CHML | ENSG00000203668 | NCBI 1122

Details for: CHML

Gene ID: 1122

Symbol: CHML

Ensembl ID: ENSG00000203668

Description: CHM like Rab escort protein

Associated with

Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Post-translational protein modification
(R-HSA-597592)
Rab gefs exchange gtp for gdp on rabs
(R-HSA-8876198)
Rab geranylgeranylation
(R-HSA-8873719)
Rab regulation of trafficking
(R-HSA-9007101)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Gdp-dissociation inhibitor activity
(GO:0005092)
Gtpase activator activity
(GO:0005096)
Intracellular protein transport
(GO:0006886)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein geranylgeranylation
(GO:0018344)
Rab-protein geranylgeranyltransferase complex
(GO:0005968)
Small gtpase-mediated signal transduction
(GO:0007264)
Small gtpase binding
(GO:0031267)
Vesicle-mediated transport
(GO:0016192)

Other Information

Proteins

Rab proteins geranylgeranyltransferase component A 2

Genular Protein ID: 582030672

Symbol: RAE2_HUMAN

Name: Rab proteins geranylgeranyltransferase component A 2

UniProtKB Accession Codes:

P26374 B2RAB9 Q17RE0 Q9H1Y4

Database IDs:

Citations:

PubMed ID: 1301160

Title: An autosomal homologue of the choroideremia gene colocalizes with the Usher syndrome type II locus on the distal part of chromosome 1q.

PubMed ID: 1301160

DOI: 10.1093/hmg/1.2.71

PubMed ID: 12242008

Title: Different structural organization of the encephalopsin gene in man and mouse.

PubMed ID: 12242008

DOI: 10.1016/s0378-1119(02)00799-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8294464

Title: REP-2, a Rab escort protein encoded by the choroideremia-like gene.

PubMed ID: 8294464

DOI: 10.1016/s0021-9258(17)42142-9

PubMed ID: 12356470

Title: Expression of mammalian Rab Escort protein-1 and -2 in yeast Saccharomyces cerevisiae.

PubMed ID: 12356470

DOI: 10.1016/s1046-5928(02)00506-5

PubMed ID: 15186776

Title: Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease.

PubMed ID: 15186776

DOI: 10.1016/j.cell.2004.05.017

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26824392

Title: Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.

PubMed ID: 26824392

DOI: 10.7554/elife.12813

PubMed ID: 29125462

Title: Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.

PubMed ID: 29125462

DOI: 10.7554/elife.31012

Sequence Information:

Length: 656
Mass: 74071
Checksum: 478481966E30BE49
Sequence:

MADNLPTEFD VVIIGTGLPE SILAAACSRS GQRVLHIDSR SYYGGNWASF SFSGLLSWLK 
EYQQNNDIGE ESTVVWQDLI HETEEAITLR KKDETIQHTE AFCYASQDME DNVEEIGALQ 
KNPSLGVSNT FTEVLDSALP EESQLSYFNS DEMPAKHTQK SDTEISLEVT DVEESVEKEK 
YCGDKTCMHT VSDKDGDKDE SKSTVEDKAD EPIRNRITYS QIVKEGRRFN IDLVSKLLYS 
QGLLIDLLIK SDVSRYVEFK NVTRILAFRE GKVEQVPCSR ADVFNSKELT MVEKRMLMKF 
LTFCLEYEQH PDEYQAFRQC SFSEYLKTKK LTPNLQHFVL HSIAMTSESS CTTIDGLNAT 
KNFLQCLGRF GNTPFLFPLY GQGEIPQGFC RMCAVFGGIY CLRHKVQCFV VDKESGRCKA 
IIDHFGQRIN AKYFIVEDSY LSEETCSNVQ YKQISRAVLI TDQSILKTDL DQQTSILIVP 
PAEPGACAVR VTELCSSTMT CMKDTYLVHL TCSSSKTARE DLESVVKKLF TPYTETEINE 
EELTKPRLLW ALYFNMRDSS GISRSSYNGL PSNVYVCSGP DCGLGNEHAV KQAETLFQEI 
FPTEEFCPPP PNPEDIIFDG DDKQPEAPGT NNVVMAKLES SEESKNLESP EKHLQN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CHML

Associated with

Other Information

An autosomal homologue of the choroideremia gene colocalizes with the Usher syndrome type II locus on the distal part of chromosome 1q. PubMed ID: 1301160

Different structural organization of the encephalopsin gene in man and mouse. PubMed ID: 12242008

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

REP-2, a Rab escort protein encoded by the choroideremia-like gene. PubMed ID: 8294464

Expression of mammalian Rab Escort protein-1 and -2 in yeast Saccharomyces cerevisiae. PubMed ID: 12356470

Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease. PubMed ID: 15186776

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases. PubMed ID: 26824392

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis. PubMed ID: 29125462