DUSP10 | ENSG00000143507 | NCBI 11221

Details for: DUSP10

Gene ID: 11221

Symbol: DUSP10

Ensembl ID: ENSG00000143507

Description: dual specificity phosphatase 10

Associated with

Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Negative regulation of mapk pathway
(R-HSA-5675221)
Oncogenic mapk signaling
(R-HSA-6802957)
Raf-independent mapk1/3 activation
(R-HSA-112409)
Raf/map kinase cascade
(R-HSA-5673001)
Signaling by mapk mutants
(R-HSA-9652817)
Signal transduction
(R-HSA-162582)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dephosphorylation
(GO:0016311)
Jun kinase binding
(GO:0008432)
Map kinase phosphatase activity
(GO:0033549)
Map kinase tyrosine/serine/threonine phosphatase activity
(GO:0017017)
Map kinase tyrosine phosphatase activity
(GO:0033550)
Mitogen-activated protein kinase p38 binding
(GO:0048273)
Myosin phosphatase activity
(GO:0017018)
Negative regulation of cell migration
(GO:0030336)
Negative regulation of epithelial cell migration
(GO:0010633)
Negative regulation of epithelial cell proliferation
(GO:0050680)
Negative regulation of epithelium regeneration
(GO:1905042)
Negative regulation of erk1 and erk2 cascade
(GO:0070373)
Negative regulation of jnk cascade
(GO:0046329)
Negative regulation of jun kinase activity
(GO:0043508)
Negative regulation of oligodendrocyte differentiation
(GO:0048715)
Negative regulation of p38mapk cascade
(GO:1903753)
Negative regulation of respiratory burst involved in inflammatory response
(GO:0060266)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Oligodendrocyte differentiation
(GO:0048709)
Peptidyl-threonine dephosphorylation
(GO:0035970)
Peptidyl-tyrosine dephosphorylation
(GO:0035335)
Peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
(GO:1990264)
Phosphatase activity
(GO:0016791)
Positive regulation of regulatory t cell differentiation
(GO:0045591)
Protein binding
(GO:0005515)
Protein tyrosine/threonine phosphatase activity
(GO:0008330)
Regulation of adaptive immune response
(GO:0002819)
Regulation of brown fat cell differentiation
(GO:0090335)
Response to lipopolysaccharide
(GO:0032496)
Stress-activated mapk cascade
(GO:0051403)

Other Information

Proteins

Dual specificity protein phosphatase 10

Genular Protein ID: 3194919034

Symbol: DUS10_HUMAN

Name: Dual specificity protein phosphatase 10

UniProtKB Accession Codes:

Q9Y6W6 D3DTB4 Q6GSI4 Q9H9Z5

Database IDs:

Citations:

PubMed ID: 10391943

Title: Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5.

PubMed ID: 10391943

DOI: 10.1074/jbc.274.28.19949

PubMed ID: 10597297

Title: MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases.

PubMed ID: 10597297

DOI: 10.1038/sj.onc.1203185

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 29043977

Title: A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis.

PubMed ID: 29043977

DOI: 10.7554/elife.27356

PubMed ID: 16806267

Title: Crystal structure of the catalytic domain of human MAP kinase phosphatase 5: structural insight into constitutively active phosphatase.

PubMed ID: 16806267

DOI: 10.1016/j.jmb.2006.05.059

PubMed ID: 17400920

Title: Crystal structure of the MAP kinase binding domain and the catalytic domain of human MKP5.

PubMed ID: 17400920

DOI: 10.1110/ps.062712807

PubMed ID: 22375048

Title: A distinct interaction mode revealed by the crystal structure of the kinase p38alpha with the MAPK binding domain of the phosphatase MKP5.

PubMed ID: 22375048

DOI: 10.1126/scisignal.2002241

Sequence Information:

Length: 482
Mass: 52642
Checksum: A8CB74ABF9498CD4
Sequence:

MPPSPLDDRV VVALSRPVRP QDLNLCLDSS YLGSANPGSN SHPPVIATTV VSLKAANLTY 
MPSSSGSARS LNCGCSSASC CTVATYDKDN QAQTQAIAAG TTTTAIGTST TCPANQMVNN 
NENTGSLSPS SGVGSPVSGT PKQLASIKII YPNDLAKKMT KCSKSHLPSQ GPVIIDCRPF 
MEYNKSHIQG AVHINCADKI SRRRLQQGKI TVLDLISCRE GKDSFKRIFS KEIIVYDENT 
NEPSRVMPSQ PLHIVLESLK REGKEPLVLK GGLSSFKQNH ENLCDNSLQL QECREVGGGA 
SAASSLLPQP IPTTPDIENA ELTPILPFLF LGNEQDAQDL DTMQRLNIGY VINVTTHLPL 
YHYEKGLFNY KRLPATDSNK QNLRQYFEEA FEFIEEAHQC GKGLLIHCQA GVSRSATIVI 
AYLMKHTRMT MTDAYKFVKG KRPIISPNLN FMGQLLEFEE DLNNGVTPRI LTPKLMGVET 
VV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: DUSP10

Associated with

Other Information

Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5. PubMed ID: 10391943

MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases. PubMed ID: 10597297

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis. PubMed ID: 29043977

Crystal structure of the catalytic domain of human MAP kinase phosphatase 5: structural insight into constitutively active phosphatase. PubMed ID: 16806267

Crystal structure of the MAP kinase binding domain and the catalytic domain of human MKP5. PubMed ID: 17400920

A distinct interaction mode revealed by the crystal structure of the kinase p38alpha with the MAPK binding domain of the phosphatase MKP5. PubMed ID: 22375048