Details for: POLG2
Associated with
Other Information
Genular Protein ID: 757451300
Symbol: DPOG2_HUMAN
Name: DNA polymerase subunit gamma-2, mitochondrial
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10608893
Title: The mitochondrial p55 accessory subunit of human DNA polymerase gamma enhances DNA binding, promotes processive DNA synthesis, and confers N-ethylmaleimide resistance.
PubMed ID: 10608893
PubMed ID: 10666468
Title: Protein sequences conserved in prokaryotic aminoacyl-tRNA synthetases are important for the activity of the processivity factor of human mitochondrial DNA polymerase.
PubMed ID: 10666468
PubMed ID: 10677218
Title: Human mitochondrial DNA polymerase holoenzyme: reconstitution and characterization.
PubMed ID: 10677218
DOI: 10.1021/bi992104w
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9153213
Title: Accessory subunit of mitochondrial DNA polymerase from Drosophila embryos. Cloning, molecular analysis, and association in the native enzyme.
PubMed ID: 9153213
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 30157269
Title: Characterization of the human homozygous R182W POLG2 mutation in mitochondrial DNA depletion syndrome.
PubMed ID: 30157269
PubMed ID: 16685652
Title: Mutant POLG2 disrupts DNA polymerase gamma subunits and causes progressive external ophthalmoplegia.
PubMed ID: 16685652
DOI: 10.1086/504303
PubMed ID: 18195150
Title: Progressive external ophthalmoplegia and vision and hearing loss in a patient with mutations in POLG2 and OPA1.
PubMed ID: 18195150
PubMed ID: 27592148
Title: Whole exome sequencing identifies a homozygous POLG2 missense variant in an infant with fulminant hepatic failure and mitochondrial DNA depletion.
PubMed ID: 27592148
PubMed ID: 31778857
Title: Whole exome sequencing identifies a homozygous POLG2 missense variant in an adult patient presenting with optic atrophy, movement disorders, premature ovarian failure and mitochondrial DNA depletion.
PubMed ID: 31778857
Sequence Information:
- Length: 485
- Mass: 54911
- Checksum: B99734BFEA249192
- Sequence:
MRSRVAVRAC HKVCRCLLSG FGGRVDAGQP ELLTERSSPK GGHVKSHAEL EGNGEHPEAP GSGEGSEALL EICQRRHFLS GSKQQLSRDS LLSGCHPGFG PLGVELRKNL AAEWWTSVVV FREQVFPVDA LHHKPGPLLP GDSAFRLVSA ETLREILQDK ELSKEQLVAF LENVLKTSGK LRENLLHGAL EHYVNCLDLV NKRLPYGLAQ IGVCFHPVFD TKQIRNGVKS IGEKTEASLV WFTPPRTSNQ WLDFWLRHRL QWWRKFAMSP SNFSSSDCQD EEGRKGNKLY YNFPWGKELI ETLWNLGDHE LLHMYPGNVS KLHGRDGRKN VVPCVLSVNG DLDRGMLAYL YDSFQLTENS FTRKKNLHRK VLKLHPCLAP IKVALDVGRG PTLELRQVCQ GLFNELLENG ISVWPGYLET MQSSLEQLYS KYDEMSILFT VLVTETTLEN GLIHLRSRDT TMKEMMHISK LKDFLIKYIS SAKNV
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.