SEC63 | ENSG00000025796 | NCBI 11231

Details for: SEC63

Gene ID: 11231

Symbol: SEC63

Ensembl ID: ENSG00000025796

Description: SEC63 homolog, protein translocation regulator

Associated with

Endoplasmic reticulum
(GO:0005783)
Liver development
(GO:0001889)
Membrane
(GO:0016020)
Nitrogen compound metabolic process
(GO:0006807)
Post-translational protein targeting to endoplasmic reticulum membrane
(GO:0006620)
Post-translational protein targeting to membrane, translocation
(GO:0031204)
Protein binding
(GO:0005515)
Protein targeting to membrane
(GO:0006612)
Protein transmembrane transporter activity
(GO:0008320)
Rna binding
(GO:0003723)
Sec62/sec63 complex
(GO:0031207)
Signaling receptor activity
(GO:0038023)
Srp-dependent cotranslational protein targeting to membrane
(GO:0006614)

Other Information

Proteins

Translocation protein SEC63 homolog

Genular Protein ID: 3837859818

Symbol: SEC63_HUMAN

Name: Translocation protein SEC63 homolog

UniProtKB Accession Codes:

Q9UGP8 O95380 Q5THN4 Q86VS9 Q8IWL0 Q9NTE0

Database IDs:

Citations:

PubMed ID: 10543453

Title: Molecular characterization of a novel mammalian DnaJ-like Sec63p homolog.

PubMed ID: 10543453

DOI: 10.1515/bc.1999.142

PubMed ID: 10799540

Title: Mammalian Sec61 is associated with Sec62 and Sec63.

PubMed ID: 10799540

DOI: 10.1074/jbc.275.19.14550

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15133510

Title: Mutations in SEC63 cause autosomal dominant polycystic liver disease.

PubMed ID: 15133510

DOI: 10.1038/ng1357

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22375059

Title: Different effects of Sec61alpha, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells.

PubMed ID: 22375059

DOI: 10.1242/jcs.096727

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29719251

Title: Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier.

PubMed ID: 29719251

DOI: 10.1016/j.celrep.2018.03.122

PubMed ID: 28375157

Title: Isolated polycystic liver disease genes define effectors of polycystin-1 function.

PubMed ID: 28375157

DOI: 10.1172/jci90129

Sequence Information:

Length: 760
Mass: 87997
Checksum: 81BBF269A3FCCF0D
Sequence:

MAGQQFQYDD SGNTFFYFLT SFVGLIVIPA TYYLWPRDQN AEQIRLKNIR KVYGRCMWYR 
LRLLKPQPNI IPTVKKIVLL AGWALFLFLA YKVSKTDREY QEYNPYEVLN LDPGATVAEI 
KKQYRLLSLK YHPDKGGDEV MFMRIAKAYA ALTDEESRKN WEEFGNPDGP QATSFGIALP 
AWIVDQKNSI LVLLVYGLAF MVILPVVVGS WWYRSIRYSG DQILIRTTQI YTYFVYKTRN 
MDMKRLIMVL AGASEFDPQY NKDATSRPTD NILIPQLIRE IGSINLKKNE PPLTCPYSLK 
ARVLLLSHLA RMKIPETLEE DQQFMLKKCP ALLQEMVNVI CQLIVMARNR EEREFRAPTL 
ASLENCMKLS QMAVQGLQQF KSPLLQLPHI EEDNLRRVSN HKKYKIKTIQ DLVSLKESDR 
HTLLHFLEDE KYEEVMAVLG SFPYVTMDIK SQVLDDEDSN NITVGSLVTV LVKLTRQTMA 
EVFEKEQSIC AAEEQPAEDG QGETNKNRTK GGWQQKSKGP KKTAKSKKKK PLKKKPTPVL 
LPQSKQQKQK QANGVVGNEA AVKEDEEEVS DKGSDSEEEE TNRDSQSEKD DGSDRDSDRE 
QDEKQNKDDE AEWQELQQSI QRKERALLET KSKITHPVYS LYFPEEKQEW WWLYIADRKE 
QTLISMPYHV CTLKDTEEVE LKFPAPGKPG NYQYTVFLRS DSYMGLDQIK PLKLEVHEAK 
PVPENHPQWD TAIEGDEDQE DSEGFEDSFE EEEEEEEDDD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SEC63

Associated with

Other Information

Molecular characterization of a novel mammalian DnaJ-like Sec63p homolog. PubMed ID: 10543453

Mammalian Sec61 is associated with Sec62 and Sec63. PubMed ID: 10799540

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

Mutations in SEC63 cause autosomal dominant polycystic liver disease. PubMed ID: 15133510

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Initial characterization of the human central proteome. PubMed ID: 21269460

Different effects of Sec61alpha, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. PubMed ID: 22375059

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier. PubMed ID: 29719251

Isolated polycystic liver disease genes define effectors of polycystin-1 function. PubMed ID: 28375157