Details for: NXPH2

Gene ID: 11249

Symbol: NXPH2

Ensembl ID: ENSG00000144227

Description: neurexophilin 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.14
    Marker Score: 3,160
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 2.81
    Marker Score: 5,808
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.65
    Marker Score: 7,565
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.62
    Marker Score: 1,382
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.19
    Marker Score: 1,510
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.18
    Marker Score: 32,548
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.04
    Marker Score: 19,199
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.9
    Marker Score: 2,127
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.55
    Marker Score: 2,929
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 868
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 1.33
    Marker Score: 3,822
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.26
    Marker Score: 46,599
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.2
    Marker Score: 548
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.15
    Marker Score: 2,340
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.11
    Marker Score: 7,409
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.1
    Marker Score: 21,925
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,801
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,024
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.99
    Marker Score: 319
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,405
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.97
    Marker Score: 4,498
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,312
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.93
    Marker Score: 490
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,739
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.91
    Marker Score: 14,286
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.91
    Marker Score: 1,658
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,282
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.83
    Marker Score: 500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 632
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.82
    Marker Score: 1,135
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,260
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.77
    Marker Score: 511
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7
    Marker Score: 2,719
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.69
    Marker Score: 315
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.64
    Marker Score: 372
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 464
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.57
    Marker Score: 2,351
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.57
    Marker Score: 346
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.56
    Marker Score: 1,285
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.54
    Marker Score: 515
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.54
    Marker Score: 1,263
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.53
    Marker Score: 2,153
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.53
    Marker Score: 352
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.52
    Marker Score: 248
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.51
    Marker Score: 247
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.5
    Marker Score: 4,718
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 473
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.49
    Marker Score: 170
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.48
    Marker Score: 153
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.45
    Marker Score: 845
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.39
    Marker Score: 4,059
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.38
    Marker Score: 172
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.38
    Marker Score: 94
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.37
    Marker Score: 126
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 370
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.37
    Marker Score: 147
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.36
    Marker Score: 213
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.36
    Marker Score: 404
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.36
    Marker Score: 132
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.34
    Marker Score: 108
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.32
    Marker Score: 143
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.32
    Marker Score: 1,342
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.32
    Marker Score: 509
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.32
    Marker Score: 189
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.31
    Marker Score: 517
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.3
    Marker Score: 11,510
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.3
    Marker Score: 124
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.29
    Marker Score: 92
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.29
    Marker Score: 76
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 0.27
    Marker Score: 79
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.27
    Marker Score: 205
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.27
    Marker Score: 726
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.27
    Marker Score: 423
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.25
    Marker Score: 220
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.25
    Marker Score: 74
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.23
    Marker Score: 52
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.23
    Marker Score: 50
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.23
    Marker Score: 155
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.21
    Marker Score: 101
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.21
    Marker Score: 52
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.21
    Marker Score: 115
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.2
    Marker Score: 108
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.2
    Marker Score: 51
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2
    Marker Score: 2,012
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2
    Marker Score: 116
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.19
    Marker Score: 322
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.18
    Marker Score: 50
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.18
    Marker Score: 103
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.18
    Marker Score: 212
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.18
    Marker Score: 82
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.17
    Marker Score: 50
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.17
    Marker Score: 44
  • Cell Name: mesothelial fibroblast (CL4023054)
    Fold Change: 0.17
    Marker Score: 50
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.17
    Marker Score: 47
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.17
    Marker Score: 229

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NXPH2 is a small, secreted protein with a molecular weight of approximately 12 kDa. It is highly expressed in various cell types, including blood vessel endothelial cells, kidney proximal convoluted tubule epithelial cells, retinal rod cells, and conventional dendritic cells. The protein has been shown to interact with various signaling molecules, including neurexophilin-related proteins, which are involved in the regulation of immune cell function and neuronal signaling. NXPH2 has also been implicated in the regulation of dendritic cell maturation and function, a process critical for the initiation of immune responses. **Pathways and Functions** NXPH2 is involved in several key pathways, including: 1. **Neuropeptide signaling pathway**: NXPH2 has been shown to interact with neuropeptides, such as neuropeptide Y, which is involved in the regulation of immune cell function and neuronal signaling. 2. **Signaling receptor binding**: NXPH2 has been shown to interact with various signaling receptors, including those involved in the regulation of immune cell function and tissue homeostasis. 3. **Dendritic cell maturation and function**: NXPH2 has been implicated in the regulation of dendritic cell maturation and function, a process critical for the initiation of immune responses. **Clinical Significance** NXPH2 has been implicated in several diseases, including: 1. **Autoimmune disorders**: NXPH2 has been shown to play a key role in the regulation of immune cell function and the maintenance of tissue homeostasis, suggesting a potential role in autoimmune disorders, such as rheumatoid arthritis and lupus. 2. **Neurological disorders**: NXPH2 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where impaired immune cell function and neuronal signaling have been observed. 3. **Cancer**: NXPH2 has been shown to be overexpressed in certain types of cancer, including breast cancer and lung cancer, suggesting a potential role in tumorigenesis and cancer progression. In conclusion, NXPH2 is a critical gene involved in the regulation of immune cell function, neuronal signaling, and tissue homeostasis. Its dysregulation has been implicated in several diseases, highlighting the potential for NXPH2 as a therapeutic target for the treatment of autoimmune disorders, neurological disorders, and cancer. Further research is needed to fully elucidate the role of NXPH2 in human disease and to explore its potential as a therapeutic agent.

Genular Protein ID: 1070523561

Symbol: NXPH2_HUMAN

Name: Neurexophilin-2

UniProtKB Accession Codes:

O95156 B7WP24 Q494R1 Q75QC3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 GO 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9570794

Title: Neurexophilins form a conserved family of neuropeptide-like glycoproteins.

PubMed ID: 9570794

DOI: 10.1523/jneurosci.18-10-03630.1998

Sequence Information:

  • Length: 264
  • Mass: 29938
  • Checksum: E793B5AD69FD0E71
  • Sequence:
    • MRLRPLPLVV VPGLLQLLFC DSKEVVHATE GLDWEDKDAP GTLVGNVVHS RIISPLRLFV 
KQSPVPKPGP MAYADSMENF WDWLANITEI QEPLARTKRR PIVKTGKFKK MFGWGDFHSN 
IKTVKLNLLI TGKIVDHGNG TFSVYFRHNS TGLGNVSVSL VPPSKVVEFE VSPQSTLETK 
ESKSFNCRIE YEKTDRAKKT ALCNFDPSKI CYQEQTQSHV SWLCSKPFKV ICIYIAFYSV 
DYKLVQKVCP DYNYHSETPY LSSG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.