Details for: ATXN2L

Gene ID: 11273

Symbol: ATXN2L

Ensembl ID: ENSG00000168488

Description: ataxin 2 like

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.82
    Marker Score: 8,935
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.51
    Marker Score: 51,272
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.49
    Marker Score: 625
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.31
    Marker Score: 80,376
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.25
    Marker Score: 1,929
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.24
    Marker Score: 11,692
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.23
    Marker Score: 10,561
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.23
    Marker Score: 5,002
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.23
    Marker Score: 1,322
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.22
    Marker Score: 11,633
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.21
    Marker Score: 422
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.2
    Marker Score: 4,443
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.19
    Marker Score: 43,951
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.17
    Marker Score: 4,539
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.17
    Marker Score: 371
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.17
    Marker Score: 852
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.17
    Marker Score: 319
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.17
    Marker Score: 703
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.15
    Marker Score: 1,222
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.15
    Marker Score: 6,802
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.11
    Marker Score: 42,080
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.11
    Marker Score: 3,106
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.11
    Marker Score: 11,432
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.1
    Marker Score: 275
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.08
    Marker Score: 1,065
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.07
    Marker Score: 1,148
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.07
    Marker Score: 10,859
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.06
    Marker Score: 378
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.06
    Marker Score: 15,874
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.04
    Marker Score: 20,771
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.03
    Marker Score: 7,915
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.03
    Marker Score: 365
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.03
    Marker Score: 566
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.03
    Marker Score: 7,646
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.02
    Marker Score: 4,247
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.02
    Marker Score: 679
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.01
    Marker Score: 3,001
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.01
    Marker Score: 1,485
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.01
    Marker Score: 565
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.01
    Marker Score: 682
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1
    Marker Score: 627
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1
    Marker Score: 351
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,612
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.99
    Marker Score: 302
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,836
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.99
    Marker Score: 999
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.98
    Marker Score: 2,402
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.98
    Marker Score: 55,017
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.98
    Marker Score: 668
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.98
    Marker Score: 476
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,377
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.97
    Marker Score: 420
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.97
    Marker Score: 336
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.97
    Marker Score: 904
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.96
    Marker Score: 1,015
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.96
    Marker Score: 905
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.96
    Marker Score: 2,610
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.96
    Marker Score: 9,649
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.96
    Marker Score: 385
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.95
    Marker Score: 20,170
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.94
    Marker Score: 225
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,384
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.94
    Marker Score: 14,679
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.92
    Marker Score: 319
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.92
    Marker Score: 274
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.91
    Marker Score: 803
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.91
    Marker Score: 768
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.91
    Marker Score: 992
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.91
    Marker Score: 370
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.91
    Marker Score: 2,468
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.9
    Marker Score: 682
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.9
    Marker Score: 279
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.9
    Marker Score: 196
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.89
    Marker Score: 2,679
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.89
    Marker Score: 2,224
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.89
    Marker Score: 669
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.89
    Marker Score: 895
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5,076
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.89
    Marker Score: 564
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.89
    Marker Score: 444
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.88
    Marker Score: 232
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,292
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.87
    Marker Score: 581
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 312
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.87
    Marker Score: 710
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.86
    Marker Score: 793
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.86
    Marker Score: 360
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.86
    Marker Score: 584
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.86
    Marker Score: 225
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.85
    Marker Score: 887
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.85
    Marker Score: 210
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.85
    Marker Score: 476
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.85
    Marker Score: 5,499
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.84
    Marker Score: 714
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.84
    Marker Score: 854
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.84
    Marker Score: 1,184
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.83
    Marker Score: 244
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.83
    Marker Score: 998

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular Expression Patterns:** ATXN2L exhibits a wide range of expression in various cell types, including myoepithelial cells of the mammary gland, fibroblasts, retinal ganglion cells, and glutamatergic cortical neurons. This diverse expression pattern suggests that ATXN2L may play a multifaceted role in cellular biology. 2. **Protein Interactions:** The ATXN2L protein, also known as Ataxin-2-like protein, has been associated with various protein interactions, including cadherin binding, cytoplasmic stress granule formation, and mRNA binding. These interactions highlight the importance of ATXN2L in maintaining cellular organization and function. 3. **Pathway Involvement:** ATXN2L is implicated in multiple cellular pathways, including cadherin binding, cytoplasmic stress granule assembly, and mRNA metabolic processes. These pathways underscore the gene's role in maintaining cellular homeostasis and function. **Pathways and Functions:** 1. **Cadherin Binding:** ATXN2L interacts with cadherin proteins, which are crucial for maintaining cell-cell adhesion and tissue structure. This interaction highlights the gene's role in regulating cellular architecture and function. 2. **Cytoplasmic Stress Granule Assembly:** ATXN2L is involved in the formation of cytoplasmic stress granules, which are dynamic structures that regulate mRNA translation and cellular stress responses. This function underscores the gene's role in maintaining cellular homeostasis and responding to stress. 3. **mRNA Binding:** ATXN2L binds to mRNA, regulating its translation and stability. This function highlights the gene's role in controlling gene expression and maintaining cellular homeostasis. 4. **Stress Granule Assembly:** ATXN2L is involved in the assembly of stress granules, which are dynamic structures that regulate mRNA translation and cellular stress responses. This function underscores the gene's role in maintaining cellular homeostasis and responding to stress. **Clinical Significance:** 1. **Neurological Disorders:** The expression of ATXN2L in retinal ganglion cells and glutamatergic cortical neurons suggests a potential role in neurological disorders, such as neurodegenerative diseases. 2. **Reproductive Disorders:** The expression of ATXN2L in myoepithelial cells of the mammary gland and Leydig cells suggests a potential role in reproductive disorders, such as infertility and endocrine dysregulation. 3. **Cancer Association:** The involvement of ATXN2L in various cellular pathways, including mRNA binding and stress granule assembly, raises the possibility of its association with cancer development and progression. 4. **Therapeutic Implications:** Further studies on ATXN2L's role in cellular biology and disease may lead to the development of novel therapeutic strategies targeting this gene and its associated pathways. In conclusion, the ATXN2L gene, with its diverse cellular expression patterns and involvement in multiple cellular pathways, holds significant promise for our understanding of cellular biology and disease. Further research on this gene and its associated pathways may lead to the development of novel therapeutic strategies and a deeper understanding of its role in maintaining cellular homeostasis and function.

Genular Protein ID: 1608903510

Symbol: ATX2L_HUMAN

Name: Ataxin-2-like protein

UniProtKB Accession Codes:

Q8WWM7 A8K1R6 B9EGM2 E9PAR9 O95135 Q63ZY4 Q6NVJ8 Q6PJW6 Q8IU61 Q8IU95 Q8WWM3 Q8WWM4 Q8WWM5 Q8WWM6 Q99703

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CTD 1 ChiTaRS 1 DMDM 1 DisGeNET 1 EMBL 20 EPD 1 Ensembl 6 ExpressionAtlas 1 GO 9 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 9 Pumba 1 RNAct 1 RefSeq 7 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11784712

Title: Cloning and characterization of a family of proteins associated with Mpl.

PubMed ID: 11784712

DOI: 10.1074/jbc.m105970200

PubMed ID: 14769358

Title: Identification and expression of the gene for human ataxin-2-related protein on chromosome 16.

PubMed ID: 14769358

DOI: 10.1016/s0014-4886(03)00287-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8896555

Title: Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2.

PubMed ID: 8896555

DOI: 10.1038/ng1196-269

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23209657

Title: Ataxin-2-like is a regulator of stress granules and processing bodies.

PubMed ID: 23209657

DOI: 10.1371/journal.pone.0050134

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25748791

Title: PRMT1-mediated arginine methylation controls ATXN2L localization.

PubMed ID: 25748791

DOI: 10.1016/j.yexcr.2015.02.022

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 1075
  • Mass: 113374
  • Checksum: 805E8B02E853C20E
  • Sequence:
    • MLKPQPLQQP SQPQQPPPTQ QAVARRPPGG TSPPNGGLPG PLATSAAPPG PPAAASPCLG 
PVAAAGSGLR RGAEGILAPQ PPPPQQHQER PGAAAIGSAR GQSTGKGPPQ SPVFEGVYNN 
SRMLHFLTAV VGSTCDVKVK NGTTYEGIFK TLSSKFELAV DAVHRKASEP AGGPRREDIV 
DTMVFKPSDV MLVHFRNVDF NYATKDKFTD SAIAMNSKVN GEHKEKVLQR WEGGDSNSDD 
YDLESDMSNG WDPNEMFKFN EENYGVKTTY DSSLSSYTVP LEKDNSEEFR QRELRAAQLA 
REIESSPQYR LRIAMENDDG RTEEEKHSAV QRQGSGRESP SLASREGKYI PLPQRVREGP 
RGGVRCSSSR GGRPGLSSLP PRGPHHLDNS SPGPGSEARG INGGPSRMSP KAQRPLRGAK 
TLSSPSNRPS GETSVPPPPA VGRMYPPRSP KSAAPAPISA SCPEPPIGSA VPTSSASIPV 
TSSVSDPGVG SISPASPKIS LAPTDVKELS TKEPGRTLEP QELARIAGKV PGLQNEQKRF 
QLEELRKFGA QFKLQPSSSP ENSLDPFPPR ILKEEPKGKE KEVDGLLTSE PMGSPVSSKT 
ESVSDKEDKP PLAPSGGTEG PEQPPPPCPS QTGSPPVGLI KGEDKDEGPV AEQVKKSTLN 
PNAKEFNPTK PLLSVNKSTS TPTSPGPRTH STPSIPVLTA GQSGLYSPQY ISYIPQIHMG 
PAVQAPQMYP YPVSNSVPGQ QGKYRGAKGS LPPQRSDQHQ PASAPPMMQA AAAAGPPLVA 
ATPYSSYIPY NPQQFPGQPA MMQPMAHYPS QPVFAPMLQS NPRMLTSGSH PQAIVSSSTP 
QYPSAEQPTP QALYATVHQS YPHHATQLHA HQPQPATTPT GSQPQSQHAA PSPVQHQAGQ 
APHLGSGQPQ QNLYHPGALT GTPPSLPPGP SAQSPQSSFP QPAAVYAIHH QQLPHGFTNM 
AHVTQAHVQT GITAAPPPHP GAPHPPQVML LHPPQSHGGP PQGAVPQSGV PALSASTPSP 
YPYIGHPQGE QPGQAPGFPG GADDRIREFS LAGGIWHGRA EGLQVGQDAR VLGGE

Genular Protein ID: 1142715268

Symbol: H3BUF6_HUMAN

Name: N/A

UniProtKB Accession Codes:

H3BUF6

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 EMBL 3 EPD 2 Ensembl 2 ExpressionAtlas 1 GO 2 GeneTree 1 GenomeRNAi 1 HGNC 1 IntAct 1 InterPro 5 MINT 1 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 1068
  • Mass: 112714
  • Checksum: 62189D66828C4AD1
  • Sequence:
    • MLKPQPLQQP SQPQQPPPTQ QAVARRPPGG TSPPNGGLPG PLATSAAPPG PPAAASPCLG 
PVAAAGSGLR RGAEGILAPQ PPPPQQHQER PGAAAIGSAR GQSTGKGPPQ SPVFEGVYNN 
SRMLHFLTAV VGSTCDVKVK NGTTYEGIFK TLSSKFELAV DAVHRKASEP AGGPRREDIV 
DTMVFKPSDV MLVHFRNVDF NYATKDKFTD SAIAMNSKVN GEHKEKVLQR WEGGDSNSDD 
YDLESDMSNG WDPNEMFKFN EENYGVKTTY DSSLSSYTVP LEKDNSEEFR QRELRAAQLA 
REIESSPQYR LRIAMENDDG RTEEEKHSAV QRQGSGRESP SLASREGKYI PLPQRVREGP 
RGGVRCSSSR GGRPGLSSLP PRGPHHLDNS SPGPGSEARG INGGPSRMSP KAQRPLRGAK 
TLSSPSNRPS GETSVPPPPA APPFLPVGRM YPPRSPKSAA PAPISASCPE PPIGSAVPTS 
SASIPVTSSV SDPGVGSISP ASPKISLAPT DVKELSTKEP GRTLEPQELA RIAGKVPGLQ 
NEQKRFQLEE LRKFGAQFKL QPSSSPENSL DPFPPRILKE EPKGKEKEVD GLLTSEPMGS 
PVSSKTESVS DKEDKPPLAP SGGTEGPEQP PPPCPSQTGS PPVGLIKGED KDEGPVAEQV 
KKSTLNPNAK EFNPTKPLLS VNKSTSTPTS PGPRTHSTPS IPVLTAGQSG LYSPQYISYI 
PQIHMGPAVQ APQMYPYPVS NSVPGQQGKY RGAKGSLPPQ RSDQHQPASA PPMMQAAAAA 
GPPLVAATPY SSYIPYNPQQ FPGQPAMMQP MAHYPSQPVF APMLQSNPRM LTSGSHPQAI 
VSSSTPQYPS AEQPTPQALY ATVHQSYPHH ATQLHAHQPQ PATTPTGSQP QSQHAAPSPV 
QHQAGQAPHL GSGQPQQNLY HPGALTGTPP SLPPGPSAQS PQSSFPQPAA VYAIHHQQLP 
HGFTNMAHVT QAHVQTGITA APPPHPGAPH PPQVMLLHPP QSHGGPPQGA VPQSGVPALS 
ASTPSPYPYI GHPQGEQPGQ APGFPGGADD RILQSHPSQQ LPFHPPGN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.