Details for: ADAMTS6

Gene ID: 11174

Symbol: ADAMTS6

Ensembl ID: ENSG00000049192

Description: ADAM metallopeptidase with thrombospondin type 1 motif 6

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.86
    Marker Score: 3,463
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 2.6
    Marker Score: 2,137
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.41
    Marker Score: 1,350
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.07
    Marker Score: 1,208
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.97
    Marker Score: 8,230
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.87
    Marker Score: 70,942
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 1.61
    Marker Score: 4,635
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.58
    Marker Score: 1,151
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.57
    Marker Score: 1,068
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.51
    Marker Score: 11,597
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.5
    Marker Score: 2,024
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169,008
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.42
    Marker Score: 2,891
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.34
    Marker Score: 2,342
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.3
    Marker Score: 3,050
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.2
    Marker Score: 21,355
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.17
    Marker Score: 18,230
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.15
    Marker Score: 690
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.12
    Marker Score: 414
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.08
    Marker Score: 4,157
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.04
    Marker Score: 1,512
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,771
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.03
    Marker Score: 1,272
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,790
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,015
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 497
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.96
    Marker Score: 5,779
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 451
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,410
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.93
    Marker Score: 633
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.92
    Marker Score: 12,142
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,730
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 363
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5,111
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.86
    Marker Score: 356
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.85
    Marker Score: 510
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.84
    Marker Score: 402
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.84
    Marker Score: 3,306
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.81
    Marker Score: 255
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.8
    Marker Score: 17,967
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.79
    Marker Score: 257
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.79
    Marker Score: 855
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 591
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,245
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.76
    Marker Score: 246
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.75
    Marker Score: 1,761
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.75
    Marker Score: 341
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 386
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.74
    Marker Score: 705
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.74
    Marker Score: 679
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 666
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3,045
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7
    Marker Score: 7,071
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.7
    Marker Score: 2,281
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.68
    Marker Score: 24,972
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.67
    Marker Score: 1,039
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.67
    Marker Score: 507
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.67
    Marker Score: 156
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.66
    Marker Score: 483
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.6
    Marker Score: 1,473
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.6
    Marker Score: 349
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.59
    Marker Score: 290
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.59
    Marker Score: 1,169
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.57
    Marker Score: 7,521
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.56
    Marker Score: 2,939
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.55
    Marker Score: 1,576
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.55
    Marker Score: 350
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.52
    Marker Score: 5,390
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.51
    Marker Score: 265
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.51
    Marker Score: 280
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.51
    Marker Score: 144
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.49
    Marker Score: 184
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.48
    Marker Score: 221
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.48
    Marker Score: 316
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.48
    Marker Score: 165
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.47
    Marker Score: 1,751
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.47
    Marker Score: 136
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.47
    Marker Score: 122
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.46
    Marker Score: 1,931
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.46
    Marker Score: 159
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.46
    Marker Score: 9,121
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.46
    Marker Score: 203
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.45
    Marker Score: 114
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.45
    Marker Score: 304
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.44
    Marker Score: 171
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.44
    Marker Score: 105
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.44
    Marker Score: 154
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.43
    Marker Score: 4,081
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.43
    Marker Score: 835
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.43
    Marker Score: 600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.43
    Marker Score: 136
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.43
    Marker Score: 271
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.43
    Marker Score: 382

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ADAMTS6 is a member of the ADAMTS family, which comprises 18 proteins that share a common structure and function. The ADAMTS6 protein is characterized by its ability to cleave and modify proteoglycans, including chondroitin sulfate and heparan sulfate proteoglycans. This enzymatic activity is mediated by the ADAMTS6 protein's catalytic domain, which contains a metalloprotease motif. The protein's thrombospondin motifs are also present, which interact with other proteins to modulate signaling pathways. ADAMTS6 is primarily expressed in cells involved in development and tissue maintenance, including lens epithelial cells, syncytiotrophoblast cells, and cerebellar granule cell precursors. The protein's expression is also observed in adult tissues, including the colon and kidney. **Pathways and Functions** ADAMTS6 plays a crucial role in various developmental processes, including: 1. **Aorta development**: ADAMTS6 is involved in the formation of the aortic valve and the aortic arch. 2. **Cardiac septum development**: The protein plays a role in the development of the cardiac septum, which separates the left and right sides of the heart. 3. **Coronary vasculature development**: ADAMTS6 is involved in the formation of the coronary vasculature, which supplies blood to the heart muscle. 4. **Kidney development**: The protein plays a role in the development of the renal vasculature and the formation of the glomerular filtration barrier. ADAMTS6 also participates in various signaling pathways, including: 1. **O-glycosylation of proteins**: The protein's enzymatic activity is involved in the modification of proteins with O-glycans, which play a role in cell signaling and cell-cell interactions. 2. **Metalloendopeptidase activity**: ADAMTS6's metalloprotease motif is involved in the cleavage of proteoglycans and other substrates. 3. **Proteolysis**: The protein's enzymatic activity is involved in the degradation of proteoglycans and other substrates. **Clinical Significance** Dysregulation of ADAMTS6 has been implicated in various diseases, including: 1. **Pulmonary valve stenosis**: A congenital heart defect characterized by the narrowing of the pulmonary valve. 2. **Aortic valve disease**: A condition characterized by the degeneration of the aortic valve. 3. **Coronary artery disease**: A condition characterized by the narrowing or blockage of the coronary arteries. 4. **Metabolic disorders**: ADAMTS6 has been implicated in the development of metabolic disorders, including obesity and type 2 diabetes. In summary, ADAMTS6 is a critical regulator of proteoglycan modification and signaling pathways involved in development and tissue maintenance. Dysregulation of the gene has been implicated in various diseases, highlighting its importance in maintaining tissue homeostasis and overall health.

Genular Protein ID: 2159622241

Symbol: ATS6_HUMAN

Name: A disintegrin and metalloproteinase with thrombospondin motifs 6

UniProtKB Accession Codes:

Q9UKP5 Q59EX6 Q5IR87 Q5IR88 Q5IR89 Q68DL1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 11 Ensembl 2 GO 11 Gene3D 4 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 4 PROSITE-ProRule 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 8 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10464288

Title: ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases.

PubMed ID: 10464288

DOI: 10.1074/jbc.274.36.25555

PubMed ID: 16129570

Title: Analysis of full length ADAMTS6 transcript reveals alternative splicing and a role for the 5' untranslated region in translational control.

PubMed ID: 16129570

DOI: 10.1016/j.gene.2005.06.011

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12697333

Title: Expression of ADAMTS metalloproteinases in the retinal pigment epithelium derived cell line ARPE-19: transcriptional regulation by TNFalpha.

PubMed ID: 12697333

DOI: 10.1016/s0167-4781(03)00047-2

Sequence Information:

  • Length: 1117
  • Mass: 125273
  • Checksum: 5901E86BC82A9A87
  • Sequence:
    • MEILWKTLTW ILSLIMASSE FHSDHRLSYS SQEEFLTYLE HYQLTIPIRV DQNGAFLSFT 
VKNDKHSRRR RSMDPIDPQQ AVSKLFFKLS AYGKHFHLNL TLNTDFVSKH FTVEYWGKDG 
PQWKHDFLDN CHYTGYLQDQ RSTTKVALSN CVGLHGVIAT EDEEYFIEPL KNTTEDSKHF 
SYENGHPHVI YKKSALQQRH LYDHSHCGVS DFTRSGKPWW LNDTSTVSYS LPINNTHIHH 
RQKRSVSIER FVETLVVADK MMVGYHGRKD IEHYILSVMN IVAKLYRDSS LGNVVNIIVA 
RLIVLTEDQP NLEINHHADK SLDSFCKWQK SILSHQSDGN TIPENGIAHH DNAVLITRYD 
ICTYKNKPCG TLGLASVAGM CEPERSCSIN EDIGLGSAFT IAHEIGHNFG MNHDGIGNSC 
GTKGHEAAKL MAAHITANTN PFSWSACSRD YITSFLDSGR GTCLDNEPPK RDFLYPAVAP 
GQVYDADEQC RFQYGATSRQ CKYGEVCREL WCLSKSNRCV TNSIPAAEGT LCQTGNIEKG 
WCYQGDCVPF GTWPQSIDGG WGPWSLWGEC SRTCGGGVSS SLRHCDSPAP SGGGKYCLGE 
RKRYRSCNTD PCPLGSRDFR EKQCADFDNM PFRGKYYNWK PYTGGGVKPC ALNCLAEGYN 
FYTERAPAVI DGTQCNADSL DICINGECKH VGCDNILGSD AREDRCRVCG GDGSTCDAIE 
GFFNDSLPRG GYMEVVQIPR GSVHIEVREV AMSKNYIALK SEGDDYYING AWTIDWPRKF 
DVAGTAFHYK RPTDEPESLE ALGPTSENLI VMVLLQEQNL GIRYKFNVPI TRTGSGDNEV 
GFTWNHQPWS ECSATCAGGV QRQEVVCKRL DDNSIVQNNY CDPDSKPPEN QRACNTEPCP 
PEWFIGDWLE CSKTCDGGMR TRAVLCIRKI GPSEEETLDY SGCLTHRPVE KEPCNNQSCP 
PQWVALDWSE CTPKCGPGFK HRIVLCKSSD LSKTFPAAQC PEESKPPVRI RCSLGRCPPP 
RWVTGDWGQC SAQCGLGQQM RTVQCLSYTG QASSDCLETV RPPSMQQCES KCDSTPISNT 
EECKDVNKVA YCPLVLKFKF CSRAYFRQMC CKTCQGH

Genular Protein ID: 532217460

Symbol: Q5IR90_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5IR90

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 3 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 16129570

Title: Analysis of full length ADAMTS6 transcript reveals alternative splicing and a role for the 5' untranslated region in translational control.

PubMed ID: 16129570

DOI: 10.1016/j.gene.2005.06.011

Sequence Information:

  • Length: 270
  • Mass: 30131
  • Checksum: 859466C1DE40145C
  • Sequence:
    • PWSECSATCA GGVQRQEVVC KRLDDNSIVQ NNYCDPDSKP PENQRACNTE PCPPEWFIGD 
WLECSKTCDG GMRTRAVLCI RKIGPSEEET LDYSGCLTHR PVEKEPCNNQ SCPPQWVALD 
WSECTPKCGP GFKHRIVLCK SSDLSKTFPA AQCPEESKPP VRIRCSLGRC PPPRWVTGDW 
GQCSAQCGLG QQMRTVQCLS YTGQASSDCL ETVRPPSMQQ CESKCDSTPI SNTEECKDVN 
KVAYCPLVLK FKFCSRAYFR QMCCKTCQGH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.