Details for: CHN1
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 29.98rCSI 38.65%PRS 60.08
-
CSI 29.36rCSI 70.23%PRS 63.98
-
CSI 28.83rCSI 62.53%PRS 64.7
-
CSI 23.04rCSI 56%PRS 56.9
-
CSI 23.01rCSI 31.46%PRS 80.04
-
CSI 22.33rCSI 73.38%PRS 63.39
-
CSI 21.31rCSI 56.74%PRS 65
-
CSI 19.84rCSI 62.02%PRS 60.56
-
CSI 16.99rCSI 61.14%PRS 56.82
-
CSI 16.8rCSI 31.46%PRS 65.19
-
CSI 16.21rCSI 61.25%PRS 59.34
-
CSI 15.77rCSI 32.41%PRS 64.75
-
CSI 15.15rCSI 30.08%PRS 73.24
-
CSI 13.44rCSI 16.72%PRS 56.78
-
CSI 12.29rCSI 39.34%PRS 74.21
-
CSI 11.64rCSI 17.11%PRS 69.96
-
CSI 11.52rCSI 23.91%PRS 73.91
-
CSI 11.15rCSI 38.18%PRS 63.71
-
CSI 10.35rCSI 60.94%PRS 59.67
-
CSI 10.16rCSI 14.58%PRS 66.88
-
CSI 9.01rCSI 7.32%PRS 76.62
-
CSI 8.99rCSI 36.62%PRS 69.45
-
CSI 8.83rCSI 43.88%PRS 72.51
-
CSI 8.76rCSI 13.98%PRS 68.8
-
CSI 8.1rCSI 21.37%PRS 84.29
-
CSI 8.04rCSI 32.43%PRS 76.62
-
CSI 7.09rCSI 14.24%PRS 66.91
-
CSI 6.98rCSI 16.12%PRS 65.1
-
CSI 6.97rCSI 15.62%PRS 59.57
-
CSI 6.95rCSI 12.28%PRS 58.06
-
CSI 6.77rCSI 15.46%PRS 68.51
-
CSI 6.56rCSI 13.31%PRS 55.39
-
CSI 6.36rCSI 8.83%PRS 75.91
-
CSI 6.17rCSI 23.3%PRS 60.06
-
CSI 6.05rCSI 8.24%PRS 68.58
-
CSI 5.89rCSI 9.48%PRS 60.56
-
CSI 5.84rCSI 50.28%PRS 64.76
-
CSI 5.81rCSI 4.6%PRS 65.41
-
CSI 5.75rCSI 42.27%PRS 64.22
-
CSI 5.74rCSI 7.85%PRS 81.72
-
CSI 5.67rCSI 9.99%PRS 73.02
-
CSI 5.55rCSI 16.38%PRS 76.47
-
CSI 5.43rCSI 15.43%PRS 73.42
-
CSI 5.23rCSI 9.17%PRS 70.51
-
CSI 5.22rCSI 6.7%PRS 73.42
-
CSI 5.18rCSI 40.11%PRS 72.06
-
CSI 5.06rCSI 8.75%PRS 68.37
-
CSI 4.99rCSI 8.03%PRS 66.94
-
CSI 4.97rCSI 7.91%PRS 69.96
-
CSI 4.92rCSI 5.68%PRS 69.4
-
CSI 4.83rCSI 6.2%PRS 67.52
-
CSI 4.82rCSI 7.16%PRS 77.39
-
CSI 4.67rCSI 25.51%PRS 73.97
-
CSI 4.52rCSI 11.63%PRS 74.49
-
CSI 4.47rCSI 4.9%PRS 79.35
-
CSI 4.41rCSI 10.05%PRS 71.29
-
CSI 4.02rCSI 17.88%PRS 77.57
-
CSI 3.83rCSI 12.84%PRS 61.11
-
CSI 3.81rCSI 4.55%PRS 58.83
-
CSI 3.76rCSI 10.9%PRS 66.4
-
CSI 3.74rCSI 24.83%PRS 72.65
-
CSI 3.69rCSI 7.35%PRS 89.46
-
CSI 3.64rCSI 16.02%PRS 65.7
-
CSI 3.64rCSI 15.13%PRS 77.36
-
CSI 3.61rCSI 6.36%PRS 82.96
-
CSI 3.57rCSI 15.19%PRS 69.78
-
CSI 3.54rCSI 5.65%PRS 80.97
-
CSI 3.41rCSI 3.36%PRS 80.12
-
CSI 3.31rCSI 6.01%PRS 68.5
-
CSI 3.26rCSI 2.87%PRS 65.99
-
CSI 3.19rCSI 20.42%PRS 74.27
-
CSI 3.11rCSI 14.89%PRS 73.92
-
CSI 3.1rCSI 5.08%PRS 66.51
-
CSI 3.04rCSI 5.1%PRS 58.87
-
CSI 3.03rCSI 18.92%PRS 68.76
-
CSI 2.68rCSI 2.81%PRS 80.66
-
CSI 2.66rCSI 4.06%PRS 73.88
-
CSI 2.62rCSI 2.08%PRS 93.37
-
CSI 2.61rCSI 3.86%PRS 81.63
-
CSI 2.61rCSI 14.74%PRS 62.89
-
CSI 2.6rCSI 6.45%PRS 76.65
-
CSI 2.6rCSI 9.91%PRS 67.94
-
CSI 2.59rCSI 62.1%PRS 57.29
-
CSI 2.58rCSI 6.73%PRS 72.3
-
CSI 2.58rCSI 8.07%PRS 63.03
-
CSI 2.57rCSI 61.89%PRS 57.84
-
CSI 2.5rCSI 6.88%PRS 72.22
-
CSI 2.43rCSI 3.31%PRS 86.02
-
CSI 2.39rCSI 1.86%PRS 80.82
-
CSI 2.37rCSI 10.6%PRS 61.33
-
CSI 2.16rCSI 2.75%PRS 82.29
-
CSI 2.14rCSI 2.93%PRS 69.14
-
CSI 2.11rCSI 5.65%PRS 68.49
-
CSI 1.8rCSI 5.21%PRS 76.85
-
CSI 1.7rCSI 26.81%PRS 79.06
-
CSI 1.65rCSI 2.61%PRS 78.89
-
CSI 1.55rCSI 7.65%PRS 85.35
-
CSI 1.48rCSI 3.27%PRS 62.79
-
CSI 1.43rCSI 4.02%PRS 72.27
-
CSI 1.38rCSI 5.47%PRS 73.65
-
CSI 0.5rCSI 1.3%PRS 70.5%
-
CSI 0.5rCSI 6.8%PRS 79.9%
-
CSI 0.7rCSI 2.7%PRS 85.5%
-
CSI 0.7rCSI 3.1%PRS 72.7%
-
CSI 0.7rCSI 2.4%PRS 79.5%
-
CSI 0.8rCSI 5.4%PRS 68.7%
-
CSI 0.8rCSI 8.8%PRS 66.7%
-
CSI 0.8rCSI 6.4%PRS 70.9%
-
CSI 0.9rCSI 1.3%PRS 77.3%
-
CSI 0.9rCSI 6.4%PRS 70.6%
-
CSI 1.0rCSI 6.2%PRS 84.1%
-
CSI 1.0rCSI 8.5%PRS 65.9%
-
CSI 1.0rCSI 16.6%PRS 87.8%
-
CSI 1.1rCSI 15.0%PRS 68.0%
-
CSI 1.1rCSI 1.3%PRS 58.7%
-
CSI 1.1rCSI 8.5%PRS 68.7%
-
CSI 1.2rCSI 10.8%PRS 79.9%
-
CSI 1.2rCSI 6.9%PRS 69.7%
-
CSI 1.2rCSI 8.4%PRS 70.6%
-
CSI 1.3rCSI 2.9%PRS 76.5%
-
CSI 1.4rCSI 5.5%PRS 73.7%
-
CSI 1.4rCSI 4.0%PRS 72.3%
-
CSI 1.5rCSI 3.3%PRS 62.8%
-
CSI 1.6rCSI 7.7%PRS 85.4%
-
CSI 1.7rCSI 2.6%PRS 78.9%
-
CSI 1.7rCSI 26.8%PRS 79.1%
-
CSI 1.8rCSI 5.2%PRS 76.9%
-
CSI 2.1rCSI 5.7%PRS 68.5%
-
CSI 2.1rCSI 2.9%PRS 69.1%
-
CSI 2.2rCSI 2.8%PRS 82.3%
-
CSI 2.4rCSI 10.6%PRS 61.3%
-
CSI 2.4rCSI 1.9%PRS 80.8%
-
CSI 2.4rCSI 3.3%PRS 86.0%
-
CSI 2.5rCSI 6.9%PRS 72.2%
-
CSI 2.6rCSI 61.9%PRS 57.8%
-
CSI 2.6rCSI 8.1%PRS 63.0%
-
CSI 2.6rCSI 6.7%PRS 72.3%
-
CSI 2.6rCSI 62.1%PRS 57.3%
-
CSI 2.6rCSI 9.9%PRS 67.9%
-
CSI 2.6rCSI 6.5%PRS 76.7%
-
CSI 2.6rCSI 14.7%PRS 62.9%
-
CSI 2.6rCSI 3.9%PRS 81.6%
-
CSI 2.6rCSI 2.1%PRS 93.4%
-
CSI 2.7rCSI 4.1%PRS 73.9%
-
CSI 2.7rCSI 2.8%PRS 80.7%
-
CSI 3.0rCSI 18.9%PRS 68.8%
-
CSI 3.0rCSI 5.1%PRS 58.9%
-
CSI 3.1rCSI 5.1%PRS 66.5%
-
CSI 3.1rCSI 14.9%PRS 73.9%
-
CSI 3.2rCSI 20.4%PRS 74.3%
-
CSI 3.3rCSI 2.9%PRS 66.0%
-
CSI 3.3rCSI 6.0%PRS 68.5%
-
CSI 3.4rCSI 3.4%PRS 80.1%
-
CSI 3.5rCSI 5.7%PRS 81.0%
-
CSI 3.6rCSI 15.2%PRS 69.8%
-
CSI 3.6rCSI 6.4%PRS 83.0%
-
CSI 3.6rCSI 15.1%PRS 77.4%
-
CSI 3.6rCSI 16.0%PRS 65.7%
-
CSI 3.7rCSI 7.4%PRS 89.5%
-
CSI 3.7rCSI 24.8%PRS 72.7%
-
CSI 3.8rCSI 10.9%PRS 66.4%
-
CSI 3.8rCSI 4.6%PRS 58.8%
-
CSI 3.8rCSI 12.8%PRS 61.1%
-
CSI 4.0rCSI 17.9%PRS 77.6%
-
CSI 4.4rCSI 10.1%PRS 71.3%
-
CSI 4.5rCSI 4.9%PRS 79.4%
-
CSI 4.5rCSI 11.6%PRS 74.5%
-
CSI 4.7rCSI 25.5%PRS 74.0%
-
CSI 4.8rCSI 7.2%PRS 77.4%
-
CSI 4.8rCSI 6.2%PRS 67.5%
-
CSI 4.9rCSI 5.7%PRS 69.4%
-
CSI 5.0rCSI 7.9%PRS 70.0%
-
CSI 5.0rCSI 8.0%PRS 66.9%
-
CSI 5.1rCSI 8.8%PRS 68.4%
-
CSI 5.2rCSI 40.1%PRS 72.1%
-
CSI 5.2rCSI 6.7%PRS 73.4%
-
CSI 5.2rCSI 9.2%PRS 70.5%
-
CSI 5.4rCSI 15.4%PRS 73.4%
-
CSI 5.6rCSI 16.4%PRS 76.5%
-
CSI 5.7rCSI 10.0%PRS 73.0%
-
CSI 5.7rCSI 7.9%PRS 81.7%
-
CSI 5.8rCSI 42.3%PRS 64.2%
-
CSI 5.8rCSI 4.6%PRS 65.4%
-
CSI 5.8rCSI 50.3%PRS 64.8%
-
CSI 5.9rCSI 9.5%PRS 60.6%
-
CSI 6.1rCSI 8.2%PRS 68.6%
-
CSI 6.2rCSI 23.3%PRS 60.1%
-
CSI 6.4rCSI 8.8%PRS 75.9%
-
CSI 6.6rCSI 13.3%PRS 55.4%
-
CSI 6.8rCSI 15.5%PRS 68.5%
-
CSI 7.0rCSI 12.3%PRS 58.1%
-
CSI 7.0rCSI 15.6%PRS 59.6%
-
CSI 7.0rCSI 16.1%PRS 65.1%
-
CSI 7.1rCSI 14.2%PRS 66.9%
-
CSI 8.0rCSI 32.4%PRS 76.6%
-
CSI 8.1rCSI 21.4%PRS 84.3%
-
CSI 8.8rCSI 14.0%PRS 68.8%
-
CSI 8.8rCSI 43.9%PRS 72.5%
-
CSI 9.0rCSI 36.6%PRS 69.5%
-
CSI 9.0rCSI 7.3%PRS 76.6%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3591359956
Symbol: CHIN_HUMAN
Name: N-chimaerin
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2299665
Title: Novel human brain cDNA encoding a 34,000 Mr protein n-chimaerin, related to both the regulatory domain of protein kinase C and BCR, the product of the breakpoint cluster region gene.
PubMed ID: 2299665
PubMed ID: 1445199
Title: Developmental regulation and neuronal expression of the mRNA of rat n-chimaerin, a p21rac GAP:cDNA sequence.
PubMed ID: 1445199
DOI: 10.1042/bj2870415
PubMed ID: 8336731
Title: Alpha 2-chimerin, an SH2-containing GTPase-activating protein for the ras-related protein p21rac derived by alternate splicing of the human n-chimerin gene, is selectively expressed in brain regions and testes.
PubMed ID: 8336731
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7867622
Title: Promoter region of the transcriptional unit for human alpha 1-chimaerin, a neuron-specific GTPase-activating protein for p21rac.
PubMed ID: 7867622
PubMed ID: 2268301
Title: Human brain n-chimaerin cDNA encodes a novel phorbol ester receptor.
PubMed ID: 2268301
DOI: 10.1042/bj2720767
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 18653847
Title: Human CHN1 mutations hyperactivate alpha2-chimaerin and cause Duane's retraction syndrome.
PubMed ID: 18653847
Sequence Information:
- Length: 459
- Mass: 53172
- Checksum: 04C4CC9BCC611389
- Sequence:
MALTLFDTDE YRPPVWKSYL YQLQQEAPHP RRITCTCEVE NRPKYYGREF HGMISREAAD QLLIVAEGSY LIRESQRQPG TYTLALRFGS QTRNFRLYYD GKHFVGEKRF ESIHDLVTDG LITLYIETKA AEYIAKMTIN PIYEHVGYTT LNREPAYKKH MPVLKETHDE RDSTGQDGVS EKRLTSLVRR ATLKENEQIP KYEKIHNFKV HTFRGPHWCE YCANFMWGLI AQGVKCADCG LNVHKQCSKM VPNDCKPDLK HVKKVYSCDL TTLVKAHTTK RPMVVDMCIR EIESRGLNSE GLYRVSGFSD LIEDVKMAFD RDGEKADISV NMYEDINIIT GALKLYFRDL PIPLITYDAY PKFIESAKIM DPDEQLETLH EALKLLPPAH CETLRYLMAH LKRVTLHEKE NLMNAENLGI VFGPTLMRSP ELDAMAALND IRYQRLVVEL LIKNEDILF