Details for: ADAMTS7

Gene ID: 11173

Symbol: ADAMTS7

Ensembl ID: ENSG00000136378

Description: ADAM metallopeptidase with thrombospondin type 1 motif 7

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.99
    Marker Score: 7,083
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.42
    Marker Score: 1,135
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.24
    Marker Score: 19,352
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.19
    Marker Score: 2,248
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.04
    Marker Score: 1,257
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,820
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,044
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.98
    Marker Score: 21,944
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.98
    Marker Score: 2,030
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,332
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,738
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.91
    Marker Score: 511
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,285
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.8
    Marker Score: 845
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,257
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 705
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 581
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.74
    Marker Score: 681
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.69
    Marker Score: 1,410
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.66
    Marker Score: 4,271
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.64
    Marker Score: 600
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.62
    Marker Score: 150
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.62
    Marker Score: 1,077
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.61
    Marker Score: 817
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.61
    Marker Score: 289
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.59
    Marker Score: 3,174
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.57
    Marker Score: 329
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.56
    Marker Score: 175
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.55
    Marker Score: 592
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.55
    Marker Score: 210
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.54
    Marker Score: 154
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.53
    Marker Score: 316
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.51
    Marker Score: 161
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.5
    Marker Score: 243
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.47
    Marker Score: 209
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.47
    Marker Score: 109
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.45
    Marker Score: 296
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.42
    Marker Score: 597
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.4
    Marker Score: 5,259
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.39
    Marker Score: 929
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.39
    Marker Score: 175
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.38
    Marker Score: 120
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.37
    Marker Score: 875
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.37
    Marker Score: 180
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.36
    Marker Score: 366
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.35
    Marker Score: 93
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.35
    Marker Score: 112
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.35
    Marker Score: 11,703
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.33
    Marker Score: 135
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.33
    Marker Score: 128
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.33
    Marker Score: 158
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.32
    Marker Score: 3,627
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.32
    Marker Score: 873
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.31
    Marker Score: 476
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.31
    Marker Score: 330
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.3
    Marker Score: 72
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.29
    Marker Score: 324
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.28
    Marker Score: 615
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.28
    Marker Score: 2,414
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.27
    Marker Score: 168
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.27
    Marker Score: 251
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.26
    Marker Score: 235
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.25
    Marker Score: 122
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.25
    Marker Score: 274
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.24
    Marker Score: 92
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.24
    Marker Score: 129
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.24
    Marker Score: 184
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.24
    Marker Score: 112
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.23
    Marker Score: 148
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.23
    Marker Score: 81
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.23
    Marker Score: 2,310
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.23
    Marker Score: 245
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.23
    Marker Score: 59
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.23
    Marker Score: 73
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.22
    Marker Score: 1,687
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.22
    Marker Score: 426
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.22
    Marker Score: 56
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.22
    Marker Score: 1,312
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.22
    Marker Score: 153
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.21
    Marker Score: 362
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.21
    Marker Score: 258
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.2
    Marker Score: 176
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.2
    Marker Score: 249
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.2
    Marker Score: 119
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.2
    Marker Score: 135
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.2
    Marker Score: 109
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.19
    Marker Score: 127
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.19
    Marker Score: 271
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.19
    Marker Score: 180
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.19
    Marker Score: 99
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.18
    Marker Score: 107
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.18
    Marker Score: 51
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.18
    Marker Score: 949
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.18
    Marker Score: 44
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.18
    Marker Score: 111

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell surface protein:** ADAMTS7 is a type II transmembrane glycoprotein, with a large extracellular domain that interacts with other proteins and ligands. 2. **Metalloendopeptidase activity:** The protein possesses a metalloprotease domain, which enables it to cleave and modify proteins, influencing various cellular processes. 3. **Thrombospondin motif:** The protein contains a thrombospondin type 1 motif, which is involved in cell adhesion and signaling. 4. **O-glycosylation:** ADAMTS7 is subject to O-glycosylation, a post-translational modification that affects its protein-protein interactions and cellular localization. 5. **Tissue-specific expression:** ADAMTS7 is expressed in various cell types, including cardiac myocytes, fibroblasts, and neurons, suggesting its involvement in multiple physiological processes. **Pathways and Functions:** 1. **Cell surface interactions:** ADAMTS7 interacts with other proteins and ligands, influencing cell adhesion, migration, and signaling. 2. **Proteolysis and protein modification:** The metalloprotease domain of ADAMTS7 enables it to cleave and modify proteins, influencing various cellular processes, including protein degradation and signaling. 3. **Chondrocyte differentiation:** ADAMTS7 regulates chondrocyte differentiation, influencing the development and maintenance of cartilage tissue. 4. **Collagen fibril organization:** The protein is involved in the organization of collagen fibrils, which is essential for maintaining tissue structure and integrity. 5. **Proteoglycan metabolism:** ADAMTS7 influences the metabolism of proteoglycans, which are crucial for maintaining the structure and function of the extracellular matrix. **Clinical Significance:** 1. **Diseases related to glycosylation:** Dysregulation of ADAMTS7 has been implicated in diseases related to O-glycosylation, such as cancer, neurodegenerative disorders, and metabolic disorders. 2. **Bone maturation and osteoarthritis:** ADAMTS7 plays a role in bone maturation and osteoarthritis, highlighting its potential as a therapeutic target for these conditions. 3. **Cardiac function and arrhythmias:** The protein's expression in cardiac myocytes suggests its involvement in cardiac function and arrhythmias, highlighting its potential as a therapeutic target for cardiac diseases. 4. **Neurological disorders:** ADAMTS7's expression in neurons and its involvement in chondrocyte differentiation and collagen fibril organization suggest its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, ADAMTS7 is a multifaceted gene involved in various biological processes, including cell surface interactions, proteolysis, and protein modification. Its dysregulation has been implicated in various diseases, highlighting its potential as a therapeutic target for human health. Further research is needed to fully elucidate the functional scope of ADAMTS7 and its implications for human health.

Genular Protein ID: 4247579629

Symbol: ATS7_HUMAN

Name: A disintegrin and metalloproteinase with thrombospondin motifs 7

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16585064

Title: ADAMTS-7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein.

PubMed ID: 16585064

DOI: 10.1096/fj.05-3877fje

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10464288

Title: ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases.

PubMed ID: 10464288

DOI: 10.1074/jbc.274.36.25555

PubMed ID: 15192113

Title: ADAMTS7B, the full-length product of the ADAMTS7 gene, is a chondroitin sulfate proteoglycan containing a mucin domain.

PubMed ID: 15192113

DOI: 10.1074/jbc.m402380200

Sequence Information:

  • Length: 1686
  • Mass: 184095
  • Checksum: AB38264B8E8DB740
  • Sequence:
  • MPGGPSPRSP APLLRPLLLL LCALAPGAPG PAPGRATEGR AALDIVHPVR VDAGGSFLSY 
    ELWPRALRKR DVSVRRDAPA FYELQYRGRE LRFNLTANQH LLAPGFVSET RRRGGLGRAH 
    IRAHTPACHL LGEVQDPELE GGLAAISACD GLKGVFQLSN EDYFIEPLDS APARPGHAQP 
    HVVYKRQAPE RLAQRGDSSA PSTCGVQVYP ELESRRERWE QRQQWRRPRL RRLHQRSVSK 
    EKWVETLVVA DAKMVEYHGQ PQVESYVLTI MNMVAGLFHD PSIGNPIHIT IVRLVLLEDE 
    EEDLKITHHA DNTLKSFCKW QKSINMKGDA HPLHHDTAIL LTRKDLCAAM NRPCETLGLS 
    HVAGMCQPHR SCSINEDTGL PLAFTVAHEL GHSFGIQHDG SGNDCEPVGK RPFIMSPQLL 
    YDAAPLTWSR CSRQYITRFL DRGWGLCLDD PPAKDIIDFP SVPPGVLYDV SHQCRLQYGA 
    YSAFCEDMDN VCHTLWCSVG TTCHSKLDAA VDGTRCGENK WCLSGECVPV GFRPEAVDGG 
    WSGWSAWSIC SRSCGMGVQS AERQCTQPTP KYKGRYCVGE RKRFRLCNLQ ACPAGRPSFR 
    HVQCSHFDAM LYKGQLHTWV PVVNDVNPCE LHCRPANEYF AEKLRDAVVD GTPCYQVRAS 
    RDLCINGICK NVGCDFEIDS GAMEDRCGVC HGNGSTCHTV SGTFEEAEGL GYVDVGLIPA 
    GAREIRIQEV AEAANFLALR SEDPEKYFLN GGWTIQWNGD YQVAGTTFTY ARRGNWENLT 
    SPGPTKEPVW IQLLFQESNP GVHYEYTIHR EAGGHDEVPP PVFSWHYGPW TKCTVTCGRG 
    VQRQNVYCLE RQAGPVDEEH CDPLGRPDDQ QRKCSEQPCP ARWWAGEWQL CSSSCGPGGL 
    SRRAVLCIRS VGLDEQSALE PPACEHLPRP PTETPCNRHV PCPATWAVGN WSQCSVTCGE 
    GTQRRNVLCT NDTGVPCDEA QQPASEVTCS LPLCRWPLGT LGPEGSGSGS SSHELFNEAD 
    FIPHHLAPRP SPASSPKPGT MGNAIEEEAP ELDLPGPVFV DDFYYDYNFI NFHEDLSYGP 
    SEEPDLDLAG TGDRTPPPHS HPAAPSTGSP VPATEPPAAK EEGVLGPWSP SPWPSQAGRS 
    PPPPSEQTPG NPLINFLPEE DTPIGAPDLG LPSLSWPRVS TDGLQTPATP ESQNDFPVGK 
    DSQSQLPPPW RDRTNEVFKD DEEPKGRGAP HLPPRPSSTL PPLSPVGSTH SSPSPDVAEL 
    WTGGTVAWEP ALEGGLGPVD SELWPTVGVA SLLPPPIAPL PEMKVRDSSL EPGTPSFPTP 
    GPGSWDLQTV AVWGTFLPTT LTGLGHMPEP ALNPGPKGQP ESLSPEVPLS SRLLSTPAWD 
    SPANSHRVPE TQPLAPSLAE AGPPADPLVV RNAGWQAGNW SECSTTCGLG AVWRPVRCSS 
    GRDEDCAPAG RPQPARRCHL RPCATWHSGN WSKCSRSCGG GSSVRDVQCV DTRDLRPLRP 
    FHCQPGPAKP PAHRPCGAQP CLSWYTSSWR ECSEACGGGE QQRLVTCPEP GLCEEALRPN 
    TTRPCNTHPC TQWVVGPWGQ CSGPCGGGVQ RRLVKCVNTQ TGLPEEDSDQ CGHEAWPESS 
    RPCGTEDCEP VEPPRCERDR LSFGFCETLR LLGRCQLPTI RTQCCRSCSP PSHGAPSRGH 
    QRVARR

Genular Protein ID: 1017985127

Symbol: Q9UFZ4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 898
  • Mass: 96732
  • Checksum: 38532F1E56F0A11B
  • Sequence:
  • VWIQLLFQES NPGVHYEYTI HREAGGHDEV PPPVFSWHYG PWTKCTVTCG RGVQRQNVYC 
    LERQAGPVDE EHCDPLGRPD DQQRKCSEQP CPARWWAGEW QLCSSSCGPG GLSRRAVLCI 
    RSVGLDEQSA LEPPACEHLP RPPTETPCNR HVPCPATWAV GNWSQCSVTC GEGTQRRNVL 
    CTNDTGVPCD EAQQPASEVT CSLPLCRWPL GTLGPEGSGS GSSSHELFNE ADFIPHHLAP 
    RPSPASSPKP GTMGNAIEEE APELDLPGPV FVDDFYYDYN FINFHEDLSY GPSEEPDLDL 
    AGTGDRTPPP HSRPAAPSTG SPVPATEPPA AKEEGVLGPW SPSPWPSQAG RSPPPPSEQT 
    PGNPLINFLP EEDTPIGAPD LGLPSLSWPR VSTDGLQTPA TPESQNDFPV GKDSQSQLPP 
    PWRDRTNEVF KDDEEPKGRG APHLPPRPSS TLPPLSPVGS THSSPSPDVA ELWTGGTVAW 
    EPALEGGLGP VDSELWPTVG VASLLPPPIA PLPEMKVRDS SLEPGTPSFP APGPGSWDLQ 
    TVAVWGTFLP TTLTGLGHMP EPALNPGPKG QPESLSPEVP LSSRLLSTPA WDSPANSHRV 
    PETQPLAPSL AEAGPPADPL VVRNASWQAG NWSECSTTCG LGAVWRPVRC SSGRDEDCAP 
    AGRPQPARRC HLRPCATWHS GNWSKCSRSC GGGSSVRDVQ CVDTRDLRPL RPFHCQPGPA 
    KPPAHRPCGA QPCLSWYTSS WRECSEACGG GEQQRLVTCP EPGLCEEALR PNTTRPCNTH 
    PCTQWVVGPW GQCSAPCGGG VQRRLVKCVN TQTGLPEEDS DQCGHEAWPE SSRPCGTEDC 
    EPVEPPRCER DRLSFGFCET LRLLGRCQLP TIRTQCCRSC SPPSHGAPSR GHQRVARR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.