ADCY6 | ENSG00000174233 | NCBI 112

Details for: ADCY6

Gene ID: 112

Symbol: ADCY6

Ensembl ID: ENSG00000174233

Description: adenylate cyclase 6

Associated with

Activation of gabab receptors
(R-HSA-991365)
Adenylate cyclase activating pathway
(R-HSA-170660)
Adenylate cyclase inhibitory pathway
(R-HSA-170670)
Adora2b mediated anti-inflammatory cytokines production
(R-HSA-9660821)
Adrenaline,noradrenaline inhibits insulin secretion
(R-HSA-400042)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Aquaporin-mediated transport
(R-HSA-445717)
Ca-dependent events
(R-HSA-111996)
Calmodulin induced events
(R-HSA-111933)
Cam pathway
(R-HSA-111997)
Dag and ip3 signaling
(R-HSA-1489509)
Disease
(R-HSA-1643685)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
G-protein mediated events
(R-HSA-112040)
Gaba b receptor activation
(R-HSA-977444)
Gaba receptor activation
(R-HSA-977443)
G alpha (i) signalling events
(R-HSA-418594)
G alpha (s) signalling events
(R-HSA-418555)
G alpha (z) signalling events
(R-HSA-418597)
Glucagon-like peptide-1 (glp1) regulates insulin secretion
(R-HSA-381676)
Glucagon signaling in metabolic regulation
(R-HSA-163359)
Gpcr downstream signalling
(R-HSA-388396)
Gper1 signaling
(R-HSA-9634597)
Hedgehog 'off' state
(R-HSA-5610787)
Infectious disease
(R-HSA-5663205)
Integration of energy metabolism
(R-HSA-163685)
Intracellular signaling by second messengers
(R-HSA-9006925)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Metabolism
(R-HSA-1430728)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Opioid signalling
(R-HSA-111885)
Parasitic infection pathways
(R-HSA-9824443)
Pka-mediated phosphorylation of creb
(R-HSA-111931)
Pka activation
(R-HSA-163615)
Pka activation in glucagon signalling
(R-HSA-164378)
Plc beta mediated events
(R-HSA-112043)
Regulation of insulin secretion
(R-HSA-422356)
Signaling by gpcr
(R-HSA-372790)
Signaling by hedgehog
(R-HSA-5358351)
Signal transduction
(R-HSA-162582)
Transmission across chemical synapses
(R-HSA-112315)
Transport of small molecules
(R-HSA-382551)
Vasopressin regulates renal water homeostasis via aquaporins
(R-HSA-432040)
Adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0007189)
Adenylate cyclase-inhibiting g protein-coupled receptor signaling pathway
(GO:0007193)
Adenylate cyclase activity
(GO:0004016)
Atp binding
(GO:0005524)
Blood vessel diameter maintenance
(GO:0097746)
Camp biosynthetic process
(GO:0006171)
Cellular response to catecholamine stimulus
(GO:0071870)
Cellular response to forskolin
(GO:1904322)
Cellular response to prostaglandin e stimulus
(GO:0071380)
Cellular response to vasopressin
(GO:1904117)
Cilium
(GO:0005929)
Dopamine receptor signaling pathway
(GO:0007212)
Intracellular signal transduction
(GO:0035556)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Negative regulation of neuron projection development
(GO:0010977)
Negative regulation of urine volume
(GO:0035811)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein kinase c binding
(GO:0005080)
Renal water homeostasis
(GO:0003091)
Stereocilium
(GO:0032420)

Other Information

Proteins

Adenylate cyclase type 6

Genular Protein ID: 3174665019

Symbol: ADCY6_HUMAN

Name: Adenylate cyclase type 6

UniProtKB Accession Codes:

O43306 Q9NR75 Q9UDB0

Database IDs:

Citations:

PubMed ID: 10978539

Title: Cloning and expression of human adenylyl cyclase type VI in normal thyroid tissues.

PubMed ID: 10978539

DOI: 10.1016/s0167-4781(00)00187-1

PubMed ID: 9455477

Title: Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9455477

DOI: 10.1093/dnares/4.5.307

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8476432

Title: A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line.

PubMed ID: 8476432

DOI: 10.1006/bbrc.1993.1415

PubMed ID: 15385642

Title: Raf kinase activation of adenylyl cyclases: isoform-selective regulation.

PubMed ID: 15385642

DOI: 10.1124/mol.66.4.921

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17916776

Title: Increased enzyme activity and beta-adrenergic mediated vasodilation in subjects expressing a single-nucleotide variant of human adenylyl cyclase 6.

PubMed ID: 17916776

DOI: 10.1161/atvbaha.107.145557

PubMed ID: 17110384

Title: Conditional stimulation of type V and VI adenylyl cyclases by G protein betagamma subunits.

PubMed ID: 17110384

DOI: 10.1074/jbc.m607522200

PubMed ID: 24319099

Title: Mutations in CNTNAP1 and ADCY6 are responsible for severe arthrogryposis multiplex congenita with axoglial defects.

PubMed ID: 24319099

DOI: 10.1093/hmg/ddt618

Sequence Information:

Length: 1168
Mass: 130615
Checksum: 127BB6E67F73AA61
Sequence:

MSWFSGLLVP KVDERKTAWG ERNGQKRSRR RGTRAGGFCT PRYMSCLRDA EPPSPTPAGP 
PRCPWQDDAF IRRGGPGKGK ELGLRAVALG FEDTEVTTTA GGTAEVAPDA VPRSGRSCWR 
RLVQVFQSKQ FRSAKLERLY QRYFFQMNQS SLTLLMAVLV LLTAVLLAFH AAPARPQPAY 
VALLACAAAL FVGLMVVCNR HSFRQDSMWV VSYVVLGILA AVQVGGALAA DPRSPSAGLW 
CPVFFVYIAY TLLPIRMRAA VLSGLGLSTL HLILAWQLNR GDAFLWKQLG ANVLLFLCTN 
VIGICTHYPA EVSQRQAFQE TRGYIQARLH LQHENRQQER LLLSVLPQHV AMEMKEDINT 
KKEDMMFHKI YIQKHDNVSI LFADIEGFTS LASQCTAQEL VMTLNELFAR FDKLAAENHC 
LRIKILGDCY YCVSGLPEAR ADHAHCCVEM GVDMIEAISL VREVTGVNVN MRVGIHSGRV 
HCGVLGLRKW QFDVWSNDVT LANHMEAGGR AGRIHITRAT LQYLNGDYEV EPGRGGERNA 
YLKEQHIETF LILGASQKRK EEKAMLAKLQ RTRANSMEGL MPRWVPDRAF SRTKDSKAFR 
QMGIDDSSKD NRGTQDALNP EDEVDEFLSR AIDARSIDQL RKDHVRRFLL TFQREDLEKK 
YSRKVDPRFG AYVACALLVF CFICFIQLLI FPHSTLMLGI YASIFLLLLI TVLICAVYSC 
GSLFPKALQR LSRSIVRSRA HSTAVGIFSV LLVFTSAIAN MFTCNHTPIR SCAARMLNLT 
PADITACHLQ QLNYSLGLDA PLCEGTMPTC SFPEYFIGNM LLSLLASSVF LHISSIGKLA 
MIFVLGLIYL VLLLLGPPAT IFDNYDLLLG VHGLASSNET FDGLDCPAAG RVALKYMTPV 
ILLVFALALY LHAQQVESTA RLDFLWKLQA TGEKEEMEEL QAYNRRLLHN ILPKDVAAHF 
LARERRNDEL YYQSCECVAV MFASIANFSE FYVELEANNE GVECLRLLNE IIADFDEIIS 
EERFRQLEKI KTIGSTYMAA SGLNASTYDQ VGRSHITALA DYAMRLMEQM KHINEHSFNN 
FQMKIGLNMG PVVAGVIGAR KPQYDIWGNT VNVSSRMDST GVPDRIQVTT DLYQVLAAKG 
YQLECRGVVK VKGKGEMTTY FLNGGPSS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ADCY6

Associated with

Other Information

Cloning and expression of human adenylyl cyclase type VI in normal thyroid tissues. PubMed ID: 10978539

Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 9455477

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. PubMed ID: 12168954

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line. PubMed ID: 8476432

Raf kinase activation of adenylyl cyclases: isoform-selective regulation. PubMed ID: 15385642

Phosphoproteome of resting human platelets. PubMed ID: 18088087

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Increased enzyme activity and beta-adrenergic mediated vasodilation in subjects expressing a single-nucleotide variant of human adenylyl cyclase 6. PubMed ID: 17916776

Conditional stimulation of type V and VI adenylyl cyclases by G protein betagamma subunits. PubMed ID: 17110384

Mutations in CNTNAP1 and ADCY6 are responsible for severe arthrogryposis multiplex congenita with axoglial defects. PubMed ID: 24319099