Details for: TP53TG1

Gene ID: 11257

Symbol: TP53TG1

Ensembl ID: ENSG00000182165

Description: TP53 target 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **TP53 interaction**: TP53TG1 is a direct target of the tumor suppressor protein TP53, which is a key regulator of cell cycle and apoptosis. 2. **Cell type specificity**: TP53TG1 is expressed in various cell types, including those involved in the development and maintenance of the respiratory, urinary, and reproductive systems. 3. **Regulation of cell cycle**: TP53TG1 is involved in regulating cell cycle progression, particularly in the G1 phase, where it helps to prevent excessive cell proliferation. 4. **Apoptosis regulation**: TP53TG1 also plays a role in regulating apoptosis, a process of programmed cell death that helps to eliminate damaged or unwanted cells. **Pathways and Functions:** 1. **Cell cycle regulation**: TP53TG1 is involved in regulating the cell cycle by interacting with TP53 and other cell cycle regulators, such as p21 and p27. 2. **Apoptosis regulation**: TP53TG1 helps to regulate apoptosis by interacting with pro-apoptotic proteins, such as BAX and BAK, and anti-apoptotic proteins, such as BCL-2. 3. **DNA damage response**: TP53TG1 is involved in the DNA damage response, where it helps to repair DNA damage and prevent mutations that can lead to cancer. 4. **Tissue development and maintenance**: TP53TG1 is expressed in tissues involved in development and maintenance, such as the pancreas, bladder, and placenta, where it helps to regulate cell growth and differentiation. **Clinical Significance:** 1. **Cancer susceptibility**: Variants in the TP53TG1 gene have been associated with an increased risk of cancer, particularly in tissues where it is highly expressed. 2. **Genetic disorders**: TP53TG1 mutations have been implicated in genetic disorders, such as Li-Fraumeni syndrome, which is characterized by an increased risk of cancer. 3. **Regulatory T cells**: TP53TG1 is expressed in regulatory T cells, which play a crucial role in maintaining immune tolerance and preventing autoimmune diseases. 4. **Therapeutic targeting**: TP53TG1 is a potential therapeutic target for cancer therapy, as its inhibition can lead to the induction of apoptosis in cancer cells. In conclusion, the TP53TG1 gene is a critical regulator of cell cycle and apoptosis in various tissues, and its dysregulation has been implicated in cancer and genetic disorders. Further research is needed to fully understand the function and clinical significance of TP53TG1.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.