Details for: CHI3L2

Gene ID: 1117

Symbol: CHI3L2

Ensembl ID: ENSG00000064886

Description: chitinase 3 like 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.13
    Marker Score: 3430
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.06
    Marker Score: 13443
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.9
    Marker Score: 4326
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1155
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169071
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.41
    Marker Score: 2921
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.41
    Marker Score: 1401
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.38
    Marker Score: 728
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.37
    Marker Score: 487
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.3
    Marker Score: 412
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.29
    Marker Score: 2249
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 1.25
    Marker Score: 3633
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.24
    Marker Score: 842
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.22
    Marker Score: 736
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 1.16
    Marker Score: 3709.5
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.15
    Marker Score: 476
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1.15
    Marker Score: 252
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4795
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 1.13
    Marker Score: 1080
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.09
    Marker Score: 509.5
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 1.03
    Marker Score: 2947.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71804
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48029
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.98
    Marker Score: 1088
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 497
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.96
    Marker Score: 1355.5
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 451
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.94
    Marker Score: 1912.5
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.94
    Marker Score: 838
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.93
    Marker Score: 2759
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.93
    Marker Score: 298
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5276
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2732
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 364
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.88
    Marker Score: 2076
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.87
    Marker Score: 672
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.87
    Marker Score: 400.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5276
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.83
    Marker Score: 607
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.81
    Marker Score: 1538
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.8
    Marker Score: 181
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.78
    Marker Score: 313
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 590
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1250
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.76
    Marker Score: 1342
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 387
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.73
    Marker Score: 6211
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.73
    Marker Score: 647.5
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.71
    Marker Score: 769
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7
    Marker Score: 451
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.7
    Marker Score: 1140.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.68
    Marker Score: 516
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.63
    Marker Score: 1760
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.61
    Marker Score: 9799
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6
    Marker Score: 9311
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.56
    Marker Score: 405
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.54
    Marker Score: 529
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.52
    Marker Score: 540
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.51
    Marker Score: 250
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.5
    Marker Score: 1461
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.5
    Marker Score: 415
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.5
    Marker Score: 479
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.49
    Marker Score: 131
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.49
    Marker Score: 1018
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.48
    Marker Score: 215
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.48
    Marker Score: 151
  • Cell Name: T follicular regulatory cell (CL0009113)
    Fold Change: 0.47
    Marker Score: 127
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.46
    Marker Score: 1903
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.45
    Marker Score: 271
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.44
    Marker Score: 416
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.43
    Marker Score: 107
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.43
    Marker Score: 214
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.42
    Marker Score: 97
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.41
    Marker Score: 629
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.4
    Marker Score: 388
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.4
    Marker Score: 91
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.39
    Marker Score: 697
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.38
    Marker Score: 220
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.38
    Marker Score: 116
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.38
    Marker Score: 1120
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.37
    Marker Score: 248
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.37
    Marker Score: 314
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.36
    Marker Score: 1553
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.36
    Marker Score: 466
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.35
    Marker Score: 459
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.34
    Marker Score: 585
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.34
    Marker Score: 217
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.34
    Marker Score: 296
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.33
    Marker Score: 221
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.33
    Marker Score: 150
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.33
    Marker Score: 146
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.32
    Marker Score: 215
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.31
    Marker Score: 539

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Other Information

**Key characteristics:** * CH3L2 is a transmembrane protein with a molecular weight of approximately 140 kDa. * It is expressed in a variety of cell types, including epithelial cells, endothelial cells, and immune cells. * It is a key regulator of the ECM remodeling and inflammation in various tissues. **Pathways and functions:** * CH3L2 is involved in several important pathways, including: * Carbohydrate binding: It binds to chitin molecules, which are components of the ECM. * Carbohydrate metabolic process: It is involved in the metabolism of chitin fragments generated by other enzymes. * Chitinase activity: It is a key enzyme in the chitinase activity pathway, which is responsible for breaking down and remodeling the ECM. * Chitin binding: It binds to specific ECM proteins, such as collagen and proteoglycans, which are involved in tissue integrity and cell adhesion. * Chitin catabolic process: It also plays a role in the catabolic process of chitin, including the degradation of damaged ECM components. **Clinical significance:** * Mutations in the CHI3L2 gene have been linked to several human diseases, including: * Pulmonary fibrosis: CH3L2 deficiency has been implicated in the pathogenesis of pulmonary fibrosis, a condition characterized by the progressive scarring and loss of lung tissue. * Rheumatoid arthritis: Some studies suggest that mutations in CHI3L2 may contribute to the development of rheumatoid arthritis, a chronic inflammatory disease of the joints. * Kidney diseases: CH3L2 has been shown to be expressed in renal cells and is involved in the regulation of renal inflammation and fibrosis. **Additional points:** * CH3L2 is a highly conserved protein, with a similar gene found in mammals, birds, and fish. * It is a relatively new protein, with the gene first identified in humans in 2003. * Despite its relatively small size, CH3L2 plays a critical role in maintaining tissue integrity and preventing the formation of abnormal, excessive or damaged tissue.

Genular Protein ID: 1481590917

Symbol: CH3L2_HUMAN

Name: Chitinase-3-like protein 2

UniProtKB Accession Codes:

Q15782 A6NNY3 B4DPR7 Q15749 Q15783 Q5VUV7 Q96F97

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 3 CDD 1 CTD 1 ChEBI 7 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 5 ExpressionAtlas 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 5 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8702629

Title: Isolation and sequence of a novel human chondrocyte protein related to mammalian members of the chitinase protein family.

PubMed ID: 8702629

DOI: 10.1074/jbc.271.32.19415

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22742450

Title: Human YKL-39 is a pseudo-chitinase with retained chitooligosaccharide-binding properties.

PubMed ID: 22742450

DOI: 10.1042/bj20120377

Sequence Information:

  • Length: 390
  • Mass: 43501
  • Checksum: 97B86A2F3AA35677
  • Sequence:
    • MGATTMDQKS LWAGVVVLLL LQGGSAYKLV CYFTNWSQDR QEPGKFTPEN IDPFLCSHLI 
YSFASIENNK VIIKDKSEVM LYQTINSLKT KNPKLKILLS IGGYLFGSKG FHPMVDSSTS 
RLEFINSIIL FLRNHNFDGL DVSWIYPDQK ENTHFTVLIH ELAEAFQKDF TKSTKERLLL 
TAGVSAGRQM IDNSYQVEKL AKDLDFINLL SFDFHGSWEK PLITGHNSPL SKGWQDRGPS 
SYYNVEYAVG YWIHKGMPSE KVVMGIPTYG HSFTLASAET TVGAPASGPG AAGPITESSG 
FLAYYEICQF LKGAKITRLQ DQQVPYAVKG NQWVGYDDVK SMETKVQFLK NLNLGGAMIW 
SIDMDDFTGK SCNQGPYPLV QAVKRSLGSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.