RNF139 | ENSG00000170881 | NCBI 11236

Details for: RNF139

Gene ID: 11236

Symbol: RNF139

Ensembl ID: ENSG00000170881

Description: ring finger protein 139

Associated with

Asparagine n-linked glycosylation
(R-HSA-446203)
Calnexin/calreticulin cycle
(R-HSA-901042)
Er quality control compartment (erqc)
(R-HSA-901032)
Metabolism of proteins
(R-HSA-392499)
N-glycan trimming in the er and calnexin/calreticulin cycle
(R-HSA-532668)
Post-translational protein modification
(R-HSA-597592)
Derlin-1 retrotranslocation complex
(GO:0036513)
Endomembrane system
(GO:0012505)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Erad pathway
(GO:0036503)
Membrane
(GO:0016020)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of translation
(GO:0017148)
Positive regulation of ubiquitin-dependent protein catabolic process
(GO:2000060)
Protease binding
(GO:0002020)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein binding
(GO:0005515)
Protein destabilization
(GO:0031648)
Protein ubiquitination
(GO:0016567)
Regulation of er to golgi vesicle-mediated transport
(GO:0060628)
Regulation of protein processing
(GO:0070613)
Signaling receptor activity
(GO:0038023)
Ubiquitin-like protein transferase activity
(GO:0019787)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin protein ligase activity
(GO:0061630)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

E3 ubiquitin-protein ligase RNF139

Genular Protein ID: 422891609

Symbol: RN139_HUMAN

Name: E3 ubiquitin-protein ligase RNF139

UniProtKB Accession Codes:

Q8WU17 B3KMD5 O75485 Q7LDL3

Database IDs:

Citations:

PubMed ID: 9689122

Title: The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8.

PubMed ID: 9689122

DOI: 10.1073/pnas.95.16.9572

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10500182

Title: RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination.

PubMed ID: 10500182

DOI: 10.1073/pnas.96.20.11364

PubMed ID: 12032852

Title: The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway.

PubMed ID: 12032852

DOI: 10.1038/sj.onc.1205437

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17016439

Title: RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene.

PubMed ID: 17016439

DOI: 10.1038/sj.onc.1210017

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19706601

Title: The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavage.

PubMed ID: 19706601

DOI: 10.1074/jbc.m109.041376

PubMed ID: 19720873

Title: The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER.

PubMed ID: 19720873

DOI: 10.1083/jcb.200906110

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068067

Title: The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways.

PubMed ID: 20068067

DOI: 10.1158/1541-7786.mcr-08-0491

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22143767

Title: Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8.

PubMed ID: 22143767

DOI: 10.1073/pnas.1112831108

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23223569

Title: Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet-associated endoplasmic reticulum membranes.

PubMed ID: 23223569

DOI: 10.1091/mbc.e12-07-0564

PubMed ID: 25239945

Title: Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u.

PubMed ID: 25239945

DOI: 10.15252/embj.201488208

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

Length: 664
Mass: 75994
Checksum: 9885F5915F019EF5
Sequence:

MAAVGPPQQQ VRMAHQQVWA ALEVALRVPC LYIIDAIFNS YPDSSQSRFC IVLQIFLRLF 
GVFASSIVLI LSQRSLFKFY TYSSAFLLAA TSVLVNYYAS LHIDFYGAYN TSAFGIELLP 
RKGPSLWMAL IVLQLTFGIG YVTLLQIHSI YSQLIILDLL VPVIGLITEL PLHIRETLLF 
TSSLILTLNT VFVLAVKLKW FYYSTRYVYL LVRHMYRIYG LQLLMEDTWK RIRFPDILRV 
FWLTRVTAQA TVLMYILRMA NETDSFFISW DDFWDLICNL IISGCDSTLT VLGMSAVISS 
VAHYLGLGIL AFIGSTEEDD RRLGFVAPVL FFILALQTGL SGLRPEERLI RLSRNMCLLL 
TAVLHFIHGM TDPVLMSLSA SHVSSFRRHF PVLFVSACLF ILPVLLSYVL WHHYALNTWL 
FAVTAFCVEL CLKVIVSLTV YTLFMIDGYY NVLWEKLDDY VYYVRSTGSI IEFIFGVVMF 
GNGAYTMMFE SGSKIRAFMM CLHAYFNIYL QAKNGWKTFM NRRTAVKKIN SLPEIKGSRL 
QEINDVCAIC YHEFTTSARI TPCNHYFHAL CLRKWLYIQD TCPMCHQKVY IEDDIKDNSN 
VSNNNGFIPP NETPEEAVRE AAAESDRELN EDDSTDCDDD VQRERNGVIQ HTGAAAEEFN 
DDTD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RNF139

Associated with

Other Information

The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8. PubMed ID: 9689122

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. PubMed ID: 10500182

The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway. PubMed ID: 12032852

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene. PubMed ID: 17016439

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavage. PubMed ID: 19706601

The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER. PubMed ID: 19720873

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways. PubMed ID: 20068067

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8. PubMed ID: 22143767

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet-associated endoplasmic reticulum membranes. PubMed ID: 23223569

Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u. PubMed ID: 25239945

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569