Details for: CHKA

Gene ID: 1119

Symbol: CHKA

Ensembl ID: ENSG00000110721

Description: choline kinase alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 265.7748
    Cell Significance Index: -41.3400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 161.9794
    Cell Significance Index: -41.0900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 81.2540
    Cell Significance Index: -33.0100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 34.6481
    Cell Significance Index: -33.0800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.2348
    Cell Significance Index: -42.2100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.0414
    Cell Significance Index: -37.6200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.7665
    Cell Significance Index: -42.4900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.1109
    Cell Significance Index: -19.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.6299
    Cell Significance Index: 521.9100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.6170
    Cell Significance Index: 118.6200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0835
    Cell Significance Index: 417.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.7899
    Cell Significance Index: 92.9800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.7762
    Cell Significance Index: 38.4800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6652
    Cell Significance Index: 164.7300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.5698
    Cell Significance Index: 39.2400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5016
    Cell Significance Index: 244.2300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.4855
    Cell Significance Index: 69.2600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.4833
    Cell Significance Index: 113.8300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3843
    Cell Significance Index: 1249.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.3595
    Cell Significance Index: 39.1700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9950
    Cell Significance Index: 26.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.9548
    Cell Significance Index: 53.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.9542
    Cell Significance Index: 36.1400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9236
    Cell Significance Index: 100.4600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8907
    Cell Significance Index: 53.4700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.8835
    Cell Significance Index: 39.0800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8759
    Cell Significance Index: 314.1600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7483
    Cell Significance Index: 10.2100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.7184
    Cell Significance Index: 15.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6353
    Cell Significance Index: 29.8600
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 0.4867
    Cell Significance Index: 4.8700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4497
    Cell Significance Index: 58.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3900
    Cell Significance Index: 70.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3796
    Cell Significance Index: 46.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.3516
    Cell Significance Index: 648.4100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.3147
    Cell Significance Index: 4.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2835
    Cell Significance Index: 533.8000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2835
    Cell Significance Index: 436.4000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.2736
    Cell Significance Index: 31.2400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2466
    Cell Significance Index: 16.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2285
    Cell Significance Index: 103.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2229
    Cell Significance Index: 121.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1985
    Cell Significance Index: 33.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1706
    Cell Significance Index: 6.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1649
    Cell Significance Index: 104.7100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1448
    Cell Significance Index: 10.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1134
    Cell Significance Index: 7.1500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1044
    Cell Significance Index: 13.3800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0938
    Cell Significance Index: 0.7600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0890
    Cell Significance Index: 5.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0880
    Cell Significance Index: 119.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0734
    Cell Significance Index: 13.9700
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.0627
    Cell Significance Index: 0.7900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0525
    Cell Significance Index: 1.1500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0496
    Cell Significance Index: 0.8400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0314
    Cell Significance Index: 0.4700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0293
    Cell Significance Index: 0.6300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0270
    Cell Significance Index: 0.7700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0214
    Cell Significance Index: 2.9400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0054
    Cell Significance Index: -4.0100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0088
    Cell Significance Index: -0.5600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0101
    Cell Significance Index: -6.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0200
    Cell Significance Index: -2.9100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0282
    Cell Significance Index: -21.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0283
    Cell Significance Index: -20.7300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0321
    Cell Significance Index: -14.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0403
    Cell Significance Index: -22.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0597
    Cell Significance Index: -1.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0880
    Cell Significance Index: -8.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0908
    Cell Significance Index: -19.1300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0928
    Cell Significance Index: -1.3700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1199
    Cell Significance Index: -13.9700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1220
    Cell Significance Index: -35.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1551
    Cell Significance Index: -11.5600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1594
    Cell Significance Index: -1.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1685
    Cell Significance Index: -17.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1756
    Cell Significance Index: -20.1100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1953
    Cell Significance Index: -5.0200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2007
    Cell Significance Index: -3.4700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2045
    Cell Significance Index: -24.1200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2063
    Cell Significance Index: -1.9000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2391
    Cell Significance Index: -2.8500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3233
    Cell Significance Index: -5.5400
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.3239
    Cell Significance Index: -1.4100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3421
    Cell Significance Index: -5.0500
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.3633
    Cell Significance Index: -3.8600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3637
    Cell Significance Index: -9.9000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4162
    Cell Significance Index: -13.3300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4339
    Cell Significance Index: -10.4100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4370
    Cell Significance Index: -34.6100
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.4904
    Cell Significance Index: -7.4600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5211
    Cell Significance Index: -11.0600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5241
    Cell Significance Index: -27.3000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5382
    Cell Significance Index: -15.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5485
    Cell Significance Index: -14.6500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5869
    Cell Significance Index: -41.5100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6066
    Cell Significance Index: -31.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6386
    Cell Significance Index: -39.1500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6418
    Cell Significance Index: -20.4400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6515
    Cell Significance Index: -21.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** CHKA is a glycosyltransferase enzyme that catalyzes the conversion of choline to cytidine diphosphate-choline (CDP-choline), a crucial step in the synthesis of phospholipids. 2. **Cellular Localization:** CHKA is predominantly found in the cytosol of various cell types, including astrocytes, epithelial cells, and fat cells. 3. **Signaling Pathways:** CHKA is involved in multiple signaling pathways, including the phospholipid metabolism pathway, which regulates cellular processes such as cell growth, differentiation, and survival. 4. **Regulation:** CHKA expression is regulated by various factors, including transcriptional and post-transcriptional mechanisms, which ensure proper expression and activity of the enzyme. **Pathways and Functions:** 1. **Choline Metabolism Pathway:** CHKA is the rate-limiting enzyme in the choline metabolism pathway, which is essential for the synthesis of phospholipids, particularly phosphatidylcholine and phosphatidylethanolamine. 2. **Lipid Droplet Formation:** CHKA is involved in the formation of lipid droplets, which are essential organelles that regulate lipid metabolism and storage. 3. **Phospholipid Biosynthesis:** CHKA is a key enzyme in the biosynthesis of phospholipids, which are essential components of cellular membranes. 4. **Cell Signaling:** CHKA is involved in various cell signaling pathways, including the phospholipid metabolism pathway, which regulates cellular processes such as cell growth, differentiation, and survival. **Clinical Significance:** 1. **Neurodegenerative Diseases:** CHKA has been implicated in various neurodegenerative diseases, including Alzheimer's disease, where impaired phospholipid metabolism is thought to contribute to disease progression. 2. **Cancer:** CHKA has been shown to be overexpressed in various types of cancer, including breast and lung cancer, where it may contribute to tumor growth and progression. 3. **Metabolic Disorders:** CHKA has been implicated in various metabolic disorders, including obesity and metabolic syndrome, where impaired phospholipid metabolism is thought to contribute to disease pathogenesis. 4. **Pharmacological Applications:** CHKA has been targeted by various pharmacological agents, including choline analogs, which have been shown to have therapeutic potential in treating various diseases, including cancer and neurodegenerative disorders. In conclusion, CHKA is a vital enzyme that plays a crucial role in maintaining cellular homeostasis and regulating various cellular processes, including lipid metabolism and cell signaling. Its dysregulation has been implicated in various diseases, including neurodegenerative disorders, cancer, and metabolic disorders. Further research is needed to fully elucidate the role of CHKA in human disease and to develop novel therapeutic strategies targeting this enzyme.

Genular Protein ID: 3721688971

Symbol: CHKA_HUMAN

Name: Choline kinase alpha

UniProtKB Accession Codes:

P35790 Q8NE29

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTC 1 CTD 1 ChEBI 21 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 2 EMBL 4 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 26 PDBsum 26 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 8 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1618328

Title: Cloning of a human choline kinase cDNA by complementation of the yeast cki mutation.

PubMed ID: 1618328

DOI: 10.1016/0014-5793(92)80625-q

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19915674

Title: Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment.

PubMed ID: 19915674

DOI: 10.1371/journal.pone.0007819

PubMed ID: 28566381

Title: Hepatitis C Virus Subverts Human Choline Kinase-alpha To Bridge Phosphatidylinositol-4-Kinase IIIalpha (PI4KIIIalpha) and NS5A and Upregulates PI4KIIIalpha Activation, Thereby Promoting the Translocation of the Ternary Complex to the Endoplasmic Reticulum for Viral Replication.

PubMed ID: 28566381

DOI: 10.1128/jvi.00355-17

PubMed ID: 34077757

Title: Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets.

PubMed ID: 34077757

DOI: 10.1016/j.molcel.2021.05.005

PubMed ID: 35202461

Title: Bi-allelic variants in CHKA cause a neurodevelopmental disorder with epilepsy and microcephaly.

PubMed ID: 35202461

DOI: 10.1093/brain/awac074

PubMed ID: 17007874

Title: Elucidation of human choline kinase crystal structures in complex with the products ADP or phosphocholine.

PubMed ID: 17007874

DOI: 10.1016/j.jmb.2006.08.084

PubMed ID: 20299452

Title: Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity.

PubMed ID: 20299452

DOI: 10.1074/jbc.m109.039024

PubMed ID: 23416529

Title: Kinetic and mechanistic characterisation of Choline Kinase-alpha.

PubMed ID: 23416529

DOI: 10.1016/j.bbapap.2013.02.008

Sequence Information:

  • Length: 457
  • Mass: 52249
  • Checksum: 65F177ABE1AA3A12
  • Sequence:
    • MKTKFCTGGE AEPSPLGLLL SCGSGSAAPA PGVGQQRDAA SDLESKQLGG QQPPLALPPP 
PPLPLPLPLP QPPPPQPPAD EQPEPRTRRR AYLWCKEFLP GAWRGLREDE FHISVIRGGL 
SNMLFQCSLP DTTATLGDEP RKVLLRLYGA ILQMRSCNKE GSEQAQKENE FQGAEAMVLE 
SVMFAILAER SLGPKLYGIF PQGRLEQFIP SRRLDTEELS LPDISAEIAE KMATFHGMKM 
PFNKEPKWLF GTMEKYLKEV LRIKFTEESR IKKLHKLLSY NLPLELENLR SLLESTPSPV 
VFCHNDCQEG NILLLEGREN SEKQKLMLID FEYSSYNYRG FDIGNHFCEW MYDYSYEKYP 
FFRANIRKYP TKKQQLHFIS SYLPAFQNDF ENLSTEEKSI IKEEMLLEVN RFALASHFLW 
GLWSIVQAKI SSIEFGYMDY AQARFDAYFH QKRKLGV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.