Details for: CHKA
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 18.21rCSI 44.25%PRS 23.79
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CSI 17.85rCSI 35.45%PRS 37.83
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CSI 16.04rCSI 35.95%PRS 25.03
-
CSI 15.3rCSI 55.07%PRS 23.51
-
CSI 10.56rCSI 22.35%PRS 59.46
-
CSI 10.04rCSI 10.28%PRS 56.71
-
CSI 9.88rCSI 12.29%PRS 40.4
-
CSI 9.21rCSI 20.57%PRS 43.9
-
CSI 8.14rCSI 9.44%PRS 48.82
-
CSI 7.63rCSI 21.02%PRS 35.33
-
CSI 7.61rCSI 21.31%PRS 52.88
-
CSI 7.43rCSI 12.47%PRS 24.5
-
CSI 6.2rCSI 16.72%PRS 46.76
-
CSI 5.87rCSI 18.35%PRS 25.54
-
CSI 5.77rCSI 10.18%PRS 23.63
-
CSI 5.75rCSI 15.01%PRS 47.45
-
CSI 5.5rCSI 8.05%PRS 40.56
-
CSI 5.49rCSI 13.2%PRS 48.68
-
CSI 5.38rCSI 12.28%PRS 32.59
-
CSI 5.3rCSI 15.72%PRS 49.23
-
CSI 5.23rCSI 7.26%PRS 37.82
-
CSI 5.14rCSI 25.55%PRS 38.24
-
CSI 5.08rCSI 11.72%PRS 31.14
-
CSI 4.79rCSI 6.15%PRS 36.2
-
CSI 4.76rCSI 26.92%PRS 26.04
-
CSI 4.61rCSI 13.35%PRS 30.63
-
CSI 4.55rCSI 4.18%PRS 44.58
-
CSI 4.32rCSI 5.43%PRS 51.12
-
CSI 4.21rCSI 3.69%PRS 47.3
-
CSI 4.19rCSI 5.73%PRS 40.69
-
CSI 4.05rCSI 6.11%PRS 39.45
-
CSI 3.89rCSI 6.28%PRS 47.95
-
CSI 3.86rCSI 6.16%PRS 32.63
-
CSI 3.8rCSI 2.95%PRS 37.92
-
CSI 3.8rCSI 4.9%PRS 25.36
-
CSI 3.8rCSI 5.8%PRS 38.34
-
CSI 3.76rCSI 4.82%PRS 34.73
-
CSI 3.75rCSI 9.98%PRS 31.46
-
CSI 3.72rCSI 3.58%PRS 38.63
-
CSI 3.49rCSI 6.53%PRS 29.11
-
CSI 3.48rCSI 7.92%PRS 37.05
-
CSI 3.36rCSI 12.6%PRS 32.29
-
CSI 3.35rCSI 5.87%PRS 31.18
-
CSI 3.17rCSI 3.95%PRS 23.2
-
CSI 3.09rCSI 2.98%PRS 29.66
-
CSI 3.09rCSI 18.17%PRS 25.7
-
CSI 3.04rCSI 7.22%PRS 43.66
-
CSI 3.01rCSI 16.17%PRS 54.25
-
CSI 3rCSI 2.23%PRS 32.56
-
CSI 2.97rCSI 11.98%PRS 36.72
-
CSI 2.97rCSI 7.25%PRS 35.03
-
CSI 2.96rCSI 3.1%PRS 35.58
-
CSI 2.96rCSI 5.94%PRS 29.14
-
CSI 2.91rCSI 5.91%PRS 22.99
-
CSI 2.83rCSI 7.17%PRS 45.59
-
CSI 2.79rCSI 4.51%PRS 36.92
-
CSI 2.77rCSI 2.9%PRS 38.58
-
CSI 2.75rCSI 65.87%PRS 23.91
-
CSI 2.68rCSI 62.47%PRS 61.12
-
CSI 2.65rCSI 63.97%PRS 24.74
-
CSI 2.64rCSI 6.54%PRS 36.13
-
CSI 2.64rCSI 2.09%PRS 27.24
-
CSI 2.56rCSI 6.49%PRS 29.9
-
CSI 2.53rCSI 5.25%PRS 36.52
-
CSI 2.48rCSI 3.18%PRS 42.5
-
CSI 2.47rCSI 9.59%PRS 47.33
-
CSI 2.42rCSI 10.27%PRS 36.77
-
CSI 2.38rCSI 4.48%PRS 58.49
-
CSI 2.32rCSI 11.89%PRS 40.71
-
CSI 2.32rCSI 1.74%PRS 40.83
-
CSI 2.29rCSI 5.5%PRS 54.92
-
CSI 2.29rCSI 2.73%PRS 24.47
-
CSI 2.28rCSI 3.03%PRS 42.06
-
CSI 2.27rCSI 3.93%PRS 29.86
-
CSI 2.26rCSI 2.37%PRS 40.2
-
CSI 2.24rCSI 9.15%PRS 36.7
-
CSI 2.19rCSI 5.15%PRS 47.63
-
CSI 2.19rCSI 1.77%PRS 38.43
-
CSI 2.15rCSI 3.84%PRS 36.3
-
CSI 2.15rCSI 2.14%PRS 32.81
-
CSI 2.11rCSI 4.66%PRS 35.26
-
CSI 2.1rCSI 3.36%PRS 41.15
-
CSI 2.09rCSI 2.86%PRS 35.45
-
CSI 2.07rCSI 2.4%PRS 33.14
-
CSI 2.07rCSI 2.97%PRS 30.57
-
CSI 2.04rCSI 3.36%PRS 42.91
-
CSI 2.01rCSI 3.06%PRS 35.13
-
CSI 2rCSI 2.49%PRS 49.03
-
CSI 1.98rCSI 6.63%PRS 28.25
-
CSI 1.98rCSI 2.32%PRS 41.79
-
CSI 1.94rCSI 2.85%PRS 34.82
-
CSI 1.91rCSI 1.68%PRS 28.56
-
CSI 1.89rCSI 7.15%PRS 25.41
-
CSI 1.89rCSI 6.05%PRS 34.96
-
CSI 1.87rCSI 4.11%PRS 41.79
-
CSI 1.85rCSI 4.78%PRS 34.72
-
CSI 1.84rCSI 1.97%PRS 35.8
-
CSI 1.83rCSI 10.43%PRS 71.68
-
CSI 1.81rCSI 4.71%PRS 37.05
-
CSI 1.79rCSI 5.83%PRS 40.54
-
CSI 0.1rCSI 1.3%PRS 59.1%
-
CSI 0.1rCSI 1.0%PRS 58.6%
-
CSI 0.2rCSI 0.8%PRS 55.1%
-
CSI 0.4rCSI 3.6%PRS 66.4%
-
CSI 0.4rCSI 1.4%PRS 48.9%
-
CSI 0.4rCSI 8.7%PRS 33.0%
-
CSI 0.5rCSI 6.6%PRS 31.6%
-
CSI 0.5rCSI 2.0%PRS 57.8%
-
CSI 0.5rCSI 5.2%PRS 40.6%
-
CSI 0.5rCSI 1.0%PRS 47.2%
-
CSI 0.5rCSI 3.4%PRS 31.6%
-
CSI 0.6rCSI 4.5%PRS 27.4%
-
CSI 0.6rCSI 2.5%PRS 41.5%
-
CSI 0.6rCSI 0.9%PRS 54.6%
-
CSI 0.6rCSI 12.8%PRS 31.8%
-
CSI 0.7rCSI 3.0%PRS 58.5%
-
CSI 0.7rCSI 0.9%PRS 44.6%
-
CSI 0.7rCSI 2.2%PRS 27.6%
-
CSI 0.8rCSI 1.7%PRS 47.7%
-
CSI 0.8rCSI 1.3%PRS 29.9%
-
CSI 0.8rCSI 2.7%PRS 28.2%
-
CSI 0.8rCSI 0.7%PRS 36.4%
-
CSI 0.9rCSI 1.7%PRS 39.5%
-
CSI 0.9rCSI 2.4%PRS 41.5%
-
CSI 0.9rCSI 1.1%PRS 29.3%
-
CSI 0.9rCSI 4.1%PRS 35.3%
-
CSI 0.9rCSI 1.3%PRS 20.3%
-
CSI 1.0rCSI 2.3%PRS 52.5%
-
CSI 1.0rCSI 2.5%PRS 28.8%
-
CSI 1.1rCSI 2.4%PRS 28.1%
-
CSI 1.1rCSI 1.8%PRS 47.6%
-
CSI 1.1rCSI 1.6%PRS 45.8%
-
CSI 1.1rCSI 6.4%PRS 41.0%
-
CSI 1.1rCSI 3.0%PRS 43.9%
-
CSI 1.1rCSI 3.1%PRS 32.2%
-
CSI 1.1rCSI 2.7%PRS 40.7%
-
CSI 1.2rCSI 6.1%PRS 48.0%
-
CSI 1.2rCSI 2.5%PRS 29.4%
-
CSI 1.2rCSI 1.8%PRS 36.2%
-
CSI 1.2rCSI 2.2%PRS 53.8%
-
CSI 1.2rCSI 4.5%PRS 33.1%
-
CSI 1.2rCSI 1.9%PRS 32.2%
-
CSI 1.2rCSI 5.3%PRS 32.8%
-
CSI 1.2rCSI 2.2%PRS 36.7%
-
CSI 1.2rCSI 2.0%PRS 26.4%
-
CSI 1.3rCSI 1.8%PRS 53.4%
-
CSI 1.3rCSI 2.8%PRS 52.9%
-
CSI 1.3rCSI 3.1%PRS 37.4%
-
CSI 1.3rCSI 3.5%PRS 61.0%
-
CSI 1.4rCSI 3.0%PRS 58.5%
-
CSI 1.4rCSI 2.1%PRS 46.6%
-
CSI 1.4rCSI 1.2%PRS 41.7%
-
CSI 1.4rCSI 2.1%PRS 48.4%
-
CSI 1.5rCSI 4.7%PRS 37.9%
-
CSI 1.5rCSI 3.0%PRS 34.1%
-
CSI 1.5rCSI 1.5%PRS 37.9%
-
CSI 1.5rCSI 4.6%PRS 50.0%
-
CSI 1.5rCSI 2.7%PRS 32.8%
-
CSI 1.5rCSI 2.7%PRS 24.7%
-
CSI 1.6rCSI 2.3%PRS 35.5%
-
CSI 1.7rCSI 2.7%PRS 30.0%
-
CSI 1.7rCSI 2.6%PRS 48.3%
-
CSI 1.7rCSI 2.5%PRS 42.3%
-
CSI 1.7rCSI 1.7%PRS 40.2%
-
CSI 1.7rCSI 5.0%PRS 29.8%
-
CSI 1.8rCSI 2.6%PRS 38.6%
-
CSI 1.8rCSI 1.5%PRS 36.5%
-
CSI 1.8rCSI 5.8%PRS 40.5%
-
CSI 1.8rCSI 4.7%PRS 37.1%
-
CSI 1.8rCSI 10.4%PRS 71.7%
-
CSI 1.8rCSI 2.0%PRS 35.8%
-
CSI 1.9rCSI 4.8%PRS 34.7%
-
CSI 1.9rCSI 4.1%PRS 41.8%
-
CSI 1.9rCSI 6.1%PRS 35.0%
-
CSI 1.9rCSI 7.2%PRS 25.4%
-
CSI 1.9rCSI 1.7%PRS 28.6%
-
CSI 1.9rCSI 2.9%PRS 34.8%
-
CSI 2.0rCSI 2.3%PRS 41.8%
-
CSI 2.0rCSI 6.6%PRS 28.3%
-
CSI 2.0rCSI 2.5%PRS 49.0%
-
CSI 2.0rCSI 3.1%PRS 35.1%
-
CSI 2.0rCSI 3.4%PRS 42.9%
-
CSI 2.1rCSI 3.0%PRS 30.6%
-
CSI 2.1rCSI 2.4%PRS 33.1%
-
CSI 2.1rCSI 2.9%PRS 35.5%
-
CSI 2.1rCSI 3.4%PRS 41.2%
-
CSI 2.1rCSI 4.7%PRS 35.3%
-
CSI 2.2rCSI 2.1%PRS 32.8%
-
CSI 2.2rCSI 3.8%PRS 36.3%
-
CSI 2.2rCSI 1.8%PRS 38.4%
-
CSI 2.2rCSI 5.2%PRS 47.6%
-
CSI 2.2rCSI 9.2%PRS 36.7%
-
CSI 2.3rCSI 2.4%PRS 40.2%
-
CSI 2.3rCSI 3.9%PRS 29.9%
-
CSI 2.3rCSI 3.0%PRS 42.1%
-
CSI 2.3rCSI 2.7%PRS 24.5%
-
CSI 2.3rCSI 5.5%PRS 54.9%
-
CSI 2.3rCSI 1.7%PRS 40.8%
-
CSI 2.3rCSI 11.9%PRS 40.7%
-
CSI 2.4rCSI 4.5%PRS 58.5%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Comma-separated if multiple.
Comma-separated if multiple.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.
Genular Protein ID: 3721688971
Symbol: CHKA_HUMAN
Name: Choline kinase alpha
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1618328
Title: Cloning of a human choline kinase cDNA by complementation of the yeast cki mutation.
PubMed ID: 1618328
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 19915674
Title: Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment.
PubMed ID: 19915674
PubMed ID: 28566381
Title: Hepatitis C Virus Subverts Human Choline Kinase-alpha To Bridge Phosphatidylinositol-4-Kinase IIIalpha (PI4KIIIalpha) and NS5A and Upregulates PI4KIIIalpha Activation, Thereby Promoting the Translocation of the Ternary Complex to the Endoplasmic Reticulum for Viral Replication.
PubMed ID: 28566381
DOI: 10.1128/jvi.00355-17
PubMed ID: 34077757
Title: Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets.
PubMed ID: 34077757
PubMed ID: 35202461
Title: Bi-allelic variants in CHKA cause a neurodevelopmental disorder with epilepsy and microcephaly.
PubMed ID: 35202461
PubMed ID: 17007874
Title: Elucidation of human choline kinase crystal structures in complex with the products ADP or phosphocholine.
PubMed ID: 17007874
PubMed ID: 20299452
Title: Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity.
PubMed ID: 20299452
PubMed ID: 23416529
Title: Kinetic and mechanistic characterisation of Choline Kinase-alpha.
PubMed ID: 23416529
Sequence Information:
- Length: 457
- Mass: 52249
- Checksum: 65F177ABE1AA3A12
- Sequence:
MKTKFCTGGE AEPSPLGLLL SCGSGSAAPA PGVGQQRDAA SDLESKQLGG QQPPLALPPP PPLPLPLPLP QPPPPQPPAD EQPEPRTRRR AYLWCKEFLP GAWRGLREDE FHISVIRGGL SNMLFQCSLP DTTATLGDEP RKVLLRLYGA ILQMRSCNKE GSEQAQKENE FQGAEAMVLE SVMFAILAER SLGPKLYGIF PQGRLEQFIP SRRLDTEELS LPDISAEIAE KMATFHGMKM PFNKEPKWLF GTMEKYLKEV LRIKFTEESR IKKLHKLLSY NLPLELENLR SLLESTPSPV VFCHNDCQEG NILLLEGREN SEKQKLMLID FEYSSYNYRG FDIGNHFCEW MYDYSYEKYP FFRANIRKYP TKKQQLHFIS SYLPAFQNDF ENLSTEEKSI IKEEMLLEVN RFALASHFLW GLWSIVQAKI SSIEFGYMDY AQARFDAYFH QKRKLGV