Details for: BAZ2A

Gene ID: 11176

Symbol: BAZ2A

Ensembl ID: ENSG00000076108

Description: bromodomain adjacent to zinc finger domain 2A

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.2
    Marker Score: 1,758
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.04
    Marker Score: 2,009
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.84
    Marker Score: 1,071
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.71
    Marker Score: 1,800
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.7
    Marker Score: 1,134
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.62
    Marker Score: 3,405
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.61
    Marker Score: 970
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.56
    Marker Score: 551
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.54
    Marker Score: 1,696
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.53
    Marker Score: 535
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.48
    Marker Score: 15,282
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.48
    Marker Score: 17,182
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.47
    Marker Score: 8,746
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.46
    Marker Score: 2,096
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.42
    Marker Score: 964
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4
    Marker Score: 2,061
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.4
    Marker Score: 639
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.38
    Marker Score: 1,898
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.37
    Marker Score: 1,580
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.36
    Marker Score: 1,710
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.35
    Marker Score: 28,858
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.35
    Marker Score: 389
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.34
    Marker Score: 578
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.33
    Marker Score: 1,443
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.32
    Marker Score: 80,905
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.31
    Marker Score: 13,304
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.31
    Marker Score: 678
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.31
    Marker Score: 312
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.3
    Marker Score: 72,832
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.28
    Marker Score: 905
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.28
    Marker Score: 5,370
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.28
    Marker Score: 10,989
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.28
    Marker Score: 1,172
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.26
    Marker Score: 310
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.24
    Marker Score: 504
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.24
    Marker Score: 388
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.24
    Marker Score: 5,040
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.24
    Marker Score: 18,504
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.23
    Marker Score: 1,455
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.22
    Marker Score: 498
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.22
    Marker Score: 352
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.22
    Marker Score: 1,472
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.22
    Marker Score: 4,711
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.21
    Marker Score: 1,172
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.21
    Marker Score: 9,273
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.21
    Marker Score: 1,289
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.2
    Marker Score: 45,730
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.2
    Marker Score: 44,251
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.19
    Marker Score: 441
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.19
    Marker Score: 1,837
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.19
    Marker Score: 696
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.19
    Marker Score: 1,577
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.18
    Marker Score: 475
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.18
    Marker Score: 11,197
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.17
    Marker Score: 491
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.17
    Marker Score: 1,094
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.17
    Marker Score: 23,209
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.17
    Marker Score: 1,239
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.16
    Marker Score: 1,252
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.16
    Marker Score: 18,147
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.16
    Marker Score: 61,230
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.15
    Marker Score: 344
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.15
    Marker Score: 1,026
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.15
    Marker Score: 991
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.15
    Marker Score: 10,781
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.14
    Marker Score: 262
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.14
    Marker Score: 395
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.14
    Marker Score: 552
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.14
    Marker Score: 359
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 1.13
    Marker Score: 297
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.13
    Marker Score: 253
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.13
    Marker Score: 391
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.13
    Marker Score: 3,175
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.13
    Marker Score: 1,461
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.13
    Marker Score: 3,571
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.13
    Marker Score: 2,478
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 1.13
    Marker Score: 332
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.13
    Marker Score: 1,171
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.13
    Marker Score: 1,514
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.13
    Marker Score: 8,375
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.12
    Marker Score: 699
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 1.12
    Marker Score: 253
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.11
    Marker Score: 735
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.11
    Marker Score: 1,196
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.11
    Marker Score: 839
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 1.11
    Marker Score: 309
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.11
    Marker Score: 274
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.11
    Marker Score: 2,605
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.11
    Marker Score: 4,345
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.1
    Marker Score: 415
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.1
    Marker Score: 577
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.1
    Marker Score: 1,103
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.09
    Marker Score: 263
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.09
    Marker Score: 1,930
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.08
    Marker Score: 2,109
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.08
    Marker Score: 1,175
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.08
    Marker Score: 736
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.08
    Marker Score: 1,083
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.08
    Marker Score: 966
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.08
    Marker Score: 10,656

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** BAZ2A is a protein-coding gene that belongs to the Bromodomain and Extra-Terminal (BET) family of proteins. It consists of a bromodomain adjacent to a zinc finger domain, which are structural motifs that recognize and bind to acetylated histones. The BAZ2A protein is highly expressed in various cell types, including immune cells, and is involved in the regulation of gene expression, chromatin remodeling, and DNA methylation. Its expression is tightly regulated, and its dysregulation has been implicated in various diseases, including cancer and autoimmune disorders. **Pathways and Functions:** BAZ2A is involved in several key pathways and functions, including: 1. **Chromatin Remodeling:** BAZ2A is a chromatin remodeler that regulates the structure and accessibility of chromatin, allowing for the recruitment of transcription factors and other regulatory proteins. 2. **Histone Binding:** The bromodomain of BAZ2A binds to acetylated histones, which are a hallmark of active chromatin. This interaction regulates the recruitment of transcription factors and other regulatory proteins to specific genomic regions. 3. **DNA Methylation:** BAZ2A is involved in the regulation of DNA methylation, a process that plays a critical role in maintaining genome stability and transcriptional homeostasis. 4. **Gene Expression Regulation:** BAZ2A regulates the expression of specific genes, including those involved in immune cell function and differentiation. 5. **Epigenetic Regulation of Gene Expression:** BAZ2A is involved in the regulation of epigenetic marks, including histone modifications and DNA methylation, which play a critical role in maintaining genome stability and transcriptional homeostasis. **Clinical Significance:** BAZ2A has been implicated in various diseases, including: 1. **Autoimmune Disorders:** Dysregulation of BAZ2A has been implicated in autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer:** BAZ2A has been implicated in the development and progression of various cancers, including leukemia and lymphoma. 3. **Immunodeficiency Disorders:** Mutations in the BAZ2A gene have been implicated in immunodeficiency disorders, such as X-linked agammaglobulinemia. 4. **Neurological Disorders:** BAZ2A has been implicated in the regulation of gene expression in the nervous system, and dysregulation of BAZ2A has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, BAZ2A is a gene that plays a critical role in the regulation of gene expression and epigenetic processes. Its involvement in various cellular processes, including chromatin remodeling, histone binding, and DNA methylation, underscores its importance in maintaining genome stability and transcriptional homeostasis. Its dysregulation has been implicated in various diseases, including autoimmune disorders, cancer, immunodeficiency disorders, and neurological disorders. Further research is needed to fully elucidate the role of BAZ2A in human health and disease.

Genular Protein ID: 609448871

Symbol: BAZ2A_HUMAN

Name: Bromodomain adjacent to zinc finger domain protein 2A

UniProtKB Accession Codes:

Q9UIF9 B3KN66 O00536 O15030 Q68DI8 Q96H26

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 24 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 15 KEGG 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 66 PDBsum 61 PRINTS 1 PRO 1 PROSITE 5 PROSITE-ProRule 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMART 5 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10662543

Title: A novel family of bromodomain genes.

PubMed ID: 10662543

DOI: 10.1006/geno.1999.6071

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 9205841

Title: Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9205841

DOI: 10.1093/dnares/4.2.141

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19578370

Title: Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing.

PubMed ID: 19578370

DOI: 10.1038/ncb1914

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25593309

Title: Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.

PubMed ID: 25593309

DOI: 10.1101/gad.252189.114

PubMed ID: 26100909

Title: BEND3 represses rDNA transcription by stabilizing a NoRC component via USP21 deubiquitinase.

PubMed ID: 26100909

DOI: 10.1073/pnas.1424705112

PubMed ID: 28801535

Title: Expansion of the ISWI chromatin remodeler family with new active complexes.

PubMed ID: 28801535

DOI: 10.15252/embr.201744011

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 1905
  • Mass: 211198
  • Checksum: F364E2AC4BF89EA2
  • Sequence:
    • MEMEANDHFN FTGLPPAPAA SGLKPSPSSG EGLYTNGSPM NFPQQGKSLN GDVNVNGLST 
VSHTTTSGIL NSAPHSSSTS HLHHPSVAYD CLWNYSQYPS ANPGSNLKDP PLLSQFSGGQ 
YPLNGILGGS RQPSSPSHNT NLRAGSQEFW ANGTQSPMGL NFDSQELYDS FPDQNFEVMP 
NGPPSFFTSP QTSPMLGSSI QTFAPSQEVG SGIHPDEAAE KEMTSVVAEN GTGLVGSLEL 
EEEQPELKMC GYNGSVPSVE SLHQEVSVLV PDPTVSCLDD PSHLPDQLED TPILSEDSLE 
PFNSLAPEPV SGGLYGIDDT ELMGAEDKLP LEDSPVISAL DCPSLNNATA FSLLADDSQT 
STSIFASPTS PPVLGESVLQ DNSFDLNNGS DAEQEEMETQ SSDFPPSLTQ PAPDQSSTIQ 
LHPATSPAVS PTTSPAVSLV VSPAASPEIS PEVCPAASTV VSPAVFSVVS PASSAVLPAV 
SLEVPLTASV TSPKASPVTS PAAAFPTASP ANKDVSSFLE TTADVEEITG EGLTASGSGD 
VMRRRIATPE EVRLPLQHGW RREVRIKKGS HRWQGETWYY GPCGKRMKQF PEVIKYLSRN 
VVHSVRREHF SFSPRMPVGD FFEERDTPEG LQWVQLSAEE IPSRIQAITG KRGRPRNTEK 
AKTKEVPKVK RGRGRPPKVK ITELLNKTDN RPLKKLEAQE TLNEEDKAKI AKSKKKMRQK 
VQRGECQTTI QGQARNKRKQ ETKSLKQKEA KKKSKAEKEK GKTKQEKLKE KVKREKKEKV 
KMKEKEEVTK AKPACKADKT LATQRRLEER QRQQMILEEM KKPTEDMCLT DHQPLPDFSR 
VPGLTLPSGA FSDCLTIVEF LHSFGKVLGF DPAKDVPSLG VLQEGLLCQG DSLGEVQDLL 
VRLLKAALHD PGFPSYCQSL KILGEKVSEI PLTRDNVSEI LRCFLMAYGV EPALCDRLRT 
QPFQAQPPQQ KAAVLAFLVH ELNGSTLIIN EIDKTLESMS SYRKNKWIVE GRLRRLKTVL 
AKRTGRSEVE MEGPEECLGR RRSSRIMEET SGMEEEEEEE SIAAVPGRRG RRDGEVDATA 
SSIPELERQI EKLSKRQLFF RKKLLHSSQM LRAVSLGQDR YRRRYWVLPY LAGIFVEGTE 
GNLVPEEVIK KETDSLKVAA HASLNPALFS MKMELAGSNT TASSPARARG RPRKTKPGSM 
QPRHLKSPVR GQDSEQPQAQ LQPEAQLHAP AQPQPQLQLQ LQSHKGFLEQ EGSPLSLGQS 
QHDLSQSAFL SWLSQTQSHS SLLSSSVLTP DSSPGKLDPA PSQPPEEPEP DEAESSPDPQ 
ALWFNISAQM PCNAAPTPPP AVSEDQPTPS PQQLASSKPM NRPSAANPCS PVQFSSTPLA 
GLAPKRRAGD PGEMPQSPTG LGQPKRRGRP PSKFFKQMEQ RYLTQLTAQP VPPEMCSGWW 
WIRDPEMLDA MLKALHPRGI REKALHKHLN KHRDFLQEVC LRPSADPIFE PRQLPAFQEG 
IMSWSPKEKT YETDLAVLQW VEELEQRVIM SDLQIRGWTC PSPDSTREDL AYCEHLSDSQ 
EDITWRGRGR EGLAPQRKTT NPLDLAVMRL AALEQNVERR YLREPLWPTH EVVLEKALLS 
TPNGAPEGTT TEISYEITPR IRVWRQTLER CRSAAQVCLC LGQLERSIAW EKSVNKVTCL 
VCRKGDNDEF LLLCDGCDRG CHIYCHRPKM EAVPEGDWFC TVCLAQQVEG EFTQKPGFPK 
RGQKRKSGYS LNFSEGDGRR RRVLLRGRES PAAGPRYSEE GLSPSKRRRL SMRNHHSDLT 
FCEIILMEME SHDAAWPFLE PVNPRLVSGY RRIIKNPMDF STMRERLLRG GYTSSEEFAA 
DALLVFDNCQ TFNEDDSEVG KAGHIMRRFF ESRWEEFYQG KQANL

Genular Protein ID: 3079210109

Symbol: F8VU39_HUMAN

Name: N/A

UniProtKB Accession Codes:

F8VU39

Database IDs:

ARBA 9 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 15 MANE-Select 1 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 9 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 6 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 5 SMR 1 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 1903
  • Mass: 210937
  • Checksum: B8DABA59162490D9
  • Sequence:
    • MEANDHFNFT GLPPAPAASG LKPSPSSGEG LYTNGSPMNF PQQGKSLNGD VNVNGLSTVS 
HTTTSGILNS APHSSSTSHL HHPSVAYDCL WNYSQYPSAN PGSNLKDPPL LSQFSGGQYP 
LNGILGGSRQ PSSPSHNTNL RAGSQEFWAN GTQSPMGLNF DSQELYDSFP DQNFEVMPNG 
PPSFFTSPQT SPMLGSSIQT FAPSQEVGSG IHPDEAAEKE MTSVVAENGT GLVGSLELEE 
EQPELKMCGY NGSVPSVESL HQEVSVLVPD PTVSCLDDPS HLPDQLEDTP ILSEDSLEPF 
NSLAPEPVSG GLYGIDDTEL MGAEDKLPLE DSPVISALDC PSLNNATAFS LLADDSQTST 
SIFASPTSPP VLGESVLQDN SFDLNNGSDA EQEEMETQSS DFPPSLTQPA PDQSSTIQLH 
PATSPAVSPT TSPAVSLVVS PAASPEISPE VCPAASTVVS PAVFSVVSPA SSAVLPAVSL 
EVPLTASVTS PKASPVTSPA AAFPTASPAN KDVSSFLETT ADVEEITGEG LTASGSGDVM 
RRRIATPEEV RLPLQHGWRR EVRIKKGSHR WQGETWYYGP CGKRMKQFPE VIKYLSRNVV 
HSVRREHFSF SPRMPVGDFF EERDTPEGLQ WVQLSAEEIP SRIQAITGKR GRPRNTEKAK 
TKEVPKVKRG RGRPPKVKIT ELLNKTDNRP LKKLEAQETL NEEDKAKIAK SKKKMRQKVQ 
RGECQTTIQG QARNKRKQET KSLKQKEAKK KSKAEKEKGK TKQEKLKEKV KREKKEKVKM 
KEKEEVTKAK PACKADKTLA TQRRLEERQR QQMILEEMKK PTEDMCLTDH QPLPDFSRVP 
GLTLPSGAFS DCLTIVEFLH SFGKVLGFDP AKDVPSLGVL QEGLLCQGDS LGEVQDLLVR 
LLKAALHDPG FPSYCQSLKI LGEKVSEIPL TRDNVSEILR CFLMAYGVEP ALCDRLRTQP 
FQAQPPQQKA AVLAFLVHEL NGSTLIINEI DKTLESMSSY RKNKWIVEGR LRRLKTVLAK 
RTGRSEVEME GPEECLGRRR SSRIMEETSG MEEEEEEESI AAVPGRRGRR DGEVDATASS 
IPELERQIEK LSKRQLFFRK KLLHSSQMLR AVSLGQDRYR RRYWVLPYLA GIFVEGTEGN 
LVPEEVIKKE TDSLKVAAHA SLNPALFSMK MELAGSNTTA SSPARARGRP RKTKPGSMQP 
RHLKSPVRGQ DSEQPQAQLQ PEAQLHAPAQ PQPQLQLQLQ SHKGFLEQEG SPLSLGQSQH 
DLSQSAFLSW LSQTQSHSSL LSSSVLTPDS SPGKLDPAPS QPPEEPEPDE AESSPDPQAL 
WFNISAQMPC NAAPTPPPAV SEDQPTPSPQ QLASSKPMNR PSAANPCSPV QFSSTPLAGL 
APKRRAGDPG EMPQSPTGLG QPKRRGRPPS KFFKQMEQRY LTQLTAQPVP PEMCSGWWWI 
RDPEMLDAML KALHPRGIRE KALHKHLNKH RDFLQEVCLR PSADPIFEPR QLPAFQEGIM 
SWSPKEKTYE TDLAVLQWVE ELEQRVIMSD LQIRGWTCPS PDSTREDLAY CEHLSDSQED 
ITWRGRGREG LAPQRKTTNP LDLAVMRLAA LEQNVERRYL REPLWPTHEV VLEKALLSTP 
NGAPEGTTTE ISYEITPRIR VWRQTLERCR SAAQVCLCLG QLERSIAWEK SVNKVTCLVC 
RKGDNDEFLL LCDGCDRGCH IYCHRPKMEA VPEGDWFCTV CLAQQVEGEF TQKPGFPKRG 
QKRKSGYSLN FSEGDGRRRR VLLRGRESPA AGPRYSEEGL SPSKRRRLSM RNHHSDLTFC 
EIILMEMESH DAAWPFLEPV NPRLVSGYRR IIKNPMDFST MRERLLRGGY TSSEEFAADA 
LLVFDNCQTF NEDDSEVGKA GHIMRRFFES RWEEFYQGKQ ANL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.