CHN1 | ENSG00000128656 | NCBI 1123

Details for: CHN1

Gene ID: 1123

Symbol: CHN1

Ensembl ID: ENSG00000128656

Description: chimerin 1

Associated with

Cdc42 gtpase cycle
(R-HSA-9013148)
Rac1 gtpase cycle
(R-HSA-9013149)
Rho gtpase cycle
(R-HSA-9012999)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Cytosol
(GO:0005829)
Ephrin receptor binding
(GO:0046875)
Ephrin receptor signaling pathway
(GO:0048013)
Gtpase activator activity
(GO:0005096)
Metal ion binding
(GO:0046872)
Motor neuron axon guidance
(GO:0008045)
Protein binding
(GO:0005515)
Regulation of axonogenesis
(GO:0050770)
Regulation of gtpase activity
(GO:0043087)
Regulation of small gtpase mediated signal transduction
(GO:0051056)

Other Information

Proteins

N-chimaerin

Genular Protein ID: 3591359956

Symbol: CHIN_HUMAN

Name: N-chimaerin

UniProtKB Accession Codes:

P15882 A8K1M6 B3KNU6 B4DV19 Q53SD6 Q53SH5 Q96FB0

Database IDs:

Citations:

PubMed ID: 2299665

Title: Novel human brain cDNA encoding a 34,000 Mr protein n-chimaerin, related to both the regulatory domain of protein kinase C and BCR, the product of the breakpoint cluster region gene.

PubMed ID: 2299665

DOI: 10.1016/0022-2836(90)90006-8

PubMed ID: 1445199

Title: Developmental regulation and neuronal expression of the mRNA of rat n-chimaerin, a p21rac GAP:cDNA sequence.

PubMed ID: 1445199

DOI: 10.1042/bj2870415

PubMed ID: 8336731

Title: Alpha 2-chimerin, an SH2-containing GTPase-activating protein for the ras-related protein p21rac derived by alternate splicing of the human n-chimerin gene, is selectively expressed in brain regions and testes.

PubMed ID: 8336731

DOI: 10.1128/mcb.13.8.4986-4998.1993

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7867622

Title: Promoter region of the transcriptional unit for human alpha 1-chimaerin, a neuron-specific GTPase-activating protein for p21rac.

PubMed ID: 7867622

DOI: 10.1111/j.1432-1033.1995.tb20183.x

PubMed ID: 2268301

Title: Human brain n-chimaerin cDNA encodes a novel phorbol ester receptor.

PubMed ID: 2268301

DOI: 10.1042/bj2720767

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 18653847

Title: Human CHN1 mutations hyperactivate alpha2-chimaerin and cause Duane's retraction syndrome.

PubMed ID: 18653847

DOI: 10.1126/science.1156121

Sequence Information:

Length: 459
Mass: 53172
Checksum: 04C4CC9BCC611389
Sequence:

MALTLFDTDE YRPPVWKSYL YQLQQEAPHP RRITCTCEVE NRPKYYGREF HGMISREAAD 
QLLIVAEGSY LIRESQRQPG TYTLALRFGS QTRNFRLYYD GKHFVGEKRF ESIHDLVTDG 
LITLYIETKA AEYIAKMTIN PIYEHVGYTT LNREPAYKKH MPVLKETHDE RDSTGQDGVS 
EKRLTSLVRR ATLKENEQIP KYEKIHNFKV HTFRGPHWCE YCANFMWGLI AQGVKCADCG 
LNVHKQCSKM VPNDCKPDLK HVKKVYSCDL TTLVKAHTTK RPMVVDMCIR EIESRGLNSE 
GLYRVSGFSD LIEDVKMAFD RDGEKADISV NMYEDINIIT GALKLYFRDL PIPLITYDAY 
PKFIESAKIM DPDEQLETLH EALKLLPPAH CETLRYLMAH LKRVTLHEKE NLMNAENLGI 
VFGPTLMRSP ELDAMAALND IRYQRLVVEL LIKNEDILF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CHN1

Associated with

Other Information

Novel human brain cDNA encoding a 34,000 Mr protein n-chimaerin, related to both the regulatory domain of protein kinase C and BCR, the product of the breakpoint cluster region gene. PubMed ID: 2299665

Developmental regulation and neuronal expression of the mRNA of rat n-chimaerin, a p21rac GAP:cDNA sequence. PubMed ID: 1445199

Alpha 2-chimerin, an SH2-containing GTPase-activating protein for the ras-related protein p21rac derived by alternate splicing of the human n-chimerin gene, is selectively expressed in brain regions and testes. PubMed ID: 8336731

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Promoter region of the transcriptional unit for human alpha 1-chimaerin, a neuron-specific GTPase-activating protein for p21rac. PubMed ID: 7867622

Human brain n-chimaerin cDNA encodes a novel phorbol ester receptor. PubMed ID: 2268301

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Human CHN1 mutations hyperactivate alpha2-chimaerin and cause Duane's retraction syndrome. PubMed ID: 18653847