DDX20 | ENSG00000064703 | NCBI 11218

Details for: DDX20

Gene ID: 11218

Symbol: DDX20

Ensembl ID: ENSG00000064703

Description: DEAD-box helicase 20

Associated with

Disease
(R-HSA-1643685)
Infectious disease
(R-HSA-5663205)
Metabolism of non-coding rna
(R-HSA-194441)
Metabolism of rna
(R-HSA-8953854)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 modulates host translation machinery
(R-HSA-9754678)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Snrnp assembly
(R-HSA-191859)
Viral infection pathways
(R-HSA-9824446)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Dna-binding transcription factor binding
(GO:0140297)
Dna binding
(GO:0003677)
Gemini of coiled bodies
(GO:0097504)
Histone deacetylase binding
(GO:0042826)
Membrane
(GO:0016020)
Mrna binding
(GO:0003729)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear body
(GO:0016604)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Oogenesis
(GO:0048477)
Positive regulation of apoptotic process
(GO:0043065)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Regulation of steroid biosynthetic process
(GO:0050810)
Rna helicase activity
(GO:0003724)
Rna polymerase ii transcription repressor complex
(GO:0090571)
Rna processing
(GO:0006396)
Smn-sm protein complex
(GO:0034719)
Smn complex
(GO:0032797)
Spliceosomal snrnp assembly
(GO:0000387)
Spliceosomal tri-snrnp complex assembly
(GO:0000244)

Other Information

Proteins

Probable ATP-dependent RNA helicase DDX20
Q9H4N4_HUMAN

Genular Protein ID: 4010717219

Symbol: DDX20_HUMAN

Name: Probable ATP-dependent RNA helicase DDX20

UniProtKB Accession Codes:

Q9UHI6 B4DWV7 Q96F72 Q9NVM3 Q9UF59 Q9UIY0 Q9Y659

Database IDs:

Citations:

PubMed ID: 10601333

Title: Gemin3: a novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and a component of gems.

PubMed ID: 10601333

DOI: 10.1083/jcb.147.6.1181

PubMed ID: 10383418

Title: Characterization of DP103, a novel DEAD box protein that binds to the Epstein-Barr virus nuclear proteins EBNA2 and EBNA3C.

PubMed ID: 10383418

DOI: 10.1074/jbc.274.27.19136

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12095920

Title: SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta.

PubMed ID: 12095920

DOI: 10.1093/hmg/11.15.1785

PubMed ID: 12668731

Title: Protein phosphatase 4 interacts with the survival of motor neurons complex and enhances the temporal localisation of snRNPs.

PubMed ID: 12668731

DOI: 10.1242/jcs.00409

PubMed ID: 16153597

Title: Transcriptional factor FOXL2 interacts with DP103 and induces apoptosis.

PubMed ID: 16153597

DOI: 10.1016/j.bbrc.2005.08.184

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17178713

Title: A comprehensive interaction map of the human survival of motor neuron (SMN) complex.

PubMed ID: 17178713

DOI: 10.1074/jbc.m608528200

PubMed ID: 18984161

Title: An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs.

PubMed ID: 18984161

DOI: 10.1016/j.cell.2008.09.020

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21800163

Title: NANOS1 and PUMILIO2 bind microRNA biogenesis factor GEMIN3, within chromatoid body in human germ cells.

PubMed ID: 21800163

DOI: 10.1007/s00418-011-0842-y

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 33963192

Title: Loss of function mutations in GEMIN5 cause a neurodevelopmental disorder.

PubMed ID: 33963192

DOI: 10.1038/s41467-021-22627-w

PubMed ID: 20510246

Title: Crystal structure of human RNA helicase A (DHX9): structural basis for unselective nucleotide base binding in a DEAD-box variant protein.

PubMed ID: 20510246

DOI: 10.1016/j.jmb.2010.05.046

PubMed ID: 20941364

Title: Comparative structural analysis of human DEAD-box RNA helicases.

PubMed ID: 20941364

DOI: 10.1371/journal.pone.0012791

Sequence Information:

Length: 824
Mass: 92241
Checksum: 76712F014B2A0CF2
Sequence:

MAAAFEASGA LAAVATAMPA EHVAVQVPAP EPTPGPVRIL RTAQDLSSPR TRTGDVLLAE 
PADFESLLLS RPVLEGLRAA GFERPSPVQL KAIPLGRCGL DLIVQAKSGT GKTCVFSTIA 
LDSLVLENLS TQILILAPTR EIAVQIHSVI TAIGIKMEGL ECHVFIGGTP LSQDKTRLKK 
CHIAVGSPGR IKQLIELDYL NPGSIRLFIL DEADKLLEEG SFQEQINWIY SSLPASKQML 
AVSATYPEFL ANALTKYMRD PTFVRLNSSD PSLIGLKQYY KVVNSYPLAH KVFEEKTQHL 
QELFSRIPFN QALVFSNLHS RAQHLADILS SKGFPAECIS GNMNQNQRLD AMAKLKHFHC 
RVLISTDLTS RGIDAEKVNL VVNLDVPLDW ETYMHRIGRA GRFGTLGLTV TYCCRGEEEN 
MMMRIAQKCN INLLPLPDPI PSGLMEECVD WDVEVKAAVH TYGIASVPNQ PLKKQIQKIE 
RTLQIQKAHG DHMASSRNNS VSGLSVKSKN NTKQKLPVKS HSECGIIEKA TSPKELGCDR 
QSEEQMKNSV QTPVENSTNS QHQVKEALPV SLPQIPCLSS FKIHQPYTLT FAELVEDYEH 
YIKEGLEKPV EIIRHYTGPG DQTVNPQNGF VRNKVIEQRV PVLASSSQSG DSESDSDSYS 
SRTSSQSKGN KSYLEGSSDN QLKDSESTPV DDRISLEQPP NGSDTPNPEK YQESPGIQMK 
TRLKEGASQR AKQSRRNLPR RSSFRLQTEA QEDDWYDCHR EIRLSFSDTY QDYEEYWRAY 
YRAWQEYYAA ASHSYYWNAQ RHPSWMAAYH MNTIYLQEMM HSNQ

Genular Protein ID: 583271243

Symbol: Q9H4N4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9H4N4

Database IDs:

Citations:

PubMed ID: 8619474

Title: A "double adaptor" method for improved shotgun library construction.

PubMed ID: 8619474

DOI: 10.1006/abio.1996.0138

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

Sequence Information:

Length: 106
Mass: 13212
Checksum: 8CA6559A8C00DE25
Sequence:

MKTRLKEGAS QRAKQSRRNL PRRSSFRLQT EAQEDDWYDC HRETRLSFSD TYQDYEEYWR 
AYYRAWQEYY AAASHSYYWN AQRHPSWMAA YHMNTIYLQE MMHSNQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: DDX20

Associated with

Other Information

Gemin3: a novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and a component of gems. PubMed ID: 10601333

Characterization of DP103, a novel DEAD box protein that binds to the Epstein-Barr virus nuclear proteins EBNA2 and EBNA3C. PubMed ID: 10383418

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta. PubMed ID: 12095920

Protein phosphatase 4 interacts with the survival of motor neurons complex and enhances the temporal localisation of snRNPs. PubMed ID: 12668731

Transcriptional factor FOXL2 interacts with DP103 and induces apoptosis. PubMed ID: 16153597

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

A comprehensive interaction map of the human survival of motor neuron (SMN) complex. PubMed ID: 17178713

An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs. PubMed ID: 18984161

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

NANOS1 and PUMILIO2 bind microRNA biogenesis factor GEMIN3, within chromatoid body in human germ cells. PubMed ID: 21800163

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Loss of function mutations in GEMIN5 cause a neurodevelopmental disorder. PubMed ID: 33963192

Crystal structure of human RNA helicase A (DHX9): structural basis for unselective nucleotide base binding in a DEAD-box variant protein. PubMed ID: 20510246

Comparative structural analysis of human DEAD-box RNA helicases. PubMed ID: 20941364

A "double adaptor" method for improved shotgun library construction. PubMed ID: 8619474

Large-scale concatenation cDNA sequencing. PubMed ID: 9110174