Details for: CHM
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 18.42rCSI 29.63%PRS 40.89
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CSI 16.56rCSI 40.24%PRS 37.45
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CSI 14.32rCSI 44.76%PRS 40.19
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CSI 13.44rCSI 48.37%PRS 37.32
-
CSI 12.58rCSI 21.11%PRS 38.72
-
CSI 10.64rCSI 40.21%PRS 39.55
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CSI 9.69rCSI 17.11%PRS 37.76
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CSI 9.14rCSI 20.19%PRS 43.03
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CSI 8.79rCSI 51.75%PRS 40.11
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CSI 6.98rCSI 6.73%PRS 46.84
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CSI 6.39rCSI 7.64%PRS 38.56
-
CSI 5.82rCSI 10.25%PRS 53.6
-
CSI 4.97rCSI 4.59%PRS 57.4
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CSI 4.76rCSI 14.66%PRS 66.15
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CSI 4.49rCSI 2.65%PRS 73.35
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CSI 4.4rCSI 3.31%PRS 61.28
-
CSI 4.03rCSI 11.46%PRS 54.54
-
CSI 3.84rCSI 3.69%PRS 56.57
-
CSI 3.66rCSI 5.01%PRS 61.93
-
CSI 3.48rCSI 8.37%PRS 74.55
-
CSI 3.41rCSI 10.67%PRS 42.67
-
CSI 3.37rCSI 2.5%PRS 49.01
-
CSI 3.33rCSI 8.44%PRS 64.82
-
CSI 3.32rCSI 13.41%PRS 54.86
-
CSI 3.32rCSI 3.99%PRS 54.46
-
CSI 3.22rCSI 4.01%PRS 36.91
-
CSI 3.13rCSI 4.6%PRS 50.37
-
CSI 3.11rCSI 7.1%PRS 48.42
-
CSI 3.1rCSI 10.63%PRS 45.69
-
CSI 3.06rCSI 5.29%PRS 46.49
-
CSI 3.05rCSI 3.52%PRS 49.84
-
CSI 2.98rCSI 2.71%PRS 70.81
-
CSI 2.96rCSI 4.4%PRS 58.27
-
CSI 2.94rCSI 3%PRS 69.85
-
CSI 2.83rCSI 3.79%PRS 65.38
-
CSI 2.81rCSI 6.18%PRS 60.29
-
CSI 2.79rCSI 3.88%PRS 55.31
-
CSI 2.76rCSI 3.19%PRS 46.33
-
CSI 2.76rCSI 39.15%PRS 47.93
-
CSI 2.75rCSI 3.54%PRS 39.85
-
CSI 2.7rCSI 55%PRS 47.47
-
CSI 2.67rCSI 64.03%PRS 37.99
-
CSI 2.65rCSI 2.61%PRS 58.86
-
CSI 2.64rCSI 5.03%PRS 71.91
-
CSI 2.62rCSI 63.21%PRS 38.89
-
CSI 2.61rCSI 2.74%PRS 59.78
-
CSI 2.57rCSI 52.39%PRS 48.76
-
CSI 2.51rCSI 5.74%PRS 55.92
-
CSI 2.44rCSI 2.12%PRS 66.9
-
CSI 2.39rCSI 5.53%PRS 46.04
-
CSI 2.36rCSI 3.76%PRS 49.26
-
CSI 2.29rCSI 5.14%PRS 39.49
-
CSI 2.27rCSI 1.75%PRS 56.18
-
CSI 2.27rCSI 3.24%PRS 58.8
-
CSI 2.26rCSI 1.83%PRS 56.79
-
CSI 2.24rCSI 2.45%PRS 60.16
-
CSI 2.23rCSI 3.16%PRS 52.67
-
CSI 2.19rCSI 5.56%PRS 46.03
-
CSI 2.19rCSI 10.48%PRS 55.92
-
CSI 2.19rCSI 5.77%PRS 65.06
-
CSI 2.18rCSI 5.81%PRS 46.18
-
CSI 2.16rCSI 1.51%PRS 59.08
-
CSI 2.12rCSI 1.75%PRS 55.27
-
CSI 2.11rCSI 4.39%PRS 53.63
-
CSI 2.08rCSI 4.18%PRS 45.6
-
CSI 2.07rCSI 4.65%PRS 74.45
-
CSI 2.01rCSI 7.53%PRS 48.53
-
CSI 2rCSI 2.57%PRS 49.65
-
CSI 1.99rCSI 2.56%PRS 53.82
-
CSI 1.98rCSI 3.24%PRS 46.03
-
CSI 1.97rCSI 8.02%PRS 51.44
-
CSI 1.95rCSI 1.51%PRS 57.72
-
CSI 1.94rCSI 1.61%PRS 58.14
-
CSI 1.93rCSI 1.3%PRS 69.01
-
CSI 1.92rCSI 1.78%PRS 56.27
-
CSI 1.89rCSI 4.93%PRS 55.7
-
CSI 1.88rCSI 5.44%PRS 46.41
-
CSI 1.86rCSI 2.95%PRS 67.48
-
CSI 1.82rCSI 2.28%PRS 66.66
-
CSI 1.82rCSI 3.18%PRS 48.45
-
CSI 1.81rCSI 3.24%PRS 55.29
-
CSI 1.8rCSI 2.29%PRS 62.66
-
CSI 1.71rCSI 3.4%PRS 54.31
-
CSI 1.71rCSI 1.33%PRS 74.3
-
CSI 1.7rCSI 6.47%PRS 47.76
-
CSI 1.66rCSI 2.98%PRS 49.39
-
CSI 1.65rCSI 4.09%PRS 54.57
-
CSI 1.62rCSI 3.29%PRS 36.47
-
CSI 1.61rCSI 1.27%PRS 43.35
-
CSI 1.6rCSI 2.19%PRS 58.43
-
CSI 1.6rCSI 3.8%PRS 57.52
-
CSI 1.59rCSI 2.13%PRS 56.96
-
CSI 1.59rCSI 6.18%PRS 76.7
-
CSI 1.53rCSI 8.65%PRS 41.7
-
CSI 1.52rCSI 3.93%PRS 51.5
-
CSI 1.48rCSI 4.74%PRS 53.55
-
CSI 1.48rCSI 1.24%PRS 61.15
-
CSI 1.47rCSI 2.34%PRS 48.75
-
CSI 1.46rCSI 2.14%PRS 60.33
-
CSI 1.46rCSI 3.49%PRS 65.27
-
CSI 0.3rCSI 1.5%PRS 54.6%
-
CSI 0.4rCSI 2.7%PRS 48.2%
-
CSI 0.4rCSI 2.9%PRS 52.6%
-
CSI 0.5rCSI 3.4%PRS 53.4%
-
CSI 0.6rCSI 3.5%PRS 51.8%
-
CSI 0.6rCSI 1.1%PRS 66.8%
-
CSI 0.6rCSI 4.7%PRS 53.0%
-
CSI 0.6rCSI 1.0%PRS 58.1%
-
CSI 0.6rCSI 3.0%PRS 76.4%
-
CSI 0.7rCSI 1.1%PRS 72.8%
-
CSI 0.7rCSI 3.0%PRS 67.4%
-
CSI 0.8rCSI 3.4%PRS 55.5%
-
CSI 0.8rCSI 1.2%PRS 52.7%
-
CSI 0.8rCSI 3.4%PRS 53.1%
-
CSI 0.8rCSI 1.2%PRS 60.8%
-
CSI 0.8rCSI 2.2%PRS 52.1%
-
CSI 0.8rCSI 1.3%PRS 46.3%
-
CSI 0.8rCSI 2.1%PRS 64.2%
-
CSI 0.8rCSI 1.0%PRS 64.8%
-
CSI 0.8rCSI 3.2%PRS 70.2%
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CSI 0.8rCSI 1.7%PRS 47.6%
-
CSI 0.9rCSI 1.3%PRS 56.9%
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CSI 0.9rCSI 3.9%PRS 47.8%
-
CSI 0.9rCSI 7.4%PRS 49.4%
-
CSI 0.9rCSI 2.7%PRS 58.0%
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CSI 1.0rCSI 2.1%PRS 54.3%
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CSI 1.0rCSI 1.7%PRS 64.7%
-
CSI 1.0rCSI 2.3%PRS 44.1%
-
CSI 1.0rCSI 2.2%PRS 44.8%
-
CSI 1.0rCSI 3.2%PRS 54.8%
-
CSI 1.0rCSI 16.0%PRS 60.7%
-
CSI 1.0rCSI 3.4%PRS 43.7%
-
CSI 1.1rCSI 1.0%PRS 64.8%
-
CSI 1.1rCSI 2.8%PRS 60.3%
-
CSI 1.1rCSI 5.2%PRS 74.9%
-
CSI 1.1rCSI 2.6%PRS 70.1%
-
CSI 1.1rCSI 2.9%PRS 54.3%
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CSI 1.1rCSI 1.7%PRS 59.7%
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CSI 1.2rCSI 2.8%PRS 64.3%
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CSI 1.2rCSI 1.6%PRS 50.6%
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CSI 1.3rCSI 10.8%PRS 43.6%
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CSI 1.3rCSI 1.8%PRS 46.4%
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CSI 1.3rCSI 3.3%PRS 47.8%
-
CSI 1.3rCSI 6.2%PRS 67.7%
-
CSI 1.3rCSI 2.4%PRS 45.0%
-
CSI 1.3rCSI 4.3%PRS 42.2%
-
CSI 1.3rCSI 1.6%PRS 52.4%
-
CSI 1.3rCSI 2.4%PRS 48.6%
-
CSI 1.4rCSI 5.2%PRS 71.9%
-
CSI 1.4rCSI 2.2%PRS 60.3%
-
CSI 1.4rCSI 2.0%PRS 61.7%
-
CSI 1.4rCSI 3.2%PRS 63.8%
-
CSI 1.5rCSI 1.3%PRS 44.5%
-
CSI 1.5rCSI 3.5%PRS 65.3%
-
CSI 1.5rCSI 2.1%PRS 60.3%
-
CSI 1.5rCSI 2.3%PRS 48.8%
-
CSI 1.5rCSI 1.2%PRS 61.2%
-
CSI 1.5rCSI 4.7%PRS 53.6%
-
CSI 1.5rCSI 3.9%PRS 51.5%
-
CSI 1.5rCSI 8.7%PRS 41.7%
-
CSI 1.6rCSI 6.2%PRS 76.7%
-
CSI 1.6rCSI 2.1%PRS 57.0%
-
CSI 1.6rCSI 3.8%PRS 57.5%
-
CSI 1.6rCSI 2.2%PRS 58.4%
-
CSI 1.6rCSI 1.3%PRS 43.4%
-
CSI 1.6rCSI 3.3%PRS 36.5%
-
CSI 1.7rCSI 4.1%PRS 54.6%
-
CSI 1.7rCSI 3.0%PRS 49.4%
-
CSI 1.7rCSI 6.5%PRS 47.8%
-
CSI 1.7rCSI 1.3%PRS 74.3%
-
CSI 1.7rCSI 3.4%PRS 54.3%
-
CSI 1.8rCSI 2.3%PRS 62.7%
-
CSI 1.8rCSI 3.2%PRS 55.3%
-
CSI 1.8rCSI 3.2%PRS 48.5%
-
CSI 1.8rCSI 2.3%PRS 66.7%
-
CSI 1.9rCSI 3.0%PRS 67.5%
-
CSI 1.9rCSI 5.4%PRS 46.4%
-
CSI 1.9rCSI 4.9%PRS 55.7%
-
CSI 1.9rCSI 1.8%PRS 56.3%
-
CSI 1.9rCSI 1.3%PRS 69.0%
-
CSI 1.9rCSI 1.6%PRS 58.1%
-
CSI 2.0rCSI 1.5%PRS 57.7%
-
CSI 2.0rCSI 8.0%PRS 51.4%
-
CSI 2.0rCSI 3.2%PRS 46.0%
-
CSI 2.0rCSI 2.6%PRS 53.8%
-
CSI 2.0rCSI 2.6%PRS 49.7%
-
CSI 2.0rCSI 7.5%PRS 48.5%
-
CSI 2.1rCSI 4.7%PRS 74.5%
-
CSI 2.1rCSI 4.2%PRS 45.6%
-
CSI 2.1rCSI 4.4%PRS 53.6%
-
CSI 2.1rCSI 1.8%PRS 55.3%
-
CSI 2.2rCSI 1.5%PRS 59.1%
-
CSI 2.2rCSI 5.8%PRS 46.2%
-
CSI 2.2rCSI 5.8%PRS 65.1%
-
CSI 2.2rCSI 10.5%PRS 55.9%
-
CSI 2.2rCSI 5.6%PRS 46.0%
-
CSI 2.2rCSI 3.2%PRS 52.7%
-
CSI 2.2rCSI 2.5%PRS 60.2%
-
CSI 2.3rCSI 1.8%PRS 56.8%
-
CSI 2.3rCSI 3.2%PRS 58.8%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3113907263
Symbol: RAE1_HUMAN
Name: Rab proteins geranylgeranyltransferase component A 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7981670
Title: Cloning and characterization of the human choroideremia gene.
PubMed ID: 7981670
DOI: 10.1093/hmg/3.7.1041
PubMed ID: 15772651
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1549574
Title: Isolation of a candidate gene for choroideremia.
PubMed ID: 1549574
PubMed ID: 2215697
Title: Cloning of a gene that is rearranged in patients with choroideraemia.
PubMed ID: 2215697
DOI: 10.1038/347674a0
PubMed ID: 1598901
Title: Detection and characterization of point mutations in the choroideremia candidate gene by PCR-SSCP analysis and direct DNA sequencing.
PubMed ID: 1598901
PubMed ID: 1904992
PubMed ID: 7957092
Title: Rab escort protein-1 is a multifunctional protein that accompanies newly prenylated rab proteins to their target membranes.
PubMed ID: 7957092
PubMed ID: 18532927
Title: Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate.
PubMed ID: 18532927
DOI: 10.1042/bj20080662
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 21905166
Title: Comprehensive mutation analysis (20 families) of the choroideremia gene reveals a missense variant that prevents the binding of REP1 with rab geranylgeranyl transferase.
PubMed ID: 21905166
DOI: 10.1002/humu.21591
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 26824392
Title: Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.
PubMed ID: 26824392
DOI: 10.7554/elife.12813
PubMed ID: 29125462
Title: Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.
PubMed ID: 29125462
DOI: 10.7554/elife.31012
PubMed ID: 7951216
PubMed ID: 19427510
Title: The functional effect of pathogenic mutations in Rab escort protein 1.
PubMed ID: 19427510
Sequence Information:
- Length: 653
- Mass: 73476
- Checksum: 7CFFAECE7BA1F3AF
- Sequence:
MADTLPSEFD VIVIGTGLPE SIIAAACSRS GRRVLHVDSR SYYGGNWASF SFSGLLSWLK EYQENSDIVS DSPVWQDQIL ENEEAIALSR KDKTIQHVEV FCYASQDLHE DVEEAGALQK NHALVTSANS TEAADSAFLP TEDESLSTMS CEMLTEQTPS SDPENALEVN GAEVTGEKEN HCDDKTCVPS TSAEDMSENV PIAEDTTEQP KKNRITYSQI IKEGRRFNID LVSKLLYSRG LLIDLLIKSN VSRYAEFKNI TRILAFREGR VEQVPCSRAD VFNSKQLTMV EKRMLMKFLT FCMEYEKYPD EYKGYEEITF YEYLKTQKLT PNLQYIVMHS IAMTSETASS TIDGLKATKN FLHCLGRYGN TPFLFPLYGQ GELPQCFCRM CAVFGGIYCL RHSVQCLVVD KESRKCKAII DQFGQRIISE HFLVEDSYFP ENMCSRVQYR QISRAVLITD RSVLKTDSDQ QISILTVPAE EPGTFAVRVI ELCSSTMTCM KGTYLVHLTC TSSKTAREDL ESVVQKLFVP YTEMEIENEQ VEKPRILWAL YFNMRDSSDI SRSCYNDLPS NVYVCSGPDC GLGNDNAVKQ AETLFQEICP NEDFCPPPPN PEDIILDGDS LQPEASESSA IPEANSETFK ESTNLGNLEE SSE
Genular Protein ID: 3829388678
Symbol: B4DRL9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 505
- Mass: 57265
- Checksum: 15F801C543052012
- Sequence:
MSCEMLTEQT PSSDPENALE VNGAEVTGEK ENHCDDKTCV PSTSAEDMSE NVPIAEDTTE QPKKNRITYS QIIKEGRRFN IDLVSKLLYS RGLLIDLLIK SNVSRYAEFK NITRILAFRE GRVEQVPCSR ADVFNSKQLT MVEKRMLMKF LTFCMEYEKY PDEYKGYEEI TFYEYLKTQK LTPNLQYIVM HSIAMTSETA SSTIDGLKAT KNFLHCLGRY GNTPFLFPLY GQGELPQCFC RMCAVFGGIY CLRHSVQCLV VDKESRKCKA IIDQFGQRII SEHFLVEDSY FPENMCSRVQ YRQISRAVLI TDRSVLKTDS DQQISILTVP AEEPGTFAVR VIELCSSTMT CMKGTYLVHL TCTSSKTARE DLESVVQKLF VPYTEMEIEN EQVEKPRILW ALYFNMRDSS DISRSCYNDL PSNVYVCSGP DCGLGNDNAV KQAETLFQEI CPNEDFCPPP PNPEDIILDG DSLQPEASES SAIPEANSET FKESTNLGNL EESSE
Genular Protein ID: 2027369497
Symbol: A8K545_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 653
- Mass: 73492
- Checksum: ED59BECE7E32A271
- Sequence:
MADTLPSEFD VIVIGTGLPE SIIAAACSRS GRRVLHVDSR SYYGGNWASF SFSGLLSWLK EYQENSDIVS DSPVWQDQIL ENEEAIALCR KDKTIQHVEV FCYASQDLHE DVEEAGALQK NHALVTSANS TEAADSAFLP TEDESLSTMS CEMLTEQTPS SDPENALEVN GAEVTGEKEN HCDDKTCVPS TSAEDMSENV PIAEDTTEQP KKNRITYSQI IKEGRRFNID LVSKLLYSRG LLIDLLIKSN VSRYAEFKNI TRILAFREGR VEQVPCSRAD VFNSKQLTMV EKRMLMKFLT FCMEYEKYPD EYKGYEEITF YEYLKTQKLT PNLQYIVMHS IAMTSETASS TIDGLKATKN FLHCLGRYGN TPFLFPLYGQ GELPQCFCRM CAVFGGIYCL RHSVQCLVVD KESRKCKAII DQFGQRIISE HFLVEDSYFP ENMCSRVQYR QISRAVLITD RSVLKTDSDQ QISILTVPAE EPGTFAVRVI ELCSSTMTCM KGTYLVHLTC TSSKTAREDL ESVVQKLFVP YTEMEIENEQ VEKPRILWAL YFNMRDSSDI SRSCYNDLPS NVYVCSGPDC GLGNDNAVKQ AETLFQEICP NEDFCPPPPN PEDIILDGDS LQPEASESSA IPEANSETFK ESTNLGNLEE SSE