Details for: INSL6

Gene ID: 11172

Symbol: INSL6

Ensembl ID: ENSG00000120210

Description: insulin like 6

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 5.51
    Marker Score: 7,645
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 4.05
    Marker Score: 12,968
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 3.92
    Marker Score: 11,258
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.3
    Marker Score: 6,549
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1,170
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 170,001
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 869
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 854
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 486
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,812
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 502
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 795
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,821
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,046
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.99
    Marker Score: 6,586
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,333
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,290
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 461
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.69
    Marker Score: 199
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.67
    Marker Score: 1,385
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.66
    Marker Score: 1,248
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.64
    Marker Score: 1,120
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.61
    Marker Score: 405
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.61
    Marker Score: 415
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.59
    Marker Score: 944
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.51
    Marker Score: 1,041
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.49
    Marker Score: 203
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.45
    Marker Score: 6,987
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.44
    Marker Score: 266
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.4
    Marker Score: 391
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.4
    Marker Score: 107
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 371
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.36
    Marker Score: 515
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.35
    Marker Score: 168
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.31
    Marker Score: 390
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.3
    Marker Score: 468
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.29
    Marker Score: 129
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.29
    Marker Score: 167
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.28
    Marker Score: 115
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.27
    Marker Score: 127
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.26
    Marker Score: 259
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.22
    Marker Score: 125
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.22
    Marker Score: 285
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.22
    Marker Score: 377
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.21
    Marker Score: 1,287
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.21
    Marker Score: 67
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.21
    Marker Score: 620
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.21
    Marker Score: 141
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.21
    Marker Score: 103
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.2
    Marker Score: 580
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.2
    Marker Score: 49
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.19
    Marker Score: 171
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.18
    Marker Score: 59
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.18
    Marker Score: 106
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.17
    Marker Score: 210
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.17
    Marker Score: 395
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.17
    Marker Score: 97
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.16
    Marker Score: 157
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.16
    Marker Score: 112
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.16
    Marker Score: 158
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.16
    Marker Score: 1,506
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.16
    Marker Score: 209
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.14
    Marker Score: 157
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.14
    Marker Score: 3,138
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.14
    Marker Score: 8,614
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.13
    Marker Score: 75
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.13
    Marker Score: 557
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.13
    Marker Score: 29
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.13
    Marker Score: 66
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.13
    Marker Score: 78
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.13
    Marker Score: 52
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.13
    Marker Score: 165
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.12
    Marker Score: 39
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.12
    Marker Score: 119
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.12
    Marker Score: 43
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.12
    Marker Score: 4,524
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.12
    Marker Score: 223
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.12
    Marker Score: 28
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.12
    Marker Score: 29
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.12
    Marker Score: 30
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.12
    Marker Score: 424
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.12
    Marker Score: 67
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.12
    Marker Score: 1,013
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.12
    Marker Score: 30

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Insulin-like Peptide**: INSL6 is classified as an insulin-like peptide, which suggests that it shares structural and functional similarities with insulin and other insulin-like peptides. 2. **Tissue-Specific Expression**: INSL6 is primarily expressed in specific tissues, including the retina, colon, and small intestine, indicating a tissue-specific function. 3. **Cellular Component Organization**: INSL6 is involved in regulating cellular component organization, which suggests that it plays a role in maintaining cellular structure and function. 4. **Hormone Activity**: INSL6 is involved in hormone activity, which suggests that it may interact with other hormones to regulate cellular processes. 5. **Signal Transduction**: INSL6 is involved in signal transduction, which suggests that it may regulate cellular responses to external stimuli. **Pathways and Functions:** 1. **Cell Proliferation**: INSL6 may regulate cellular proliferation by interacting with other signaling pathways, such as the PI3K/AKT pathway, to promote cell growth and division. 2. **Differentiation**: INSL6 may regulate cellular differentiation by interacting with other signaling pathways, such as the Wnt/β-catenin pathway, to promote cell specialization and differentiation. 3. **Hormone Regulation**: INSL6 may interact with other hormones, such as insulin and glucagon, to regulate glucose metabolism and energy balance. 4. **Cellular Component Organization**: INSL6 may regulate cellular component organization by interacting with other proteins to maintain cellular structure and function. **Clinical Significance:** 1. **Cancer**: INSL6 may play a role in the development and progression of certain cancers, such as colon cancer and breast cancer, by regulating cellular proliferation and differentiation. 2. **Neurodegenerative Diseases**: INSL6 may play a role in the development and progression of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, by regulating cellular proliferation and differentiation in the brain. 3. **Diabetes**: INSL6 may play a role in the development and progression of diabetes by regulating glucose metabolism and energy balance. 4. **Gastrointestinal Diseases**: INSL6 may play a role in the development and progression of gastrointestinal diseases, such as inflammatory bowel disease, by regulating cellular proliferation and differentiation in the gut epithelium. In conclusion, INSL6 is a novel insulin-like peptide that has significant implications for our understanding of cellular proliferation, differentiation, and hormone regulation. Further research is necessary to elucidate the molecular mechanisms underlying the functions of INSL6 and to explore its potential therapeutic applications in various diseases.

Genular Protein ID: 1524039556

Symbol: INSL6_HUMAN

Name: Insulin-like peptide INSL6

UniProtKB Accession Codes:

Q9Y581 A0AVS0 Q9NS16

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 2 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 10598589

Title: Cloning of two novel mammalian paralogs of relaxin/insulin family proteins and their expression in testis and kidney.

PubMed ID: 10598589

DOI: 10.1210/mend.13.12.0388

PubMed ID: 10819760

Title: Identification of INSL6, a new member of the insulin family that is expressed in the testis of the human and Rat.

PubMed ID: 10819760

DOI: 10.1095/biolreprod62.6.1593

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 213
  • Mass: 24860
  • Checksum: 12A097659CFAC471
  • Sequence:
    • MPRLLRLSLL WLGLLLVRFS RELSDISSAR KLCGRYLVKE IEKLCGHANW SQFRFEEETP 
FSRLIAQASE KVEAYSPYQF ESPQTASPAR GRGTNPVSTS WEEAVNSWEM QSLPEYKDKK 
GYSPLGKTRE FSSSHNINVY IHENAKFQKK RRNKIKTLSN LFWGHHPQRK RRGYSEKCCL 
TGCTKEELSI ACLPYIDFKR LKEKRSSLVT KIY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.