Details for: NXPH3

Gene ID: 11248

Symbol: NXPH3

Ensembl ID: ENSG00000182575

Description: neurexophilin 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 871
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.17
    Marker Score: 18,306
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,693
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 797
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.03
    Marker Score: 2,087
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,830
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,055
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.97
    Marker Score: 2,465
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.97
    Marker Score: 1,837
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,351
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,738
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,287
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.84
    Marker Score: 401
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,261
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.66
    Marker Score: 394
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.6
    Marker Score: 396
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.58
    Marker Score: 5,487
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.57
    Marker Score: 4,934
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.55
    Marker Score: 231
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 146
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.54
    Marker Score: 238
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.52
    Marker Score: 119
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.43
    Marker Score: 245
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.42
    Marker Score: 608
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.39
    Marker Score: 667
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.35
    Marker Score: 376
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.35
    Marker Score: 182
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.3
    Marker Score: 304
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.28
    Marker Score: 80
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.26
    Marker Score: 581
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.26
    Marker Score: 243
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.25
    Marker Score: 520
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.24
    Marker Score: 156
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.22
    Marker Score: 57
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.21
    Marker Score: 68
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2
    Marker Score: 243
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.2
    Marker Score: 370
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.19
    Marker Score: 471
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.18
    Marker Score: 1,728
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.17
    Marker Score: 161
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.16
    Marker Score: 98
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.16
    Marker Score: 629
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.16
    Marker Score: 413
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.15
    Marker Score: 171
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.14
    Marker Score: 58
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.14
    Marker Score: 39
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.14
    Marker Score: 90
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.13
    Marker Score: 35
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.13
    Marker Score: 128
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.13
    Marker Score: 129
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.13
    Marker Score: 43
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.13
    Marker Score: 131
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.13
    Marker Score: 202
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.13
    Marker Score: 758
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.12
    Marker Score: 519
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.12
    Marker Score: 1,360
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.12
    Marker Score: 70
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.12
    Marker Score: 108
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.12
    Marker Score: 119
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.12
    Marker Score: 112
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.11
    Marker Score: 88
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.11
    Marker Score: 139
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.11
    Marker Score: 987
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.11
    Marker Score: 100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.11
    Marker Score: 842
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.11
    Marker Score: 95
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.11
    Marker Score: 98
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.11
    Marker Score: 71
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.11
    Marker Score: 4,003
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.11
    Marker Score: 33
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.1
    Marker Score: 133
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.1
    Marker Score: 61
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1
    Marker Score: 202
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.1
    Marker Score: 36
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.1
    Marker Score: 403
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1
    Marker Score: 379
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.09
    Marker Score: 63
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.09
    Marker Score: 102
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.09
    Marker Score: 65
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.09
    Marker Score: 51
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.09
    Marker Score: 30
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.09
    Marker Score: 35
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.09
    Marker Score: 555
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.09
    Marker Score: 1,827
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.08
    Marker Score: 45
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.08
    Marker Score: 74
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.08
    Marker Score: 18
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.08
    Marker Score: 28
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.08
    Marker Score: 237
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.08
    Marker Score: 29
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.08
    Marker Score: 19

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NXPH3 is a member of the neurexophilin family, which is characterized by its ability to interact with neuropeptides and other signaling molecules. The protein is primarily expressed in cells of the immune system, including granulocyte monocyte progenitor cells, early T lineage precursors, and intestinal crypt stem cells. Additionally, NXPH3 is also found in neural cells, such as cerebral cortex GABAergic interneurons and forebrain radial glial cells, highlighting its potential role in the nervous system. **Pathways and Functions:** NXPH3 is involved in various signaling pathways, including the neuropeptide signaling pathway, which is crucial for regulating immune responses, pain perception, and mood regulation. The protein's interaction with neuropeptides, such as neuropeptide Y (NPY), has been shown to modulate immune cell function, including the activation and proliferation of T cells and the production of cytokines. Furthermore, NXPH3 has been implicated in cellular homeostasis, regulating the balance between stem cell self-renewal and differentiation. **Clinical Significance:** Dysregulation of NXPH3 has been associated with various diseases, including autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis, as well as neurological conditions, such as Alzheimer's disease and Parkinson's disease. The protein's role in immune regulation and cellular homeostasis makes it a potential therapeutic target for the treatment of these diseases. Additionally, NXPH3's involvement in the neuropeptide signaling pathway highlights its potential role in modulating pain perception and mood regulation, making it a potential target for the treatment of mood disorders. **Implications for Immunology and Cellular Biology:** The study of NXPH3 has significant implications for our understanding of immune regulation and cellular homeostasis. The protein's role in modulating immune responses and cellular balance highlights the importance of maintaining the delicate balance between immune cell activation and suppression. Furthermore, the protein's involvement in the neuropeptide signaling pathway underscores the complex interplay between the immune system and the nervous system. In conclusion, NXPH3 is a critical protein involved in regulating immune responses, cellular homeostasis, and maintaining tissue integrity. Its dysregulation has been associated with various diseases, making it a potential therapeutic target for the treatment of autoimmune disorders, neurological conditions, and mood disorders. Further research is needed to fully elucidate the functions of NXPH3 and its role in human disease.

Genular Protein ID: 4110561216

Symbol: NXPH3_HUMAN

Name: Neurexophilin-3

UniProtKB Accession Codes:

O95157 Q8NDC3 Q8TBF6 Q9ULR1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10574461

Title: Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.

PubMed ID: 10574461

DOI: 10.1093/dnares/6.5.329

PubMed ID: 9570794

Title: Neurexophilins form a conserved family of neuropeptide-like glycoproteins.

PubMed ID: 9570794

DOI: 10.1523/jneurosci.18-10-03630.1998

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

Sequence Information:

  • Length: 252
  • Mass: 28127
  • Checksum: 74D2B3D5A89D221F
  • Sequence:
    • MQLTRCCFVF LVQGSLYLVI CGQDDGPPGS EDPERDDHEG QPRPRVPRKR GHISPKSRPM 
ANSTLLGLLA PPGEAWGILG QPPNRPNHSP PPSAKVKKIF GWGDFYSNIK TVALNLLVTG 
KIVDHGNGTF SVHFQHNATG QGNISISLVP PSKAVEFHQE QQIFIEAKAS KIFNCRMEWE 
KVERGRRTSL CTHDPAKICS RDHAQSSATW SCSQPFKVVC VYIAFYSTDY RLVQKVCPDY 
NYHSDTPYYP SG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.