score: 206
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.7
    Marker Score: 174
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 640
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2,937
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.65
    Marker Score: 814
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.65
    Marker Score: 5,546
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.64
    Marker Score: 2,685
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6
    Marker Score: 37,191
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.6
    Marker Score: 607
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.57
    Marker Score: 496
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.57
    Marker Score: 760
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.54
    Marker Score: 142
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.54
    Marker Score: 300
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.53
    Marker Score: 503
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.53
    Marker Score: 342
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.52
    Marker Score: 168
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.52
    Marker Score: 586
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.51
    Marker Score: 3,044
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.5
    Marker Score: 368
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.5
    Marker Score: 245
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.48
    Marker Score: 1,428
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.48
    Marker Score: 511
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.47
    Marker Score: 1,926
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.47
    Marker Score: 147
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.46
    Marker Score: 6,842
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.45
    Marker Score: 213
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.44
    Marker Score: 220
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.44
    Marker Score: 4,100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.43
    Marker Score: 458
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.43
    Marker Score: 286
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.43
    Marker Score: 269
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.43
    Marker Score: 178
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.42
    Marker Score: 342
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.42
    Marker Score: 284
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.4
    Marker Score: 384
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.4
    Marker Score: 413
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.37
    Marker Score: 1,016
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.37
    Marker Score: 1,547
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.36
    Marker Score: 115
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.36
    Marker Score: 196
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.36
    Marker Score: 149
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.35
    Marker Score: 147
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.35
    Marker Score: 2,695
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.35
    Marker Score: 175
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.35
    Marker Score: 589
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.35
    Marker Score: 1,282
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.35
    Marker Score: 277
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.34
    Marker Score: 719
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.34
    Marker Score: 120
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.34
    Marker Score: 3,493
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.33
    Marker Score: 152
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.33
    Marker Score: 468
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.33
    Marker Score: 158
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.32
    Marker Score: 766
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.32
    Marker Score: 330
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.31
    Marker Score: 1,318
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.31
    Marker Score: 289
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.31
    Marker Score: 197
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.31
    Marker Score: 138
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.31
    Marker Score: 879
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.31
    Marker Score: 6,151
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.31
    Marker Score: 1,257
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.3
    Marker Score: 90
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.3
    Marker Score: 151
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3
    Marker Score: 1,186
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.3
    Marker Score: 3,902
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.29
    Marker Score: 10,869
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.29
    Marker Score: 182
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.29
    Marker Score: 74
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.28
    Marker Score: 85
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.28
    Marker Score: 1,090

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **WD repeat domain**: WDHD1 contains a WD repeat domain, a conserved structural motif found in proteins involved in protein-protein interactions and chromatin binding. 2. **HMG-box domain**: The gene also encodes an HMG-box domain, a DNA-binding motif that allows WDHD1 to interact with specific DNA sequences and regulate gene expression. 3. **Cell-type specificity**: WDHD1 is expressed in various cell types, including mural cells, cardiac endothelial cells, and intestinal epithelial cells, suggesting a specific role in tissue development and maintenance. 4. **DNA-binding properties**: WDHD1 exhibits DNA-binding properties, allowing it to interact with specific DNA sequences and regulate gene expression. **Pathways and Functions:** 1. **DNA replication and repair**: WDHD1 is involved in DNA replication and repair processes, including chromatin binding and DNA binding, which are essential for maintaining genome stability. 2. **Cell cycle regulation**: WDHD1 regulates cell cycle progression by interacting with proteins involved in the cell cycle machinery, such as cyclin-dependent kinases and cyclin-dependent kinase inhibitors. 3. **Chromatin remodeling**: WDHD1 participates in chromatin remodeling, a process that allows for the dynamic reorganization of chromatin structure and gene expression regulation. 4. **Protein-protein interactions**: WDHD1 interacts with various proteins, including histone-modifying enzymes and transcription factors, which are essential for regulating gene expression and cellular processes. **Clinical Significance:** 1. **Cancer association**: WDHD1 has been implicated in cancer development and progression, particularly in colorectal cancer, where it is overexpressed and associated with poor prognosis. 2. **Neurological disorders**: WDHD1 has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it is thought to play a role in regulating gene expression and protein interactions involved in neurodegeneration. 3. **Cardiovascular disease**: WDHD1 has been associated with cardiovascular disease, particularly in relation to cardiac endothelial cell function and vascular remodeling. 4. **Gene therapy**: WDHD1 has been identified as a potential target for gene therapy in cancer and neurological disorders, where its dysregulation is thought to contribute to disease pathology. In conclusion, WDHD1 is a novel gene that plays a critical role in DNA replication, repair, and cell cycle regulation. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, and cardiovascular disease. Further research is needed to fully understand the functions and clinical significance of WDHD1, but its identification as a key regulator of cellular processes has significant implications for the development of novel therapeutic strategies.

Genular Protein ID: 2004749675

Symbol: WDHD1_HUMAN

Name: Acidic nucleoplasmic DNA-binding protein 1

UniProtKB Accession Codes:

O75717 C9JW18 F6W0U7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 3 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 8 PRO 1 PROSITE 4 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17761813

Title: Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication.

PubMed ID: 17761813

DOI: 10.1101/gad.1585607

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19805216

Title: Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins.

PubMed ID: 19805216

DOI: 10.1073/pnas.0908039106

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22570476

Title: Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication.

PubMed ID: 22570476

DOI: 10.1074/jbc.m112.359018

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 35585232

Title: Fast and efficient DNA replication with purified human proteins.

PubMed ID: 35585232

DOI: 10.1038/s41586-022-04759-1

PubMed ID: 32453425

Title: CryoEM structures of human CMG-ATPgammaS-DNA and CMG-AND-1 complexes.

PubMed ID: 32453425

DOI: 10.1093/nar/gkaa429

PubMed ID: 34694004

Title: Structure of a human replisome shows the organisation and interactions of a DNA replication machine.

PubMed ID: 34694004

DOI: 10.15252/embj.2021108819

PubMed ID: 34700328

Title: A conserved mechanism for regulating replisome disassembly in eukaryotes.

PubMed ID: 34700328

DOI: 10.1038/s41586-021-04145-3

Sequence Information:

  • Length: 1129
  • Mass: 125967
  • Checksum: DD3E3613CA6AE70A
  • Sequence:
    • MPATRKPMRY GHTEGHTEVC FDDSGSFIVT CGSDGDVRIW EDLDDDDPKF INVGEKAYSC 
ALKSGKLVTA VSNNTIQVHT FPEGVPDGIL TRFTTNANHV VFNGDGTKIA AGSSDFLVKI 
VDVMDSSQQK TFRGHDAPVL SLSFDPKDIF LASASCDGSV RVWQISDQTC AISWPLLQKC 
NDVINAKSIC RLAWQPKSGK LLAIPVEKSV KLYRRESWSH QFDLSDNFIS QTLNIVTWSP 
CGQYLAAGSI NGLIIVWNVE TKDCMERVKH EKGYAICGLA WHPTCGRISY TDAEGNLGLL 
ENVCDPSGKT SSSKVSSRVE KDYNDLFDGD DMSNAGDFLN DNAVEIPSFS KGIINDDEDD 
EDLMMASGRP RQRSHILEDD ENSVDISMLK TGSSLLKEEE EDGQEGSIHN LPLVTSQRPF 
YDGPMPTPRQ KPFQSGSTPL HLTHRFMVWN SIGIIRCYND EQDNAIDVEF HDTSIHHATH 
LSNTLNYTIA DLSHEAILLA CESTDELASK LHCLHFSSWD SSKEWIIDLP QNEDIEAICL 
GQGWAAAATS ALLLRLFTIG GVQKEVFSLA GPVVSMAGHG EQLFIVYHRG TGFDGDQCLG 
VQLLELGKKK KQILHGDPLP LTRKSYLAWI GFSAEGTPCY VDSEGIVRML NRGLGNTWTP 
ICNTREHCKG KSDHYWVVGI HENPQQLRCI PCKGSRFPPT LPRPAVAILS FKLPYCQIAT 
EKGQMEEQFW RSVIFHNHLD YLAKNGYEYE ESTKNQATKE QQELLMKMLA LSCKLEREFR 
CVELADLMTQ NAVNLAIKYA SRSRKLILAQ KLSELAVEKA AELTATQVEE EEEEEDFRKK 
LNAGYSNTAT EWSQPRFRNQ VEEDAEDSGE ADDEEKPEIH KPGQNSFSKS TNSSDVSAKS 
GAVTFSSQGR VNPFKVSASS KEPAMSMNSA RSTNILDNMG KSSKKSTALS RTTNNEKSPI 
IKPLIPKPKP KQASAASYFQ KRNSQTNKTE EVKEENLKNV LSETPAICPP QNTENQRPKT 
GFQMWLEENR SNILSDNPDF SDEADIIKEG MIRFRVLSTE ERKVWANKAK GETASEGTEA 
KKRKRVVDES DETENQEEKA KENLNLSKKQ KPLDFSTNQK LSAFAFKQE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.