Details for: FAM107A

Gene ID: 11170

Symbol: FAM107A

Ensembl ID: ENSG00000168309

Description: family with sequence similarity 107 member A

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 5.16
    Marker Score: 14,579
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.59
    Marker Score: 9,137
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.49
    Marker Score: 3,003
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.85
    Marker Score: 60,723
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.77
    Marker Score: 1,823
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.28
    Marker Score: 665
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.07
    Marker Score: 4,716
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.05
    Marker Score: 1,225
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.95
    Marker Score: 3,889
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.87
    Marker Score: 2,700
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.71
    Marker Score: 6,335
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.64
    Marker Score: 2,377
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1,158
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.56
    Marker Score: 332
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 168,043
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.46
    Marker Score: 10,878
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.45
    Marker Score: 337
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.43
    Marker Score: 448
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.42
    Marker Score: 2,410
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.4
    Marker Score: 417
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 860
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.35
    Marker Score: 713
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.29
    Marker Score: 4,978
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.26
    Marker Score: 3,600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 846
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.22
    Marker Score: 568
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.2
    Marker Score: 2,277
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4,790
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.14
    Marker Score: 1,149
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.13
    Marker Score: 17,718
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.12
    Marker Score: 1,505
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.08
    Marker Score: 498
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.07
    Marker Score: 445
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.06
    Marker Score: 948
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.03
    Marker Score: 929
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.01
    Marker Score: 420
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,787
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,012
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.99
    Marker Score: 22,019
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.97
    Marker Score: 1,047
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.97
    Marker Score: 840
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,410
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.93
    Marker Score: 215
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,295
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.93
    Marker Score: 245
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.92
    Marker Score: 786
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,731
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.91
    Marker Score: 505
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.91
    Marker Score: 218
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.9
    Marker Score: 1,278
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.88
    Marker Score: 6,710
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,276
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.87
    Marker Score: 3,348
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.86
    Marker Score: 541
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.86
    Marker Score: 248
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.85
    Marker Score: 1,559
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.85
    Marker Score: 646
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.84
    Marker Score: 1,981
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.84
    Marker Score: 1,370
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.79
    Marker Score: 527
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.79
    Marker Score: 172
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.78
    Marker Score: 831
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,255
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.77
    Marker Score: 510
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 703
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.76
    Marker Score: 1,906
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.75
    Marker Score: 11,288
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.75
    Marker Score: 28,495
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 457
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.69
    Marker Score: 23,828
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.68
    Marker Score: 607
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.68
    Marker Score: 685
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.67
    Marker Score: 185
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.66
    Marker Score: 164
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.66
    Marker Score: 1,619
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.64
    Marker Score: 1,293
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.63
    Marker Score: 967
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.62
    Marker Score: 464
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.61
    Marker Score: 206
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.59
    Marker Score: 150
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 240
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 454
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.56
    Marker Score: 154
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.55
    Marker Score: 534
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.54
    Marker Score: 209
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.52
    Marker Score: 520
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.51
    Marker Score: 4,408
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.51
    Marker Score: 2,127
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.51
    Marker Score: 5,221
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.49
    Marker Score: 242
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.49
    Marker Score: 450

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FAM107A is a small, non-coding RNA gene that has been implicated in the regulation of several cellular processes. Its primary function is to modulate the actin cytoskeleton, which is essential for maintaining cell shape, motility, and intracellular trafficking. FAM107A has been shown to interact with various proteins, including actin-modulating proteins, kinases, and adaptors, to regulate the dynamics of the actin cytoskeleton. Additionally, FAM107A has been found to be involved in the regulation of cell growth, differentiation, and survival, highlighting its importance in maintaining tissue homeostasis. **Pathways and Functions:** FAM107A is involved in several key cellular pathways, including: 1. **Actin cytoskeleton regulation:** FAM107A modulates the dynamics of the actin cytoskeleton, regulating its assembly, disassembly, and organization. 2. **Cell migration:** FAM107A is involved in the regulation of cell migration, which is essential for tissue repair, immune responses, and cancer metastasis. 3. **Synaptic plasticity:** FAM107A has been implicated in the regulation of synaptic plasticity, which is crucial for learning and memory. 4. **Cell growth and differentiation:** FAM107A regulates cell growth and differentiation, influencing the development and maintenance of various tissues. 5. **Stress response:** FAM107A has been shown to be involved in the regulation of stress response pathways, including the unfolded protein response (UPR). **Clinical Significance:** FAM107A has been found to be significantly expressed in various human tissues, including tracheal goblet cells, alveolar capillary type 1 endothelial cells, and mature astrocytes. Its dysregulation has been implicated in several diseases, including: 1. **Cancer:** FAM107A has been found to be downregulated in various types of cancer, including breast, lung, and colon cancer. 2. **Neurological disorders:** FAM107A has been implicated in the regulation of synaptic plasticity, and its dysregulation has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Inflammatory diseases:** FAM107A has been shown to be involved in the regulation of inflammatory responses, and its dysregulation has been linked to inflammatory diseases, including atherosclerosis and rheumatoid arthritis. In conclusion, FAM107A is a critical regulator of various cellular processes, including actin cytoskeleton organization, cell migration, and synaptic plasticity. Its dysregulation has been implicated in several diseases, highlighting the importance of FAM107A in maintaining tissue homeostasis and preventing disease. Further research is needed to fully elucidate the mechanisms by which FAM107A regulates cellular processes and to explore its therapeutic potential.

Genular Protein ID: 3589129282

Symbol: F107A_HUMAN

Name: N/A

UniProtKB Accession Codes:

O95990 B3KNQ4 B7ZAY5 J3KR61 Q96NH4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 6 ExpressionAtlas 1 GO 25 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 4 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10564580

Title: Loss of expression of the DRR1 gene at chromosomal segment 3p21.1 in renal cell carcinoma.

PubMed ID: 10564580

DOI: 10.1002/(sici)1098-2264(200001)27:1<1::aid-gcc1>3.0.co;2-6

PubMed ID: 10702698

Title: Isolation and characterization of the novel gene, TU3A, in a commonly deleted region on 3p14.3->p14.2 in renal cell carcinoma.

PubMed ID: 10702698

DOI: 10.1159/000015452

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11256614

Title: Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.

PubMed ID: 11256614

DOI: 10.1093/embo-reports/kvd058

PubMed ID: 20543869

Title: DRR drives brain cancer invasion by regulating cytoskeletal-focal adhesion dynamics.

PubMed ID: 20543869

DOI: 10.1038/onc.2010.216

PubMed ID: 21969592

Title: Tumor suppressor down-regulated in renal cell carcinoma 1 (DRR1) is a stress-induced actin bundling factor that modulates synaptic efficacy and cognition.

PubMed ID: 21969592

DOI: 10.1073/pnas.1103318108

PubMed ID: 28604741

Title: A novel nuclear complex of DRR1, F-actin and COMMD1 involved in NF-kappaB degradation and cell growth suppression in neuroblastoma.

PubMed ID: 28604741

DOI: 10.1038/onc.2017.181

Sequence Information:

  • Length: 144
  • Mass: 17455
  • Checksum: 90C192C723D68A36
  • Sequence:
    • MYSEIQRERA DIGGLMARPE YREWNPELIK PKKLLNPVKA SRSHQELHRE LLMNHRRGLG 
VDSKPELQRV LEHRRRNQLI KKKKEELEAK RLQCPFEQEL LRRQQRLNQL EKPPEKEEDH 
APEFIKVREN LRRIATLTSE EREL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.