Details for: IRAK3

Gene ID: 11213

Symbol: IRAK3

Ensembl ID: ENSG00000090376

Description: interleukin 1 receptor associated kinase 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.68
    Marker Score: 1,599
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.18
    Marker Score: 1,083
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.05
    Marker Score: 4,941
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.95
    Marker Score: 1,091
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.92
    Marker Score: 2,790
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.91
    Marker Score: 106,716
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.77
    Marker Score: 4,415
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.71
    Marker Score: 2,135
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.7
    Marker Score: 946
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.64
    Marker Score: 1,880
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.6
    Marker Score: 3,087
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.57
    Marker Score: 568
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.55
    Marker Score: 39,660
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.54
    Marker Score: 761
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.54
    Marker Score: 2,995
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.53
    Marker Score: 873
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.46
    Marker Score: 6,055
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.35
    Marker Score: 1,554
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.31
    Marker Score: 480
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.28
    Marker Score: 842
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.27
    Marker Score: 367
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.2
    Marker Score: 7,309
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.18
    Marker Score: 1,265
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.14
    Marker Score: 8,765
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.14
    Marker Score: 11,586
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4,763
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.13
    Marker Score: 1,133
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.1
    Marker Score: 735
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.09
    Marker Score: 277
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.05
    Marker Score: 253
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,737
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.04
    Marker Score: 657
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.03
    Marker Score: 330
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.02
    Marker Score: 2,071
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1
    Marker Score: 678
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,758
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,982
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.99
    Marker Score: 412
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.99
    Marker Score: 320
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,401
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.97
    Marker Score: 365
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.97
    Marker Score: 15,100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 495
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 450
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,406
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.95
    Marker Score: 249
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.94
    Marker Score: 10,931
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.93
    Marker Score: 198
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.93
    Marker Score: 434
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.91
    Marker Score: 1,065
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.91
    Marker Score: 1,012
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.91
    Marker Score: 642
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.91
    Marker Score: 926
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,722
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 363
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.91
    Marker Score: 818
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.89
    Marker Score: 798
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.88
    Marker Score: 639
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.87
    Marker Score: 240
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4,967
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,266
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.86
    Marker Score: 224
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.86
    Marker Score: 453
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.86
    Marker Score: 370
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.85
    Marker Score: 2,172
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.84
    Marker Score: 312
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.84
    Marker Score: 268
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 633
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.83
    Marker Score: 997
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.82
    Marker Score: 1,499
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.82
    Marker Score: 704
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.81
    Marker Score: 1,172
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.8
    Marker Score: 232
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.79
    Marker Score: 12,762
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.79
    Marker Score: 4,732
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.77
    Marker Score: 267
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.77
    Marker Score: 270
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.77
    Marker Score: 2,973
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.76
    Marker Score: 25,994
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1,240
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.75
    Marker Score: 978
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 681
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.75
    Marker Score: 1,196
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 386
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.74
    Marker Score: 233
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.74
    Marker Score: 1,911
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.74
    Marker Score: 794
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.73
    Marker Score: 181
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.73
    Marker Score: 170
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.73
    Marker Score: 421
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.72
    Marker Score: 365
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.71
    Marker Score: 1,295
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.71
    Marker Score: 425
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.71
    Marker Score: 440
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.7
    Marker Score: 243
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.7
    Marker Score: 461
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.7
    Marker Score: 312
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.69
    Marker Score: 337
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IRAK3 is a type I transmembrane protein that belongs to the IRAK family of kinases, which are essential for the activation of the MyD88-dependent toll-like receptor (TLR) signaling pathway. IRAK3 is specifically expressed in various immune cells, including macrophages, monocytes, and dendritic cells, and is also found in non-immune cells, such as endothelial cells and neurons. The protein is characterized by its ability to phosphorylate and activate downstream signaling molecules, including IRAK1, IRAK2, and TRAF6, which ultimately lead to the activation of NF-κB and the production of inflammatory cytokines. **Pathways and Functions:** IRAK3 is involved in several key signaling pathways, including: 1. **MyD88-dependent TLR signaling pathway:** IRAK3 is essential for the activation of the MyD88-dependent TLR signaling pathway, which is responsible for the recognition of PAMPs and the production of inflammatory cytokines. 2. **Cytokine-mediated signaling pathway:** IRAK3 is also involved in the regulation of cytokine production, including the production of IL-1β, IL-6, and IL-12. 3. **Innate immune system:** IRAK3 plays a critical role in the activation of innate immune cells, including macrophages and dendritic cells, which are essential for the recognition and elimination of pathogens. **Clinical Significance:** IRAK3 has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases:** IRAK3 has been linked to the development of autoimmune diseases, such as rheumatoid arthritis and lupus, where dysregulation of the IRAK3 pathway leads to excessive cytokine production and tissue damage. 2. **Infectious diseases:** IRAK3 has been shown to play a critical role in the recognition and elimination of pathogens, including bacteria, viruses, and fungi. 3. **Cancer:** IRAK3 has been implicated in the regulation of tumor immune evasion and the development of cancer, where dysregulation of the IRAK3 pathway leads to impaired immune surveillance and tumor growth. In conclusion, IRAK3 is a critical component of the innate immune system, playing a pivotal role in the recognition of PAMPs and the activation of downstream signaling cascades. Its dysregulation has been implicated in various immune-related disorders, highlighting the importance of IRAK3 in maintaining immune homeostasis and preventing disease. **Future Directions:** Further research is needed to fully elucidate the mechanisms of IRAK3 signaling and its role in immune-related disorders. Potential areas of investigation include: 1. **IRAK3 inhibitors:** The development of IRAK3 inhibitors could provide a novel therapeutic approach for the treatment of autoimmune diseases and cancer. 2. **IRAK3-targeted therapies:** The use of IRAK3-targeted therapies could help to restore immune function in patients with IRAK3-related disorders. 3. **IRAK3 expression and regulation:** The regulation of IRAK3 expression and its impact on immune function in different tissues and cell types remains an area of ongoing research. By continuing to explore the mechanisms of IRAK3 signaling and its role in immune-related disorders, we can gain a deeper understanding of the complex interactions between the innate immune system and the development of disease.

Genular Protein ID: 3468779948

Symbol: IRAK3_HUMAN

Name: Interleukin-1 receptor-associated kinase 3

UniProtKB Accession Codes:

Q9Y616 B4DQ57

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CPTAC 2 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 8 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 36 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 3 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10383454

Title: IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family.

PubMed ID: 10383454

DOI: 10.1074/jbc.274.27.19403

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17503328

Title: IRAK-M is involved in the pathogenesis of early-onset persistent asthma.

PubMed ID: 17503328

DOI: 10.1086/518259

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 29686383

Title: The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation.

PubMed ID: 29686383

DOI: 10.1038/s41467-018-03886-6

PubMed ID: 33238146

Title: Dimeric Structure of the Pseudokinase IRAK3 Suggests an Allosteric Mechanism for Negative Regulation.

PubMed ID: 33238146

DOI: 10.1016/j.str.2020.11.004

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 596
  • Mass: 67767
  • Checksum: D050150B7BDA5B9A
  • Sequence:
    • MAGNCGARGA LSAHTLLFDL PPALLGELCA VLDSCDGALG WRGLAERLSS SWLDVRHIEK 
YVDQGKSGTR ELLWSWAQKN KTIGDLLQVL QEMGHRRAIH LITNYGAVLS PSEKSYQEGG 
FPNILFKETA NVTVDNVLIP EHNEKGILLK SSISFQNIIE GTRNFHKDFL IGEGEIFEVY 
RVEIQNLTYA VKLFKQEKKM QCKKHWKRFL SELEVLLLFH HPNILELAAY FTETEKFCLI 
YPYMRNGTLF DRLQCVGDTA PLPWHIRIGI LIGISKAIHY LHNVQPCSVI CGSISSANIL 
LDDQFQPKLT DFAMAHFRSH LEHQSCTINM TSSSSKHLWY MPEEYIRQGK LSIKTDVYSF 
GIVIMEVLTG CRVVLDDPKH IQLRDLLREL MEKRGLDSCL SFLDKKVPPC PRNFSAKLFC 
LAGRCAATRA KLRPSMDEVL NTLESTQASL YFAEDPPTSL KSFRCPSPLF LENVPSIPVE 
DDESQNNNLL PSDEGLRIDR MTQKTPFECS QSEVMFLSLD KKPESKRNEE ACNMPSSSCE 
ESWFPKYIVP SQDLRPYKVN IDPSSEAPGH SCRSRPVESS CSSKFSWDEY EQYKKE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.