Details for: SNF8

Gene ID: 11267

Symbol: SNF8

Ensembl ID: ENSG00000159210

Description: SNF8 subunit of ESCRT-II

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.98
    Marker Score: 2,395
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.94
    Marker Score: 4,427
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.92
    Marker Score: 2,152
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.69
    Marker Score: 6,647
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.68
    Marker Score: 6,215
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.67
    Marker Score: 7,193
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.66
    Marker Score: 2,446
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.63
    Marker Score: 7,821
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.62
    Marker Score: 1,726
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.6
    Marker Score: 55,527
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.6
    Marker Score: 3,336
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.59
    Marker Score: 16,135
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.59
    Marker Score: 1,680
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.59
    Marker Score: 6,498
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.57
    Marker Score: 13,491
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.56
    Marker Score: 1,954
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.55
    Marker Score: 977
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.54
    Marker Score: 1,030
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.54
    Marker Score: 1,450
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.53
    Marker Score: 844
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.53
    Marker Score: 39,181
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.52
    Marker Score: 3,569
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.51
    Marker Score: 16,957
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.5
    Marker Score: 2,491
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.48
    Marker Score: 5,250
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.45
    Marker Score: 2,471
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.43
    Marker Score: 2,687
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.42
    Marker Score: 702
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.41
    Marker Score: 8,984
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.41
    Marker Score: 330
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.41
    Marker Score: 3,193
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.4
    Marker Score: 3,334
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.38
    Marker Score: 2,200
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.38
    Marker Score: 577
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.37
    Marker Score: 2,422
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.37
    Marker Score: 18,020
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.37
    Marker Score: 645
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.37
    Marker Score: 5,265
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.37
    Marker Score: 307
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.36
    Marker Score: 10,646
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.36
    Marker Score: 458
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.36
    Marker Score: 701
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.36
    Marker Score: 393
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.36
    Marker Score: 1,453
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.36
    Marker Score: 1,378
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.36
    Marker Score: 3,420
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.35
    Marker Score: 919
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.35
    Marker Score: 1,406
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.34
    Marker Score: 464
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.34
    Marker Score: 625
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.34
    Marker Score: 503
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.33
    Marker Score: 838
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.33
    Marker Score: 472
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.33
    Marker Score: 317
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.33
    Marker Score: 2,131
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.32
    Marker Score: 3,595
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.31
    Marker Score: 430
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.29
    Marker Score: 1,861
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.29
    Marker Score: 11,181
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.28
    Marker Score: 1,974
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.28
    Marker Score: 682
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.27
    Marker Score: 475
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.27
    Marker Score: 926
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.27
    Marker Score: 359
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.26
    Marker Score: 3,382
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.26
    Marker Score: 1,188
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.25
    Marker Score: 603
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.25
    Marker Score: 1,718
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.25
    Marker Score: 69,793
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.25
    Marker Score: 9,269
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.24
    Marker Score: 1,336
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.24
    Marker Score: 538
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.23
    Marker Score: 701
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.22
    Marker Score: 1,395
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.21
    Marker Score: 300
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.21
    Marker Score: 493
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.21
    Marker Score: 41,128
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.2
    Marker Score: 346
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.2
    Marker Score: 712
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.2
    Marker Score: 1,147
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.19
    Marker Score: 1,191
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.18
    Marker Score: 352
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.18
    Marker Score: 3,253
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.17
    Marker Score: 2,853
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.17
    Marker Score: 1,042
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.17
    Marker Score: 11,738
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 1.17
    Marker Score: 373
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.16
    Marker Score: 369
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.16
    Marker Score: 1,796
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.16
    Marker Score: 307
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.16
    Marker Score: 295
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.15
    Marker Score: 368
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.14
    Marker Score: 455
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.14
    Marker Score: 1,147
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.13
    Marker Score: 2,155
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.13
    Marker Score: 1,204
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.13
    Marker Score: 401
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.13
    Marker Score: 565
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.13
    Marker Score: 1,189
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.13
    Marker Score: 252

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SNF8 is a protein that belongs to the sorting nexin family, which is characterized by its ability to regulate membrane trafficking and protein sorting. SNF8 is specifically involved in the ESCRT-II complex, which is responsible for the formation and maturation of multivesicular bodies (MVBs). MVBs are membrane-bound vesicles that are involved in the sorting and degradation of proteins and lipids. SNF8's role in the ESCRT-II complex suggests that it plays a critical part in regulating the endocytic pathway and maintaining cellular membrane homeostasis. **Pathways and Functions** SNF8 is involved in multiple cellular pathways, including: 1. **Endocytic recycling**: SNF8 regulates the sorting and degradation of proteins and lipids within the endocytic pathway. 2. **Exosomal secretion**: SNF8 is involved in the regulation of exosomal secretion, which is critical for the transmission of proteins and lipids between cells. 3. **Autophagy**: SNF8 plays a role in regulating autophagy, a process by which cells recycle damaged or dysfunctional proteins and lipids. 4. **Viral infection**: SNF8 is involved in the regulation of viral infection pathways, including the formation and maturation of MVBs that are used to sort and degrade viral proteins. 5. **Regulation of transcription**: SNF8 regulates the activity of RNA polymerase II, which is involved in the transcription of genes. **Clinical Significance** Dysregulation of SNF8 has been implicated in various diseases, including: 1. **Cancer**: SNF8 mutations have been identified in various types of cancer, including breast, lung, and colon cancer. 2. **Neurodegenerative diseases**: SNF8 has been implicated in the regulation of protein degradation and clearance in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Infectious diseases**: SNF8 plays a critical role in regulating viral infection pathways, making it a potential target for the treatment of viral infections. In conclusion, SNF8 is a critical protein that plays a key role in regulating various cellular pathways, including endocytic recycling, exosomal secretion, autophagy, and viral infection. Its dysregulation has been implicated in various diseases, highlighting the importance of SNF8 in maintaining cellular homeostasis and responding to environmental changes.

Genular Protein ID: 657588429

Symbol: SNF8_HUMAN

Name: Vacuolar-sorting protein SNF8

UniProtKB Accession Codes:

Q96H20 Q8IXY3 Q9UN50

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 3 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 30 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10419521

Title: Cloning and characterization of the EAP30 subunit of the ELL complex that confers derepression of transcription by RNA polymerase II.

PubMed ID: 10419521

DOI: 10.1074/jbc.274.31.21981

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14505570

Title: The protein network of HIV budding.

PubMed ID: 14505570

DOI: 10.1016/s0092-8674(03)00714-1

PubMed ID: 14519844

Title: Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins.

PubMed ID: 14519844

DOI: 10.1073/pnas.2133846100

PubMed ID: 16857164

Title: RILP interacts with the VPS22 component of the ESCRT-II complex.

PubMed ID: 16857164

DOI: 10.1016/j.bbrc.2006.07.007

PubMed ID: 17010938

Title: RILP interacts with VPS22 and VPS36 of ESCRT-II and regulates their membrane recruitment.

PubMed ID: 17010938

DOI: 10.1016/j.bbrc.2006.09.064

PubMed ID: 16260042

Title: Rapid identification of 14-3-3-binding proteins by protein microarray analysis.

PubMed ID: 16260042

DOI: 10.1016/j.jneumeth.2005.09.015

PubMed ID: 16973552

Title: Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release.

PubMed ID: 16973552

DOI: 10.1128/jvi.01049-06

PubMed ID: 17959629

Title: RILP is required for the proper morphology and function of late endosomes.

PubMed ID: 17959629

DOI: 10.1242/jcs.017301

PubMed ID: 17714434

Title: Vps22/EAP30 in ESCRT-II mediates endosomal sorting of growth factor and chemokine receptors destined for lysosomal degradation.

PubMed ID: 17714434

DOI: 10.1111/j.1600-0854.2007.00630.x

PubMed ID: 18031739

Title: Differential functions of Hrs and ESCRT proteins in endocytic membrane trafficking.

PubMed ID: 18031739

DOI: 10.1016/j.yexcr.2007.10.014

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22660413

Title: Syndecan-syntenin-ALIX regulates the biogenesis of exosomes.

PubMed ID: 22660413

DOI: 10.1038/ncb2502

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 18539118

Title: Integrated structural model and membrane targeting mechanism of the human ESCRT-II complex.

PubMed ID: 18539118

DOI: 10.1016/j.devcel.2008.04.004

Sequence Information:

  • Length: 258
  • Mass: 28864
  • Checksum: FD6CBA6BC0A4485E
  • Sequence:
    • MHRRGVGAGA IAKKKLAEAK YKERGTVLAE DQLAQMSKQL DMFKTNLEEF ASKHKQEIRK 
NPEFRVQFQD MCATIGVDPL ASGKGFWSEM LGVGDFYYEL GVQIIEVCLA LKHRNGGLIT 
LEELHQQVLK GRGKFAQDVS QDDLIRAIKK LKALGTGFGI IPVGGTYLIQ SVPAELNMDH 
TVVLQLAEKN GYVTVSEIKA SLKWETERAR QVLEHLLKEG LAWLDLQAPG EAHYWLPALF 
TDLYSQEITA EEAREALP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.