Details for: CHI3L2

Gene ID: 1117

Symbol: CHI3L2

Ensembl ID: ENSG00000064886

Description: chitinase 3 like 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 38.5097
    Cell Significance Index: -5.9900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 23.8130
    Cell Significance Index: -6.0400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 7.2585
    Cell Significance Index: -6.9300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.8582
    Cell Significance Index: -5.9900
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 4.0046
    Cell Significance Index: 22.2900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 4.0044
    Cell Significance Index: 245.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.5479
    Cell Significance Index: 165.4200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.6385
    Cell Significance Index: 42.3300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.2323
    Cell Significance Index: -5.9800
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 1.7909
    Cell Significance Index: 37.3500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.5037
    Cell Significance Index: 106.3500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.4876
    Cell Significance Index: -5.8700
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 1.2451
    Cell Significance Index: 8.9600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.0600
    Cell Significance Index: 22.9700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0570
    Cell Significance Index: 201.1500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0282
    Cell Significance Index: 132.8400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0054
    Cell Significance Index: 99.4600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7109
    Cell Significance Index: 641.8500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.6436
    Cell Significance Index: 487.1900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.5408
    Cell Significance Index: 8.5800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4735
    Cell Significance Index: 22.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4688
    Cell Significance Index: 76.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4389
    Cell Significance Index: 194.0600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4116
    Cell Significance Index: 3.7900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3689
    Cell Significance Index: 40.1300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.2140
    Cell Significance Index: 1.4500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2107
    Cell Significance Index: 24.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1685
    Cell Significance Index: 11.6600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0657
    Cell Significance Index: 4.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0591
    Cell Significance Index: 3.8100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.0487
    Cell Significance Index: 0.3000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0458
    Cell Significance Index: 2.7500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0453
    Cell Significance Index: 0.9700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0415
    Cell Significance Index: 1.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0199
    Cell Significance Index: 3.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0191
    Cell Significance Index: 0.5500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0137
    Cell Significance Index: 0.6000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0084
    Cell Significance Index: 0.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0054
    Cell Significance Index: 0.1900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0010
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0012
    Cell Significance Index: -2.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0038
    Cell Significance Index: -6.9200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0045
    Cell Significance Index: -6.9900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0054
    Cell Significance Index: -7.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0086
    Cell Significance Index: -5.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0087
    Cell Significance Index: -1.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0096
    Cell Significance Index: -7.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0103
    Cell Significance Index: -7.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0105
    Cell Significance Index: -5.7600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0112
    Cell Significance Index: -0.2800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0121
    Cell Significance Index: -6.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0137
    Cell Significance Index: -1.8800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0139
    Cell Significance Index: -0.6300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0142
    Cell Significance Index: -6.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0155
    Cell Significance Index: -5.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0162
    Cell Significance Index: -3.2500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0192
    Cell Significance Index: -0.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0193
    Cell Significance Index: -3.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0237
    Cell Significance Index: -2.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0260
    Cell Significance Index: -7.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0295
    Cell Significance Index: -6.2200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0316
    Cell Significance Index: -3.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0379
    Cell Significance Index: -6.4700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0405
    Cell Significance Index: -5.8800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0414
    Cell Significance Index: -4.8200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0427
    Cell Significance Index: -0.5500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0453
    Cell Significance Index: -1.4500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0560
    Cell Significance Index: -6.4200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0583
    Cell Significance Index: -6.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0632
    Cell Significance Index: -3.2900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0650
    Cell Significance Index: -0.9800
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: -0.0695
    Cell Significance Index: -0.3200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0695
    Cell Significance Index: -4.3800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0760
    Cell Significance Index: -3.9600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0895
    Cell Significance Index: -6.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0898
    Cell Significance Index: -6.8900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1118
    Cell Significance Index: -6.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1124
    Cell Significance Index: -3.0000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1125
    Cell Significance Index: -4.6100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1152
    Cell Significance Index: -1.6500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1218
    Cell Significance Index: -6.1600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1239
    Cell Significance Index: -3.6500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1328
    Cell Significance Index: -7.4500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1370
    Cell Significance Index: -3.6700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1395
    Cell Significance Index: -4.0000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1455
    Cell Significance Index: -7.6400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1473
    Cell Significance Index: -5.1600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1509
    Cell Significance Index: -3.8800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1580
    Cell Significance Index: -5.8000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1640
    Cell Significance Index: -5.3700
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1649
    Cell Significance Index: -2.2800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1658
    Cell Significance Index: -5.2800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1671
    Cell Significance Index: -7.3900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1833
    Cell Significance Index: -3.7300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1854
    Cell Significance Index: -4.6300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1864
    Cell Significance Index: -1.5200
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1874
    Cell Significance Index: -1.5500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1903
    Cell Significance Index: -5.5900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1907
    Cell Significance Index: -5.1100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1926
    Cell Significance Index: -7.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Tissue-specific expression**: CHI3L2 is expressed in various cell types, including pneumocytes, type II pneumocytes, acinar cells of the salivary gland, colon goblet cells, and renal cells, suggesting its involvement in maintaining tissue integrity and function. 2. **Chitinase and lipase activities**: CHI3L2 exhibits both chitinase and lipase activities, which are crucial for its role in modulating the extracellular matrix and regulating cell signaling pathways. 3. **Carbohydrate-binding properties**: CHI3L2 possesses a carbohydrate-binding domain, which enables it to interact with chitin and other glycosaminoglycans, thereby influencing cellular behavior and tissue function. **Pathways and Functions:** 1. **Chitin catabolic process**: CHI3L2 plays a key role in the degradation of chitin, a polysaccharide component of the extracellular matrix, which is essential for maintaining tissue homeostasis and regulating cellular behavior. 2. **Extracellular matrix remodeling**: CHI3L2's chitinase activity contributes to the remodeling of the extracellular matrix, which is critical for tissue repair, inflammation, and immune responses. 3. **Cell signaling and proliferation**: CHI3L2's lipase activity and carbohydrate-binding properties influence cell signaling pathways, including the regulation of cell proliferation, differentiation, and survival. 4. **Immune responses**: CHI3L2 has been implicated in modulating immune responses, including the regulation of inflammation, cell-mediated immunity, and the production of cytokines and chemokines. **Clinical Significance:** 1. **Respiratory diseases**: CHI3L2 has been associated with various respiratory diseases, including chronic obstructive pulmonary disease (COPD), asthma, and pulmonary fibrosis, highlighting its potential as a biomarker and therapeutic target. 2. **Cancer**: Elevated CHI3L2 expression has been observed in various types of cancer, including lung, breast, and colon cancer, suggesting its involvement in tumorigenesis and metastasis. 3. **Inflammatory disorders**: CHI3L2's role in modulating inflammation and immune responses makes it a potential therapeutic target for treating inflammatory disorders, such as rheumatoid arthritis and inflammatory bowel disease. In conclusion, CHI3L2 is a multifunctional protein that plays a critical role in maintaining tissue homeostasis, regulating cell signaling pathways, and modulating immune responses. Its involvement in various diseases, including respiratory and inflammatory disorders, highlights its potential as a biomarker and therapeutic target. Further research is needed to fully elucidate the mechanisms underlying CHI3L2's functions and to explore its therapeutic applications.

Genular Protein ID: 1481590917

Symbol: CH3L2_HUMAN

Name: Chitinase-3-like protein 2

UniProtKB Accession Codes:

Q15782 A6NNY3 B4DPR7 Q15749 Q15783 Q5VUV7 Q96F97

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 3 CDD 1 CTD 1 ChEBI 7 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8702629

Title: Isolation and sequence of a novel human chondrocyte protein related to mammalian members of the chitinase protein family.

PubMed ID: 8702629

DOI: 10.1074/jbc.271.32.19415

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22742450

Title: Human YKL-39 is a pseudo-chitinase with retained chitooligosaccharide-binding properties.

PubMed ID: 22742450

DOI: 10.1042/bj20120377

Sequence Information:

  • Length: 390
  • Mass: 43501
  • Checksum: 97B86A2F3AA35677
  • Sequence:
    • MGATTMDQKS LWAGVVVLLL LQGGSAYKLV CYFTNWSQDR QEPGKFTPEN IDPFLCSHLI 
YSFASIENNK VIIKDKSEVM LYQTINSLKT KNPKLKILLS IGGYLFGSKG FHPMVDSSTS 
RLEFINSIIL FLRNHNFDGL DVSWIYPDQK ENTHFTVLIH ELAEAFQKDF TKSTKERLLL 
TAGVSAGRQM IDNSYQVEKL AKDLDFINLL SFDFHGSWEK PLITGHNSPL SKGWQDRGPS 
SYYNVEYAVG YWIHKGMPSE KVVMGIPTYG HSFTLASAET TVGAPASGPG AAGPITESSG 
FLAYYEICQF LKGAKITRLQ DQQVPYAVKG NQWVGYDDVK SMETKVQFLK NLNLGGAMIW 
SIDMDDFTGK SCNQGPYPLV QAVKRSLGSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.