Details for: CHN1

Gene ID: 1123

Symbol: CHN1

Ensembl ID: ENSG00000128656

Description: chimerin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 377.2536
    Cell Significance Index: -58.6800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 234.5419
    Cell Significance Index: -59.4900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 121.6421
    Cell Significance Index: -57.4300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 103.5551
    Cell Significance Index: -42.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 47.6011
    Cell Significance Index: -58.6900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 44.1349
    Cell Significance Index: -42.1400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 20.5505
    Cell Significance Index: -63.1200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.0733
    Cell Significance Index: -59.4800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.6154
    Cell Significance Index: -27.6100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 6.4590
    Cell Significance Index: 184.3200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 4.9681
    Cell Significance Index: 106.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 4.2781
    Cell Significance Index: 287.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 3.9102
    Cell Significance Index: 219.4200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.5646
    Cell Significance Index: 157.6700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 3.4422
    Cell Significance Index: 56.7200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.3945
    Cell Significance Index: 128.5400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.2478
    Cell Significance Index: 170.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.2079
    Cell Significance Index: 643.5100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 3.1402
    Cell Significance Index: 41.8900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 2.6346
    Cell Significance Index: 20.3100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.6243
    Cell Significance Index: 32.5500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.0932
    Cell Significance Index: 756.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9191
    Cell Significance Index: 329.6700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9152
    Cell Significance Index: 181.6200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.6791
    Cell Significance Index: 14.8700
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.5821
    Cell Significance Index: 8.1400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5644
    Cell Significance Index: 34.6900
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.5347
    Cell Significance Index: 5.5700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4655
    Cell Significance Index: 59.6700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4167
    Cell Significance Index: 31.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.4123
    Cell Significance Index: 187.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.4090
    Cell Significance Index: 259.7500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.3598
    Cell Significance Index: 489.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3159
    Cell Significance Index: 486.3000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1995
    Cell Significance Index: 37.9600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1244
    Cell Significance Index: 112.3300
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.0852
    Cell Significance Index: 0.9400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0724
    Cell Significance Index: 136.4100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0120
    Cell Significance Index: 6.5600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0043
    Cell Significance Index: 0.1500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0045
    Cell Significance Index: -0.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0090
    Cell Significance Index: -16.5100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0222
    Cell Significance Index: -13.8700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0261
    Cell Significance Index: -19.3600
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0305
    Cell Significance Index: -0.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0424
    Cell Significance Index: -23.9100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0843
    Cell Significance Index: -63.8000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1027
    Cell Significance Index: -14.9300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.1284
    Cell Significance Index: -56.7900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1341
    Cell Significance Index: -0.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1571
    Cell Significance Index: -7.1200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1647
    Cell Significance Index: -47.3800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1652
    Cell Significance Index: -5.7400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1659
    Cell Significance Index: -34.9500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1830
    Cell Significance Index: -29.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1840
    Cell Significance Index: -33.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2198
    Cell Significance Index: -37.5300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2251
    Cell Significance Index: -29.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2327
    Cell Significance Index: -31.9500
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.2497
    Cell Significance Index: -2.2000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.2514
    Cell Significance Index: -24.8700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2611
    Cell Significance Index: -2.8500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2927
    Cell Significance Index: -7.0200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.3489
    Cell Significance Index: -42.9100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.3795
    Cell Significance Index: -41.2800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4062
    Cell Significance Index: -21.1600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4222
    Cell Significance Index: -43.9700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4437
    Cell Significance Index: -27.2000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4548
    Cell Significance Index: -53.6400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4666
    Cell Significance Index: -54.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.4790
    Cell Significance Index: -48.9300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4844
    Cell Significance Index: -55.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.5442
    Cell Significance Index: -15.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5506
    Cell Significance Index: -63.0800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5698
    Cell Significance Index: -35.9100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6063
    Cell Significance Index: -48.0200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.6190
    Cell Significance Index: -42.8100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6457
    Cell Significance Index: -21.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6854
    Cell Significance Index: -51.0800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6908
    Cell Significance Index: -22.0000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.7929
    Cell Significance Index: -47.6000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.8123
    Cell Significance Index: -13.9200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.8187
    Cell Significance Index: -57.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.8255
    Cell Significance Index: -23.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.8277
    Cell Significance Index: -53.4000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.8593
    Cell Significance Index: -40.3900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.8962
    Cell Significance Index: -17.7200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.9067
    Cell Significance Index: -15.1800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.9157
    Cell Significance Index: -13.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9618
    Cell Significance Index: -30.8100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.0097
    Cell Significance Index: -27.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.0155
    Cell Significance Index: -52.7500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.0639
    Cell Significance Index: -22.5800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0891
    Cell Significance Index: -32.0800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.0894
    Cell Significance Index: -28.6500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.1425
    Cell Significance Index: -28.5600
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -1.1596
    Cell Significance Index: -12.0100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -1.1724
    Cell Significance Index: -16.7900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.2093
    Cell Significance Index: -42.3700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.2107
    Cell Significance Index: -14.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CHN1 is a cytoplasmic protein that belongs to the Rho GTPase-activating protein (RhoGAP) family. It is characterized by its ability to regulate the activity of small GTPases, including Cdc42, Rac1, and RhoA, by accelerating their GTP hydrolysis. This action modulates various signaling pathways, including those involved in cytoskeleton reorganization, cell migration, and immune responses. **Pathways and Functions:** CHN1 is involved in several key pathways, including: 1. **Cytoskeleton dynamics:** CHN1 regulates the activity of Cdc42 and Rac1, which are essential for cytoskeleton reorganization and cell migration. 2. **Ephrin receptor signaling:** CHN1 interacts with Ephrin receptors to modulate their signaling activity, which is involved in axon guidance, cell migration, and immune responses. 3. **Rho GTPase cycle:** CHN1 regulates the activity of RhoA, which is involved in cell contraction, cytoskeleton organization, and immune responses. 4. **Signaling by Rho GTPases:** CHN1 modulates the activity of Rho GTPases, including Miro and RhobtB3, which are involved in axon guidance and immune responses. CHN1's functions in these pathways are essential for various cellular processes, including: * Axon guidance and neuronal development * Cell migration and immune responses * Cytoskeleton organization and dynamics * Signaling by Rho GTPases **Significantly Expressed Cells:** CHN1 is highly expressed in various cell types, including: * Epithelial cells of the alveolus of the lung * Mature astrocytes * GABAergic amacrine cells * Ciliary muscle cells * Pulmonary interstitial fibroblasts * Glycinergic neurons * Pyramidal neurons * Astrocytes of the cerebral cortex * Cerebral cortex neurons **Clinical Significance:** Dysregulation of CHN1 has been implicated in various diseases, including: * Neurological disorders, such as Alzheimer's disease and Parkinson's disease * Immune disorders, such as multiple sclerosis and rheumatoid arthritis * Cancer, including metastasis and tumor growth Understanding the role of CHN1 in these diseases can provide valuable insights into the development of novel therapeutic strategies. In conclusion, CHN1 is a multifunctional GTPase regulator that plays a crucial role in various cellular processes, including cytoskeleton dynamics, signaling pathways, and immune responses. Further research on CHN1's functions and dysregulation in disease can lead to the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 3591359956

Symbol: CHIN_HUMAN

Name: N-chimaerin

UniProtKB Accession Codes:

P15882 A8K1M6 B3KNU6 B4DV19 Q53SD6 Q53SH5 Q96FB0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 3 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2299665

Title: Novel human brain cDNA encoding a 34,000 Mr protein n-chimaerin, related to both the regulatory domain of protein kinase C and BCR, the product of the breakpoint cluster region gene.

PubMed ID: 2299665

DOI: 10.1016/0022-2836(90)90006-8

PubMed ID: 1445199

Title: Developmental regulation and neuronal expression of the mRNA of rat n-chimaerin, a p21rac GAP:cDNA sequence.

PubMed ID: 1445199

DOI: 10.1042/bj2870415

PubMed ID: 8336731

Title: Alpha 2-chimerin, an SH2-containing GTPase-activating protein for the ras-related protein p21rac derived by alternate splicing of the human n-chimerin gene, is selectively expressed in brain regions and testes.

PubMed ID: 8336731

DOI: 10.1128/mcb.13.8.4986-4998.1993

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7867622

Title: Promoter region of the transcriptional unit for human alpha 1-chimaerin, a neuron-specific GTPase-activating protein for p21rac.

PubMed ID: 7867622

DOI: 10.1111/j.1432-1033.1995.tb20183.x

PubMed ID: 2268301

Title: Human brain n-chimaerin cDNA encodes a novel phorbol ester receptor.

PubMed ID: 2268301

DOI: 10.1042/bj2720767

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 18653847

Title: Human CHN1 mutations hyperactivate alpha2-chimaerin and cause Duane's retraction syndrome.

PubMed ID: 18653847

DOI: 10.1126/science.1156121

Sequence Information:

  • Length: 459
  • Mass: 53172
  • Checksum: 04C4CC9BCC611389
  • Sequence:
    • MALTLFDTDE YRPPVWKSYL YQLQQEAPHP RRITCTCEVE NRPKYYGREF HGMISREAAD 
QLLIVAEGSY LIRESQRQPG TYTLALRFGS QTRNFRLYYD GKHFVGEKRF ESIHDLVTDG 
LITLYIETKA AEYIAKMTIN PIYEHVGYTT LNREPAYKKH MPVLKETHDE RDSTGQDGVS 
EKRLTSLVRR ATLKENEQIP KYEKIHNFKV HTFRGPHWCE YCANFMWGLI AQGVKCADCG 
LNVHKQCSKM VPNDCKPDLK HVKKVYSCDL TTLVKAHTTK RPMVVDMCIR EIESRGLNSE 
GLYRVSGFSD LIEDVKMAFD RDGEKADISV NMYEDINIIT GALKLYFRDL PIPLITYDAY 
PKFIESAKIM DPDEQLETLH EALKLLPPAH CETLRYLMAH LKRVTLHEKE NLMNAENLGI 
VFGPTLMRSP ELDAMAALND IRYQRLVVEL LIKNEDILF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.