PDCD10 | ENSG00000114209 | NCBI 11235

Details for: PDCD10

Gene ID: 11235

Symbol: PDCD10

Ensembl ID: ENSG00000114209

Description: programmed cell death 10

Associated with

Angiogenesis
(GO:0001525)
Cellular response to leukemia inhibitory factor
(GO:1990830)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endothelium development
(GO:0003158)
Establishment of golgi localization
(GO:0051683)
Extracellular exosome
(GO:0070062)
Far/sin/stripak complex
(GO:0090443)
Golgi apparatus
(GO:0005794)
Golgi membrane
(GO:0000139)
Golgi reassembly
(GO:0090168)
Intrinsic apoptotic signaling pathway in response to hydrogen peroxide
(GO:0036481)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
(GO:1903588)
Negative regulation of cell migration involved in sprouting angiogenesis
(GO:0090051)
Negative regulation of gene expression
(GO:0010629)
Plasma membrane
(GO:0005886)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of intracellular protein transport
(GO:0090316)
Positive regulation of map kinase activity
(GO:0043406)
Positive regulation of notch signaling pathway
(GO:0045747)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of protein serine/threonine kinase activity
(GO:0071902)
Positive regulation of stress-activated mapk cascade
(GO:0032874)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein kinase binding
(GO:0019901)
Protein stabilization
(GO:0050821)
Regulation of angiogenesis
(GO:0045765)
Regulation of golgi organization
(GO:1903358)
Regulation of rho protein signal transduction
(GO:0035023)
Stress-activated protein kinase signaling cascade
(GO:0031098)
Stress fiber assembly
(GO:0043149)
Wound healing, spreading of cells
(GO:0044319)

Other Information

Proteins

Programmed cell death protein 10

Genular Protein ID: 2835407588

Symbol: PDC10_HUMAN

Name: Programmed cell death protein 10

UniProtKB Accession Codes:

Q9BUL8 A8K515 D3DNN5 O14811

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15543491

Title: Mutations within the programmed cell death 10 gene cause cerebral cavernous malformations.

PubMed ID: 15543491

DOI: 10.1086/426952

PubMed ID: 17360971

Title: PDCD10 interacts with Ste20-related kinase MST4 to promote cell growth and transformation via modulation of the ERK pathway.

PubMed ID: 17360971

DOI: 10.1091/mbc.e06-07-0608

PubMed ID: 19370760

Title: Functional analyses of human and zebrafish 18-amino acid in-frame deletion pave the way for domain mapping of the cerebral cavernous malformation 3 protein.

PubMed ID: 19370760

DOI: 10.1002/humu.20996

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20332113

Title: CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation.

PubMed ID: 20332113

DOI: 10.1242/jcs.061341

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27807006

Title: RHO binding to FAM65A regulates Golgi reorientation during cell migration.

PubMed ID: 27807006

DOI: 10.1242/jcs.198614

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 20489202

Title: Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity.

PubMed ID: 20489202

DOI: 10.1074/jbc.m110.128470

Sequence Information:

Length: 212
Mass: 24702
Checksum: 5AA613F71FAAEF56
Sequence:

MRMTMEEMKN EAETTSMVSM PLYAVMYPVF NELERVNLSA AQTLRAAFIK AEKENPGLTQ 
DIIMKILEKK SVEVNFTESL LRMAADDVEE YMIERPEPEF QDLNEKARAL KQILSKIPDE 
INDRVRFLQT IKDIASAIKE LLDTVNNVFK KYQYQNRRAL EHQKKEFVKY SKSFSDTLKT 
YFKDGKAINV FVSANRLIHQ TNLILQTFKT VA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PDCD10

Associated with

Other Information

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mutations within the programmed cell death 10 gene cause cerebral cavernous malformations. PubMed ID: 15543491

PDCD10 interacts with Ste20-related kinase MST4 to promote cell growth and transformation via modulation of the ERK pathway. PubMed ID: 17360971

Functional analyses of human and zebrafish 18-amino acid in-frame deletion pave the way for domain mapping of the cerebral cavernous malformation 3 protein. PubMed ID: 19370760

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation. PubMed ID: 20332113

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

RHO binding to FAM65A regulates Golgi reorientation during cell migration. PubMed ID: 27807006

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity. PubMed ID: 20489202