CHKA | ENSG00000110721 | NCBI 1119

Details for: CHKA

Gene ID: 1119

Symbol: CHKA

Ensembl ID: ENSG00000110721

Description: choline kinase alpha

Associated with

Glycerophospholipid biosynthesis
(R-HSA-1483206)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Phospholipid metabolism
(R-HSA-1483257)
Synthesis of pc
(R-HSA-1483191)
Synthesis of pe
(R-HSA-1483213)
Atp binding
(GO:0005524)
Cdp-choline pathway
(GO:0006657)
Choline kinase activity
(GO:0004103)
Cholinesterase activity
(GO:0004104)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Ethanolamine kinase activity
(GO:0004305)
Lipid droplet
(GO:0005811)
Lipid metabolic process
(GO:0006629)
Lipid transport
(GO:0006869)
Phosphatidylcholine biosynthetic process
(GO:0006656)
Phosphatidylethanolamine biosynthetic process
(GO:0006646)
Phosphorylation
(GO:0016310)
Protein homodimerization activity
(GO:0042803)
Protein tyrosine kinase activity
(GO:0004713)

Other Information

Proteins

Choline kinase alpha

Genular Protein ID: 3721688971

Symbol: CHKA_HUMAN

Name: Choline kinase alpha

UniProtKB Accession Codes:

P35790 Q8NE29

Database IDs:

Citations:

PubMed ID: 1618328

Title: Cloning of a human choline kinase cDNA by complementation of the yeast cki mutation.

PubMed ID: 1618328

DOI: 10.1016/0014-5793(92)80625-q

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19915674

Title: Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment.

PubMed ID: 19915674

DOI: 10.1371/journal.pone.0007819

PubMed ID: 28566381

Title: Hepatitis C Virus Subverts Human Choline Kinase-alpha To Bridge Phosphatidylinositol-4-Kinase IIIalpha (PI4KIIIalpha) and NS5A and Upregulates PI4KIIIalpha Activation, Thereby Promoting the Translocation of the Ternary Complex to the Endoplasmic Reticulum for Viral Replication.

PubMed ID: 28566381

DOI: 10.1128/jvi.00355-17

PubMed ID: 34077757

Title: Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets.

PubMed ID: 34077757

DOI: 10.1016/j.molcel.2021.05.005

PubMed ID: 35202461

Title: Bi-allelic variants in CHKA cause a neurodevelopmental disorder with epilepsy and microcephaly.

PubMed ID: 35202461

DOI: 10.1093/brain/awac074

PubMed ID: 17007874

Title: Elucidation of human choline kinase crystal structures in complex with the products ADP or phosphocholine.

PubMed ID: 17007874

DOI: 10.1016/j.jmb.2006.08.084

PubMed ID: 20299452

Title: Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity.

PubMed ID: 20299452

DOI: 10.1074/jbc.m109.039024

Sequence Information:

Length: 457
Mass: 52249
Checksum: 65F177ABE1AA3A12
Sequence:

MKTKFCTGGE AEPSPLGLLL SCGSGSAAPA PGVGQQRDAA SDLESKQLGG QQPPLALPPP 
PPLPLPLPLP QPPPPQPPAD EQPEPRTRRR AYLWCKEFLP GAWRGLREDE FHISVIRGGL 
SNMLFQCSLP DTTATLGDEP RKVLLRLYGA ILQMRSCNKE GSEQAQKENE FQGAEAMVLE 
SVMFAILAER SLGPKLYGIF PQGRLEQFIP SRRLDTEELS LPDISAEIAE KMATFHGMKM 
PFNKEPKWLF GTMEKYLKEV LRIKFTEESR IKKLHKLLSY NLPLELENLR SLLESTPSPV 
VFCHNDCQEG NILLLEGREN SEKQKLMLID FEYSSYNYRG FDIGNHFCEW MYDYSYEKYP 
FFRANIRKYP TKKQQLHFIS SYLPAFQNDF ENLSTEEKSI IKEEMLLEVN RFALASHFLW 
GLWSIVQAKI SSIEFGYMDY AQARFDAYFH QKRKLGV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CHKA

Associated with

Other Information

Cloning of a human choline kinase cDNA by complementation of the yeast cki mutation. PubMed ID: 1618328

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment. PubMed ID: 19915674

Hepatitis C Virus Subverts Human Choline Kinase-alpha To Bridge Phosphatidylinositol-4-Kinase IIIalpha (PI4KIIIalpha) and NS5A and Upregulates PI4KIIIalpha Activation, Thereby Promoting the Translocation of the Ternary Complex to the Endoplasmic Reticulum for Viral Replication. PubMed ID: 28566381

Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets. PubMed ID: 34077757

Bi-allelic variants in CHKA cause a neurodevelopmental disorder with epilepsy and microcephaly. PubMed ID: 35202461

Elucidation of human choline kinase crystal structures in complex with the products ADP or phosphocholine. PubMed ID: 17007874

Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity. PubMed ID: 20299452