Details for: ADCY6

Gene ID: 112

Symbol: ADCY6

Ensembl ID: ENSG00000174233

Description: adenylate cyclase 6

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.04
    Marker Score: 45477
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.48
    Marker Score: 5268
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.45
    Marker Score: 1379
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.35
    Marker Score: 755
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.34
    Marker Score: 490
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.19
    Marker Score: 10236
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.17
    Marker Score: 10977
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.17
    Marker Score: 4509
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.16
    Marker Score: 18097
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.15
    Marker Score: 10890
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.11
    Marker Score: 1228
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.11
    Marker Score: 599
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.09
    Marker Score: 1677
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.03
    Marker Score: 63362
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.01
    Marker Score: 4126.5
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.01
    Marker Score: 265
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71781
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48005
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.98
    Marker Score: 2158
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 497.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.96
    Marker Score: 35517.5
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 452
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.95
    Marker Score: 9813
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.95
    Marker Score: 820
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2729
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.91
    Marker Score: 13579.5
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.9
    Marker Score: 1039
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.89
    Marker Score: 6858
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5006
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.84
    Marker Score: 767.5
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.83
    Marker Score: 16590
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.83
    Marker Score: 31602
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.83
    Marker Score: 556
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 606
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 309
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.75
    Marker Score: 809
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.74
    Marker Score: 361
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.73
    Marker Score: 1852
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.73
    Marker Score: 1960
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.73
    Marker Score: 519
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.73
    Marker Score: 723
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.72
    Marker Score: 734
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.72
    Marker Score: 1378
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 643
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7
    Marker Score: 12338
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2905
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.66
    Marker Score: 133
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.66
    Marker Score: 313
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.65
    Marker Score: 430
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.65
    Marker Score: 1474
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.64
    Marker Score: 672
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.64
    Marker Score: 2640
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.63
    Marker Score: 677
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.62
    Marker Score: 13215.5
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.61
    Marker Score: 256
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.6
    Marker Score: 2877
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.59
    Marker Score: 1347
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.59
    Marker Score: 567
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.58
    Marker Score: 2696
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.57
    Marker Score: 165
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.57
    Marker Score: 840
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.57
    Marker Score: 494
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.57
    Marker Score: 238.5
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.57
    Marker Score: 709
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.56
    Marker Score: 217
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.56
    Marker Score: 582
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.56
    Marker Score: 355.5
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.55
    Marker Score: 1740
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 438
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.55
    Marker Score: 288
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.54
    Marker Score: 252
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.54
    Marker Score: 203
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.53
    Marker Score: 755
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.52
    Marker Score: 404
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.52
    Marker Score: 554
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.52
    Marker Score: 255
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.51
    Marker Score: 120
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.5
    Marker Score: 293
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.49
    Marker Score: 185
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.49
    Marker Score: 162
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.49
    Marker Score: 16570
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.49
    Marker Score: 205
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.49
    Marker Score: 284
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.49
    Marker Score: 914
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.48
    Marker Score: 167
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.48
    Marker Score: 461
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.47
    Marker Score: 3015
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.47
    Marker Score: 192.5
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.47
    Marker Score: 173
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.47
    Marker Score: 116
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.47
    Marker Score: 134
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.46
    Marker Score: 551
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.45
    Marker Score: 252

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Other Information

**Key characteristics:** * ADCY6 is a transmembrane protein that is expressed in a variety of cell types. * It is a glycoprotein that is composed of 140 amino acids. * It is a member of the ADCY family of enzymes, which are involved in the regulation of fluid and electrolyte balance. * It has two transmembrane domains, a N-terminal domain and a C-terminal domain. * The N-terminal domain is responsible for binding to the GPCR for glucagon. * The C-terminal domain is responsible for regulating the activity of the enzyme. **Pathways and functions:** * ADCY6 is involved in the regulation of insulin secretion by binding to the GPCR for glucagon. * When ADCY6 binds to the GPCR, it activates the enzyme. * Activation of ADCY6 leads to the phosphorylation of a number of substrates, including the insulin receptor. * Phosphorylation of the insulin receptor inhibits its interaction with its target proteins, which leads to the release of insulin into the bloodstream. **Clinical significance:** * Mutations in ADCY6 have been linked to a number of human diseases, including diabetes and heart failure. * ADCY6 inhibitors are being investigated as a treatment for these diseases. **Additional notes:** * ADCY6 is a highly conserved protein, with a similar protein found in other mammals. * It is a well-characterized protein that has been extensively studied in model systems. * ADCY6 is a promising target for the treatment of diabetes and heart failure.

Genular Protein ID: 3174665019

Symbol: ADCY6_HUMAN

Name: Adenylate cyclase type 6

UniProtKB Accession Codes:

O43306 Q9NR75 Q9UDB0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 3 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 15 RefSeq 2 Rhea 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 5 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10978539

Title: Cloning and expression of human adenylyl cyclase type VI in normal thyroid tissues.

PubMed ID: 10978539

DOI: 10.1016/s0167-4781(00)00187-1

PubMed ID: 9455477

Title: Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9455477

DOI: 10.1093/dnares/4.5.307

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8476432

Title: A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line.

PubMed ID: 8476432

DOI: 10.1006/bbrc.1993.1415

PubMed ID: 15385642

Title: Raf kinase activation of adenylyl cyclases: isoform-selective regulation.

PubMed ID: 15385642

DOI: 10.1124/mol.66.4.921

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17916776

Title: Increased enzyme activity and beta-adrenergic mediated vasodilation in subjects expressing a single-nucleotide variant of human adenylyl cyclase 6.

PubMed ID: 17916776

DOI: 10.1161/atvbaha.107.145557

PubMed ID: 17110384

Title: Conditional stimulation of type V and VI adenylyl cyclases by G protein betagamma subunits.

PubMed ID: 17110384

DOI: 10.1074/jbc.m607522200

PubMed ID: 24319099

Title: Mutations in CNTNAP1 and ADCY6 are responsible for severe arthrogryposis multiplex congenita with axoglial defects.

PubMed ID: 24319099

DOI: 10.1093/hmg/ddt618

Sequence Information:

  • Length: 1168
  • Mass: 130615
  • Checksum: 127BB6E67F73AA61
  • Sequence:
    • MSWFSGLLVP KVDERKTAWG ERNGQKRSRR RGTRAGGFCT PRYMSCLRDA EPPSPTPAGP 
PRCPWQDDAF IRRGGPGKGK ELGLRAVALG FEDTEVTTTA GGTAEVAPDA VPRSGRSCWR 
RLVQVFQSKQ FRSAKLERLY QRYFFQMNQS SLTLLMAVLV LLTAVLLAFH AAPARPQPAY 
VALLACAAAL FVGLMVVCNR HSFRQDSMWV VSYVVLGILA AVQVGGALAA DPRSPSAGLW 
CPVFFVYIAY TLLPIRMRAA VLSGLGLSTL HLILAWQLNR GDAFLWKQLG ANVLLFLCTN 
VIGICTHYPA EVSQRQAFQE TRGYIQARLH LQHENRQQER LLLSVLPQHV AMEMKEDINT 
KKEDMMFHKI YIQKHDNVSI LFADIEGFTS LASQCTAQEL VMTLNELFAR FDKLAAENHC 
LRIKILGDCY YCVSGLPEAR ADHAHCCVEM GVDMIEAISL VREVTGVNVN MRVGIHSGRV 
HCGVLGLRKW QFDVWSNDVT LANHMEAGGR AGRIHITRAT LQYLNGDYEV EPGRGGERNA 
YLKEQHIETF LILGASQKRK EEKAMLAKLQ RTRANSMEGL MPRWVPDRAF SRTKDSKAFR 
QMGIDDSSKD NRGTQDALNP EDEVDEFLSR AIDARSIDQL RKDHVRRFLL TFQREDLEKK 
YSRKVDPRFG AYVACALLVF CFICFIQLLI FPHSTLMLGI YASIFLLLLI TVLICAVYSC 
GSLFPKALQR LSRSIVRSRA HSTAVGIFSV LLVFTSAIAN MFTCNHTPIR SCAARMLNLT 
PADITACHLQ QLNYSLGLDA PLCEGTMPTC SFPEYFIGNM LLSLLASSVF LHISSIGKLA 
MIFVLGLIYL VLLLLGPPAT IFDNYDLLLG VHGLASSNET FDGLDCPAAG RVALKYMTPV 
ILLVFALALY LHAQQVESTA RLDFLWKLQA TGEKEEMEEL QAYNRRLLHN ILPKDVAAHF 
LARERRNDEL YYQSCECVAV MFASIANFSE FYVELEANNE GVECLRLLNE IIADFDEIIS 
EERFRQLEKI KTIGSTYMAA SGLNASTYDQ VGRSHITALA DYAMRLMEQM KHINEHSFNN 
FQMKIGLNMG PVVAGVIGAR KPQYDIWGNT VNVSSRMDST GVPDRIQVTT DLYQVLAAKG 
YQLECRGVVK VKGKGEMTTY FLNGGPSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.