Details for: DUSP10

Gene ID: 11221

Symbol: DUSP10

Ensembl ID: ENSG00000143507

Description: dual specificity phosphatase 10

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.04
    Marker Score: 5,634
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.4
    Marker Score: 665
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.38
    Marker Score: 5,727
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.38
    Marker Score: 3,384
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.36
    Marker Score: 2,580
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.32
    Marker Score: 897
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.29
    Marker Score: 777
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.29
    Marker Score: 4,962
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.27
    Marker Score: 409
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.18
    Marker Score: 18,389
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.07
    Marker Score: 1,127
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.07
    Marker Score: 39,351
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,735
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,960
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,399
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 478
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.92
    Marker Score: 274
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 433
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.92
    Marker Score: 1,598
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,715
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.9
    Marker Score: 282
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4,979
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.86
    Marker Score: 493
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.81
    Marker Score: 8,158
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.81
    Marker Score: 3,474
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.8
    Marker Score: 15,997
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.79
    Marker Score: 1,881
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.76
    Marker Score: 1,800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.76
    Marker Score: 3,193
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.76
    Marker Score: 1,538
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.76
    Marker Score: 2,243
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.75
    Marker Score: 4,501
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.75
    Marker Score: 1,216
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 299
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 553
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.72
    Marker Score: 4,652
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 372
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.71
    Marker Score: 1,994
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.7
    Marker Score: 533
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.7
    Marker Score: 446
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 633
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.69
    Marker Score: 1,134
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.68
    Marker Score: 827
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.68
    Marker Score: 935
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.68
    Marker Score: 229
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.67
    Marker Score: 330
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.66
    Marker Score: 3,548
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.65
    Marker Score: 233
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.63
    Marker Score: 599
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.63
    Marker Score: 151
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.63
    Marker Score: 894
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.62
    Marker Score: 291
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.62
    Marker Score: 297
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.61
    Marker Score: 275
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.61
    Marker Score: 1,390
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.61
    Marker Score: 23,042
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.61
    Marker Score: 229
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.6
    Marker Score: 598
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.6
    Marker Score: 504
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.59
    Marker Score: 290
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.59
    Marker Score: 865
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.59
    Marker Score: 385
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.58
    Marker Score: 338
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.58
    Marker Score: 570
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.58
    Marker Score: 3,517
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.58
    Marker Score: 424
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.56
    Marker Score: 5,541
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.56
    Marker Score: 142
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.55
    Marker Score: 1,366
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.54
    Marker Score: 187
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.54
    Marker Score: 115
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.54
    Marker Score: 366
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.53
    Marker Score: 426
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.53
    Marker Score: 386
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.53
    Marker Score: 351
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.53
    Marker Score: 586
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.53
    Marker Score: 485
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.52
    Marker Score: 2,148
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.52
    Marker Score: 1,356
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.52
    Marker Score: 559
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.52
    Marker Score: 272
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.51
    Marker Score: 13,177
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.51
    Marker Score: 216
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.51
    Marker Score: 348
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.51
    Marker Score: 135
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.51
    Marker Score: 1,477
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.5
    Marker Score: 159
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.5
    Marker Score: 1,431
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.5
    Marker Score: 6,601
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.5
    Marker Score: 129
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.49
    Marker Score: 685
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.49
    Marker Score: 205
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.49
    Marker Score: 862
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.48
    Marker Score: 106
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.48
    Marker Score: 146
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.48
    Marker Score: 97

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Dual specificity phosphatase activity**: DUSP10 possesses the ability to remove phosphate groups from both tyrosine and threonine residues in its target proteins, making it a versatile regulator of signaling pathways. 2. **Widespread expression**: DUSP10 is expressed in various cell types, including immune cells, epithelial cells, and neural cells, highlighting its importance in multiple physiological processes. 3. **Stress and immune activation response**: DUSP10 expression is significantly elevated in response to stress, inflammation, and immune activation, suggesting its role as a key regulator of the immune response. 4. **Negative regulation of signaling pathways**: DUSP10 is involved in the negative regulation of multiple signaling pathways, including MAPK, JNK, and ERK cascades, which are crucial for cell migration, proliferation, and differentiation. **Pathways and Functions:** 1. **MAPK signaling pathway**: DUSP10 negatively regulates the MAPK pathway, which is involved in cell migration, proliferation, and differentiation. 2. **JNK signaling pathway**: DUSP10 also negatively regulates the JNK pathway, which is involved in cell survival, apoptosis, and immune responses. 3. **ERK signaling pathway**: DUSP10 negatively regulates the ERK pathway, which is involved in cell proliferation, differentiation, and survival. 4. **Regulation of immune responses**: DUSP10 is involved in the regulation of adaptive immune responses, including T cell differentiation and function. 5. **Regulation of epithelial cell migration and proliferation**: DUSP10 negatively regulates the migration and proliferation of epithelial cells, which is essential for tissue repair and maintenance. **Clinical Significance:** 1. **Inflammatory diseases**: DUSP10 dysregulation has been implicated in various inflammatory diseases, including arthritis, asthma, and inflammatory bowel disease. 2. **Cancer**: DUSP10 expression is altered in various types of cancer, suggesting its potential role as a tumor suppressor or oncogene. 3. **Neurological disorders**: DUSP10 dysregulation has been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 4. **Immunodeficiency disorders**: DUSP10 dysregulation has been implicated in immunodeficiency disorders, including HIV infection and immunodeficiency associated with chronic inflammation. In conclusion, DUSP10 is a critical regulator of signaling pathways involved in immune responses, cell migration, proliferation, and differentiation. Its dysregulation has been implicated in various diseases, including inflammatory, neurological, and immunodeficiency disorders. Further research is needed to fully elucidate the role of DUSP10 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 3194919034

Symbol: DUS10_HUMAN

Name: Dual specificity protein phosphatase 10

UniProtKB Accession Codes:

Q9Y6W6 D3DTB4 Q6GSI4 Q9H9Z5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 12 ChEMBL 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 3 ELM 1 EMBL 11 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 31 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 19 PDBsum 15 PRINTS 2 PRO 1 PROSITE 4 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 9 SABIO-RK 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10391943

Title: Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5.

PubMed ID: 10391943

DOI: 10.1074/jbc.274.28.19949

PubMed ID: 10597297

Title: MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases.

PubMed ID: 10597297

DOI: 10.1038/sj.onc.1203185

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 29043977

Title: A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis.

PubMed ID: 29043977

DOI: 10.7554/elife.27356

PubMed ID: 16806267

Title: Crystal structure of the catalytic domain of human MAP kinase phosphatase 5: structural insight into constitutively active phosphatase.

PubMed ID: 16806267

DOI: 10.1016/j.jmb.2006.05.059

PubMed ID: 17400920

Title: Crystal structure of the MAP kinase binding domain and the catalytic domain of human MKP5.

PubMed ID: 17400920

DOI: 10.1110/ps.062712807

PubMed ID: 22375048

Title: A distinct interaction mode revealed by the crystal structure of the kinase p38alpha with the MAPK binding domain of the phosphatase MKP5.

PubMed ID: 22375048

DOI: 10.1126/scisignal.2002241

Sequence Information:

  • Length: 482
  • Mass: 52642
  • Checksum: A8CB74ABF9498CD4
  • Sequence:
    • MPPSPLDDRV VVALSRPVRP QDLNLCLDSS YLGSANPGSN SHPPVIATTV VSLKAANLTY 
MPSSSGSARS LNCGCSSASC CTVATYDKDN QAQTQAIAAG TTTTAIGTST TCPANQMVNN 
NENTGSLSPS SGVGSPVSGT PKQLASIKII YPNDLAKKMT KCSKSHLPSQ GPVIIDCRPF 
MEYNKSHIQG AVHINCADKI SRRRLQQGKI TVLDLISCRE GKDSFKRIFS KEIIVYDENT 
NEPSRVMPSQ PLHIVLESLK REGKEPLVLK GGLSSFKQNH ENLCDNSLQL QECREVGGGA 
SAASSLLPQP IPTTPDIENA ELTPILPFLF LGNEQDAQDL DTMQRLNIGY VINVTTHLPL 
YHYEKGLFNY KRLPATDSNK QNLRQYFEEA FEFIEEAHQC GKGLLIHCQA GVSRSATIVI 
AYLMKHTRMT MTDAYKFVKG KRPIISPNLN FMGQLLEFEE DLNNGVTPRI LTPKLMGVET 
VV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.