IRAK3 | ENSG00000090376 | NCBI 11213

Details for: IRAK3

Gene ID: 11213

Symbol: IRAK3

Ensembl ID: ENSG00000090376

Description: interleukin 1 receptor associated kinase 3

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-1 signaling
(R-HSA-9020702)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Signaling by interleukins
(R-HSA-449147)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Atp binding
(GO:0005524)
Cellular response to lipopolysaccharide
(GO:0071222)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytoplasm
(GO:0005737)
Interleukin-1-mediated signaling pathway
(GO:0070498)
Intracellular signal transduction
(GO:0035556)
Magnesium ion binding
(GO:0000287)
Myd88-dependent toll-like receptor signaling pathway
(GO:0002755)
Negative regulation of cytokine-mediated signaling pathway
(GO:0001960)
Negative regulation of innate immune response
(GO:0045824)
Negative regulation of interleukin-6 production
(GO:0032715)
Negative regulation of interleukin-12 production
(GO:0032695)
Negative regulation of macrophage cytokine production
(GO:0010936)
Negative regulation of map kinase activity
(GO:0043407)
Negative regulation of nf-kappab transcription factor activity
(GO:0032088)
Negative regulation of protein-containing complex disassembly
(GO:0043242)
Negative regulation of protein catabolic process
(GO:0042177)
Negative regulation of toll-like receptor signaling pathway
(GO:0034122)
Negative regulation of tumor necrosis factor production
(GO:0032720)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of macrophage tolerance induction
(GO:0010933)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Protein kinase binding
(GO:0019901)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Regulation of protein-containing complex disassembly
(GO:0043244)
Response to exogenous dsrna
(GO:0043330)
Response to interleukin-1
(GO:0070555)
Response to lipopolysaccharide
(GO:0032496)
Response to peptidoglycan
(GO:0032494)
Response to virus
(GO:0009615)
Toll signaling pathway
(GO:0008063)

Other Information

Proteins

Interleukin-1 receptor-associated kinase 3

Genular Protein ID: 3468779948

Symbol: IRAK3_HUMAN

Name: Interleukin-1 receptor-associated kinase 3

UniProtKB Accession Codes:

Q9Y616 B4DQ57

Database IDs:

Citations:

PubMed ID: 10383454

Title: IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family.

PubMed ID: 10383454

DOI: 10.1074/jbc.274.27.19403

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17503328

Title: IRAK-M is involved in the pathogenesis of early-onset persistent asthma.

PubMed ID: 17503328

DOI: 10.1086/518259

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 29686383

Title: The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation.

PubMed ID: 29686383

DOI: 10.1038/s41467-018-03886-6

PubMed ID: 33238146

Title: Dimeric Structure of the Pseudokinase IRAK3 Suggests an Allosteric Mechanism for Negative Regulation.

PubMed ID: 33238146

DOI: 10.1016/j.str.2020.11.004

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 596
Mass: 67767
Checksum: D050150B7BDA5B9A
Sequence:

MAGNCGARGA LSAHTLLFDL PPALLGELCA VLDSCDGALG WRGLAERLSS SWLDVRHIEK 
YVDQGKSGTR ELLWSWAQKN KTIGDLLQVL QEMGHRRAIH LITNYGAVLS PSEKSYQEGG 
FPNILFKETA NVTVDNVLIP EHNEKGILLK SSISFQNIIE GTRNFHKDFL IGEGEIFEVY 
RVEIQNLTYA VKLFKQEKKM QCKKHWKRFL SELEVLLLFH HPNILELAAY FTETEKFCLI 
YPYMRNGTLF DRLQCVGDTA PLPWHIRIGI LIGISKAIHY LHNVQPCSVI CGSISSANIL 
LDDQFQPKLT DFAMAHFRSH LEHQSCTINM TSSSSKHLWY MPEEYIRQGK LSIKTDVYSF 
GIVIMEVLTG CRVVLDDPKH IQLRDLLREL MEKRGLDSCL SFLDKKVPPC PRNFSAKLFC 
LAGRCAATRA KLRPSMDEVL NTLESTQASL YFAEDPPTSL KSFRCPSPLF LENVPSIPVE 
DDESQNNNLL PSDEGLRIDR MTQKTPFECS QSEVMFLSLD KKPESKRNEE ACNMPSSSCE 
ESWFPKYIVP SQDLRPYKVN IDPSSEAPGH SCRSRPVESS CSSKFSWDEY EQYKKE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: IRAK3

Associated with

Other Information

IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. PubMed ID: 10383454

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

IRAK-M is involved in the pathogenesis of early-onset persistent asthma. PubMed ID: 17503328

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation. PubMed ID: 29686383

Dimeric Structure of the Pseudokinase IRAK3 Suggests an Allosteric Mechanism for Negative Regulation. PubMed ID: 33238146

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846