Details for: CHEK2

Gene ID: 11200

Symbol: CHEK2

Ensembl ID: ENSG00000183765

Description: checkpoint kinase 2

Associated with

Other Information

Genular Protein ID: 1335862908

Symbol: CHK2_HUMAN

Name: Serine/threonine-protein kinase Chk2

UniProtKB Accession Codes:

O96017 A8K3Y9 B7ZBF3 B7ZBF4 B7ZBF5 Q6QA03 Q6QA04 Q6QA05 Q6QA06 Q6QA07 Q6QA08 Q6QA10 Q6QA11 Q6QA12 Q6QA13 Q9HBS5 Q9HCQ8 Q9UGF0 Q9UGF1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CORUM 1 CPTAC 3 CPTC 1 CTD 1 ChEBI 16 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 3 DrugCentral 1 EC 3 ELM 1 EMBL 24 EPD 1 Ensembl 12 EvolutionaryTrace 1 ExpressionAtlas 1 GO 37 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 9 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 5 OrthoDB 1 PANTHER 2 PDB 46 PDBsum 38 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 13 Pumba 1 RNAct 1 Reactome 8 RefSeq 6 Rhea 6 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9836640

Title: Linkage of ATM to cell cycle regulation by the Chk2 protein kinase.

PubMed ID: 9836640

DOI: 10.1126/science.282.5395.1893

PubMed ID: 9889122

Title: A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase.

PubMed ID: 9889122

DOI: 10.1016/s0960-9822(99)80041-4

PubMed ID: 10097108

Title: A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage.

PubMed ID: 10097108

DOI: 10.1073/pnas.96.7.3745

PubMed ID: 15361853

Title: Alternative splicing and mutation status of CHEK2 in stage III breast cancer.

PubMed ID: 15361853

DOI: 10.1038/sj.onc.1207928

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10724175

Title: hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response.

PubMed ID: 10724175

DOI: 10.1038/35004614

PubMed ID: 10973490

Title: Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro.

PubMed ID: 10973490

DOI: 10.1073/pnas.190030497

PubMed ID: 11390408

Title: The hCds1 (Chk2)-FHA domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionizing radiation.

PubMed ID: 11390408

DOI: 10.1074/jbc.m104414200

PubMed ID: 11298456

Title: The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis.

PubMed ID: 11298456

DOI: 10.1038/35071124

PubMed ID: 12094328

Title: A CHEK2 genetic variant contributing to a substantial fraction of familial breast cancer.

PubMed ID: 12094328

DOI: 10.1086/341943

PubMed ID: 11901158

Title: Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain.

PubMed ID: 11901158

DOI: 10.1074/jbc.m200822200

PubMed ID: 12402044

Title: PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2.

PubMed ID: 12402044

DOI: 10.1038/ncb869

PubMed ID: 12364621

Title: 53BP1, a mediator of the DNA damage checkpoint.

PubMed ID: 12364621

DOI: 10.1126/science.1076182

PubMed ID: 12810724

Title: The promyelocytic leukemia protein protects p53 from Mdm2-mediated inhibition and degradation.

PubMed ID: 12810724

DOI: 10.1074/jbc.m301264200

PubMed ID: 12717439

Title: Chk2 activates E2F-1 in response to DNA damage.

PubMed ID: 12717439

DOI: 10.1038/ncb974

PubMed ID: 12607004

Title: MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways.

PubMed ID: 12607004

DOI: 10.1038/nature01447

PubMed ID: 15279791

Title: The Chk2 protein kinase.

PubMed ID: 15279791

DOI: 10.1016/j.dnarep.2004.03.033

PubMed ID: 15342622

Title: The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway.

PubMed ID: 15342622

DOI: 10.1074/jbc.m409961200

PubMed ID: 16163388

Title: ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage.

PubMed ID: 16163388

DOI: 10.1038/sj.emboj.7600812

PubMed ID: 16311512

Title: Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase.

PubMed ID: 16311512

DOI: 10.1038/sj.cdd.4401801

PubMed ID: 16481012

Title: Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage.

PubMed ID: 16481012

DOI: 10.1016/j.mrfmmm.2005.12.002

PubMed ID: 17380128

Title: Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage.

PubMed ID: 17380128

DOI: 10.1038/sj.emboj.7601652

PubMed ID: 17715138

Title: Stability of checkpoint kinase 2 is regulated via phosphorylation at serine 456.

PubMed ID: 17715138

DOI: 10.1074/jbc.m704642200

PubMed ID: 17101782

Title: Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes.

PubMed ID: 17101782

DOI: 10.1128/mcb.01068-06

PubMed ID: 18728393

Title: Nek6 is involved in G2/M phase cell cycle arrest through DNA damage-induced phosphorylation.

PubMed ID: 18728393

DOI: 10.4161/cc.7.17.6551

PubMed ID: 18644861

Title: Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379.

PubMed ID: 18644861

DOI: 10.1128/mcb.00821-08

PubMed ID: 18317453

Title: The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage.

PubMed ID: 18317453

DOI: 10.1038/onc.2008.17

PubMed ID: 19164942

Title: Polo-like kinase 4 phosphorylates Chk2.

PubMed ID: 19164942

DOI: 10.4161/cc.8.2.7355

PubMed ID: 20364141

Title: The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells.

PubMed ID: 20364141

DOI: 10.1038/ncb2051

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21618645

Title: A recurrent CHEK2 p.H371Y mutation is associated with breast cancer risk in Chinese women.

PubMed ID: 21618645

DOI: 10.1002/humu.21538

PubMed ID: 22266820

Title: The E3 ligase RNF8 regulates KU80 removal and NHEJ repair.

PubMed ID: 22266820

DOI: 10.1038/nsmb.2211

PubMed ID: 25361978

Title: Chk2 and REGgamma-dependent DBC1 regulation in DNA damage induced apoptosis.

PubMed ID: 25361978

DOI: 10.1093/nar/gku1065

PubMed ID: 32001251

Title: The Viral SUMO-Targeted Ubiquitin Ligase ICP0 is Phosphorylated and Activated by Host Kinase Chk2.

PubMed ID: 32001251

DOI: 10.1016/j.jmb.2020.01.021

PubMed ID: 12049740

Title: Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2.

PubMed ID: 12049740

DOI: 10.1016/s1097-2765(02)00527-0

PubMed ID: 16794575

Title: Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange.

PubMed ID: 16794575

DOI: 10.1038/sj.emboj.7601209

PubMed ID: 19782031

Title: Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase.

PubMed ID: 19782031

DOI: 10.1016/j.molcel.2009.09.007

PubMed ID: 24825908

Title: Collaborator of ARF (CARF) regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling.

PubMed ID: 24825908

DOI: 10.1074/jbc.m114.547208

PubMed ID: 10617473

Title: Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome.

PubMed ID: 10617473

DOI: 10.1126/science.286.5449.2528

PubMed ID: 11461078

Title: Mutation analysis of the CHK2 gene in families with hereditary breast cancer.

PubMed ID: 11461078

DOI: 10.1054/bjoc.2001.1858

PubMed ID: 11719428

Title: Destabilization of CHK2 by a missense mutation associated with Li-Fraumeni Syndrome.

PubMed ID: 11719428

PubMed ID: 12052256

Title: Mutation analysis of the CHK2 gene in breast carcinoma and other cancers.

PubMed ID: 12052256

DOI: 10.1186/bcr435

PubMed ID: 12454775

Title: CHEK2 variants in susceptibility to breast cancer and evidence of retention of the wild type allele in tumours.

PubMed ID: 12454775

DOI: 10.1038/sj.bjc.6600637

PubMed ID: 11746983

Title: Mutations of the CHK2 gene are found in some osteosarcomas, but are rare in breast, lung, and ovarian tumors.

PubMed ID: 11746983

DOI: 10.1002/gcc.1207

PubMed ID: 12533788

Title: Mutations in CHEK2 associated with prostate cancer risk.

PubMed ID: 12533788

DOI: 10.1086/346094

PubMed ID: 12610780

Title: Variants in CHEK2 other than 1100delC do not make a major contribution to breast cancer susceptibility.

PubMed ID: 12610780

DOI: 10.1086/373965

PubMed ID: 14612911

Title: CHEK2 variants associate with hereditary prostate cancer.

PubMed ID: 14612911

DOI: 10.1038/sj.bjc.6601425

PubMed ID: 15492928

Title: CHEK2 is a multiorgan cancer susceptibility gene.

PubMed ID: 15492928

DOI: 10.1086/426403

PubMed ID: 15535844

Title: Frequency of CHEK2 mutations in a population based, case-control study of breast cancer in young women.

PubMed ID: 15535844

DOI: 10.1186/bcr933

PubMed ID: 15087378

Title: A novel founder CHEK2 mutation is associated with increased prostate cancer risk.

PubMed ID: 15087378

DOI: 10.1158/0008-5472.can-04-0341

PubMed ID: 15095295

Title: Limited relevance of the CHEK2 gene in hereditary breast cancer.

PubMed ID: 15095295

DOI: 10.1002/ijc.20073

PubMed ID: 15239132

Title: CHEK2 variant I157T may be associated with increased breast cancer risk.

PubMed ID: 15239132

DOI: 10.1002/ijc.20299

PubMed ID: 15649950

Title: Functional and genomic approaches reveal an ancient CHEK2 allele associated with breast cancer in the Ashkenazi Jewish population.

PubMed ID: 15649950

DOI: 10.1093/hmg/ddi052

PubMed ID: 15810020

Title: Association of two mutations in the CHEK2 gene with breast cancer.

PubMed ID: 15810020

DOI: 10.1002/ijc.21022

PubMed ID: 15818573

Title: Homozygosity for a CHEK2*1100delC mutation identified in familial colorectal cancer does not lead to a severe clinical phenotype.

PubMed ID: 15818573

DOI: 10.1002/path.1764

PubMed ID: 25619829

Title: A novel recurrent CHEK2 Y390C mutation identified in high-risk Chinese breast cancer patients impairs its activity and is associated with increased breast cancer risk.

PubMed ID: 25619829

DOI: 10.1038/onc.2014.443

Sequence Information:

  • Length: 543
  • Mass: 60915
  • Checksum: 28890ACF3C1F3408
  • Sequence:
    • MSRESDVEAQ QSHGSSACSQ PHGSVTQSQG SSSQSQGISS SSTSTMPNSS QSSHSSSGTL 
SSLETVSTQE LYSIPEDQEP EDQEPEEPTP APWARLWALQ DGFANLECVN DNYWFGRDKS 
CEYCFDEPLL KRTDKYRTYS KKHFRIFREV GPKNSYIAYI EDHSGNGTFV NTELVGKGKR 
RPLNNNSEIA LSLSRNKVFV FFDLTVDDQS VYPKALRDEY IMSKTLGSGA CGEVKLAFER 
KTCKKVAIKI ISKRKFAIGS AREADPALNV ETEIEILKKL NHPCIIKIKN FFDAEDYYIV 
LELMEGGELF DKVVGNKRLK EATCKLYFYQ MLLAVQYLHE NGIIHRDLKP ENVLLSSQEE 
DCLIKITDFG HSKILGETSL MRTLCGTPTY LAPEVLVSVG TAGYNRAVDC WSLGVILFIC 
LSGYPPFSEH RTQVSLKDQI TSGKYNFIPE VWAEVSEKAL DLVKKLLVVD PKARFTTEEA 
LRHPWLQDED MKRKFQDLLS EENESTALPQ VLAQPSTSRK RPREGEAEGA ETTKRPAVCA 
AVL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.