Details for: CA5B

Gene ID: 11238

Symbol: CA5B

Ensembl ID: ENSG00000169239

Description: carbonic anhydrase 5B

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.38
    Marker Score: 5,919
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.34
    Marker Score: 2,073
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.32
    Marker Score: 12,379
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.3
    Marker Score: 777
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.3
    Marker Score: 12,335
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.29
    Marker Score: 1,566
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.28
    Marker Score: 78,891
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.28
    Marker Score: 11,001
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.26
    Marker Score: 5,290
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.26
    Marker Score: 46,342
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.23
    Marker Score: 26,337
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.19
    Marker Score: 17,756
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.18
    Marker Score: 44,786
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.18
    Marker Score: 62,168
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.16
    Marker Score: 4,477
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.12
    Marker Score: 22,348
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.12
    Marker Score: 8,594
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.12
    Marker Score: 1,950
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.08
    Marker Score: 2,645
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.07
    Marker Score: 940
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.06
    Marker Score: 16,662
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.04
    Marker Score: 10,693
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.03
    Marker Score: 3,263
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.03
    Marker Score: 4,264
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.01
    Marker Score: 4,116
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.01
    Marker Score: 1,977
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1
    Marker Score: 433
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,730
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,955
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.99
    Marker Score: 10,077
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.99
    Marker Score: 597
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,398
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.98
    Marker Score: 11,345
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.97
    Marker Score: 712
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.97
    Marker Score: 509
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.96
    Marker Score: 1,059
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.96
    Marker Score: 647
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 484
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.94
    Marker Score: 680
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 439
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.92
    Marker Score: 996
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.91
    Marker Score: 2,005
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,719
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.9
    Marker Score: 529
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.89
    Marker Score: 835
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.89
    Marker Score: 497
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.89
    Marker Score: 2,093
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.87
    Marker Score: 1,776
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4,958
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 312
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.87
    Marker Score: 421
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.86
    Marker Score: 832
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.85
    Marker Score: 979
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.85
    Marker Score: 837
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.85
    Marker Score: 248
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.83
    Marker Score: 1,606
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.83
    Marker Score: 1,115
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.83
    Marker Score: 1,220
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.81
    Marker Score: 255
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.81
    Marker Score: 276
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 608
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.79
    Marker Score: 256
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.79
    Marker Score: 1,084
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.78
    Marker Score: 975
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 309
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.77
    Marker Score: 3,222
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.76
    Marker Score: 611
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.76
    Marker Score: 241
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1,237
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.76
    Marker Score: 622
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.75
    Marker Score: 544
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.74
    Marker Score: 834
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.73
    Marker Score: 791
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.73
    Marker Score: 462
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 376
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.72
    Marker Score: 445
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.71
    Marker Score: 403
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 621
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.67
    Marker Score: 233
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.67
    Marker Score: 980
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.67
    Marker Score: 37,626
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.66
    Marker Score: 332
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.66
    Marker Score: 231
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.66
    Marker Score: 1,843
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.64
    Marker Score: 338
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.64
    Marker Score: 3,839
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.64
    Marker Score: 441
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.63
    Marker Score: 582
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.63
    Marker Score: 203
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.63
    Marker Score: 548
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.63
    Marker Score: 562
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.63
    Marker Score: 483
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.62
    Marker Score: 231
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.62
    Marker Score: 363
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.62
    Marker Score: 550
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.62
    Marker Score: 449
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.61
    Marker Score: 624

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Mitochondrial localization**: CA5B is primarily localized to the mitochondrial matrix, where it participates in the reversible hydration of carbon dioxide, a process essential for maintaining pH homeostasis within the cell. 2. **Zinc ion binding**: CA5B exhibits a high affinity for zinc ions, which are essential cofactors for its enzymatic activity. 3. **Carbonate dehydratase activity**: CA5B catalyzes the reversible hydration of carbon dioxide, a reaction that is critical for maintaining cellular pH homeostasis. 4. **One-carbon metabolic process**: CA5B is involved in the one-carbon metabolic pathway, which is essential for the synthesis of nucleotides and the metabolism of amino acids. **Pathways and Functions:** 1. **Immune response**: CA5B is significantly expressed in T-helper 22 cells, a subset of immune cells that play a crucial role in regulating the immune response. 2. **Neurological function**: CA5B is expressed in neurons, including those found in the cerebral cortex, lens epithelium, and other brain regions. 3. **Metabolism**: CA5B participates in the one-carbon metabolic pathway, which is essential for the synthesis of nucleotides and the metabolism of amino acids. 4. **Response to bacterium**: CA5B is involved in the response to bacterial infections, where it helps to regulate the pH homeostasis and maintain the integrity of the cell membrane. **Clinical Significance:** 1. **Neurodegenerative diseases**: Dysregulation of CA5B has been implicated in various neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Immune disorders**: CA5B has been linked to immune disorders, including multiple sclerosis and inflammatory bowel disease. 3. **Cancer**: CA5B has been found to be overexpressed in various types of cancer, including breast cancer and lung cancer. 4. **Therapeutic potential**: CA5B inhibitors have been identified as potential therapeutic agents for the treatment of neurodegenerative diseases and cancer. In conclusion, the carbonic anhydrase 5B gene plays a critical role in regulating pH homeostasis, metabolism, and immune response. Its dysregulation has been implicated in various diseases, including neurodegenerative disorders and cancer. Further research is needed to fully understand the mechanisms underlying CA5B's role in human disease and to identify potential therapeutic agents.

Genular Protein ID: 1145220157

Symbol: CAH5B_HUMAN

Name: Carbonic anhydrase 5B, mitochondrial

UniProtKB Accession Codes:

Q9Y2D0 A8K4T5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DrugBank 4 DrugCentral 1 EC 2 EMBL 4 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10409679

Title: Human mitochondrial carbonic anhydrase VB: cDNA cloning, mRNA expression, subcellular localization, and mapping to chromosome X.

PubMed ID: 10409679

DOI: 10.1074/jbc.274.30.21228

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17705204

Title: Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste.

PubMed ID: 17705204

DOI: 10.1002/anie.200701189

PubMed ID: 17314045

Title: Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I.

PubMed ID: 17314045

DOI: 10.1016/j.bmcl.2007.01.113

PubMed ID: 19186056

Title: A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.

PubMed ID: 19186056

DOI: 10.1016/j.bmcl.2009.01.038

PubMed ID: 19206230

Title: Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors.

PubMed ID: 19206230

DOI: 10.1021/ja809683v

Sequence Information:

  • Length: 317
  • Mass: 36434
  • Checksum: 7CA11920EFF2588A
  • Sequence:
    • MVVMNSLRVI LQASPGKLLW RKFQIPRFMP ARPCSLYTCT YKTRNRALHP LWESVDLVPG 
GDRQSPINIR WRDSVYDPGL KPLTISYDPA TCLHVWNNGY SFLVEFEDST DKSVIKGGPL 
EHNYRLKQFH FHWGAIDAWG SEHTVDSKCF PAELHLVHWN AVRFENFEDA ALEENGLAVI 
GVFLKLGKHH KELQKLVDTL PSIKHKDALV EFGSFDPSCL MPTCPDYWTY SGSLTTPPLS 
ESVTWIIKKQ PVEVDHDQLE QFRTLLFTSE GEKEKRMVDN FRPLQPLMNR TVRSSFRHDY 
VLNVQAKPKP ATSQATP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.