Genular: Defining Cellular Identity and Function

Details for: PMF1

Gene ID: 11243

Symbol: PMF1

Ensembl ID: ENSG00000160783

Description: polyamine modulated factor 1

Associated with

Amplification of signal from the kinetochores
(R-HSA-141424)
Amplification of signal from unattached kinetochores via a mad2 inhibitory signal
(R-HSA-141444)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Eml4 and nudc in mitotic spindle formation
(R-HSA-9648025)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Separation of sister chromatids
(R-HSA-2467813)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Attachment of spindle microtubules to kinetochore
(GO:0008608)
Cell division
(GO:0051301)
Chromosome segregation
(GO:0007059)
Cytosol
(GO:0005829)
Golgi apparatus
(GO:0005794)
Intracellular membrane-bounded organelle
(GO:0043231)
Kinetochore
(GO:0000776)
Leucine zipper domain binding
(GO:0043522)
Mis12/mind type complex
(GO:0000444)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of dna-templated transcription
(GO:0045893)
Protein binding
(GO:0005515)
Spindle pole
(GO:0000922)
Transcription by rna polymerase ii
(GO:0006366)
Transcription coactivator activity
(GO:0003713)
Transcription regulator complex
(GO:0005667)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: pancreatic A cell (CL0000171)
Fold Change: 4.01
Marker Score: 3,924
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 2.19
Marker Score: 952
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 2.11
Marker Score: 1,934
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 1.94
Marker Score: 4,056
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.86
Marker Score: 7,323
Cell Name: neural crest cell (CL0011012)
Fold Change: 1.77
Marker Score: 1,896
Cell Name: kidney cell (CL1000497)
Fold Change: 1.73
Marker Score: 1,153
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.71
Marker Score: 3,600
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.69
Marker Score: 1,790
Cell Name: pro-T cell (CL0000827)
Fold Change: 1.66
Marker Score: 6,809
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.65
Marker Score: 3,878
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: 1.56
Marker Score: 948
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.52
Marker Score: 2,243
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.51
Marker Score: 5,588
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 1.5
Marker Score: 1,414
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 1.49
Marker Score: 3,658
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 1.47
Marker Score: 2,430
Cell Name: pneumocyte (CL0000322)
Fold Change: 1.44
Marker Score: 2,322
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.44
Marker Score: 5,548
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.43
Marker Score: 336
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 1.41
Marker Score: 3,901
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 1.38
Marker Score: 11,912
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 1.37
Marker Score: 966
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 1.36
Marker Score: 5,266
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 1.34
Marker Score: 1,326
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.29
Marker Score: 1,449
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.29
Marker Score: 708
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 1.25
Marker Score: 1,304
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 1.24
Marker Score: 365
Cell Name: decidual cell (CL2000002)
Fold Change: 1.24
Marker Score: 5,356
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.22
Marker Score: 1,288
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 1.2
Marker Score: 449
Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.19
Marker Score: 2,705
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 1.18
Marker Score: 341
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 1.17
Marker Score: 6,135
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.16
Marker Score: 2,640
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 1.14
Marker Score: 1,123
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 1.13
Marker Score: 1,923
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.13
Marker Score: 2,753
Cell Name: epithelial cell (CL0000066)
Fold Change: 1.12
Marker Score: 1,784
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.12
Marker Score: 1,165
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 1.12
Marker Score: 808
Cell Name: radial glial cell (CL0000681)
Fold Change: 1.11
Marker Score: 411
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 1.11
Marker Score: 1,714
Cell Name: stem cell (CL0000034)
Fold Change: 1.11
Marker Score: 2,643
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.11
Marker Score: 2,211
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 1.11
Marker Score: 446
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 1.1
Marker Score: 566
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 1.09
Marker Score: 1,159
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.09
Marker Score: 12,228
Cell Name: PP cell (CL0000696)
Fold Change: 1.08
Marker Score: 244
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 1.08
Marker Score: 355
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 1.08
Marker Score: 382
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.08
Marker Score: 848
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 1.06
Marker Score: 904
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 1.06
Marker Score: 208
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1.06
Marker Score: 1,071
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.05
Marker Score: 36,527
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 1.05
Marker Score: 4,384
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 1.05
Marker Score: 631
Cell Name: lung secretory cell (CL1000272)
Fold Change: 1.05
Marker Score: 934
Cell Name: proerythroblast (CL0000547)
Fold Change: 1.05
Marker Score: 710
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 1.04
Marker Score: 6,803
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 1.04
Marker Score: 580
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 1.04
Marker Score: 333
Cell Name: mesodermal cell (CL0000222)
Fold Change: 1.03
Marker Score: 13,558
Cell Name: peptic cell (CL0000155)
Fold Change: 1.03
Marker Score: 430
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 1.03
Marker Score: 645
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.02
Marker Score: 645
Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 1.01
Marker Score: 258
Cell Name: ionocyte (CL0005006)
Fold Change: 1.01
Marker Score: 306
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.01
Marker Score: 1,781
Cell Name: mature T cell (CL0002419)
Fold Change: 1
Marker Score: 9,947
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,643
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.99
Marker Score: 8,542
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47,865
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 0.99
Marker Score: 313
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 0.98
Marker Score: 671
Cell Name: enteric neuron (CL0007011)
Fold Change: 0.98
Marker Score: 524
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,383
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.95
Marker Score: 2,546
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.95
Marker Score: 710
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 0.94
Marker Score: 324
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2,388
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.93
Marker Score: 478
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.93
Marker Score: 3,852
Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.92
Marker Score: 924
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.92
Marker Score: 768
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.92
Marker Score: 5,245
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.92
Marker Score: 434
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,723
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.91
Marker Score: 980
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.9
Marker Score: 450
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 0.9
Marker Score: 902
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 0.89
Marker Score: 462
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.89
Marker Score: 361
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.89
Marker Score: 1,253
Cell Name: adventitial cell (CL0002503)
Fold Change: 0.88
Marker Score: 218
Cell Name: acinar cell (CL0000622)
Fold Change: 0.88
Marker Score: 620
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.87
Marker Score: 1,411

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

Description

**Key Characteristics:** 1. **Expression Pattern:** PMF1 is highly expressed in various cell types, including pancreatic A and D cells, choroid plexus epithelial cells, epithelial cells of nephrons, placental villous trophoblasts, neural crest cells, kidney cells, pancreatic acinar cells, and kidney epithelial cells. 2. **Mitotic Regulation:** PMF1 plays a critical role in the amplification of signals from kinetochores, attachment of spindle microtubules, and resolution of sister chromatid cohesion. 3. **Polyamine Modulation:** PMF1 is modulated by polyamines, which are essential for various cellular processes, including cell growth, proliferation, and differentiation. 4. **Leucine Zipper Domain Binding:** PMF1 contains a leucine zipper domain, which is involved in protein-protein interactions and transcriptional regulation. **Pathways and Functions:** 1. **Amplification of Signal from Kinetochores:** PMF1 is involved in the amplification of signals from kinetochores, which is crucial for accurate chromosome segregation during mitosis. 2. **Attachment of Spindle Microtubules to Kinetochore:** PMF1 plays a role in the attachment of spindle microtubules to kinetochores, which is essential for the proper alignment of chromosomes during mitosis. 3. **Resolution of Sister Chromatid Cohesion:** PMF1 is involved in the resolution of sister chromatid cohesion, which is necessary for the separation of sister chromatids during mitosis. 4. **Positive Regulation of DNA-templated Transcription:** PMF1 positively regulates DNA-templated transcription, which is essential for gene expression and cellular proliferation. **Clinical Significance:** 1. **Cancer:** PMF1 has been implicated in various types of cancer, including pancreatic cancer, where it is often overexpressed and associated with poor prognosis. 2. **Neurological Disorders:** PMF1 has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it may play a role in the regulation of mitotic processes and DNA damage response. 3. **Genetic Disorders:** PMF1 has been associated with genetic disorders, such as Down syndrome, where it may contribute to the development of mitotic errors and genomic instability. 4. **Pharmacological Applications:** PMF1 has potential as a therapeutic target for various diseases, including cancer and neurological disorders, where its inhibition or modulation may lead to improved treatment outcomes. In conclusion, PMF1 is a critical regulator of mitotic processes, playing a pivotal role in the amplification of signals from kinetochores, attachment of spindle microtubules, and resolution of sister chromatid cohesion. Its significant expression in various cell types and involvement in multiple cellular pathways make it an attractive target for therapeutic interventions in various diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.