Details for: DUSP12

Gene ID: 11266

Symbol: DUSP12

Ensembl ID: ENSG00000081721

Description: dual specificity phosphatase 12

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.04
    Marker Score: 1,633
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.2
    Marker Score: 2,528
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,706
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,931
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,394
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.97
    Marker Score: 1,091
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,395
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.93
    Marker Score: 984
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.92
    Marker Score: 262
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 475
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,698
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.88
    Marker Score: 351
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,291
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.87
    Marker Score: 930
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.86
    Marker Score: 805
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.85
    Marker Score: 1,134
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.85
    Marker Score: 1,778
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4,779
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.84
    Marker Score: 11,027
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.83
    Marker Score: 878
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.83
    Marker Score: 456
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.83
    Marker Score: 523
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.82
    Marker Score: 517
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.82
    Marker Score: 2,234
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.81
    Marker Score: 9,466
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.81
    Marker Score: 272
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.78
    Marker Score: 7,883
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.78
    Marker Score: 2,118
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,264
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.77
    Marker Score: 1,302
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 585
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.76
    Marker Score: 410
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.76
    Marker Score: 764
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.75
    Marker Score: 352
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.74
    Marker Score: 556
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.74
    Marker Score: 4,805
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.74
    Marker Score: 1,500
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.73
    Marker Score: 531
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.73
    Marker Score: 233
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.73
    Marker Score: 350
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.73
    Marker Score: 484
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 371
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.72
    Marker Score: 746
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.71
    Marker Score: 422
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.71
    Marker Score: 885
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.7
    Marker Score: 2,610
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.7
    Marker Score: 477
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.7
    Marker Score: 1,651
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2,918
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 634
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.69
    Marker Score: 704
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.68
    Marker Score: 356
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.67
    Marker Score: 727
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.67
    Marker Score: 447
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.67
    Marker Score: 200
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.66
    Marker Score: 1,302
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.66
    Marker Score: 154
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.66
    Marker Score: 349
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.65
    Marker Score: 414
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.65
    Marker Score: 2,517
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.65
    Marker Score: 2,539
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.63
    Marker Score: 220
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.63
    Marker Score: 402
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.63
    Marker Score: 2,618
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.63
    Marker Score: 415
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.63
    Marker Score: 1,275
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.62
    Marker Score: 3,044
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.61
    Marker Score: 1,004
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.6
    Marker Score: 567
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.6
    Marker Score: 924
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.6
    Marker Score: 490
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.6
    Marker Score: 360
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.59
    Marker Score: 713
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.59
    Marker Score: 246
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.59
    Marker Score: 1,872
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.59
    Marker Score: 592
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.59
    Marker Score: 1,749
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.59
    Marker Score: 240
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.58
    Marker Score: 522
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.58
    Marker Score: 290
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.58
    Marker Score: 203
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.58
    Marker Score: 561
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.58
    Marker Score: 510
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.58
    Marker Score: 167
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.58
    Marker Score: 560
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.58
    Marker Score: 2,360
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.58
    Marker Score: 232
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.57
    Marker Score: 526
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.57
    Marker Score: 419
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.57
    Marker Score: 262
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 151
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.57
    Marker Score: 819
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.56
    Marker Score: 375
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.56
    Marker Score: 194
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.56
    Marker Score: 380
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.56
    Marker Score: 29,627
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.56
    Marker Score: 381

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DUSP12 is a unique member of the PTP family, characterized by its ability to dephosphorylate multiple phosphotyrosine and phosphoserine/threonine residues. This dual specificity phosphatase activity allows DUSP12 to modulate a wide range of signaling pathways, including those involved in cell proliferation, migration, and apoptosis. DUSP12 is also known to interact with various proteins, including kinases, receptor tyrosine kinases, and G-protein coupled receptors, further highlighting its importance in signal transduction. **Pathways and Functions:** DUSP12 is involved in several key signaling pathways, including: 1. **MAPK/ERK pathway**: DUSP12 dephosphorylates and inactivates the MAPK/ERK kinase, MEK, thereby regulating cell growth and differentiation. 2. **PI3K/AKT pathway**: DUSP12 dephosphorylates and activates the PI3K/AKT kinase, promoting cell survival and anti-apoptotic signaling. 3. **Wnt/β-catenin pathway**: DUSP12 regulates the activity of β-catenin, a key component of the Wnt signaling pathway, which is involved in cell proliferation and differentiation. 4. **G-protein coupled receptor signaling**: DUSP12 interacts with G-protein coupled receptors, modulating their signaling pathways and influencing cell behavior. DUSP12's functions are diverse, including: 1. **Cell growth regulation**: DUSP12 modulates cell growth and proliferation by regulating key signaling pathways. 2. **Apoptosis regulation**: DUSP12 influences apoptosis by dephosphorylating and inactivating pro-apoptotic kinases. 3. **Cell migration and invasion**: DUSP12 regulates cell migration and invasion by modulating signaling pathways involved in these processes. 4. **Neuroprotection**: DUSP12 has been implicated in neuroprotection, particularly in the context of neurodegenerative diseases. **Clinical Significance:** DUSP12's dysregulation has been implicated in various diseases, including: 1. **Cancer**: Overexpression of DUSP12 has been associated with cancer progression and poor prognosis. 2. **Neurodegenerative diseases**: DUSP12's role in neuroprotection has been explored in the context of Alzheimer's disease and Parkinson's disease. 3. **Immune disorders**: DUSP12 has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 4. **Cardiovascular disease**: DUSP12's involvement in signaling pathways has been linked to cardiovascular disease, including hypertension and atherosclerosis. In conclusion, DUSP12 is a multifunctional protein that plays a critical role in various cellular processes, including cell growth, differentiation, and survival. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its mechanisms of action and potential therapeutic targets.

Genular Protein ID: 2580530638

Symbol: DUS12_HUMAN

Name: Dual specificity protein phosphatase 12

UniProtKB Accession Codes:

Q9UNI6 Q5VXA8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 13 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 3 EMBL 4 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 2 PIRSF 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 Rhea 9 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10446167

Title: Identification of the human YVH1 protein-tyrosine phosphatase orthologue reveals a novel zinc binding domain essential for in vivo function.

PubMed ID: 10446167

DOI: 10.1074/jbc.274.34.23991

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24531476

Title: The family-wide structure and function of human dual-specificity protein phosphatases.

PubMed ID: 24531476

DOI: 10.1107/s1399004713029866

Sequence Information:

  • Length: 340
  • Mass: 37687
  • Checksum: 56B52192B42C73EB
  • Sequence:
    • MLEAPGPSDG CELSNPSASR VSCAGQMLEV QPGLYFGGAA AVAEPDHLRE AGITAVLTVD 
SEEPSFKAGP GVEDLWRLFV PALDKPETDL LSHLDRCVAF IGQARAEGRA VLVHCHAGVS 
RSVAIITAFL MKTDQLPFEK AYEKLQILKP EAKMNEGFEW QLKLYQAMGY EVDTSSAIYK 
QYRLQKVTEK YPELQNLPQE LFAVDPTTVS QGLKDEVLYK CRKCRRSLFR SSSILDHREG 
SGPIAFAHKR MTPSSMLTTG RQAQCTSYFI EPVQWMESAL LGVMDGQLLC PKCSAKLGSF 
NWYGEQCSCG RWITPAFQIH KNRVDEMKIL PVLGSQTGKI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.