Details for: SLC6A14

Gene ID: 11254

Symbol: SLC6A14

Ensembl ID: ENSG00000268104

Description: solute carrier family 6 member 14

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 8.45
    Marker Score: 23,860
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.09
    Marker Score: 1,398
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.77
    Marker Score: 1,207
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.66
    Marker Score: 817
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.38
    Marker Score: 3,155
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.33
    Marker Score: 8,678
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.29
    Marker Score: 939
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.24
    Marker Score: 1,995
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.18
    Marker Score: 552
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.12
    Marker Score: 324
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.1
    Marker Score: 7,322
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.05
    Marker Score: 714
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.05
    Marker Score: 434
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.97
    Marker Score: 446
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.94
    Marker Score: 257
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,310
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.88
    Marker Score: 254
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.88
    Marker Score: 6,553
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,283
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.84
    Marker Score: 884
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.82
    Marker Score: 1,500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.76
    Marker Score: 539
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2,989
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.64
    Marker Score: 409
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.63
    Marker Score: 8,512
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 479
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.58
    Marker Score: 339
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.58
    Marker Score: 678
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.56
    Marker Score: 2,964
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.55
    Marker Score: 1,035
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.47
    Marker Score: 142
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.45
    Marker Score: 143
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.44
    Marker Score: 3,812
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.44
    Marker Score: 891
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.44
    Marker Score: 434
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.43
    Marker Score: 972
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.43
    Marker Score: 257
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.43
    Marker Score: 185
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.42
    Marker Score: 188
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.34
    Marker Score: 325
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.34
    Marker Score: 331
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.34
    Marker Score: 356
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.33
    Marker Score: 298
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.32
    Marker Score: 2,067
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.31
    Marker Score: 347
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.29
    Marker Score: 462
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.29
    Marker Score: 91
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.29
    Marker Score: 886
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 91
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.26
    Marker Score: 235
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.26
    Marker Score: 489
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.25
    Marker Score: 1,212
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.25
    Marker Score: 147
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.25
    Marker Score: 63
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.24
    Marker Score: 148
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.24
    Marker Score: 3,715
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.22
    Marker Score: 392
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.22
    Marker Score: 374
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.21
    Marker Score: 55
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.2
    Marker Score: 72
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.2
    Marker Score: 45
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.19
    Marker Score: 249
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.19
    Marker Score: 45
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.18
    Marker Score: 2,917
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.18
    Marker Score: 70
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.18
    Marker Score: 45
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.18
    Marker Score: 92
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.18
    Marker Score: 44
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.18
    Marker Score: 46
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.18
    Marker Score: 367
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.17
    Marker Score: 168
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.17
    Marker Score: 69
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.17
    Marker Score: 592
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.17
    Marker Score: 81
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.16
    Marker Score: 41
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.16
    Marker Score: 109
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.16
    Marker Score: 45
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.16
    Marker Score: 44
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.15
    Marker Score: 155
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.15
    Marker Score: 361
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.15
    Marker Score: 68
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.15
    Marker Score: 44
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.15
    Marker Score: 152
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.14
    Marker Score: 99
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.14
    Marker Score: 45
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.14
    Marker Score: 43
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.14
    Marker Score: 42
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.14
    Marker Score: 79
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.13
    Marker Score: 35

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SLC6A14 is a member of the solute carrier family 6, which is characterized by its ability to transport various substrates across the plasma membrane. This gene is specifically involved in the transport of neutral, basic amino acids, such as alanine, beta-alanine, and proline, as well as aromatic amino acids like phenylalanine and tyrosine. The transport activity of SLC6A14 is mediated by a sodium-dependent mechanism, which is essential for maintaining the proper balance of amino acids across the plasma membrane. **Pathways and Functions:** SLC6A14 is involved in various cellular processes, including: 1. **Amino acid transport**: SLC6A14 plays a critical role in the transport of amino acids across the plasma membrane, which is essential for maintaining proper amino acid homeostasis in the body. 2. **Neurotransmitter transport**: SLC6A14 is also involved in the transport of neurotransmitters, such as glycine and GABA, across the plasma membrane, which is essential for regulating neuronal activity. 3. **Bile salt and organic acid transport**: SLC6A14 is involved in the transport of bile salts and organic acids across the plasma membrane, which is essential for maintaining proper lipid metabolism. 4. **Response to toxic substances**: SLC6A14 may play a role in the transport of toxic substances, such as heavy metals, across the plasma membrane, which is essential for maintaining proper cellular homeostasis. **Clinical Significance:** The dysfunction of SLC6A14 has been implicated in various immunological disorders, including: 1. **Obesity**: Variants of SLC6A14 have been associated with an increased risk of obesity, highlighting its potential role in regulating energy metabolism. 2. **Neurological disorders**: The dysfunction of SLC6A14 has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. 3. **Cancer**: SLC6A14 may play a role in the transport of amino acids across the plasma membrane, which is essential for cancer cell growth and proliferation. 4. **Infectious diseases**: The dysfunction of SLC6A14 may contribute to the development of infectious diseases, such as HIV/AIDS, by impairing the transport of amino acids across the plasma membrane. **Conclusion:** In conclusion, SLC6A14 is a critical gene that plays a pivotal role in the transport of various amino acids across the plasma membrane. Its dysfunction has been implicated in various immunological disorders, highlighting its potential as a therapeutic target for the treatment of these diseases. Further research is necessary to fully understand the mechanisms of SLC6A14 and its role in maintaining proper immunological function.

Genular Protein ID: 3352803796

Symbol: S6A14_HUMAN

Name: Amino acid transporter ATB0+

UniProtKB Accession Codes:

Q9UN76 Q5H942

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 63 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EMBL 7 EPD 1 Ensembl 1 GO 21 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 21 SAM 1 SMR 1 STRING 1 SUPFAM 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10446133

Title: Cloning and functional expression of a human Na(+) and Cl(-)-dependent neutral and cationic amino acid transporter B(0+).

PubMed ID: 10446133

DOI: 10.1074/jbc.274.34.23740

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17855766

Title: Transport of butyryl-L-carnitine, a potential prodrug, via the carnitine transporter OCTN2 and the amino acid transporter ATB(0,+).

PubMed ID: 17855766

DOI: 10.1152/ajpgi.00233.2007

PubMed ID: 18599538

Title: Human solute carrier SLC6A14 is the beta-alanine carrier.

PubMed ID: 18599538

DOI: 10.1113/jphysiol.2008.154500

PubMed ID: 14660737

Title: Do allelic variants of SLC6A14 predispose to obesity?

PubMed ID: 14660737

DOI: 10.1172/jci20448

PubMed ID: 14660752

Title: The SLC6A14 gene shows evidence of association with obesity.

PubMed ID: 14660752

DOI: 10.1172/jci17491

Sequence Information:

  • Length: 642
  • Mass: 72153
  • Checksum: E0FCDD5F173128C0
  • Sequence:
    • MDKLKCPSFF KCREKEKVSA SSENFHVGEN DENQDRGNWS KKSDYLLSMI GYAVGLGNVW 
RFPYLTYSNG GGAFLIPYAI MLALAGLPLF FLECSLGQFA SLGPVSVWRI LPLFQGVGIT 
MVLISIFVTI YYNVIIAYSL YYMFASFQSE LPWKNCSSWS DKNCSRSPIV THCNVSTVNK 
GIQEIIQMNK SWVDINNFTC INGSEIYQPG QLPSEQYWNK VALQRSSGMN ETGVIVWYLA 
LCLLLAWLIV GAALFKGIKS SGKVVYFTAL FPYVVLLILL VRGATLEGAS KGISYYIGAQ 
SNFTKLKEAE VWKDAATQIF YSLSVAWGGL VALSSYNKFK NNCFSDAIVV CLTNCLTSVF 
AGFAIFSILG HMAHISGKEV SQVVKSGFDL AFIAYPEALA QLPGGPFWSI LFFFMLLTLG 
LDSQFASIET ITTTIQDLFP KVMKKMRVPI TLGCCLVLFL LGLVCVTQAG IYWVHLIDHF 
CAGWGILIAA ILELVGIIWI YGGNRFIEDT EMMIGAKRWI FWLWWRACWF VITPILLIAI 
FIWSLVQFHR PNYGAIPYPD WGVALGWCMI VFCIIWIPIM AIIKIIQAKG NIFQRLISCC 
RPASNWGPYL EQHRGERYKD MVDPKKEADH EIPTVSGSRK PE

Genular Protein ID: 412790425

Symbol: B2R8J1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R8J1

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 4 GenomeRNAi 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SAM 2 SUPFAM 1

Sequence Information:

  • Length: 642
  • Mass: 72139
  • Checksum: CF347E5F17298BCA
  • Sequence:
    • MDKLKCPSFF KCREKEKVSA SSENFHVGEN DENQDRGNWS KKSDYLLSMI GYAVGLGNVW 
RFPYLTYSNG GGAFLIPYAI MLALAGLPLF FLECSLGQFA SLGPVSVWRI LPLFQGVGIT 
MVLISIFVTI YYNVIIAYSL YYMFASFQSE LPWKNCSSWS DKNCSRSPIV THCNVSTVNK 
GIQEIIQMNK SWVDINNFTC INGSEIYQPG QLPSEQYWNK VALQRSSGMN ETGVIVWYLA 
LCLLLAWLIV GAALFKGIKS SGKVVYFTAL FPYVVLLILL VRGATLEGAS KGISYYIGAQ 
SNFTKLKEAE VWKDAATQIF YSLSVAWGGL VALSSYNKFK NNCFSDAIVV CLTNCLTSVF 
AGFAIFSILG HMAHISGKEV SQVVKSGFDL AFIAYPEALA QLPGGPFWSI LFFFMLLTLG 
LDSQFASIET ITTTIQDLFP KVMKKMRVPI TLGCCLVLFL LGLVCVTQAG IYWVHLIDHF 
CAGWGILIAA ILELVGIIWI YGGNRFVEDT EMMIGAKRWI FWLWWRACWF VITPILLIAI 
FIWSLVQFHR PNYGAIPYPD WGVALGWCMI VFCIIWIPIM AIIKIIQAKG NIFQRLISCC 
RPASNWGPYL EQHRGERYKD MVDPKKEADH EIPTVSGSRK PE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.