Details for: SLC2A6

Gene ID: 11182

Symbol: SLC2A6

Ensembl ID: ENSG00000160326

Description: solute carrier family 2 member 6

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.55
    Marker Score: 1,801
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 1.81
    Marker Score: 1,101
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169,269
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.17
    Marker Score: 492
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.17
    Marker Score: 1,802
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.17
    Marker Score: 1,221
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.16
    Marker Score: 2,257
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.14
    Marker Score: 2,760
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.11
    Marker Score: 1,205
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,776
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.01
    Marker Score: 277
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 494
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 448
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.95
    Marker Score: 2,362
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,410
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,278
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.92
    Marker Score: 620
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,730
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.91
    Marker Score: 50,645
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,274
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 312
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.86
    Marker Score: 7,365
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.86
    Marker Score: 416
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.84
    Marker Score: 51,659
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.82
    Marker Score: 3,417
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.8
    Marker Score: 784
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.79
    Marker Score: 476
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,262
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 572
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 662
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.72
    Marker Score: 8,327
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2,996
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.71
    Marker Score: 284
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.67
    Marker Score: 628
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.67
    Marker Score: 230
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 169
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.66
    Marker Score: 6,259
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.62
    Marker Score: 23,006
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.62
    Marker Score: 219
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.62
    Marker Score: 5,806
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.58
    Marker Score: 131
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.57
    Marker Score: 132
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.54
    Marker Score: 13,908
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.52
    Marker Score: 533
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.52
    Marker Score: 333
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.52
    Marker Score: 624
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.52
    Marker Score: 511
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.5
    Marker Score: 561
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.5
    Marker Score: 375
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.47
    Marker Score: 193
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.45
    Marker Score: 604
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.45
    Marker Score: 166
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.45
    Marker Score: 559
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.45
    Marker Score: 443
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.44
    Marker Score: 186
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.44
    Marker Score: 650
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.44
    Marker Score: 2,019
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.43
    Marker Score: 1,773
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.43
    Marker Score: 1,652
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.43
    Marker Score: 250
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.42
    Marker Score: 566
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.42
    Marker Score: 725
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.41
    Marker Score: 500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.41
    Marker Score: 837
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.41
    Marker Score: 651
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.41
    Marker Score: 269
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.4
    Marker Score: 379
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.39
    Marker Score: 174
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.38
    Marker Score: 120
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.38
    Marker Score: 5,662
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.38
    Marker Score: 1,024
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.37
    Marker Score: 238
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.37
    Marker Score: 13,902
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.36
    Marker Score: 96
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.36
    Marker Score: 121
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.36
    Marker Score: 600
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.36
    Marker Score: 113
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.36
    Marker Score: 7,065
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.35
    Marker Score: 361
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.35
    Marker Score: 140
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.34
    Marker Score: 127
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.34
    Marker Score: 140
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.33
    Marker Score: 209
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.33
    Marker Score: 106
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.33
    Marker Score: 2,515
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.33
    Marker Score: 215
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.32
    Marker Score: 224
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.32
    Marker Score: 675
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.32
    Marker Score: 952
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.32
    Marker Score: 284
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.32
    Marker Score: 180
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.32
    Marker Score: 149
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.31
    Marker Score: 98
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.3
    Marker Score: 2,007
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3
    Marker Score: 3,055
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.3
    Marker Score: 78
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.3
    Marker Score: 433
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.3
    Marker Score: 173

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SLC2A6 is a member of the solute carrier family 2 (SLC2) and is characterized by its high affinity for glucose and fructose. The gene is highly expressed in cells that require rapid glucose uptake, such as immune cells, neurons, and epithelial cells. SLC2A6 is also involved in the transport of other sugars, including dehydroascorbic acid and fructose. The protein structure consists of 12 transmembrane domains, allowing for the selective transport of molecules across the plasma membrane. **Pathways and Functions:** SLC2A6 is involved in various cellular processes, including: 1. **Glucose and Fructose Transport:** SLC2A6 plays a crucial role in the transport of glucose and fructose across cell membranes, particularly in tissues that require rapid glucose uptake. 2. **Dehydroascorbic Acid Transport:** SLC2A6 is also involved in the transport of dehydroascorbic acid, a precursor to vitamin C, across cell membranes. 3. **Regulation of Glycolytic Process:** SLC2A6 helps regulate the glycolytic process by controlling the influx of glucose into cells, which is essential for energy production. 4. **Lysosomal Membrane and Protein Binding:** SLC2A6 is also involved in the transport of molecules across the lysosomal membrane and binds to proteins, influencing cellular signaling pathways. **Significance in Diseases:** SLC2A6 has been implicated in various diseases, including: 1. **Diabetes:** SLC2A6 has been shown to play a role in the regulation of glucose uptake in pancreatic beta cells, making it a potential target for the treatment of diabetes. 2. **Neurodegenerative Diseases:** The gene has been linked to neurodegenerative diseases such as Alzheimer's and Parkinson's, where impaired glucose transport is thought to contribute to disease progression. 3. **Cancer:** SLC2A6 has been found to be overexpressed in certain types of cancer, suggesting its potential role in cancer progression and metastasis. 4. **Reproductive Disorders:** The gene has been implicated in reproductive disorders such as polycystic ovary syndrome (PCOS), where impaired glucose transport is thought to contribute to insulin resistance and metabolic dysregulation. In conclusion, SLC2A6 is a critical gene involved in the transport of various sugars across cell membranes, playing a crucial role in maintaining cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying SLC2A6 function and its role in disease pathogenesis.

Genular Protein ID: 1740275261

Symbol: GTR6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UGQ3 A6NNU6 Q5SXD7 Q8NCC2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 3 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 9 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10970791

Title: Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes.

PubMed ID: 10970791

DOI: 10.1042/bj3500771

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 30431159

Title: GLUT6 is a lysosomal transporter that is regulated by inflammatory stimuli and modulates glycolysis in macrophages.

PubMed ID: 30431159

DOI: 10.1002/1873-3468.13298

Sequence Information:

  • Length: 507
  • Mass: 54539
  • Checksum: 32C6E2EB11588477
  • Sequence:
    • MQEPLLGAEG PDYDTFPEKP PPSPGDRARV GTLQNKRVFL ATFAAVLGNF SFGYALVYTS 
PVIPALERSL DPDLHLTKSQ ASWFGSVFTL GAAAGGLSAM ILNDLLGRKL SIMFSAVPSA 
AGYALMAGAH GLWMLLLGRT LTGFAGGLTA ACIPVYVSEI APPGVRGALG ATPQLMAVFG 
SLSLYALGLL LPWRWLAVAG EAPVLIMILL LSFMPNSPRF LLSRGRDEEA LRALAWLRGT 
DVDVHWEFEQ IQDNVRRQSS RVSWAEARAP HVCRPITVAL LMRLLQQLTG ITPILVYLQS 
IFDSTAVLLP PKDDAAIVGA VRLLSVLIAA LTMDLAGRKV LLFVSAAIMF AANLTLGLYI 
HFGPRPLSPN STAGLESESW GDLAQPLAAP AGYLTLVPLL ATMLFIMGYA VGWGPITWLL 
MSEVLPLRAR GVASGLCVLA SWLTAFVLTK SFLPVVSTFG LQVPFFFFAA ICLVSLVFTG 
CCVPETKGRS LEQIESFFRT GRRSFLR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.