Details for: STRAP

Gene ID: 11171

Symbol: STRAP

Ensembl ID: ENSG00000023734

Description: serine/threonine kinase receptor associated protein

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.58
    Marker Score: 87,695
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.37
    Marker Score: 5,793
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.33
    Marker Score: 4,874
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.29
    Marker Score: 4,653
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.25
    Marker Score: 2,531
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.17
    Marker Score: 10,683
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.16
    Marker Score: 898
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.15
    Marker Score: 9,275
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.15
    Marker Score: 2,297
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.15
    Marker Score: 2,297
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.14
    Marker Score: 3,634
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.12
    Marker Score: 1,330
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.07
    Marker Score: 27,363
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.07
    Marker Score: 2,933
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.05
    Marker Score: 2,061
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.04
    Marker Score: 1,915
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.03
    Marker Score: 1,596
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.01
    Marker Score: 1,717
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.01
    Marker Score: 2,131
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2
    Marker Score: 13,032
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.98
    Marker Score: 2,092
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.97
    Marker Score: 1,312
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.96
    Marker Score: 1,235
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.95
    Marker Score: 67,635
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.95
    Marker Score: 485
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.95
    Marker Score: 19,738
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.94
    Marker Score: 5,293
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.94
    Marker Score: 653
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.94
    Marker Score: 19,535
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.94
    Marker Score: 3,375
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.94
    Marker Score: 914
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.93
    Marker Score: 995
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.93
    Marker Score: 485
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.93
    Marker Score: 2,328
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.91
    Marker Score: 7,079
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.91
    Marker Score: 2,747
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.91
    Marker Score: 2,292
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.9
    Marker Score: 7,783
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.89
    Marker Score: 4,438
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.88
    Marker Score: 3,123
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.87
    Marker Score: 1,765
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.86
    Marker Score: 7,327
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.85
    Marker Score: 1,101
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.85
    Marker Score: 7,135
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.85
    Marker Score: 625
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.84
    Marker Score: 21,413
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.83
    Marker Score: 1,914
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.83
    Marker Score: 3,442
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.83
    Marker Score: 675
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.83
    Marker Score: 15,743
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.83
    Marker Score: 961
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.81
    Marker Score: 5,165
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.8
    Marker Score: 1,309
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.8
    Marker Score: 429
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.77
    Marker Score: 2,906
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.75
    Marker Score: 432
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.74
    Marker Score: 3,644
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.74
    Marker Score: 850
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.72
    Marker Score: 19,369
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.72
    Marker Score: 914
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.71
    Marker Score: 4,595
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.71
    Marker Score: 385
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.71
    Marker Score: 688
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.71
    Marker Score: 606
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.7
    Marker Score: 10,360
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.7
    Marker Score: 662
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.7
    Marker Score: 5,042
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.7
    Marker Score: 1,831
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.69
    Marker Score: 10,825
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.69
    Marker Score: 4,600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.68
    Marker Score: 2,680
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.68
    Marker Score: 1,970
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.67
    Marker Score: 88,487
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.67
    Marker Score: 1,199
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.67
    Marker Score: 4,619
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.66
    Marker Score: 914
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.66
    Marker Score: 2,297
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.65
    Marker Score: 2,193
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.64
    Marker Score: 1,581
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.63
    Marker Score: 487
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.63
    Marker Score: 4,115
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.63
    Marker Score: 2,248
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.62
    Marker Score: 5,106
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.61
    Marker Score: 9,572
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.61
    Marker Score: 655
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 1.61
    Marker Score: 730
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.6
    Marker Score: 1,160
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.6
    Marker Score: 606
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.59
    Marker Score: 1,330
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.59
    Marker Score: 15,756
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.59
    Marker Score: 2,341
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.59
    Marker Score: 2,446
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.59
    Marker Score: 1,610
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.58
    Marker Score: 3,764
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.58
    Marker Score: 2,830
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.58
    Marker Score: 554
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.58
    Marker Score: 546
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.58
    Marker Score: 952
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.58
    Marker Score: 370
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.57
    Marker Score: 417

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** STRAP is a protein that interacts with serine/threonine kinase receptors, modulating their activity and influencing downstream signaling pathways. This protein is highly expressed in various cell types, including fibroblasts, epithelial cells, and neural crest cells. Its expression is also notable in specific tissues, such as the mammary gland and prostate, highlighting its role in tissue-specific functions. **Pathways and Functions:** STRAP is involved in multiple signaling pathways, including: 1. **Negative regulation of TGF-β receptor signaling**: STRAP acts as a negative regulator of the TGF-β signaling pathway, which is crucial for cell growth, differentiation, and immune responses. 2. **Downregulation of TGF-β receptor signaling**: STRAP also contributes to the downregulation of TGF-β receptor signaling, which is essential for maintaining tissue homeostasis and preventing excessive cell growth. 3. **Alternative mRNA splicing**: STRAP is involved in the regulation of alternative mRNA splicing, which is a critical process in gene expression and cellular differentiation. 4. **Smn-Sm protein complex**: STRAP interacts with the Smn-Sm protein complex, which plays a crucial role in RNA processing and splicing. **Clinical Significance:** STRAP's involvement in immune regulation and cellular homeostasis makes it a potential target for therapeutic interventions in various diseases, including: 1. **Cancer**: Alterations in STRAP expression have been linked to cancer development and progression, highlighting its potential as a biomarker or therapeutic target. 2. **Autoimmune diseases**: STRAP's role in modulating immune responses makes it a potential target for treating autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Neurological disorders**: STRAP's involvement in neuronal differentiation and survival suggests its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, STRAP is a multifunctional protein that plays a critical role in regulating immune responses, cellular differentiation, and signaling pathways. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its mechanisms and potential therapeutic applications. **Recommendations for Future Research:** 1. **Investigate STRAP's role in specific disease models**: Further studies are needed to elucidate STRAP's role in various disease models, including cancer, autoimmune diseases, and neurological disorders. 2. **Elucidate STRAP's interaction with other proteins**: The identification of STRAP's interacting partners will provide insights into its mechanisms of action and potential therapeutic targets. 3. **Develop STRAP-based therapeutic strategies**: The development of STRAP-based therapeutic strategies will require a deeper understanding of its role in disease and its potential as a target for intervention. By continuing to explore the intricacies of STRAP, we can uncover new insights into its role in immune regulation and cellular homeostasis, ultimately leading to the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 2336282655

Symbol: STRAP_HUMAN

Name: Serine-threonine kinase receptor-associated protein

UniProtKB Accession Codes:

Q9Y3F4 B2R5S5 B4DNJ6 Q5TZT4 Q9NTK0 Q9UQC8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10049359

Title: unr, a cellular cytoplasmic RNA-binding protein with five cold-shock domains, is required for internal initiation of translation of human rhinovirus RNA.

PubMed ID: 10049359

DOI: 10.1101/gad.13.4.437

PubMed ID: 10646843

Title: Molecular cloning and characterization of human MAWD, a novel protein containing WD-40 repeats frequently overexpressed in breast cancer.

PubMed ID: 10646843

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15848170

Title: Unrip is a component of SMN complexes active in snRNP assembly.

PubMed ID: 15848170

DOI: 10.1016/j.febslet.2005.03.034

PubMed ID: 16159890

Title: Unrip, a factor implicated in cap-independent translation, associates with the cytosolic SMN complex and influences its intracellular localization.

PubMed ID: 16159890

DOI: 10.1093/hmg/ddi343

PubMed ID: 16251192

Title: Regulation of transforming growth factor-beta signaling and PDK1 kinase activity by physical interaction between PDK1 and serine-threonine kinase receptor-associated protein.

PubMed ID: 16251192

DOI: 10.1074/jbc.m507539200

PubMed ID: 17178713

Title: A comprehensive interaction map of the human survival of motor neuron (SMN) complex.

PubMed ID: 17178713

DOI: 10.1074/jbc.m608528200

PubMed ID: 18984161

Title: An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs.

PubMed ID: 18984161

DOI: 10.1016/j.cell.2008.09.020

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29186683

Title: TRIM48 Promotes ASK1 Activation and Cell Death through Ubiquitination-Dependent Degradation of the ASK1-Negative Regulator PRMT1.

PubMed ID: 29186683

DOI: 10.1016/j.celrep.2017.11.007

Sequence Information:

  • Length: 350
  • Mass: 38438
  • Checksum: CFCB34D3946290E2
  • Sequence:
    • MAMRQTPLTC SGHTRPVVDL AFSGITPYGY FLISACKDGK PMLRQGDTGD WIGTFLGHKG 
AVWGATLNKD ATKAATAAAD FTAKVWDAVS GDELMTLAHK HIVKTVDFTQ DSNYLLTGGQ 
DKLLRIYDLN KPEAEPKEIS GHTSGIKKAL WCSEDKQILS ADDKTVRLWD HATMTEVKSL 
NFNMSVSSME YIPEGEILVI TYGRSIAFHS AVSLDPIKSF EAPATINSAS LHPEKEFLVA 
GGEDFKLYKY DYNSGEELES YKGHFGPIHC VRFSPDGELY ASGSEDGTLR LWQTVVGKTY 
GLWKCVLPEE DSGELAKPKI GFPETTEEEL EEIASENSDC IFPSAPDVKA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.