ADCY6 | ENSG00000174233 | NCBI 112

Details for: ADCY6

Gene ID: 112

Symbol: ADCY6

Ensembl ID: ENSG00000174233

Description: adenylate cyclase 6

Associated with

Activation of gabab receptors
(R-HSA-991365)
Adenylate cyclase activating pathway
(R-HSA-170660)
Adenylate cyclase inhibitory pathway
(R-HSA-170670)
Adora2b mediated anti-inflammatory cytokines production
(R-HSA-9660821)
Adrenaline,noradrenaline inhibits insulin secretion
(R-HSA-400042)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Aquaporin-mediated transport
(R-HSA-445717)
Ca-dependent events
(R-HSA-111996)
Calmodulin induced events
(R-HSA-111933)
Cam pathway
(R-HSA-111997)
Cellular responses to mechanical stimuli
(R-HSA-9855142)
Cellular responses to stimuli
(R-HSA-8953897)
Dag and ip3 signaling
(R-HSA-1489509)
Disease
(R-HSA-1643685)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
G-protein mediated events
(R-HSA-112040)
Gaba b receptor activation
(R-HSA-977444)
Gaba receptor activation
(R-HSA-977443)
G alpha (i) signalling events
(R-HSA-418594)
G alpha (s) signalling events
(R-HSA-418555)
G alpha (z) signalling events
(R-HSA-418597)
Glucagon-like peptide-1 (glp1) regulates insulin secretion
(R-HSA-381676)
Glucagon signaling in metabolic regulation
(R-HSA-163359)
Gpcr downstream signalling
(R-HSA-388396)
Gper1 signaling
(R-HSA-9634597)
Hedgehog 'off' state
(R-HSA-5610787)
High laminar flow shear stress activates signaling by piezo1 and pecam1:cdh5:kdr in endothelial cells
(R-HSA-9856530)
Infectious disease
(R-HSA-5663205)
Integration of energy metabolism
(R-HSA-163685)
Intracellular signaling by second messengers
(R-HSA-9006925)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Metabolism
(R-HSA-1430728)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Opioid signalling
(R-HSA-111885)
Parasitic infection pathways
(R-HSA-9824443)
Pka-mediated phosphorylation of creb
(R-HSA-111931)
Pka activation
(R-HSA-163615)
Pka activation in glucagon signalling
(R-HSA-164378)
Plc beta mediated events
(R-HSA-112043)
Regulation of insulin secretion
(R-HSA-422356)
Response of endothelial cells to shear stress
(R-HSA-9860931)
Signaling by gpcr
(R-HSA-372790)
Signaling by hedgehog
(R-HSA-5358351)
Signal transduction
(R-HSA-162582)
Transmission across chemical synapses
(R-HSA-112315)
Transport of small molecules
(R-HSA-382551)
Vasopressin regulates renal water homeostasis via aquaporins
(R-HSA-432040)
Adenylate cyclase-activating dopamine receptor signaling pathway
(GO:0007191)
Adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0007189)
Adenylate cyclase-inhibiting g protein-coupled receptor signaling pathway
(GO:0007193)
Adenylate cyclase activity
(GO:0004016)
Atp binding
(GO:0005524)
Blood vessel diameter maintenance
(GO:0097746)
Camp biosynthetic process
(GO:0006171)
Cellular response to catecholamine stimulus
(GO:0071870)
Cellular response to forskolin
(GO:1904322)
Cellular response to prostaglandin e stimulus
(GO:0071380)
Cellular response to vasopressin
(GO:1904117)
Cilium
(GO:0005929)
Intracellular signal transduction
(GO:0035556)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Negative regulation of neuron projection development
(GO:0010977)
Negative regulation of urine volume
(GO:0035811)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein kinase c binding
(GO:0005080)
Renal water homeostasis
(GO:0003091)
Stereocilium
(GO:0032420)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 147.8670
Cell Significance Index: -23.0000
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 89.8900
Cell Significance Index: -22.8000
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 48.0238
Cell Significance Index: -19.5100
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 33.3372
Cell Significance Index: -22.3700
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 20.3955
Cell Significance Index: -19.4700
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 18.6462
Cell Significance Index: -22.9900
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 5.8489
Cell Significance Index: -23.0800
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 2.0728
Cell Significance Index: 337.1300
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.9739
Cell Significance Index: 151.4800
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.8950
Cell Significance Index: 85.9000
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.2982
Cell Significance Index: 141.2000
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 1.2947
Cell Significance Index: 19.5100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.1489
Cell Significance Index: 24.8900
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.0220
Cell Significance Index: 27.3900
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.9546
Cell Significance Index: 27.5100
Cell Name: adipocyte of breast (CL0002617)
Fold Change: 0.8847
Cell Significance Index: 11.1400
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.8572
Cell Significance Index: 170.1100
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.7768
Cell Significance Index: 11.6400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.7763
Cell Significance Index: 155.7200
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7585
Cell Significance Index: 684.8300
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.6557
Cell Significance Index: 34.0600
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.6037
Cell Significance Index: 216.5400
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.5165
Cell Significance Index: 35.7200
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.4366
Cell Significance Index: 78.7100
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4083
Cell Significance Index: 40.3900
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.3268
Cell Significance Index: 226.0400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.3221
Cell Significance Index: 15.0200
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.3062
Cell Significance Index: 4.5200
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.2541
Cell Significance Index: 7.1000
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.2268
Cell Significance Index: 5.6700
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.2152
Cell Significance Index: 4.6000
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.2002
Cell Significance Index: 7.0400
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1984
Cell Significance Index: 24.4000
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1812
Cell Significance Index: 98.9400
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.1727
Cell Significance Index: 9.0000
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.1617
Cell Significance Index: 3.5400
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.1412
Cell Significance Index: 1.3000
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.1310
Cell Significance Index: 2.7900
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0998
Cell Significance Index: 6.1400
Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: 0.0988
Cell Significance Index: 0.4300
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0817
Cell Significance Index: 15.5400
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0793
Cell Significance Index: 10.8900
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0570
Cell Significance Index: 25.8900
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0319
Cell Significance Index: 14.0900
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0109
Cell Significance Index: 20.5900
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0076
Cell Significance Index: 0.4800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0018
Cell Significance Index: 1.1700
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0013
Cell Significance Index: 0.1700
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0035
Cell Significance Index: -2.5900
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0040
Cell Significance Index: -7.3800
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0046
Cell Significance Index: -7.0200
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0171
Cell Significance Index: -23.2800
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0178
Cell Significance Index: -1.1500
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0201
Cell Significance Index: -3.4400
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0241
Cell Significance Index: -18.2400
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0288
Cell Significance Index: -21.3600
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0393
Cell Significance Index: -24.5400
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0399
Cell Significance Index: -22.5100
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0456
Cell Significance Index: -2.5600
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0488
Cell Significance Index: -3.2800
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0611
Cell Significance Index: -17.5800
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0616
Cell Significance Index: -7.1800
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0754
Cell Significance Index: -10.9600
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0821
Cell Significance Index: -1.1200
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0961
Cell Significance Index: -6.8000
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1124
Cell Significance Index: -11.4800
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1163
Cell Significance Index: -3.1700
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1191
Cell Significance Index: -15.3900
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1194
Cell Significance Index: -5.6100
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1201
Cell Significance Index: -25.3100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1407
Cell Significance Index: -16.1200
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1869
Cell Significance Index: -13.9300
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1903
Cell Significance Index: -5.0800
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1933
Cell Significance Index: -20.1300
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.2106
Cell Significance Index: -5.0500
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2330
Cell Significance Index: -5.9900
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2551
Cell Significance Index: -8.1700
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2619
Cell Significance Index: -20.7400
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.2700
Cell Significance Index: -6.5400
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.2787
Cell Significance Index: -2.8900
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2858
Cell Significance Index: -17.5200
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.2931
Cell Significance Index: -5.7200
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2970
Cell Significance Index: -7.8100
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3002
Cell Significance Index: -15.7600
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: -0.3294
Cell Significance Index: -3.5700
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3297
Cell Significance Index: -9.4500
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.3548
Cell Significance Index: -6.0800
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3627
Cell Significance Index: -11.5500
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.3631
Cell Significance Index: -3.0500
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3714
Cell Significance Index: -12.1600
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.3868
Cell Significance Index: -8.2100
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.3904
Cell Significance Index: -11.1400
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.4005
Cell Significance Index: -5.1400
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.4421
Cell Significance Index: -9.1700
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.4480
Cell Significance Index: -9.6800
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.4484
Cell Significance Index: -15.7100
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.4505
Cell Significance Index: -13.2700
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.4586
Cell Significance Index: -2.9900
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.4591
Cell Significance Index: -9.6100
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.4592
Cell Significance Index: -7.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** ADCY6 exhibits several key characteristics that define its function and regulation. These include: 1. **GPCR activation**: ADCY6 is activated by GPCRs, which are a large family of cell surface receptors that respond to a wide range of ligands, including hormones, neurotransmitters, and cytokines. 2. **cAMP production**: ADCY6 catalyzes the conversion of ATP into cAMP, which serves as a secondary messenger molecule that activates various downstream effectors, including protein kinase A (PKA) and phospholipase C (PLC). 3. **Regulation by G proteins**: ADCY6 is regulated by G proteins, which are heterotrimeric complexes that dissociate upon activation by GPCRs, leading to the activation of ADCY6 and subsequent cAMP production. 4. **Involvement in various signaling pathways**: ADCY6 is involved in multiple signaling pathways, including the activation of gabab receptors, adenylate cyclase-activating GPCR signaling pathways, and the regulation of insulin secretion. **Pathways and Functions** ADCY6 plays a central role in various cellular processes, including: 1. **Cardiac function**: ADCY6 is expressed in cardiac myocytes and is involved in the regulation of cardiac contractility and relaxation. 2. **Renal function**: ADCY6 is expressed in renal interstitial pericytes and is involved in the regulation of renal water homeostasis and blood vessel diameter maintenance. 3. **Metabolism**: ADCY6 is involved in the regulation of glucose and lipid metabolism, including the regulation of insulin secretion and glucagon signaling. 4. **Immune responses**: ADCY6 is involved in the regulation of immune responses, including the production of anti-inflammatory cytokines and the regulation of Leishmania parasite growth and survival. 5. **Neurotransmission**: ADCY6 is expressed in various neuronal populations and is involved in the regulation of neurotransmission, including the regulation of dopamine and glutamate receptors. **Clinical Significance** ADCY6 has significant clinical implications, particularly in the context of: 1. **Cardiac disease**: Mutations in ADCY6 have been associated with cardiac arrhythmias and other cardiac disorders. 2. **Renal disease**: ADCY6 dysfunction has been implicated in renal water homeostasis disorders, such as diabetes insipidus. 3. **Metabolic disorders**: ADCY6 is involved in the regulation of glucose and lipid metabolism, and dysfunction has been implicated in metabolic disorders, such as type 2 diabetes. 4. **Infectious diseases**: ADCY6 is involved in the regulation of immune responses, and dysfunction has been implicated in infectious diseases, such as Leishmania parasite infections. In conclusion, ADCY6 is a critical enzyme involved in various cellular processes, including signal transduction, metabolism, and immune responses. Its clinical significance highlights the importance of understanding the regulation and function of this gene in maintaining cellular homeostasis and responding to environmental stimuli.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Adenylate cyclase type 6

Genular Protein ID: 3174665019

Symbol: ADCY6_HUMAN

Name: Adenylate cyclase type 6

UniProtKB Accession Codes:

O43306 Q9NR75 Q9UDB0

Database IDs:

Citations:

PubMed ID: 10978539

Title: Cloning and expression of human adenylyl cyclase type VI in normal thyroid tissues.

PubMed ID: 10978539

DOI: 10.1016/s0167-4781(00)00187-1

PubMed ID: 9455477

Title: Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9455477

DOI: 10.1093/dnares/4.5.307

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8476432

Title: A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line.

PubMed ID: 8476432

DOI: 10.1006/bbrc.1993.1415

PubMed ID: 15385642

Title: Raf kinase activation of adenylyl cyclases: isoform-selective regulation.

PubMed ID: 15385642

DOI: 10.1124/mol.66.4.921

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17916776

Title: Increased enzyme activity and beta-adrenergic mediated vasodilation in subjects expressing a single-nucleotide variant of human adenylyl cyclase 6.

PubMed ID: 17916776

DOI: 10.1161/atvbaha.107.145557

PubMed ID: 17110384

Title: Conditional stimulation of type V and VI adenylyl cyclases by G protein betagamma subunits.

PubMed ID: 17110384

DOI: 10.1074/jbc.m607522200

PubMed ID: 24319099

Title: Mutations in CNTNAP1 and ADCY6 are responsible for severe arthrogryposis multiplex congenita with axoglial defects.

PubMed ID: 24319099

DOI: 10.1093/hmg/ddt618

Sequence Information:

Length: 1168
Mass: 130615
Checksum: 127BB6E67F73AA61
Sequence:

MSWFSGLLVP KVDERKTAWG ERNGQKRSRR RGTRAGGFCT PRYMSCLRDA EPPSPTPAGP 
PRCPWQDDAF IRRGGPGKGK ELGLRAVALG FEDTEVTTTA GGTAEVAPDA VPRSGRSCWR 
RLVQVFQSKQ FRSAKLERLY QRYFFQMNQS SLTLLMAVLV LLTAVLLAFH AAPARPQPAY 
VALLACAAAL FVGLMVVCNR HSFRQDSMWV VSYVVLGILA AVQVGGALAA DPRSPSAGLW 
CPVFFVYIAY TLLPIRMRAA VLSGLGLSTL HLILAWQLNR GDAFLWKQLG ANVLLFLCTN 
VIGICTHYPA EVSQRQAFQE TRGYIQARLH LQHENRQQER LLLSVLPQHV AMEMKEDINT 
KKEDMMFHKI YIQKHDNVSI LFADIEGFTS LASQCTAQEL VMTLNELFAR FDKLAAENHC 
LRIKILGDCY YCVSGLPEAR ADHAHCCVEM GVDMIEAISL VREVTGVNVN MRVGIHSGRV 
HCGVLGLRKW QFDVWSNDVT LANHMEAGGR AGRIHITRAT LQYLNGDYEV EPGRGGERNA 
YLKEQHIETF LILGASQKRK EEKAMLAKLQ RTRANSMEGL MPRWVPDRAF SRTKDSKAFR 
QMGIDDSSKD NRGTQDALNP EDEVDEFLSR AIDARSIDQL RKDHVRRFLL TFQREDLEKK 
YSRKVDPRFG AYVACALLVF CFICFIQLLI FPHSTLMLGI YASIFLLLLI TVLICAVYSC 
GSLFPKALQR LSRSIVRSRA HSTAVGIFSV LLVFTSAIAN MFTCNHTPIR SCAARMLNLT 
PADITACHLQ QLNYSLGLDA PLCEGTMPTC SFPEYFIGNM LLSLLASSVF LHISSIGKLA 
MIFVLGLIYL VLLLLGPPAT IFDNYDLLLG VHGLASSNET FDGLDCPAAG RVALKYMTPV 
ILLVFALALY LHAQQVESTA RLDFLWKLQA TGEKEEMEEL QAYNRRLLHN ILPKDVAAHF 
LARERRNDEL YYQSCECVAV MFASIANFSE FYVELEANNE GVECLRLLNE IIADFDEIIS 
EERFRQLEKI KTIGSTYMAA SGLNASTYDQ VGRSHITALA DYAMRLMEQM KHINEHSFNN 
FQMKIGLNMG PVVAGVIGAR KPQYDIWGNT VNVSSRMDST GVPDRIQVTT DLYQVLAAKG 
YQLECRGVVK VKGKGEMTTY FLNGGPSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ADCY6

Associated with

Cells (max top 100)

Other Information

Cloning and expression of human adenylyl cyclase type VI in normal thyroid tissues. PubMed ID: 10978539

Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 9455477

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. PubMed ID: 12168954

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line. PubMed ID: 8476432

Raf kinase activation of adenylyl cyclases: isoform-selective regulation. PubMed ID: 15385642

Phosphoproteome of resting human platelets. PubMed ID: 18088087

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Increased enzyme activity and beta-adrenergic mediated vasodilation in subjects expressing a single-nucleotide variant of human adenylyl cyclase 6. PubMed ID: 17916776

Conditional stimulation of type V and VI adenylyl cyclases by G protein betagamma subunits. PubMed ID: 17110384

Mutations in CNTNAP1 and ADCY6 are responsible for severe arthrogryposis multiplex congenita with axoglial defects. PubMed ID: 24319099