Details for: RNF24

Gene ID: 11237

Symbol: RNF24

Ensembl ID: ENSG00000101236

Description: ring finger protein 24

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.97
    Marker Score: 100,389
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.44
    Marker Score: 12,811
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.41
    Marker Score: 12,931
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.3
    Marker Score: 45,724
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.23
    Marker Score: 84,597
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.17
    Marker Score: 8,976
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.14
    Marker Score: 1,895
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.14
    Marker Score: 31,927
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.1
    Marker Score: 77,491
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.06
    Marker Score: 15,824
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.05
    Marker Score: 6,858
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.97
    Marker Score: 9,114
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.96
    Marker Score: 1,360
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.94
    Marker Score: 14,617
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.92
    Marker Score: 7,405
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.9
    Marker Score: 40,546
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.9
    Marker Score: 1,102
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.86
    Marker Score: 17,534
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.81
    Marker Score: 111,479
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.8
    Marker Score: 17,125
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.78
    Marker Score: 4,087
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.7
    Marker Score: 14,592
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.65
    Marker Score: 2,000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.63
    Marker Score: 16,872
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.59
    Marker Score: 1,833
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.58
    Marker Score: 662
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.58
    Marker Score: 2,433
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.54
    Marker Score: 593
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.47
    Marker Score: 5,977
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,533
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.44
    Marker Score: 2,936
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.41
    Marker Score: 451
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.4
    Marker Score: 672
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.39
    Marker Score: 1,466
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.39
    Marker Score: 814
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.38
    Marker Score: 3,425
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.37
    Marker Score: 1,475
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.31
    Marker Score: 737
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.3
    Marker Score: 998
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.29
    Marker Score: 737
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.26
    Marker Score: 1,779
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.2
    Marker Score: 1,220
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.19
    Marker Score: 860
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.18
    Marker Score: 1,319
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.17
    Marker Score: 39,897
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.17
    Marker Score: 2,251
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.17
    Marker Score: 375
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.16
    Marker Score: 18,202
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.16
    Marker Score: 333
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.15
    Marker Score: 313
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.13
    Marker Score: 714
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.13
    Marker Score: 470
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.12
    Marker Score: 3,200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.12
    Marker Score: 968
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.12
    Marker Score: 1,399
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.1
    Marker Score: 1,372
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.09
    Marker Score: 1,321
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.09
    Marker Score: 2,482
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.08
    Marker Score: 602
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.07
    Marker Score: 17,249
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.07
    Marker Score: 621
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.06
    Marker Score: 59,364
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.06
    Marker Score: 695
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.03
    Marker Score: 1,832
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.03
    Marker Score: 1,275
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.03
    Marker Score: 11,568
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.01
    Marker Score: 575
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1
    Marker Score: 5,998
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,709
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1
    Marker Score: 1,340
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,934
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.99
    Marker Score: 1,232
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.99
    Marker Score: 592
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,393
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.98
    Marker Score: 1,507
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.97
    Marker Score: 527
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.95
    Marker Score: 1,012
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.95
    Marker Score: 236
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.95
    Marker Score: 447
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.94
    Marker Score: 1,586
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,399
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.94
    Marker Score: 212
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.94
    Marker Score: 6,120
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.94
    Marker Score: 236
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 484
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.94
    Marker Score: 12,359
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.93
    Marker Score: 1,353
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 440
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.93
    Marker Score: 9,415
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.93
    Marker Score: 325
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.92
    Marker Score: 584
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.92
    Marker Score: 1,353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,709
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.9
    Marker Score: 230
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.9
    Marker Score: 315
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.9
    Marker Score: 390
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.9
    Marker Score: 302
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.9
    Marker Score: 1,268
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.88
    Marker Score: 437
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.88
    Marker Score: 284

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNF24, encoded by the ENSG00000101236 gene, is a member of the RING finger protein family, characterized by its unique structural motif. Its expression is predominantly observed in cells of the nervous system, including Purkinje cells, neurons, and cortical interneurons. The gene's significantly expressed cells suggest a specialized role in the development and maintenance of neural circuits. **Pathways and Functions:** RNF24's involvement in various cellular pathways is a subject of ongoing research. The gene's association with the Golgi apparatus, Golgi membrane, protein binding, and zinc ion binding suggests a role in protein regulation, modification, and degradation. These processes are crucial for maintaining cellular homeostasis and responding to environmental changes. Notably, RNF24's interaction with zinc ions implies a potential role in modulating the activity of enzymes and proteins involved in signal transduction pathways. **Clinical Significance:** Despite its intriguing characteristics, the clinical significance of RNF24 remains unclear. However, its expression in specific cell types, such as cortical interneurons, highlights the importance of this gene in the development and function of neural circuits. Alterations in RNF24 expression or function may contribute to neurological disorders, such as epilepsy, schizophrenia, or autism spectrum disorder. Further research is necessary to elucidate the molecular mechanisms underlying RNF24's role in these conditions and to explore potential therapeutic strategies. **Implications and Future Directions:** The study of RNF24 offers a unique opportunity to investigate the complex relationships between gene expression, protein regulation, and neural function. Future research should focus on: 1. Elucidating the molecular mechanisms underlying RNF24's role in neural circuit development and function. 2. Investigating the genetic and environmental factors that regulate RNF24 expression and its impact on neurological disorders. 3. Developing novel therapeutic strategies targeting RNF24 or its associated pathways to treat diseases related to altered neural circuit function. In conclusion, RNF24's enigmatic nature belies a complex and intriguing role in cellular processes. Further research is necessary to unravel the mysteries of this gene and its potential implications for human health and disease.

Genular Protein ID: 441139761

Symbol: RNF24_HUMAN

Name: RING finger protein 24

UniProtKB Accession Codes:

Q9Y225 D3DVZ2 D3DVZ3 Q9UMH1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 4 EvolutionaryTrace 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 7 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17850865

Title: RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC.

PubMed ID: 17850865

DOI: 10.1016/j.ceca.2007.07.009

Sequence Information:

  • Length: 148
  • Mass: 17210
  • Checksum: 66C240C3A5991EA5
  • Sequence:
    • MSSDFPHYNF RMPNIGFQNL PLNIYIVVFG TAIFVFILSL LFCCYLIRLR HQAHKEFYAY 
KQVILKEKVK ELNLHELCAV CLEDFKPRDE LGICPCKHAF HRKCLIKWLE VRKVCPLCNM 
PVLQLAQLHS KQDRGPPQGP LPGAENIV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.