CHIT1 | ENSG00000133063 | NCBI 1118

Details for: CHIT1

Gene ID: 1118

Symbol: CHIT1

Ensembl ID: ENSG00000133063

Description: chitinase 1

Associated with

Digestion
(R-HSA-8935690)
Digestion and absorption
(R-HSA-8963743)
Digestion of dietary carbohydrate
(R-HSA-189085)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Neutrophil degranulation
(R-HSA-6798695)
Chitinase activity
(GO:0004568)
Chitin binding
(GO:0008061)
Chitin catabolic process
(GO:0006032)
Endochitinase activity
(GO:0008843)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Hydrolase activity, hydrolyzing o-glycosyl compounds
(GO:0004553)
Immune response
(GO:0006955)
Lysosome
(GO:0005764)
Polysaccharide catabolic process
(GO:0000272)
Polysaccharide digestion
(GO:0044245)
Response to bacterium
(GO:0009617)
Specific granule lumen
(GO:0035580)
Tertiary granule lumen
(GO:1904724)

Other Information

Proteins

Chitotriosidase-1

Genular Protein ID: 3063702423

Symbol: CHIT1_HUMAN

Name: Chitotriosidase-1

UniProtKB Accession Codes:

Q13231 B3KNW6 J3KN09 Q0VGG5 Q0VGG6 Q3ZAR1 Q6ISC2 Q9H3V8 Q9UDJ8

Database IDs:

Citations:

PubMed ID: 7592832

Title: Cloning of a cDNA encoding chitotriosidase, a human chitinase produced by macrophages.

PubMed ID: 7592832

DOI: 10.1074/jbc.270.44.26252

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7836450

Title: Purification and characterization of human chitotriosidase, a novel member of the chitinase family of proteins.

PubMed ID: 7836450

DOI: 10.1074/jbc.270.5.2198

PubMed ID: 9748235

Title: The human chitotriosidase gene. Nature of inherited enzyme deficiency.

PubMed ID: 9748235

DOI: 10.1074/jbc.273.40.25680

PubMed ID: 11960986

Title: Structure of human chitotriosidase. Implications for specific inhibitor design and function of mammalian chitinase-like lectins.

PubMed ID: 11960986

DOI: 10.1074/jbc.m201636200

PubMed ID: 12639956

Title: Crystal structures of allosamidin derivatives in complex with human macrophage chitinase.

PubMed ID: 12639956

DOI: 10.1074/jbc.m300362200

PubMed ID: 15664516

Title: Specificity and affinity of natural product cyclopentapeptide inhibitors against A. fumigatus, human, and bacterial chitinases.

PubMed ID: 15664516

DOI: 10.1016/j.chembiol.2004.10.013

PubMed ID: 17464953

Title: Type 1 Gaucher disease: null and hypomorphic novel chitotriosidase mutations-implications for diagnosis and therapeutic monitoring.

PubMed ID: 17464953

DOI: 10.1002/humu.20524

PubMed ID: 19725875

Title: Common G102S polymorphism in chitotriosidase differentially affects activity towards 4-methylumbelliferyl substrates.

PubMed ID: 19725875

DOI: 10.1111/j.1742-4658.2009.07259.x

Sequence Information:

Length: 466
Mass: 51681
Checksum: B4312D1E885E386D
Sequence:

MVRSVAWAGF MVLLMIPWGS AAKLVCYFTN WAQYRQGEAR FLPKDLDPSL CTHLIYAFAG 
MTNHQLSTTE WNDETLYQEF NGLKKMNPKL KTLLAIGGWN FGTQKFTDMV ATANNRQTFV 
NSAIRFLRKY SFDGLDLDWE YPGSQGSPAV DKERFTTLVQ DLANAFQQEA QTSGKERLLL 
SAAVPAGQTY VDAGYEVDKI AQNLDFVNLM AYDFHGSWEK VTGHNSPLYK RQEESGAAAS 
LNVDAAVQQW LQKGTPASKL ILGMPTYGRS FTLASSSDTR VGAPATGSGT PGPFTKEGGM 
LAYYEVCSWK GATKQRIQDQ KVPYIFRDNQ WVGFDDVESF KTKVSYLKQK GLGGAMVWAL 
DLDDFAGFSC NQGRYPLIQT LRQELSLPYL PSGTPELEVP KPGQPSEPEH GPSPGQDTFC 
QGKADGLYPN PRERSSFYSC AAGRLFQQSC PTGLVFSNSC KCCTWN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CHIT1

Associated with

Other Information

Cloning of a cDNA encoding chitotriosidase, a human chitinase produced by macrophages. PubMed ID: 7592832

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Purification and characterization of human chitotriosidase, a novel member of the chitinase family of proteins. PubMed ID: 7836450

The human chitotriosidase gene. Nature of inherited enzyme deficiency. PubMed ID: 9748235

Structure of human chitotriosidase. Implications for specific inhibitor design and function of mammalian chitinase-like lectins. PubMed ID: 11960986

Crystal structures of allosamidin derivatives in complex with human macrophage chitinase. PubMed ID: 12639956

Specificity and affinity of natural product cyclopentapeptide inhibitors against A. fumigatus, human, and bacterial chitinases. PubMed ID: 15664516

Type 1 Gaucher disease: null and hypomorphic novel chitotriosidase mutations-implications for diagnosis and therapeutic monitoring. PubMed ID: 17464953

Common G102S polymorphism in chitotriosidase differentially affects activity towards 4-methylumbelliferyl substrates. PubMed ID: 19725875