Details for: DDX19B

Gene ID: 11269

Symbol: DDX19B

Ensembl ID: ENSG00000157349

Description: DEAD-box helicase 19B

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.17
    Marker Score: 71,855
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.13
    Marker Score: 9,675
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.12
    Marker Score: 10,674
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.07
    Marker Score: 2,031
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.07
    Marker Score: 10,019
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.04
    Marker Score: 4,016
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.03
    Marker Score: 38,027
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.02
    Marker Score: 16,021
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.01
    Marker Score: 15,066
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.01
    Marker Score: 7,719
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,720
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,944
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,397
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.96
    Marker Score: 36,488
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,398
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 478
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 434
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.92
    Marker Score: 1,417
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.91
    Marker Score: 18,177
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,703
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5,117
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.87
    Marker Score: 365
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5,238
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.84
    Marker Score: 595
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.83
    Marker Score: 717
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.83
    Marker Score: 1,746
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.8
    Marker Score: 479
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.79
    Marker Score: 1,280
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.76
    Marker Score: 1,788
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.75
    Marker Score: 1,112
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.75
    Marker Score: 3,125
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 567
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 295
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 373
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.71
    Marker Score: 1,266
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.71
    Marker Score: 753
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.71
    Marker Score: 3,483
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.71
    Marker Score: 193
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2,897
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.69
    Marker Score: 1,396
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.67
    Marker Score: 405
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.67
    Marker Score: 1,648
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.66
    Marker Score: 602
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.66
    Marker Score: 1,371
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.65
    Marker Score: 2,520
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.65
    Marker Score: 13,837
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.64
    Marker Score: 200
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.64
    Marker Score: 129
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.62
    Marker Score: 2,998
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.62
    Marker Score: 611
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.6
    Marker Score: 410
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.59
    Marker Score: 1,629
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.58
    Marker Score: 207
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.58
    Marker Score: 926
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.58
    Marker Score: 987
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.58
    Marker Score: 319
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.57
    Marker Score: 431
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.57
    Marker Score: 383
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.57
    Marker Score: 379
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 239
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.57
    Marker Score: 686
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.57
    Marker Score: 637
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.56
    Marker Score: 601
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.56
    Marker Score: 181
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.56
    Marker Score: 2,205
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.56
    Marker Score: 358
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.56
    Marker Score: 2,394
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.55
    Marker Score: 2,263
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.55
    Marker Score: 388
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.54
    Marker Score: 1,106
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.54
    Marker Score: 559
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.53
    Marker Score: 426
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.53
    Marker Score: 301
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.53
    Marker Score: 130
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.53
    Marker Score: 116
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.52
    Marker Score: 468
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.52
    Marker Score: 2,741
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.52
    Marker Score: 114
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.52
    Marker Score: 487
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.52
    Marker Score: 121
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.52
    Marker Score: 190
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.51
    Marker Score: 244
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.51
    Marker Score: 822
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.51
    Marker Score: 538
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.51
    Marker Score: 293
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.51
    Marker Score: 114
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.51
    Marker Score: 99
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.5
    Marker Score: 526
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.5
    Marker Score: 116
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.5
    Marker Score: 267
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.5
    Marker Score: 311
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.5
    Marker Score: 206
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.5
    Marker Score: 3,159
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.49
    Marker Score: 1,206
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.49
    Marker Score: 357
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.49
    Marker Score: 147
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.49
    Marker Score: 12,540
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.49
    Marker Score: 117

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DDX19B is a member of the DEAD-box helicase family, characterized by its ATP-dependent RNA helicase activity. This enzyme is involved in unwinding RNA secondary structures, facilitating mRNA export from the nucleus, and regulating RNA translation. DDX19B is predominantly expressed in neuronal cells, with high levels of expression observed in L2/3-6 intratelencephalic projecting glutamatergic neurons, corticothalamic-projecting glutamatergic cortical neurons, and GABAergic cortical interneurons. The gene's expression pattern suggests a specific role in regulating neuronal excitability and synaptic transmission. **Pathways and Functions:** DDX19B is implicated in various cellular pathways, including: 1. **ATP-dependent RNA helicase activity:** DDX19B unwinds RNA secondary structures, facilitating mRNA export from the nucleus and regulating RNA translation. 2. **Cytoplasmic stress granule assembly:** DDX19B is involved in the formation and disassembly of cytoplasmic stress granules, which regulate mRNA translation and stress response. 3. **RNA export from the nucleus:** DDX19B facilitates the export of mRNA from the nucleus to the cytoplasm, regulating gene expression and protein synthesis. 4. **Protein binding:** DDX19B interacts with various proteins, including RNA-binding proteins and histone chaperones, to regulate gene expression and chromatin remodeling. **Clinical Significance:** DDX19B's role in neuronal development and function has significant implications for the diagnosis and treatment of neurodegenerative diseases. Alterations in DDX19B expression have been linked to: 1. **Neurodevelopmental disorders:** Mutations in DDX19B have been associated with neurodevelopmental disorders, such as autism spectrum disorder and intellectual disability. 2. **Neurodegenerative diseases:** DDX19B's involvement in regulating neuronal excitability and synaptic transmission suggests its potential role in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 3. **Cancer:** DDX19B's expression in cardiac muscle myoblasts and cardiac endothelial cells highlights its potential role in cancer development and progression. In conclusion, DDX19B is a crucial gene involved in various cellular processes, including RNA helicase activity, mRNA export from the nucleus, and cytoplasmic stress granule assembly. Its specific expression pattern in neuronal cells suggests a pivotal role in regulating neuronal excitability, synaptic transmission, and neurodegenerative diseases. Further studies are necessary to fully elucidate the molecular mechanisms underlying DDX19B's functions and its clinical significance.

Genular Protein ID: 2306437495

Symbol: DD19B_HUMAN

Name: ATP-dependent RNA helicase DDX19B

UniProtKB Accession Codes:

Q9UMR2 B3KNE9 B4DXS6 E7EMK4 Q6FIB7 Q6IAE0 Q96KE7 Q9H0U0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChEBI 9 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EC 1 EMBL 16 EPD 1 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 9 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 RefSeq 8 Rhea 1 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10428971

Title: Dbp5, a DEAD-box protein required for mRNA export, is recruited to the cytoplasmic fibrils of nuclear pore complex via a conserved interaction with CAN/Nup159p.

PubMed ID: 10428971

DOI: 10.1093/emboj/18.15.4332

PubMed ID: 12219940

Title: Identification and characterization of a gene coding a novel isoform of DEAD-box protein.

PubMed ID: 12219940

DOI: 10.1071/rd01028

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 19244245

Title: The DEXD/H-box RNA helicase DDX19 is regulated by an alpha-helical switch.

PubMed ID: 19244245

DOI: 10.1074/jbc.c900018200

PubMed ID: 19219046

Title: The mRNA export protein DBP5 binds RNA and the cytoplasmic nucleoporin NUP214 in a mutually exclusive manner.

PubMed ID: 19219046

DOI: 10.1038/nsmb.1561

PubMed ID: 19208808

Title: Structural and functional analysis of the interaction between the nucleoporin Nup214 and the DEAD-box helicase Ddx19.

PubMed ID: 19208808

DOI: 10.1073/pnas.0813267106

Sequence Information:

  • Length: 479
  • Mass: 53927
  • Checksum: 8F6F93B12B7E9871
  • Sequence:
    • MATDSWALAV DEQEAAAESL SNLHLKEEKI KPDTNGAVVK TNANAEKTDE EEKEDRAAQS 
LLNKLIRSNL VDNTNQVEVL QRDPNSPLYS VKSFEELRLK PQLLQGVYAM GFNRPSKIQE 
NALPLMLAEP PQNLIAQSQS GTGKTAAFVL AMLSQVEPAN KYPQCLCLSP TYELALQTGK 
VIEQMGKFYP ELKLAYAVRG NKLERGQKIS EQIVIGTPGT VLDWCSKLKF IDPKKIKVFV 
LDEADVMIAT QGHQDQSIRI QRMLPRNCQM LLFSATFEDS VWKFAQKVVP DPNVIKLKRE 
EETLDTIKQY YVLCSSRDEK FQALCNLYGA ITIAQAMIFC HTRKTASWLA AELSKEGHQV 
ALLSGEMMVE QRAAVIERFR EGKEKVLVTT NVCARGIDVE QVSVVINFDL PVDKDGNPDN 
ETYLHRIGRT GRFGKRGLAV NMVDSKHSMN ILNRIQEHFN KKIERLDTDD LDEIEKIAN

Genular Protein ID: 2848013578

Symbol: B4DL69_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DL69

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 4 GO 3 Gene3D 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 2 RefSeq 1 SMART 2 SUPFAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 328
  • Mass: 37356
  • Checksum: 7135EB3FEC13C52C
  • Sequence:
    • MLSQVEPANK YPQCLCLSPT YELALQTGKV IEQMGKFYPE LKLAYAVRGN KLERGQKISE 
QIVIGTPGTV LDWCSKLKFI DPKKIKVFVL DEADVMIATQ GHQDQSIRIQ RMLPRNCQML 
LFSATFEDSV WKFAQKVVPD PNVIKLKREE ETLDTIKQYY VLCSSRDEKF QALCNLYGAI 
TIAQAMIFCH TRKTASWLAA ELSKEGHQVA LLSGEMMVEQ RAAVIERFRE GKEKVLVTTN 
VCARGIDVEQ VSVVINFDLP VDKDGNPDNE TYLHRIGRTG RFGKRGLAVN MVDSKHSMNI 
LNRIQEHFNK KIERLDTDDL DEIEKIAN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.