Details for: CHIT1

Gene ID: 1118

Symbol: CHIT1

Ensembl ID: ENSG00000133063

Description: chitinase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: 1.7868
    Cell Significance Index: 28.7300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.8376
    Cell Significance Index: -1.8300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.6418
    Cell Significance Index: 9.9300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2262
    Cell Significance Index: 6.0600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1857
    Cell Significance Index: 1.7100
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.1255
    Cell Significance Index: 1.2400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1023
    Cell Significance Index: 2.5500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.0877
    Cell Significance Index: 1.0900
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.0478
    Cell Significance Index: 0.4400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0407
    Cell Significance Index: 1.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0394
    Cell Significance Index: 11.3400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0338
    Cell Significance Index: 0.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0285
    Cell Significance Index: 1.0800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0210
    Cell Significance Index: 0.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0192
    Cell Significance Index: 3.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0117
    Cell Significance Index: 2.3300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0097
    Cell Significance Index: 0.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0096
    Cell Significance Index: 0.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0032
    Cell Significance Index: 0.6500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0009
    Cell Significance Index: 1.7300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0005
    Cell Significance Index: -1.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0006
    Cell Significance Index: -0.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0007
    Cell Significance Index: -0.0800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0007
    Cell Significance Index: -0.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0007
    Cell Significance Index: -1.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0012
    Cell Significance Index: -1.6500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0015
    Cell Significance Index: -0.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0026
    Cell Significance Index: -0.2700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0028
    Cell Significance Index: -2.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0030
    Cell Significance Index: -2.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0035
    Cell Significance Index: -1.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0037
    Cell Significance Index: -2.0400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0040
    Cell Significance Index: -2.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0040
    Cell Significance Index: -2.5100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0073
    Cell Significance Index: -1.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0080
    Cell Significance Index: -1.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0103
    Cell Significance Index: -1.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0111
    Cell Significance Index: -2.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0127
    Cell Significance Index: -1.6400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0159
    Cell Significance Index: -2.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0162
    Cell Significance Index: -1.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0197
    Cell Significance Index: -2.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0202
    Cell Significance Index: -1.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0216
    Cell Significance Index: -2.2500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0234
    Cell Significance Index: -0.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0234
    Cell Significance Index: -1.8000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0310
    Cell Significance Index: -2.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0316
    Cell Significance Index: -2.3600
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0343
    Cell Significance Index: -0.3000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0350
    Cell Significance Index: -0.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0353
    Cell Significance Index: -1.9800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0355
    Cell Significance Index: -1.6700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0397
    Cell Significance Index: -2.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0452
    Cell Significance Index: -2.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0478
    Cell Significance Index: -2.2300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0480
    Cell Significance Index: -1.3700
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0486
    Cell Significance Index: -0.6100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0502
    Cell Significance Index: -0.8500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0537
    Cell Significance Index: -1.8800
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0550
    Cell Significance Index: -0.6500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0554
    Cell Significance Index: -1.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0561
    Cell Significance Index: -1.9700
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0576
    Cell Significance Index: -0.6700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0583
    Cell Significance Index: -1.9100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0589
    Cell Significance Index: -2.5600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0599
    Cell Significance Index: -3.0300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0607
    Cell Significance Index: -1.4800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0630
    Cell Significance Index: -2.0100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0680
    Cell Significance Index: -2.1500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0704
    Cell Significance Index: -1.8100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0712
    Cell Significance Index: -0.9000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0755
    Cell Significance Index: -2.7700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0760
    Cell Significance Index: -2.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0760
    Cell Significance Index: -2.0700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0761
    Cell Significance Index: -2.2400
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0769
    Cell Significance Index: -0.8600
  • Cell Name: immature neutrophil (CL0000776)
    Fold Change: -0.0774
    Cell Significance Index: -0.5900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0782
    Cell Significance Index: -1.9500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0787
    Cell Significance Index: -2.3100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0792
    Cell Significance Index: -3.2400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0802
    Cell Significance Index: -0.7600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0809
    Cell Significance Index: -2.3200
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0817
    Cell Significance Index: -0.7200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0820
    Cell Significance Index: -1.2100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0862
    Cell Significance Index: -1.1500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0863
    Cell Significance Index: -2.2700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0864
    Cell Significance Index: -2.4900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0899
    Cell Significance Index: -2.2900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0907
    Cell Significance Index: -2.1800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0929
    Cell Significance Index: -2.3200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0929
    Cell Significance Index: -1.8900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0932
    Cell Significance Index: -2.3300
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0951
    Cell Significance Index: -1.0400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0977
    Cell Significance Index: -1.3400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0991
    Cell Significance Index: -2.4000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0997
    Cell Significance Index: -1.2900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1000
    Cell Significance Index: -2.1600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1005
    Cell Significance Index: -1.3400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1008
    Cell Significance Index: -2.1400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1046
    Cell Significance Index: -2.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CHIT1 is a secreted glycosyl hydrolase enzyme that exhibits chitinase activity, specifically hydrolyzing chitin into chitotrioside. Its structure consists of a catalytic domain and a chitin-binding domain, which allows it to recognize and bind to chitin. CHIT1 is a member of the family 18 glycosyl hydrolases and shares sequence homology with other chitinases, such as chitinase-3-like protein (CHI3L1). The enzyme is activated by calcium ions and exhibits a pH-dependent activity. **Pathways and Functions** The CHIT1 enzyme is involved in several biological pathways, including: 1. **Immune response**: CHIT1 plays a crucial role in the recognition and clearance of pathogens and their components, such as chitin, from the extracellular environment. It is involved in the activation of immune cells, including neutrophils and macrophages, and the production of pro-inflammatory cytokines. 2. **Innate immune system**: CHIT1 is a key component of the innate immune system, which provides the first line of defense against pathogens. It recognizes and binds to chitin, triggering an immune response and promoting the clearance of pathogens. 3. **Cell signaling**: CHIT1 can modulate cell signaling pathways, including the NF-κB and MAPK pathways, which are involved in the regulation of immune responses and inflammation. 4. **Tissue remodeling**: CHIT1 has been implicated in tissue remodeling processes, including wound healing and fibrosis. **Clinical Significance** Dysregulation of CHIT1 has been implicated in several diseases, including: 1. **Inflammatory disorders**: CHIT1 has been associated with inflammatory disorders, such as rheumatoid arthritis and asthma, which are characterized by excessive inflammation and tissue damage. 2. **Cancer**: CHIT1 has been found to be overexpressed in various types of cancer, including breast, lung, and colorectal cancer, and has been implicated in tumor progression and metastasis. 3. **Neurodegenerative diseases**: CHIT1 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, which are characterized by inflammation and tissue damage in the central nervous system. 4. **Wound healing**: CHIT1 has been shown to play a crucial role in wound healing, and its dysregulation can lead to impaired wound healing and tissue damage. In conclusion, CHIT1 is a key enzyme involved in the degradation of chitin and plays a crucial role in the immune response, innate immune system, and tissue remodeling processes. Its dysregulation has been implicated in several diseases, highlighting the importance of CHIT1 in maintaining immune homeostasis and tissue health.

Genular Protein ID: 3063702423

Symbol: CHIT1_HUMAN

Name: Chitotriosidase-1

UniProtKB Accession Codes:

Q13231 B3KNW6 J3KN09 Q0VGG5 Q0VGG6 Q3ZAR1 Q6ISC2 Q9H3V8 Q9UDJ8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 2 CCDS 2 CDD 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EC 2 EMBL 10 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 2 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 23 PDBsum 23 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 2 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7592832

Title: Cloning of a cDNA encoding chitotriosidase, a human chitinase produced by macrophages.

PubMed ID: 7592832

DOI: 10.1074/jbc.270.44.26252

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7836450

Title: Purification and characterization of human chitotriosidase, a novel member of the chitinase family of proteins.

PubMed ID: 7836450

DOI: 10.1074/jbc.270.5.2198

PubMed ID: 9748235

Title: The human chitotriosidase gene. Nature of inherited enzyme deficiency.

PubMed ID: 9748235

DOI: 10.1074/jbc.273.40.25680

PubMed ID: 11960986

Title: Structure of human chitotriosidase. Implications for specific inhibitor design and function of mammalian chitinase-like lectins.

PubMed ID: 11960986

DOI: 10.1074/jbc.m201636200

PubMed ID: 12639956

Title: Crystal structures of allosamidin derivatives in complex with human macrophage chitinase.

PubMed ID: 12639956

DOI: 10.1074/jbc.m300362200

PubMed ID: 15664516

Title: Specificity and affinity of natural product cyclopentapeptide inhibitors against A. fumigatus, human, and bacterial chitinases.

PubMed ID: 15664516

DOI: 10.1016/j.chembiol.2004.10.013

PubMed ID: 17464953

Title: Type 1 Gaucher disease: null and hypomorphic novel chitotriosidase mutations-implications for diagnosis and therapeutic monitoring.

PubMed ID: 17464953

DOI: 10.1002/humu.20524

PubMed ID: 19725875

Title: Common G102S polymorphism in chitotriosidase differentially affects activity towards 4-methylumbelliferyl substrates.

PubMed ID: 19725875

DOI: 10.1111/j.1742-4658.2009.07259.x

Sequence Information:

  • Length: 466
  • Mass: 51681
  • Checksum: B4312D1E885E386D
  • Sequence:
    • MVRSVAWAGF MVLLMIPWGS AAKLVCYFTN WAQYRQGEAR FLPKDLDPSL CTHLIYAFAG 
MTNHQLSTTE WNDETLYQEF NGLKKMNPKL KTLLAIGGWN FGTQKFTDMV ATANNRQTFV 
NSAIRFLRKY SFDGLDLDWE YPGSQGSPAV DKERFTTLVQ DLANAFQQEA QTSGKERLLL 
SAAVPAGQTY VDAGYEVDKI AQNLDFVNLM AYDFHGSWEK VTGHNSPLYK RQEESGAAAS 
LNVDAAVQQW LQKGTPASKL ILGMPTYGRS FTLASSSDTR VGAPATGSGT PGPFTKEGGM 
LAYYEVCSWK GATKQRIQDQ KVPYIFRDNQ WVGFDDVESF KTKVSYLKQK GLGGAMVWAL 
DLDDFAGFSC NQGRYPLIQT LRQELSLPYL PSGTPELEVP KPGQPSEPEH GPSPGQDTFC 
QGKADGLYPN PRERSSFYSC AAGRLFQQSC PTGLVFSNSC KCCTWN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.